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Jurnal Biomedika dan Kesehatan
Published by Universitas Trisakti
ISSN : 2621539x     EISSN : 26215470     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health
Jurnal Biomedika dan Kesehatan is an official publication of Faculty of Medicine Trisakti University. Jurnal Biomedika dan Kesehatan is a third-monthly medical journal that publishes new research findings on a wide variety of topics of importance to biomedical science and clinical practice. Jurnal Biomedika dan Kesehatan online contains both the current issue and an online archive that can be accessed through browsing, advanced searching, or collections by disease or topic.
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Search results for , issue "Vol 7 No 3 (2024)" : 11 Documents clear
ST-Depresi pada Infark Miokard Akut dengan Elevasi Segmen ST–Pentingnya Perubahan Resiprokal pada Elevasi Segmen ST yang Minimal Myrtha, Risalina; Wijayanto, Matthew Aldo; Putri, Desy Puspa; Hermawati, Berty Denny
Jurnal Biomedika dan Kesehatan Vol 7 No 3 (2024)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2024.v7.339-344

Abstract

Coronary artery disease remains the leading cause of mortality globally. Management of ST-elevation myocardial infarction (STEMI) starts from the point of first medical contact. Time delay to treatment influences the mortality in STEMI patients. The aim of this study is to underline the importance of reciprocal ECG changes in helping diagnosis STEMI with subtle ST elevation. We present an obese and hypertensive male patient with atypical symptoms of MI and was diagnosed as peptic ulcer. The ECG showed subtle ST elevation in inferior ECG leads and reciprocal changes in I and aVL. Highly sensitive troponin was elevated. Serial ECG showed evolution, thus revealed acute inferior MI. Successful percutaneous coronary intervention was performed. ECG is one of the most important diagnosis tools in STEMI and a cornerstone to direct the decision to immediate reperfusion therapy. Minimal ST-elevation often leads to inappropriate diagnosis, thus delayed the time to reperfusion. A study shows that 11-23% of STEMI do not reach the cutoff for accepted ECG criteria. In a study of infarctions with minimal ST-elevation, reciprocal changes are reported in 58% of all cases. Reciprocal ECG changes is extremely useful to help identifying STEMI in the absence of obvious ST-elevation on ECG
Terapi Bekam: Efek Anti Peradangan dalam Pengobatan Tradisional Wahyuni, Dian; Legiran, Legiran; Saleh, Irsan; Salim, Eddy Mart
Jurnal Biomedika dan Kesehatan Vol 7 No 3 (2024)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2024.v7.374-390

Abstract

This comprehensive literature review consolidates findings from 11 diverse scholarly articles exploring the efficacy of cupping therapy as an anti-inflammatory intervention. The review encompasses studies investigating various clinical applications and experimental models to delineate the therapy's anti-inflammatory effects. The research method utilized the Publish or Perish application to access databases such as PubMed, Scopus, and Google Scholar. The screening process was based on predetermined inclusion and exclusion criteria. Article quality was assessed using the Crowe Critical Appraisal Tool (CCAT). Standard forms were used to extract important information from articles: Authors’ name, Year; Research title; Population; data; Findings. Data were analyzed narratively to generate thematic synthesis. The reviewed studies revealed significant outcomes across multiple domains. Clinical trials demonstrated the efficacy of cupping therapy in managing pain in osteoarthritis and idiopathic menorrhagia. Narrative reviews and experimental studies highlighted its potential in sports injury management and its influence on changes in local blood flow. Additionally, investigations provided insights into its immunomodulatory effects in cancer patients, allergic asthma models, and inflammatory conditions like acute herpes zoster. Synthesizing these findings emphasized the diverse anti-inflammatory effects of cupping therapy across various health conditions, elucidating its mechanisms and potential applications. The therapy exhibited promising outcomes in pain management, inflammation reduction, and modulation of immune responses.
Hubungan Indeks Massa Tubuh dengan Kekuatan Genggam Tangan pada Lansia di PSTW Sabai Nan Aluih Siregar, Fatia Putri Barokah; Irawati, Lili; MYH, Etriyel; Fasrini, Ulya Uti; Wahid, Irza; Abdiana, Abdiana
Jurnal Biomedika dan Kesehatan Vol 7 No 3 (2024)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2024.v7.312-321

Abstract

Background The aging process results in physiological changes in the body, such as decreased muscle strength and impaired balance, so that the risk of falls, injury and dependency increases in the elderly. Changes in the nutritional status of the elderly who tend to be predominantly underweight also occur due to the aging process and have an impact on the muscle strength of the elderly in the long term. This study aims to determine the relationship between BMI and hand grip strength in the elderly at PSTW Sabai Nan Aluih Sicincin. Methods This study is an analytical and secondary research with a cross-sectional design, involving 62 elderly individuals from PSTW Sabai Nan Aluih Sicincin as the population. All population members meeting the inclusion criteria and excluding outliers were considered as the research sample. The inclusion criteria encompassed complete data such as BMI, handgrip strength, age, weight, knee height, and gender. Two outlier samples were excluded based on the exclusion criteria. Bivariate data analysis utilized the Chi-square statistical test. Results The research findings indicate that most elderly women at PSTW Sabai Nan Aluih Sicincin have normal to overweight BMI, while elderly men have underweight BMI. Elderly women at PSTW Sabai Nan Aluih Sicincin exhibit abnormal handgrip strength, whereas elderly men have normal handgrip strength. Furthermore, there is no significant relationship (p=0.676) between BMI and handgrip strength values among the elderly at PSTW Sabai Nan Aluih Sicincin. Conclusions This study concluded that there was no significant relationship between BMI and hand grip strength scores in the elderly at PSTW Sabai Nan Aluih Sicincin.
Kardiomiopati peripartum vs Kardiomiopati peripartum dengan preeklamsia: dari pendekatan biomolekuler hingga manajemen Fahreza, Lufthi; Winato, Brigad Mahardika; Nugrahani, Annisa Dewi; Arianto, Steven
Jurnal Biomedika dan Kesehatan Vol 7 No 3 (2024)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2024.v7.351-361

Abstract

Peripartum cardiomyopathy (PPCM) is a potentially life-threatening pregnancy-related condition that typically occurs during the peripartum period. It is characterized by impaired function of the left ventricle and heart failure. Preeclampsia is recognized as a risk factor for PPCM and can coexist with this condition. However, there is limited available data that explains the variations in treatment approaches between cases of peripartum cardiomyopathy with and without preeclampsia. Hence, the objective of this study is to examine the distinctions between PPCM and PPCM accompanied by preeclampsia, encompassing their molecular, pathogenic, and pathophysiological aspects, as well as their treatment and management strategies. These factors could potentially play a role in influencing the treatment of patients diagnosed with peripartum cardiomyopathy. A thorough review of existing literature was conducted between June and August 2023. Articles were retrieved from medical databases including PubMed, EBSCOhost, Medline, SAGE, JSTOR, and ScienceDirect, utilizing keywords such as "Peripartum Cardiomyopathy," "PPCM," "Preeclampsia," "Biomolecular," and "Treatment." This study encompassed original articles written in either English or Indonesian, focusing on a ten-year time frame. Articles categorized as literature reviews, systematic reviews, and/or meta-analyses were excluded from consideration in this study. The Results of this review, In instances of PPCM accompanied by preeclampsia, the secretion of sFlt1 from the placenta is notably elevated compared to cases of PPCM alone. PPCM and PPCM with preeclampsia exhibit distinct pathogenic and pathophysiological characteristics. Patients with concentric left ventricular remodeling (PPCM with preeclampsia) may not derive the same degree of benefit from angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, or beta-blockers as those with eccentric left ventricular remodeling (PPCM without preeclampsia). The Conclusion of this review, PPCM and PPCM with preeclampsia are differentiated by underlying biomolecular factors, pathogenesis, and pathophysiology. Furthermore, they respond differently to treatment and have different approaches to management.
Pengaruh Pemberian Expressive Writing Therapy Terhadap Penurunan Skor Body Image Distress pada Pasien Kanker Payudara Pasca Mastektomi di Jawa Tengah, Indonesia Widanti, Nabila Syifa Marta; Kusumadewi, Andrian Fajar; Ismanto, Silas Henry
Jurnal Biomedika dan Kesehatan Vol 7 No 3 (2024)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2024.v7.293-303

Abstract

Background Breast cancer is the most frequently diagnosed cancer worldwide, including in Indonesia, with the highest cancer survivors in Central Java. Mastectomy is one of the procedures in breast cancer treatment which result in major physical and mental alteration, possibly causing Body Image Distress (BID), risking them for depression and suicide. Expressive Writing Therapy (EWT) is an intervention that has been proven to reduce BID in breast cancer patients. Objective: This study aimed to analyze the impact of providing EWT on reducing post-mastectomy breast cancer patients Methods This is an experimental study using a two-group pretest-posttest with CG design conducted on 46 respondents at the oncology surgery clinic at a General Hospital in Central Java. Sample obtained using purposive sampling technique. BID scores were measured using the Body Image Scale (BIS). Data were analyzed in univariate, bivariate, and multivariate analysis using SPSS. Results Data analysis using Mann-Whitney Test showed a significant difference in BID scores reduction between intervention group (IG) and control group (CG) (p=0.00, significance p<0.05). Multivariate analysis using Linear Regression Test showed a significant influence of EWT on reducing BID scores (p=0.00). Conclusions Expressive Writing Therapy (EWT) significantly reduces BID scores in post-mastectomy breast cancer patients in a General Hospital in Central Java, Indonesia.
Perbandingan Hasil Pemeriksaan Leukosit, Trombosit, Hemoglobin, dan NLR pada Pasien Sepsis dan Syok Sepsis di PICU RSUP Dr. M. Djamil Padang Saldi, Aisyah Afiah Izzaty; Mariko, Rinang; Almurdi, Almurdi
Jurnal Biomedika dan Kesehatan Vol 7 No 3 (2024)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2024.v7.329-338

Abstract

Background Sepsis and septic shock are global health problems with high morbidity and mortality rates. The ability to identify sepsis and septic shock with tools available in health facilities in Indonesia is an important step in reducing the morbidity and mortality of this disease. One of the tests that can be performed is a complete blood count such as the number of leukocytes, platelets, hemoglobin levels, and neutrophil-lymphocyte ratio (NLR). The costs incurred for complete blood counts are low and generally available in all health facilities. Methods This study is an analytical observational study with a cross sectional research design using medical record data of sepsis and septic shock patients in the PICU of RSUP Dr. M. Djamil Padang in 2020 - 2022. Univariate analysis is presented in the form of a frequency distribution table and bivariate analysis using the Chi Square test. Results The results showed that the most common diagnosis was septic shock (74.5%), male (57.5%), age under one year (38.3%), and death outcome (59.6%). Bivariate analysis found that there was a difference in platelet count between sepsis and septic shock (p=0.004) and there was a difference in NLR between sepsis and septic shock (p=0.024). Conclusions The conclusion of this study is that there are differences in platelet count and NLR between sepsis and septic shock patients in the PICU of RSUP Dr. M. Djamil Padang.
Miopia pada Anak dan Faktor Risikonya Selama Pandemi COVID-19: Sebuah Tinjauan Sistematis Tan, Sabrina; Yulia, Dian Estu
Jurnal Biomedika dan Kesehatan Vol 7 No 3 (2024)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2024.v7.362-373

Abstract

Myopia or near-sightedness is the most common ophthalmologic disorder in the world. Myopia prevalence has significantly increased over the last decade, especially in the pediatric population. During the COVID-19 pandemic, governments worldwide implemented home quarantine and school closures to contain and mitigate the virus’s spread. This resulted in increased screen time, more time doing near-work activities, and decreased time spent outdoors. This study was to compare myopia progression in children before and during the COVID-19 pandemic and examine pandemic-related lifestyle risk factors for myopia progression. Methods of this study were A comprehensive search of Ovid MEDLINE and PubMed for potential articles was conducted following the PRISMA 2020 guidelines. The data extracted from each included studies included epidemiologic data on myopia in children, changes in spherical equivalent (SE), and the amount of outdoor activity, screen time, and near work before and during the COVID-19 pandemic home quarantine. This review included six studies, comprising two retrospective cohort studies, three prospective cohort studies, and one cross-sectional study. Epidemiological data showed increased pediatric myopia cases and a greater SE difference during the COVID-19 pandemic. During the pandemic, it was reported that children spent more time on screens, engaging in near-work activities, and less time outdoors. Multiple logistic regression analyses consistently showed increased screen time as a significant risk factor for myopia in children during the pandemic, while outdoor time and time spent doing near-work activities were not statistically significant. Conclusion of this study where Myopia progression in children was more rapid during the COVID-19 pandemic, with increased screen time identified as a risk factor. More research is needed to further investigate other pandemic-related risk factors for myopia in children.
Efektif Pemeriksaan CT-Scan Kepala Non-Kontras Berdasarkan Gender Dengan Menggunakan Kalkulator Dosis Radiasi Di RS Hermina Bitung Darmawan, Ifan Aji; Juliantara, I Putu Eka; Adi, Langkir Sapto; Astien, Astien; Wahab, Revalita
Jurnal Biomedika dan Kesehatan Vol 7 No 3 (2024)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2024.v7.274-281

Abstract

Background The need for CT Scan radiology examinations, which offer more detailed image results than X-rays, continues to increase. Head CT scans are the most frequently performed examinations, reaching 60%. Objective This study aims to evaluate the effective dose distribution of radiation to the tissues involved in head CT-Scan examinations at RS Hermina Bitung and assess its compliance with the regulations set by the Indonesia Diagnostic Reference Level (I-DRL). Methods This study involved 100 patients, consisting of 50 men and 50 women. Data in the form of Dose Length Product (DLP) values were collected from each patient and converted to effective dose using a radiation dose calculator. Results The results showed that 6 out of 100 samples exceeded the dose limit set by the Nuclear Energy Regulatory Agency (BAPETEN). Factors that affect the effective dose include exposure, body weight, object thickness, scan length, age, tissue weight, tissue sensitivity, FOV, and pitch. Nonetheless, the overall average effective dose of the patients was still within the I-DRL. Conclusions Factor such as gender can affect the effective dose received by patients. The 75 percentile value of the effective dose of non-contrast head CT-Scan examination at Hermina Bitung Hospital is in accordance with the provisions of the I-DRL. The radiation dose calculator used can be applied in Indonesia, but still requires increased information literacy regarding its use.
Pengaruh Minuman Sinbiotik dari Susu Kefir dan Konsentrat Bengkuang (Pachyrhizus erosus) terhadap Kadar Malondialdehid Jaringan Usus Tikus Hiperlipidemia Aprillia, Viola; Utami, Rizki Fajar; Pramaningtyas, Miranti Dewi
Jurnal Biomedika dan Kesehatan Vol 7 No 3 (2024)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2024.v7.304-311

Abstract

Background Intestinal tissue damage is one of the effects of increased reactive oxygen species (ROS) in hyperlipidemia. Cells damaged by hyperlipidemia experience changes in the biomarker malondialdehyde (MDA). The use of jicama extract and kefir alone has shown the ability to lower cholesterol levels. This study aims to determine the effect of the combination of jicama extract and kefir milk as a synbiotic drink on MDA levels in the intestines of hyperlipidemic rats. Methods Twenty-five male Wistar rats were divided into 5 groups, consisting of negative control (K-) and positive control (K+) groups and three treatment groups (P1, P2, P3). Hyperlipid induction using quail egg yolk. The dose of quail egg yolk was 5ml/200grBW. The intervention group was given a synbiotic drink with a dose of 5ml/200grBW with 3 types of kefir milk and jicama extract combination formulations. Intestinal MDA levels were measured after termination and the data were analyzed using statistical software. Results The level of MDA in intestine (nmol/ml) were 11.78±0.21 (K+), 0.73±0.05 (K-), 5.38±0.28 (P1), 3.02±0.14 (P2), 1.59±0.11 (P3). The analysis of the results of the MDA level showed significant differences in all groups after being given synbiotic drinks (p <0.001). Conclusions Combination of jicama extract and kefir as synbiotic drinks significantly affect the intestinal MDA levels of hyperlipidemic rats.
Hubungan antara Tingkat Pemahaman Piktogram (Label Keamanan Kimia) dan Sikap terhadap Kepatuhan Kesehatan dan Keselamatan Kerja di Laboratorium Kimia Universitas Nusa Cendana Karolus Tokan, Yohanes; Roga, Anderias Umbu; Muntasir, Muntasir; Ratu, Jacob M; Riwu, Magdarita
Jurnal Biomedika dan Kesehatan Vol 7 No 3 (2024)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2024.v7.282-292

Abstract

Background Students' knowledge of OHS is a basic knowledge that must be possessed by students before and during experiments in chemistry laboratories. Hazard pictograms warn us of the presence of hazardous chemicals. Student compliance with OHS and basic knowledge that students must have before and during experiments in chemistry laboratories. This research was to analyze the relationship between the level of knowledge, skills, and occupational health and safety (OHS) compliance in the Chemistry Laboratory at Nusa Cendana University to minimize risks and prevent occupational accidents in the Laboratory. Methods Observational analytical research with cross-sectional design. The population was students of Chemical Education (FKIP), Chemical Science Students (FST), and Pharmacy Students (FKKH) of Nusa Cendana University. A sample of 75 samples was taken. Data were collected using a questionnaire that was observed during February - March 2024. Measurement of the average value of compliance, attitude, and knowledge between the three study programs using statistical analysis conducted is univariate and bivariate using the chi-square test (p=0.05). Results The attitude variable has a significant effect on compliance. In the skill variable statistical results on SPSS version 25 with Chi-Square analysis, the results obtained a p-value of 0.330 (>0.05) which can be concluded that there is no relationship between OSH compliance in Nusa cendana university students.  The attitude variable has a significant effect on compliance. The positive coefficient value indicates that the influence exerted by attitude on compliance is positive. Statistical results on SPSS version 25 with Chi-Square analysis, the results obtained a p-value of 0.000 (>0.05) which can be concluded that there is a relationship between the level of attitude towards OHS compliance in students.     Conclusions The level of knowledge of students does not have a significant effect on compliance in OHS, while Attitude, has a significant effect on OHS Laboratory OHS.

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