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All Journal Jambura Journal of Health Sciences and Research Journal Syifa Sciences and Clinical Research (JSSCR) Jurnal Sibermas (Sinergi Pemberdayaan Masyarakat) Indonesian Journal of Pharmaceutical Education International Journal of Health Science & Medical Research Jurnal Farmasi Teknologi Sediaan dan Kosmetika (JFTSK) Journal of Community and Clinical Pharmacy Journal of Pharmacology and Natural Products
Julianty Akuba
Universitas Negeri Gorontalo
Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Education Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary

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DETERMINATION OF SUN PROTECTION FACTOR (SPF) VALUE IN LIME (CITRUS AURANTIFOLIA) PEEL EXTRACT USING UV-VIS SPECTROPHOTOMETRY METHOD AM Andy Suryadi; Mahdalena SY Pakaya; Endah Nurrohwinta Djuwarno; Julianty Akuba
Jambura Journal of Health Sciences and Research Vol 3, No 2 (2021): JULI: JAMBURA JOURNAL OF HEALTH SCIENCES AND RESEARCH
Publisher : Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35971/jjhsr.v3i2.10319

Abstract

Lime (Citrus aurantifolia) is a plant that contains phenolic compounds, such as phenols, flavonoids, and tannins. With this content, lime peel extract has the potential as a sunscreen and has antioxidant activity. Sunscreen compounds refer to ones that can protect the skin from the effect of ultraviolet radiation. At first, the peel was extracted by maceration method using three solvents with different polarity (n-hexane, ethyl acetate, and 70% ethanol). The preliminary test found that the ethyl acetate and ethanol 70% extracts positively contained phenol, tannin, and flavonoid compounds, which were marked by a color change in the sample and continued to test the sunscreen activity. Further, the sunscreen activity test was determined based on the determination of the Sun Protection Factor (SPF) value that was done at 290-320 nm (wavelength) with a 5 nm interval.  The results showed that the sunscreen activity of the peel extract is very good at a concentration of 200 ppm for ethyl acetate extract with a value of 28.8; meanwhile, ethanol extracts 70% and ethyl acetate extracts of 400 and 600 ppm concentrations with an average SPF value of 24, 42.5, 42.2 and 81.8, respectively, are included in ultra protection because they have an SPF value of 15.     
FORMULASI EMULGEL DARI EKSTRAK DAUN KELOR (Moringa oleifera LAM) SERTA EVALUASI AKTIVITAS ANTIOKSIDAN DENGAN METODE DPPH Nurul Istiqomah; Juliyanti Akuba; Muhammad Taupik
Journal Syifa Sciences and Clinical Research Vol 3, No 1 (2021): Volume 3 Edisi 1 2021
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v3i1.9874

Abstract

Moringa (Moringa oleifera Lam) is one of the plants that has high antioxidant activity, especially in the leaves. Emulgel is one of the topical dosage which dermatologically has several beneficial properties, namely thixotropic, not oily, easy to spread, easy to clean, soft, easy to wash, long lasting, transparent and comfortable when used. The purpose of this research was to formulate moringa (Moringa oleifera Lam) leaves extract into emulgel dosage forms and determine the antioxidant activity of the dosage using DPPH method.The research began with extraction of moringa leaves and optimization of the base by varying the concentration of carbopol 940 as gelling consisting of F1 0.5%, F2 1%, F3 1.5% and F4 2%. The base that met the requirements of good physical stability was F2.  The F2 base was then made into emulgel dosage with 3 concentration variations of the extract, namely F2a 4%, F2b 5% and F2c 6%. The physical stability test result of each formula met the organoleptic test,the pH test, the dispersion test, the adhesion test, the viscosity test, and the freeze-thaw test. The One way ANOVA statistical test result showed that the p value was greater than 0.05, which meant that the emulgel dosage had good physical stability. The IC50values of each antioxidant activity result were F2a (t0 = 120.464 g/mL; t28 = 144.887 g/mL), F2b (t0 = 113.642 g/mL; t28 = 128.407g/mL), F2c (t0 = 74.745 g/mL; t28 = 90.618 g/mL). The statistical results of the t-test showed thep value = 0,027, (0.05), This indicated that there were significant difference results of the antioxidant activity test between the three formulas on the first day (t0) and on the 28th day (t28).
Pemberdayaan Siswa Sekolah Dasar Dalam Pelatihan Dan Edukasi Apoteker Cilik Dalam Rangka Pencapaian Desa Peduli Kesehatan Di Kecamatan Pagimana Widy Susanti Abdulkadir; Juliyanty Akuba
Jurnal Sibermas (Sinergi Pemberdayaan Masyarakat) Vol 11, No 1 (2022): Jurnal Sibermas (Sinergi Bersama Masyarakat)
Publisher : Univeristas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37905/sibermas.v11i1.12044

Abstract

Apoteker merupakan tenaga kesehatan yang memiliki keahlian di  bidang  obat-obatan. Banyaknya masyarakat yang  belum  mengenal  profesi  apoteker.  Melalui  apoteker  cilik  ini  kita  berusaha  untuk  mengenalkan  profesi  apoteker  sebagai  salah  satuvtenaga  kesehatan yang  memiliki  keahlian  dibidang  penggunaan  obat kepada  masyarakat.  Penting  untuk bisa memberikan pengenalan terhadap dunia kesehatan pada anak-anak sejak mereka kecil,  salah satunya melalui program apoteker cilik. Saat  ini,  pemberdayaan  program  pendidikan kesehatan  serta pelayanan  kesehatan  di  usia dini  terutama  di  level    sekolah  dasar  (SD)  telah  mulai  berkembang.  Tujuan  kegiatan  pengabdian  kepada  masyarakat  ini  adalah  memperkenalkan  profesi  apoteker  sebagai  salah  satu  tenaga  kesehatan  dan  sumber  informasi  obat  serta  memberikan  pelatihan  keterampilan  dan  edukasi  tentang  penggunaan  obat  yang  tepat Pelaksanaan pengabdian kepada masyarakat di Sekolah Dasar  desa Taloyon dan desa Sepa Kecamatan Pagimana.Pengenalan kepada anak usia dini dalam memperkenalkan profesi Apoteker kepada siswa SD dapat meningkatkan pengetahuan masyarakat atas profesi Apoteker, serta memperkenalkan istilah Apoteker Cilik akan meningkatkan popularitas profesi Apoteker. Edukasi obat kepada anak usia dini harus terus ditingkatkan supaya membawa perubahan mindset mengenai pengetahuan dan kesadaran tentang penggunaan obat secara tepat.
Isolasi dan Karakterisasi Bakteri Endofit dari Akar Pare (Momordica charantia L.) Mahdalena Sy. Pakaya; Julianty Akuba; Dizky Ramadani Putri Papeo; Andi Makkulawu; Ade Ari Puspitadewi
Journal Syifa Sciences and Clinical Research Vol 4, No 1 (2022): Volume 4 Edisi 1 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i1.15536

Abstract

Endophytic bacteria are microbes that grow on plant tissue and can form a colony on plant tissue without producing a negative effect on the host. The endophytic bacteria have the potential to have the same activity and produce secondary metabolite as their host. The root of bitter melon (momordica charantia L.) has been known to have antibacterial activity, thus enabling the presence of endophytic bacteria, which also have antibacterial potential.This present research aims to isolate and characterize endophytic bacteria found in bitter melon (Momordica charantia L. The method used in the isolation stage is direct lanting so that the endophytic bacteria are obtained from plant tissue; macroscopic and microscopic characterization stage; inhibition test stage; inhibition test stage using disc method (Kirby-Bauer). In accordance with the results of macroscopic and microscopic characterization, the two bacteria indicate different characteristics.
Variasi Konsentrasi Bahan Pengikat Dari Pati Biji Durian (Durio Zibethinus)Terhadap Mutu Fisik Pada Formulasi Tablet Hisap Vitamin C Nur Ain Thomas; Fika Nuzul Ramadhani; Juliyanti Akuba; Ariani H. Hutuba
Journal Syifa Sciences and Clinical Research Vol 4, No 2 (2022): Volume 4 Edisi 2 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i2.4317

Abstract

Starch of durian (Durio Zibethinus) seed is an accessible potential material to be utilized as binding agent in tablet. This study attempts to discover the influence of starch concentrate of durian seed in different percentages, i.e., 20%, 25%, and 30%, as binding agent towards the physical quality (by conducting tests i.e. weight uniformity test, hardness test, friability test, dissolution test, and organoleptic evaluation) towards vitamin C lozenges tablet formulation. Three formulae with different durian seed concentrate variation of F1 (20%), F2 (25%), and F3 (30%) were applied during the formulation of vitamin C lozenges. The result indicates that F2 and F3 formulae fulfilled all the test conducted, while the F1 formula only passed the weight uniformity test, taste response test, and organoleptic test. Based on the results of the study, F3 fulfilled all evaluations carried out, namely F3 4.07 kg hardness test, 0.30% friability test, 443.3 seconds dissolution test. F2 hardness test 3.79 kg, fragility test 0.34% solubility test 402 seconds. F1 hardness test 3.17 kg, fragility test 1.33%, soluble time test, 302.3 seconds. the conclusion obtained from the ANOVA-One way test is that there is a significant disintegration time difference of all formulas and continued by the Post-Hoct test to see the comparison of each formula with a confidence level (95%).
Analisis Manajemen Pengelolaan Logistik Sediaan Farmasi dan Perbekalan Kesehatan di Instalasi Farmasi Widy Susanti Abdulkadir; Madania Madania; Teti S. Tuloli; Nur Rasdianah; Juliyanty Akuba
Indonesian Journal of Pharmaceutical Education Vol 2, No 1 (2022): Januari-April 2022
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v2i1.11399

Abstract

Drug management is a set of optimally conducted activities related to the aspects of drug planning, procurement, storing, distribution, and extermination. This was done to achieve the proper drug amount, types, supply, maintenance, and medication. Earlier observstion revealed problems in managing pharmaceutical stock and consumables, where some of the stocks are empty. This qualitative descriptive research focus on identifying pharmaceutical logistic stock and health supplies comprising drug planning, procurement, storing, distribution, and extermination in the pharmaceutical unit of Gorontalo. The primary data were obtained from questionnaires based on technical guidance by the health ministry while the secondary were obtained from related documents. Based on the findings, the pharmaceutical stock planning and storing process at the pharmacy unit did not meet the health ministry standards, which is opposite to the procurement, distribution, and extermination process.
Analisis Biaya dan Nilai Utilitas pada Pasien Hemodialisis yang Diberikan Terapi Erythropoiesis di Rumah Sakit Madania Madania; Tety Sutriyati Tuloli; Nur Rasdianah; Juliyanty Akuba
Indonesian Journal of Pharmaceutical Education Vol 1, No 3 (2021): September-Desember 2021
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v1i3.11360

Abstract

Chronic kidney failure is a condition where there is a gradual decline in kidney function. Chronic kidney disease is often followed by complications of anemia. The use of erythropoietin therapy in chronic renal failure patients undergoing hemodialysis requires no small amount of money. This affects the quality of life (utility). The purpose of this study is to measure costs and utility values using the EQ-5D-5L (EuroQol-Five Dimensions) instrument, VAS (Visual Analog Scale), and costs based on the patient's perspective at Prof.Aloei Saboe Hospital. This study is a prospective cross-sectional approach. Data was collected using the EQ-5D-5L and EQ-VAS questionnaires. The subjects of the study were hemodialysis patients as many as 45 met the inclusion criteria. The results showed that the most widely used Erythropoietin therapy was single Hemapo. The results of the calculation of the estimated cost of each hemodialysis patient from the perspective of a patient for one month of therapy are Rp. 7,112,000. The average expenditure of patient transportation costs is Rp. 50,111. The average cost of food for the patient is Rp. 25,000.Utility value based on average Indonesian set value 0.673 (sufficiently feeling well)and VAS score 71.4 (health status is quite healthy).
PROCESSING OF MEDICAL MASK WASTE IN GORONTALO CITY DURING THE COVID-19 PANDEMIC Nur Ayini S. Lalu; Moh. Rivai Nakoe; Julianty Akuba; Laksmyn Kadir
International Journal of Health Science & Medical Research Vol 2, No 2 (2023): August 2023
Publisher : UNG

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37905/ijhsmr.v2i2.19264

Abstract

The disposal of disposable masks has raised concerns among environmentalists. Disposable medical mask waste is currently easy to find because people throw it away everywhere in intact condition. When people throw away masks carelessly, it is difficult to distinguish the use of shows by people with excellent or diseased health conditions. The problem in this research is the improper management of medical masks. This research method aims to analyze the frequency of using masks when leaving the house and the practice of processing medical mask waste used by the people of Gorontalo City. This type of research is quantitative with a cross-sectional design and analytic descriptive method. The population in this study were all people living in the City of Gorontalo in 2 sub-districts, namely Kota Timur and Kota Utara, with a sample size of 379 samples from the City of East and 377 representatives from the City of North. The results showed that the processing of medical masks in Gorontalo City during the Covid-19 Pandemic was not on target; this was evidenced by the processing of medical mask waste in Kota Timur District, which was disposed of carelessly as much as 36.5%, while medical mask waste was processed by cutting and 16.7% were burnt for the East Kota sub-district and 15.9% processed and reused. This study concluded that in the processing of medical masks in Gorontalo City during the Covid-19 pandemic for the East City District, many were still disposed of carelessly. In contrast, most medical mask users were washed and reused for the North City District. In comparison, for the North sub-district, it was 4.2%; even out of the 377 respondents surveyed, 361 medical mask users washed and reused. This is very worrying for environmental experts because the repeated use of medical masks will particularly impact oral health.Keywords: Processing; Waste; Medical mask.
Potensi Interaksi Obat Antidiabetes Melitus Tipe-2 dengan Obat Antihipertensi Widy Susanti Abdulkadir; Endah Nurrohwinta Djuwarno; Nur Rasdianah; Juliyanty Akuba; Mimi Fauziah Tahir
Journal Syifa Sciences and Clinical Research Vol 5, No 2 (2023): Volume 5 Edisi 2 2023
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v5i2.18042

Abstract

The effect caused by the use of antidiabetic and antihypertensive drugs combination needs to be considered. The treatment therapy of the patient has the potential risk of drug interactions that are beneficial or detrimental to the patient. This study aims to determine the potential drug interactions in combinations of antidiabetic and antihypertensive drugs. This research is a descriptive study with a cross-sectional design and retrospective data collection. The sample used is medical records of diabetes mellitus patients with comorbid hypertension from January to December 2021 at Batudaa Public Health Center, Gorontalo Regency. The results showed that there were more female patients than male patients. Based on this study. there were 49 female patients (70%), while the largest age group of 50-59 years included 29 patients (41,43%). Whereas, those with the highest potential for drug interactions were metformin and amlodipine, totaling 54 patients (77%). The mechanism of interaction in this study was the pharmacodynamic phase, and the potential to cause the effect was hypoglycemic through the severity of the interaction was moderate level. 
IN VIVO TESTING OF ANTIPYRETIC LEAVES OF FENCE (JATROPHA CURCAS L) ORIGIN GORONTALO Widy Susanti Abdulkadir; Juliyanty Akuba; Endah Nurrohwinta Djuwarno; Dizky Ramadani Papeo; Arief Ibnu Haryanto
International Journal of Health Science & Medical Research Vol 2, No 2 (2023): August 2023
Publisher : UNG

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37905/ijhsmr.v2i2.19428

Abstract

Jatropha (Jatropha Curcas L) is a plant that has been used empirically as a fever reducer. Fever is one of the symptoms of the disease which is characterized by a significant increase in body temperature. The novelty of this study was due to the effectiveness of Jatropha Curca L. leaf extract as an antipyretic. The purpose of this study was to determine the dose of antipyretic effectiveness of Jatropha Curcas (Jatropha Curcas L) Leaf Extract in Male Mice (Mus Musculus). Extraction by maceration using 96% ethanol solvent. 15 male mice (Mus Musculus) were divided into 5 groups, namely negative control (Na-cmc 1%), positive control (Paracetamol), and the treatment group given Jatropha leaf extract with doses of 150, 200, 250 mg/kgBW. Peptone 10% 1 ml orally as a fever inducer. And observed at 30, 60, 90 and 120 minutes after treatment. The data obtained were analyzed using one-way ANNOVA followed by the LSD test to determine differences between groups. The results showed that the leaf extract of Jatropha Curcas (Jatropha Curcas L) had an antipyretic effect where the most effective dose was at a dose of 250 mg/kgBW because it has a very stable temperature reducing power and effectiveness is comparable to Paracetamol. The conclusion of this study is that Jatropha Curcas L extract at a dose of 250 mg/kg can be used as an antipyretic.
Co-Authors Ade Ari Puspitadewi AM Andy Suryadi Andi Makkulawu Anindia Mangulu Ariani H. Hutuba Arief Ibnu Haryanto Dizky Ramadani Papeo Endah Nurrohwinta Djuwarno Faradila Ratu Cindana Fika Nuzul Ramadhani Hamsidar Hasan Handriansyah pakaya Hiola, Faramita Lahay, Astiara Laksmyn Kadir Madania, Madania Mahdalena Sy Pakaya mahdalena sy. pakaya Melly Agustin Is Puhi Mimi Fauziah Tahir Moh. Rivai Nakoe Mohamad Reski Manno Muhammad Taupik Multiani S Latif Multiani S. Latif Nur Ain Thomas Nur Ain Thomas Nur Ayini S Lalu Nur Rasdianah Nurul Istiqomah Pakaya, Meri Isriani Papeo, Dizky Ramadani Putri Rifka Anggraini Anggai Safira Mahadewi Mamu Sulistya Yasin Teti Sutriyati Tuloli Teti Sutriyati Tuloli Tety Sutriyati Tuloli Widy Susanti Abdulkadir Widy Susanti Abdulkadir Widy Susanti Abdulkadir