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Journal Syifa Sciences and Clinical Research (JSSCR)
Published by Universitas Negeri Gorontalo
ISSN : 26568187     EISSN : 26569612     DOI : 10.37311/jsscr
Core Subject : Health, Science,
Chemistry Medicine & Pharmacology
Journal Syifa Sciences & Clinical Research (JSSCR) is a national journal intended as a communication forum for scientists from many practitioners who use Pharmacology Development in research.
Arjuna Subject : -
Articles 196 Documents
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Analysis of Hydroquinone Content in Whitening Cream by Spectrophotometry UV-Vis Method Efprio Nensa Kurniawan; Fajar Nugraha; Hadi Kurniawan
Journal Syifa Sciences and Clinical Research Vol 4, No 3 (2022): Volume 4 Edisi 3 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i3.15285

Abstract

Hydroquinone is an ingredient that is often added in whitening creams with the aim of whitening the skin. According to BPOM Regulation No.23 of 2019, hydroquinone has been banned from its use as a bleach or lightener in cosmetics. The use of hydroquinone can only be used for nails with a level of 0.02%, as well as hair dye oxidizers with a maximum level of 0.3%. The mechanism of hydroquinone in whitening the skin is the toxic effect of hydroquinone on melanocytes, and through inhibition of the process of melanin formation. This study aims to identify and determine the levels of hydroquinone contained in whitening creams circulating in Pontianak City. The research method used in this study is descriptive non-experimental, where as many as 10 samples of whitening cream circulating in Pontianak City were obtained using purposive sampling techniques. Identification of hydroquinone is carried out qualitatively using FeCl3 1% reagent, and benedict reagent. Determination of hydroquinone levels in the sample is done quantitatively using a UV-Vis spectrophotometer. Based on the calculation of validation parameters, the equation y = 0.0251x – 0.0029, linearity value with relation coefficient (r) of 0.9999, %recovery of 100.15%, precision with a value of %RSD of 0.4899%, LOD of 0.2742 ppm and LOQ of 0.9140 ppm. Based on the results obtained, as many as 8 samples of positive whitening creams contained hydroquinone with a sample level of A of 3.1630%; sample B of 2.7322%; C sample of 2.5335%; sample D of 2.3216%; G sample is 2.5118%; H sample of 3.3171%; sample I was 2.4409 and sample J was 0.5571%.
Senyawa Antidiabetes Fraksi Aktif Daun Ketapang (Terminalia catappa L.) Hamsidar Hasan; Endah Nurrohwinta Djuwarno; Hasrita Samudi; Widy Susanti Abdulkadir; Faramita Hiola
Journal Syifa Sciences and Clinical Research Vol 4, No 2 (2022): Volume 4 Edisi 2 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i2.15656

Abstract

Antidiabetic is a compound that has a vital role in treating diabetes mellitus. Diabetes mellitus is a chronic metabolic disorder that is characterized by an increase in blood sugar levels. The use of traditional medicine is relatively cheaper and safer compared to synthetic drugs. One of the plants that is often used in traditional herbal medicine is ketapang (Terminalia catappa L.) because it contains a secondary metabolite compound that acts as an antidiabetic. Thus, this present study aimed to determine the n-hexane, ethyl acetate, and methanol extracts that had antidiabetic efficacy on blood sugar levels and compound group that acts as antidiabetic. The research employed mehods of multiple maceration, phytochemical screening, thin layer chromatography, and antidiabetic test, while the most effective antidiabetic efficacy was then continued to the fractionation stage using vacuum liquid chromatography and gravity column chromatography. Furthermore, the preparative thin layer chromatography (PTLC) analysi, UV-Vis zspectrometry and FTIR were carried out. The research findings revealed that the maximum wavelength of active fraction in ketapang (Terminalia catappa L.) leaves was 410.50 nm, and FTIR spectrum had functional groups of O-H (hydroxyl) C=O (carbonyl Co (aliphatic), C-O (ether) and CH3. Based on the finding, it could be concluded, that antidiabetic compound that plays a role in active fraction of ketapang (Terminalia Cappy L.) leaves was a flavonoid compound.
Evaluasi Pengobatan Radioterapi Pada Pasien Kanker Herlinda Mahdania Harun; Nurul Jannah; Idawati Idawati; Zul Fikar Ahmad
Journal Syifa Sciences and Clinical Research Vol 4, No 3 (2022): Volume 4 Edisi 3 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i3.15794

Abstract

Cancer is one of the leading causes of death in the world. Riskesdas data in 2018, that there is an increase in the prevalence of cancer in Indonesia every year and treatment with radiation/irradiation. The purpose of this study was to describe the characteristics (gender, age, education level, occupation), type of cancer, and duration of treatment as well as side effects obtained by cancer patients during or after radiotherapy treatment. The location of the research was carried out at the RSI. Faisal Makassar. This type of research is quantitative descriptive with consecutive sampling. Data was collected using medical records of cancer patients who underwent radiotherapy and then telephone interviews based on questionnaires. Data analysis in this study is descriptive quantitative univariate analysis to describe the distribution of each research variable. Research results obtained 49 cancer patients who underwent radiotherapy, the characteristics of the most respondents were the 46-52 year age group by 26.5% (13 people), female 71.4% (35 people), the last high school education was 44,9% (22 people), work as a housewife by 44.9% (22 people), the most type of cancer diagnosis is cervical cancer by 28.6% (14 people), the length of treatment received for 3 months is 40 times radiation treatment/therapy, and the perceived side effects of radiotherapy were weakness, pain, and dermatitis in the radiation area.
Formulasi Sediaan Sabun Cair Dari Ekstrak Etanol Daun Kersen (Muntingia calabura L.) Andi Nurpati Panaungi; Hasma Hasma
Journal Syifa Sciences and Clinical Research Vol 4, No 3 (2022): Volume 4 Edisi 3 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i3.16483

Abstract

Cherry leaves (Muntingia calabura L.) is a plant that has many medicinal properties. One part of the plant that is widely used is the leaf which contains flavonoid compounds, saponins and tannins found in cherry leaves so that it has strong antioxidant activity which can be efficacious as skin lightening and antiseptic. This study aims to formulate liquid soap ethanol extract of cherry leaves (Muntingia calabura L.). This type of research was carried out in an experimental laboratory using the maceration method to produce a thick extract from cherry leaves. There were 3 formulas for liquid soap with different extract concentrations, namely FI (3%), FII (6%), and FIII (9%). Tests for liquid soap preparations of cherry leaves extract include organoleptic tests (shape, smell, color), homogeneity test, pH test, foam height test, and water content test. From the results of research conducted on organoleptic tests, FI(3%) has has a liquid form, brown color and a distinctive aroma. and FIII(9%) has a slightly thick liquid form, dark brown color, and a distinctive aroma. In the homogeneity test on all formulas get homogeneous results. In the pH test FI(3%) with a pH of 8, FII(6%) and FIII(9%) with a pH of 9. In the FI(3%) foam height test with a foam height of 8.5 cm, FII(6%) with a foam height 7.7 cm, FIII(9%) with foam height 7.1 cm. on the water content test FI(3%) with a water content of 56.25%, FII(6%) with a water content of 53.75%, FIII(9%) with a water content of 48.00%. So it can be concluded that the liquid soap formulations FI(3%), FII(6%), and FIII(9%) meet the requirements set by SNI in every test of liquid soap preparations. So that cherry leaf extract can be formulated into liquid soap with extract concentrations of 3%, 6% and 9%.
Rasionalitas Penggunaan Obat Antituberkulosis Pada Pasien Tuberkulosis Paru Rawat Jalan Jeshy Milantika; Muhammad Akib Yuswar; Nera Umilia Purwanti
Journal Syifa Sciences and Clinical Research Vol 4, No 3 (2022): Volume 4 Edisi 3 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i3.15602

Abstract

Tuberculosis is an infectious disease caused by the bacterium Mycobacterium tuberculosis. Tuberculosis is easily transmitted through the air or from a source of transmission, namely patients with positive AFB (acid-fast bacilli) tuberculosis when coughing or sneezing. The purpose of this study was to evaluate the rationale for using OAT in pulmonary TB patients and examine the relationship between gender, age, chronic comorbidities and duration of treatment with treatment outcomes. The method used in this research is descriptive observational method with a cross sectional design. The sample used was 60 people. Data collection was carried out retrospectively using medical record data and patient prescriptions in the outpatient installation of RSUD dr. Soedarso Pontianak for the period January-December 2020. The results showed that the rationality of using antituberculosis drugs in pulmonary TB patients based on the right indications was obtained by 100%, the right patient 100%, the right drug 96.7%, the right dose 85%, and the right time giving 95%.
Isolasi dan Uji Aktivitas Antiinflamasi Ekstrak Daun Andong (Cordyline fructicosa (L) A.Chev) Endah Nurrohwinta Djuwarno; Hamsidar Hasan; Mahdalena Sy. Pakaya; Faramita Hiola; Dewa Ayu Puspita
Journal Syifa Sciences and Clinical Research Vol 4, No 3 (2022): Volume 4 Edisi 3 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i3.15740

Abstract

Andong (Cordyline fructicosa (L) A. Chev) is used as traditional medicine, the use of this traditional medicine is related to the content of secondary metabolites contained in the andong plant. Empirically people use this plant as an antioxidant, the compound that acts as an antoixidant is related to antiinflamasi. The purpose of this study was to isolate secondary metabolites from the extracts of N-Hexane, Ethyl Acetate, and Methanol from Andong (Cordyline fructicosa (L) A. Chev) leaves and to determine the anti-inflamatory effect of the isolated secondary metabolites of Andong (Cordyline fructicosa (L) A. Chev) leaves through in vitro with red blood cell stabilization method. Several methods are used in the isolation of these compounds, namely extraction, identification of compound, fractionation of KCV and KKG, KLT,KLTP, and characterizationof compounds using UV-VIS spectrophotometry and FTIR. The results of UV-VIS characterization show a maximum wavelength of 434 nm, and the results of  FTIR characterization indicate the presence of a functional groups namely O-H (Hidroxyl) at a wave number of 3448,72 cm-1, C-H (Aliphatic) at a wave number of 2954,95 cm-1, 2920,23 cm-1, and 2852,72 cm-1, aliphatic compounds are supported by the presence of CH2 and CH3 at wave number of 1463,97 cm-1 and 1379,10 cm-1, C=O (conjugated carbonyl) at wave number of 1721,79 cm-1, C=C at wave number of 1633,71 cm-1, C-O at wave number of 1294,24 cm-1. So it is very likely that the compounds in Andong leaves isolate are flavonoid compounds. Furthermore, the activity of results of the isolation is tested where the isolate whit a concentration of 100 ppm signifies the highest anti-inflamatory activity, with the ability to stabilize red blood cell membranes of 80,142 %.
Analisis Efektivitas Biaya Penggunaan Kortikosteroid Inhalasi Pada Pasien Asma Rawat Jalan di Rumah Sakit Shinta Nia Putri; Liza Pratiwi; Shoma Rizkifani
Journal Syifa Sciences and Clinical Research Vol 4, No 3 (2022): Volume 4 Edisi 3 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i3.15452

Abstract

West Kalimantan is in the 6th highest order whose prevalence of asthma exceeds the national rate of 2.4% in 2018. Asthma therapy with inhaled corticosteroids that take a long time needs to be cost-effective so as not to increase the patient's immediate medical costs.  This study aims to determine the cost-effectiveness of using inhaled corticosteroids given to outpatients at Dr. Agoesdjam Hospital, Ketapang Regency. The study was conducted in a cross-sectional retrospective manner by taking data on patient medical records for the January-December 2020 period.  The sampling technique is carried out by purposive sampling. The pharmacoeconomic analysis carried out is Cost Effectiveness Analysis (CEA). The Average Cost Effectiveness Analysis (ACER) and Incremental Cost Effectiveness Analysis (ICER) methods  are used to analyze the most cost-effective inhaled corticosteroids. The results of the study were obtained with the characteristics of the study subjects based on gender the number of male patients n=23 (39%) and female n=36 (61%). The conclution of this research are the percentage of effectiveness of the use of inhaled corticosteroids at Dr. Agoesdjam Hospital, Ketapang Regency in 2020 is 33-100% and the most effective inhaled corticosteroids are flutiase combinations; Brotec; Combivent with an effectiveness of 100% with an ACER value of Rp. 731.45.
Factors Associated with the Level of Non-Adherence to Take Antituberculosis drugs Garuda Nusantara Putra Utomo; Helmia Hasan; Sulistiawati Sulistiawati
Journal Syifa Sciences and Clinical Research Vol 5, No 1 (2023): Volume 5 Edisi 1 2023
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v5i1.15616

Abstract

Non-adherence to take antituberculosis drugs is one of the causes of tuberculosis (TB) resistance. However, in Indonesia no study identified the factors associated with the level of non-adherence to take antituberculosis drugs in Multi-Drug Resistant Tuberculosis (MDR-TB) patients when they were still pulmonary drug-sensitive TB survivors. The aim of this study was to identify factors associated with the level of non-adherence to take antituberculosis drugs. This was a cross-sectional study which was conducted from October 2021 to December 2021 at Dr. Soetomo Hospital Surabaya. The dependent variable was the level of non-adherence to take antituberculosis drugs, while the independent variables were age, gender, education level, income, distance from home to health care service, role of health workers, role of superintendent of swallowing drugs (PMO), and side effects. Forty out of the 195 secondary-resistant MDR-TB patients were selected as subjects for this study based on their willingness. The instrument was questionnaire which had been tested for its validity and reliability. The results of bivariate analysis showed that gender, the role of PMO, and side effects had a significance of p0.05. The results of the bivariate analysis indicated that gender, role of PMO, and side effects have significance value p0.05. The conclusion of this study is gender, role of PMO, and side effects are associated with the level of non-adherence to take antituberculosis drugs.
Studi Kasus : Pengetahuan dan Persepsi Masyarakat Tentang Vaksin Covid-19 Teti Sutriati Tuloli; Nur Rasdianah; Nur Ain Thomas; Madania Madania; Devie Ariany Daud
Journal Syifa Sciences and Clinical Research Vol 4, No 3 (2022): Volume 4 Edisi 3 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i3.15930

Abstract

The Covid-19 vaccine is still often rejected by the public, especially those who are in places with a lack of information. This affects the public knowledge and perception of the Covid-19 Vaccine. The objective of this study is to determine the level of public knowledge and perception about the Covid-19 Vaccine and to determine the correlation between the characteristics of public and perception of the Covid-19 vaccine and the correlation between the level of public knowledge and perception about the Covid-19 Vaccine. This research is observational research with a quantitative descriptive research design using a cross-sectional approach. The findings indicate that the knowledge level of the people in Tuladenggi Village about the Covid-19 Vaccine in the low category is 22%, medium category is 46%, and high category is 33%. On the other hand, the perception of people in Tuladenggi Village about Covid-19 Vaccine in the negative category is 21%, the neutral category is 25%, and the positive category is 55%. Some of the respondents' characteristics, namely Age, Occupation, Education, Marital Status, Disease History, Vaccination Status, Vaccine Type, and Symptoms, have a significant correlation with perception, with a p-value lower than 0.005. In contrast, Gender and Religion do not have a significant correlation with perception, with a value, higher than 0.005. The correlation between the level of public knowledge about vaccine and perception obtains p-value of 0.000 (p0.05).
Studi Efek Samping Obat Antituberkulosis (OAT) Pada Pasien TB Paru Nur Rasdianah; Madania Madania; Teti Sutriati Tuloli; Widy Susanti Abdulkadir; Hidayat Ahmad; Tri Bella Angraini Suwandi
Journal Syifa Sciences and Clinical Research Vol 4, No 3 (2022): Volume 4 Edisi 3 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i3.16657

Abstract

Tuberculosis is a contagious infection caused by Mycobacterium tuberculosis. Tuberculosis can be cured if the patients receive maximum treatment, but most patients feel uncomfortable with the side effects of the antituberculosis drugs consumed so patients experience drop out during the treatment period. This research aims to evaluate the side effects of antituberculosis drugs and their management in patients with pulmonary TB at RSUD Dr. MM Dunda Limboto after receiving antituberculosis drugs category 1. This is observational descriptive research using the prospective method for 1 month with 45 patients as the sample. The finding shows that the most common side effects suffered by pulmonary TB patients after taking antituberculosis drugs category 1 are reddish urine by 31 patients (69%), malaise by 21 patients (47%), dizziness by 17 patients (38%), and nausea by 13 patients (29%). The side effect that occurs the least is an increase in the value of SGOT/SGPT by 2 patients (4%). The conclusion is that the most common side effects experienced are reddish urine, malaise, dizziness, and nausea. Handling of side effects of antituberculosis drugs is done by giving symptomatic drugs such as antiemetics, analgesics, antipyretics and vitamin B6 to patients who experience side effects.

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