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Journal Syifa Sciences and Clinical Research (JSSCR)
Published by Universitas Negeri Gorontalo
ISSN : 26568187     EISSN : 26569612     DOI : 10.37311/jsscr
Core Subject : Health, Science,
Chemistry Medicine & Pharmacology
Journal Syifa Sciences & Clinical Research (JSSCR) is a national journal intended as a communication forum for scientists from many practitioners who use Pharmacology Development in research.
Arjuna Subject : -
Articles 196 Documents
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Identifikasi Kandungan Natrium Nitrit Pada Jajanan Ayam Krispi Pedagang Kaki Lima Harli Frimana; Fajar Nugraha; Hadi Kurniawan
Journal Syifa Sciences and Clinical Research Vol 5, No 1 (2023): Volume 5 Edisi 1 2023
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v5i1.15746

Abstract

Sodium nitrite is a food additive that is often used as a preservative in processed meats such as crispy chicken, but excessive and continuous use can cause toxic effects on the body. The purpose of this study was to identify sodium nitrite in crispy chicken in Pontianak city with limits determined by the Regulation of the Head of BPOM RI No 36 of 2013. The research method used in this study was descriptive non-experimental, where as many as 5 samples of crispy chicken were samples A, B, C, D, and E sold by several street vendors in Pontianak City were obtained using purposive sampling technique. Identification of sodium nitrite was carried out qualitatively using BaCl2, AgNO3, and Griess reagents. A positive result for the BaCl2  if it contains sodium nitrite will result in no precipitate forming, a positive result for the AgNO3 will produce a white precipitate, while a positive result for the griess reagent will produce a red-purplish color. The results of the qualitative test using BaCl2 and AgNO3 showed that none of the 5 samples tested were positive for sodium nitrite, while the qualitative test using griess reagent showed that out of the 5 samples tested there were 2 samples containing positive sodium nitrite, namely samples A and D, so that it can be concluded that samples A and D contained positive sodium nitrite in crispy chicken sold by several street vendors in Pontianak city
Perbedaan Pengetahuan dan Sikap Masyarakat Terhadap Pemberian Booklet dan Video Dagusibu Antibiotik Madania Madania; Nur Rasdianah; Nur Ain Thomas; Faramita Hiola; Sri Nur'ain E. Ahmad
Journal Syifa Sciences and Clinical Research Vol 4, No 2 (2022): Volume 4 Edisi 2 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i2.15547

Abstract

Inappropriate use of antibiotics is common in the world, both in the community and in the hospital environment, which can lead to antibiotic resistance. The purpose of this study was to determine the knowledge and attitudes of the community before and after being given the booklet and video of dagusibu antibiotics and to determine the differences and influence of community knowledge and attitudes towards the administration of the booklet and video of the dagusibu antibiotic in Lopo Village, Batudaa Pantai Sub-District, Gorontalo Regency. This research applied a quasi-experimental design with the provision of booklets and videos before and after being given education. The number of samples was 74 which were taken using non-probability sampling technique. Research data were analyzed using Wilcoxon test and Man-Whitney test. The results showed that most of the community's knowledge before being given education was still in the sufficient category (57% booklet and 62% video), and the community's attitude was in the negative category (73% booklet and 84% percent video). Meanwhile, after being given education, the community's knowledge had increased to a good category (72% booklet and 86% videos), and community's attitudes had increased to a positive category (93% booklets and videos 98%) as well. Therefore, it can be concluded that there was a significant effect on increasing knowledge and attitude after being given booklets and videos (P0.1), and there was no significant difference between giving booklets and videos on increasing community’s knowledge and attitudes (P0.1).
Tingkat Pengetahuan Masyarakat Terhadap Tindakan Penggunaan Antibiotik Tanpa Resep Dokter Madania Madania; A. Mu’thi Andy Suryadi; Fika Nuzul Ramadhani; Andi Makkulawu; Dizky Ramadani Putri Papeo
Journal Syifa Sciences and Clinical Research Vol 4, No 3 (2022): Volume 4 Edisi 3 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i3.7141

Abstract

Antibiotics is a subtance that can kill or weaken an organism such as bacteria, parasite, or fungi.  The use of antibiotics always triggers a problem, such as the use of it without any medical prescription. It sometimes happens caused by some factors such as the lack of people’s knowledge concerning the consumption of antibiotics. This research aims at investigating the correlation between the respondent’s characteristics toward knowledge, attitude, and action. Also, it is to investigate the correlation between knowledge and attitude toward the consumption of antibiotics without medical prescription. The research design applies analytical observation with cross sectional approach. The research subjects are 96 respondents selected by purposive sampling technique. The research instrument is questionnaires consisting of questionnaire of knowledge, attitude, and action. The method of data analysis is multiple correlation. Findings reveal that the people’s level of knowledge is still low obtaining 47,7% of score, the people’s attitude is categorized negative (supporting the consumption of antibiotics without medical) obtaining 54,2%, the people’s action categorized not appropriate obtaining 57,3%, there is correlation between education and job toward knowledge, attitude, and action (p0,05), there is no correlation between age and sex toward knowledge, attitude, and action (p0,05), and there is a correlation between knowledge and attitude toward action (p=0,000).
Uji Kualitatif dan Penetapan Kadar dengan Metode Spiking pada Logam Pb di Dalam Minuman Kopi Kaleng Husnafa Patriani; Fajar Nugraha; Hadi Kurniawan
Journal Syifa Sciences and Clinical Research Vol 5, No 1 (2023): Volume 5 Edisi 1 2023
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v5i1.15802

Abstract

Lead (Pb) is a heavy metal that is naturally present in the earth’s crust. This metal is dispersed in nature in small amounts through natural processes. Lead that accumulates in the environment is not biodegradable and its toxicity does not change. Contamination of lead (Pb) meta; in canned drinks can occur due to imperfect packaging, damage or rust. Lead metal is obtained from soldering tools. This study aims to identify the presence of Pb metal in canned coffee drinks. In addition, to find out the method of preparation that was carried out correctly the spiking method was used. Samples were taken in Pontianak City with purposive sampling technique. The sample of this research is canned coffee drinks with 3 different brands (brands A, B and C) circulating in the city of Pontianak. The qualitative test was carried out using 0.5 N KI reagent and 2 M HCl which was dropped into the sample. A positive result on a sample that was dripped with 0.5 N KI reagent was a yellow precipitate, while a positive result on a sample that was dripped with 2 M HCl reagent was a white precipitate. The spiking method was carried out by adding 0.3 mL of 1000 ppm Pb standard solution and adding the sample to a volume of 2 mL. Then, wet digestion was carried out using 10 mL HNO3 and 2 mL H2O2 as solvent. The results of the qualitative test showed that all samples with 0.5 N KI reagent were clear and black precipitate formed. All samples that were dropped with 2 M HCl reagent were clear and no precipitate was formed. In assay by spiking method, the levels obtained are 73.54 mg/kg and % recovery is 86.667%. All tested samples did not contain Pb metal and the preparation method used was correct.
Efek Antihiperurisemia Ekstrak Etanol Daun Pandan (Pandanus Amaryllifolius ) Pada Mencit (Mus Musculus) Widysusanti Abdulkadir; Dizky Ramadani Putri Papeo; Juliyanty Akuba; Andi Makkulawu
Journal Syifa Sciences and Clinical Research Vol 4, No 2 (2022): Volume 4 Edisi 2 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i2.7719

Abstract

Hyperuricemia is a condition in which the kidneys fail to excrete uric acid, resulting in high levels of uric acid. (Kaneko et al., 2014). Uric acid will be excreted into the kidneys along with urine. The decrease of uric acid secretion into the kidney tubules due to interference of uric acid elimination to the kidneys which causes uric acid levels in the blood to increase (Ningtiyas Ramadhian, 2016). An adult male is suffering from hyperuricemia when his serum uric acid level is more than 7.0 mg/dl, while hyperuricemia in adult women occurs when the serum uric acid level is above 6.0 mg/dl. Hyperuricemia therapy management in the community is very diverse, ranging from traditional medicines and synthetic drugs. One of the traditional plants used as traditional medicine is pandan leaves. This study aimed to determine the anti-hyperuricemia effect of ethanol extract of Pandanus amaryllifolius leaves on mice (Mus musculus L.). The study involved 25 male mice which were divided into 5 groups; each group consisted of five male mice. Group I was a negative control with Na-CMC 1% w/v, while Group II was a positive control with Allopurinol 0.117 g w/v. Further, Groups III, IV, and V were given Ethanol Extract of 0.5 gr w/v, 1 g w/v, 1.5 g w/v of Pandan Leaves, respectively. The results showed that there was no significant decrease in uric acid levels in group I. Meanwhile, Groups II, III, IV, and V showed a significant reduction in uric acid levels with identical effectiveness. The results of the study were then tested using the One-Way ANOVA statistical test; the p-value was 0.01 (α 0.01). The best dose was 1.5 g of extract since there was a significant difference from the pandan leaves extract with 1.5 g (p 0.01). In conclusion, pandan leaves extract can reduce uric acid levels in the blood. This was evidenced by a decrease of 4.1 mg/dl in uric acid levels in mice during the experiment.
Variasi Konsentrasi Bahan Pengikat Dari Pati Biji Durian (Durio Zibethinus)Terhadap Mutu Fisik Pada Formulasi Tablet Hisap Vitamin C Nur Ain Thomas; Fika Nuzul Ramadhani; Juliyanti Akuba; Ariani H. Hutuba
Journal Syifa Sciences and Clinical Research Vol 4, No 2 (2022): Volume 4 Edisi 2 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i2.4317

Abstract

Starch of durian (Durio Zibethinus) seed is an accessible potential material to be utilized as binding agent in tablet. This study attempts to discover the influence of starch concentrate of durian seed in different percentages, i.e., 20%, 25%, and 30%, as binding agent towards the physical quality (by conducting tests i.e. weight uniformity test, hardness test, friability test, dissolution test, and organoleptic evaluation) towards vitamin C lozenges tablet formulation. Three formulae with different durian seed concentrate variation of F1 (20%), F2 (25%), and F3 (30%) were applied during the formulation of vitamin C lozenges. The result indicates that F2 and F3 formulae fulfilled all the test conducted, while the F1 formula only passed the weight uniformity test, taste response test, and organoleptic test. Based on the results of the study, F3 fulfilled all evaluations carried out, namely F3 4.07 kg hardness test, 0.30% friability test, 443.3 seconds dissolution test. F2 hardness test 3.79 kg, fragility test 0.34% solubility test 402 seconds. F1 hardness test 3.17 kg, fragility test 1.33%, soluble time test, 302.3 seconds. the conclusion obtained from the ANOVA-One way test is that there is a significant disintegration time difference of all formulas and continued by the Post-Hoct test to see the comparison of each formula with a confidence level (95%).
Identifikasi Bakteri Batang Gram Negatif Pada Potongan Kuku Pedagang Nasi Tumpang Di Pasar Tradisional binti mu'arofah; Audit Putra Yulian
Journal Syifa Sciences and Clinical Research Vol 5, No 1 (2023): Volume 5 Edisi 1 2023
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v5i1.17284

Abstract

Food is one of the basic human needs, there are many kinds of food vendors scattered around us, including traditional markets. The typical food of the City of Kediri is Rice Tumpang, which is sold in many market areas, picking vegetables by hand directly and on average almost all sellers do not use handscoons. This can cause bacterial contamination from the seller's fingernails to move to the food. Bacteria can enter the nails if the nails are 1-3 cm long, the state of the wound or tear, which is damaged can cause bacteria to enter. Therefore, the cleanliness of the rice seller's nails must be trimmed regularly. This study aims to determine the type of Gram-negative bacteria on the nails of Tumpang rice sellers. The sampling technique used was total sampling. Examination was carried out on 16 samples of nail clippings on the right hand 0.5-1.5 mm. The results of the identification of Gram Negative Rod Bacteria in Nail Clips of Tumpang Rice Sellers at the Traditional Market in Mojoroto, Kediri City were 10 samples of Pseudomonas sp. (62.5%), 3 samples of Klebsiella sp. (18.75%), 2 samples of Escherichia coli (12. 5%), and 1 sample of Proteus sp. (6.25%). These bacteria can be found in the nails of Tumpang rice sellers because they do not apply personal hygiene such as washing their hands with soap, not cutting their nails once a week, when selling they do not use disposable plastic handscoons, and do not always clean the selling area. Conclusion: 10 Pseudomonas sp. samples (62.5%), 3 Klebsiella samples sp. (18.75%), 2 Escherichia coli samples (12.5%), and 1 Proteus sp. sample (6.25%) were obtained.
Prevalensi Kejadian Infeksi HIV Sebagai Screening Test Deteksi AIDS Dengan Metode Imunokromatografi Pada Komunitas Homoseksual erawati erawati erawati; Siska Kusumawardani; Leni Anggraini Puspita Sari
Journal Syifa Sciences and Clinical Research Vol 5, No 1 (2023): Volume 5 Edisi 1 2023
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v5i1.17164

Abstract

Human Immunodeficiency Virus (HIV) is a virus that can cause AIDS by attacking white blood cells, namely Cluster Of Differentiation 4 (CD4) cells so it can damage the human immune system. After several years the number of viruses increases so that the immune system is no longer able to fight the incoming disease. Acquired Immuno Deficiency Syndrome (AIDS) often manifests with various opportunistic infections, malignancies, metabolic disorders and others. Homosexual men have a greater risk of contracting HIV/AIDS than heterosexual men, particularly through risky sexual behavior, namely sex with more than one partner and anal sex. This study aims to determine the presence or absence of HIV antibodies in the Homosexual Community at the Pesantren I Public Health Center, Kediri City. The research design used is descriptive research design with quota sampling technique. In HIV testing using the Immunochromatography method with whoole blood the Homosexual Community of Gay. The principle of the examination is a qualitative test method by looking at the color changes on the test strip. The results of the study of 30 respondents, there were 2 positive results of HIV antibodies with a percentage of 7% and 28 negative results of HIV antibodies with a percentage of 93%. The conclusion of this study is that HIV examination using the immunochromatographic method can be used to detect the presence of HIV antibodies and can be used as a screening test for AIDS detection in the Homosexual Community.
Karakterisasi Bobot Jenis dan Identifikasi Kalsium Pada Susu Kedelai Bart Agus Raya; Hadi Kurniawan; Fajar Nugraha
Journal Syifa Sciences and Clinical Research Vol 5, No 1 (2023): Volume 5 Edisi 1 2023
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v5i1.15830

Abstract

Soy milk is a drink that is good for health because it contains protein, unsaturated fatty acids, vitamins, carbohydrates and important minerals needed by the body such as calcium. Calcium functions to help the process of forming bones and teeth, blood clotting, muscle contraction, transmitting nerve cell signals, maintaining bone density, supplements in lowering LDL cholesterol levels. This study aims to determine the density characteristics of soy milk produced and to identify the calcium content qualitatively in soy milk drinks circulating in Pontianak City. The research method used in this study is descriptive non-experimental using 3 samples of soy milk circulating in Pontianak City with purposive sampling technique. Sample preparation in this study was carried out by wet digestion using HNO3 65% p.a solvent. Qualitative identification of calcium content was carried out using 5% ammonium oxalate reagent. The presence of a white precipitate after the addition of 5% ammonium oxalate indicates a positive calcium in the sample. Characterization of the specific gravity of soy milk was carried out using a pycnometer. The results obtained in this study are samples of soy milk A, B and C are positive for calcium because they form a white precipitate when soy milk samples are added with 5% ammonium oxalate reagent and the density of soy milk A, B and C is 1, respectively. ,00894905 g/mL, 1.008108836 g/mL and 1.008789684 g/mL.
Formulasi Sabun Mandi Padat Ekstrak Daun Jeruk Bali (Citrus Maxima Merr.) sebagai Antibakteri terhadap Staphyloccous aureus Noela Riski Riani Sumbung; Vivin Nopiyanti; Siti Aisiyah; Reslely Harjanti
Journal Syifa Sciences and Clinical Research Vol 5, No 1 (2023): Volume 5 Edisi 1 2023
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v5i1.16874

Abstract

Solid bath soap is one of the most common cosmetic preparations used by the public to clean the body from dirt. Grapefruit leaves contain flavonoids that are able to maintain healthy skin, and can inhibit the growth of bacteria. The purpose of this study was to formulate the leaf extract of grapefruit into a solid bath soap that has good physical and stability qualities and to determine its antibacterial effect against S. aureus. Grapefruit leaves were macerated with 96% ethanol solvent then the extract obtained was formulated into solid soap preparations with extract variations, namely 1; 3 and 5%. Furthermore, physical quality and stability tests have been carried out as well as testing the antibacterial activity of the bath soap preparations against S. aureus bacteria by agar diffusion method by means of wells. The final stage was statistical data analysis. The results showed that the solid bath soap preparations with grapefruit leaf extract had good physical quality and stability, the formulation of solid bath preparations with extract concentrations of 1%, 3%, and 5% had antibacterial activity with an average diameter of the inhibition zone against S. aureus bacteria were 5.6 mm, 7 mm and 10.8 mm, respectively, which were included in the moderate to strong category. The formulation with the addition of 5% extract had the most effective antibacterial activity with an average inhibition zone of 10.8 mm.

Page 15 of 20 | Total Record : 196

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