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JURNAL FARMASIMED (JFM)
Published by Institut Kesehatan Medistra Lubuk Pakam
ISSN : -     EISSN : 26550814     DOI : -
Core Subject : Health,
Medicine & Pharmacology
Jurnal FARMASIMED (JFM) Volume I Nomor 1 Periode Mei - Oktober Tahun 2018. Jurnal ini memberikan ruang bagi akademisi, peneliti dan pengguna hasil penelitian dan pengabdian untuk mendiseminasikan, menginformasikan, mendiskusikan dan menggunakan hasil penelitian dan pengabdian sebagai upaya meningkatkan kualitas kebijakan di bidang farmasi yang berbasis ilmiah dan dapat dipertanggung jawabkan. Jurnal ini menyajikan hasil penelitian, pengabdian masyarakat serta artikel ilmiah di bidang farmasi.
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Articles 33 Documents
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Search results for , issue "Vol 7 No 2 (2025): Jurnal Farmasimed (JFM)" : 33 Documents clear
Analysis of Strategic Business Planning for a New Pharmacy in the Depok Area Putra, Gunawan Satria; Saragih, Sahat; Hatta , Iha Haryani
Jurnal FARMASIMED (JFM) Vol 7 No 2 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v7i2.2618

Abstract

This study evaluates the business strategies of new pharmacies in Depok post the Covid-19 pandemic, which experienced significant growth. Despite the emergence of numerous new pharmacies in 2024, their management is deemed to fall short of pharmaceutical standards. This research aims to analyze the implemented business strategies, their alignment with vision and mission, and relevant strategies for performance improvement. The research method employed is descriptive qualitative, utilizing SWOT analysis as a data analysis tool. Data collection was conducted through in-depth interviews with 9 informants from 6 pharmacies and a concise survey. The respondents were pharmacy owners and managers. The findings indicate that these six pharmacies lack a structured business strategy plan. The primary performance metric used is sales turnover. Business vision and mission have not been established, hindering the alignment of business strategies. Implemented business strategies remain normative, such as promotions via brochures, pamphlets, and discounts. The resulting business strategy recommendations encompass two key aspects: fulfilling pharmaceutical service standards and enhancing financial performance. Pharmaceutical service standards include drug consultation, medical records, drug availability, patient education, and legal compliance. Financial performance improvement can be achieved through price adjustments, operational cost efficiency, sales growth, inventory management, service diversification, and customer satisfaction. It is recommended that pharmacies engage with local communities to socialize programs and services. Informal approaches are considered more effective.
Effort to Reduce The Incidence of Anemia in Grade XII Students of SMAN 1 Sei Rampah Using The Action Research Approach M Taufik Alfyan; Felix Kasim; Fadlilah Widyaningsih; anggraeni, Ratih
Jurnal FARMASIMED (JFM) Vol 7 No 2 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v7i2.2637

Abstract

Anemia is a condition of low hemoglobin levels in the blood. This condition often occurs in adolescent girls due to menstrual cycles and a tendency to diet. Adolescent girls who suffer from anemia are at risk of giving birth to babies with low birth weight and stunting. The incidence of anemia is very high in North Sumatra, one of which is in Sei Rampah District. Because of this condition, researchers feel the need to make efforts to reduce the incidence of anemia by providing iron tablets. The action research method was carried out to determine whether there were changes in hemoglobin levels in the anemia group of grade XII SMAN 1 Sei Rampah students who were given intervention. The students' hemoglobin levels were measured to group which ones had the potential for anemia, then given iron tablets once a week for 4 weeks and then their hemoglobin levels were measured again. Action research plays a role in achieving a decrease in the incidence of anemia. Researchers concluded that there was an increase hemoglobin levels by 96.7% in the group of female students categorized as anemic after the intervention of anemia concept education and the provision of iron tablets with assistance.
Evaluation of Pioglitazone Vildagliptin Combination on Lipid Profiles for Outpatients with Type II Diabetes Mellitus Kusumaningrum, Yunita Dyah; Firandi, Adelia; Hasmono, Didik; Aryani, Dhita; Wardhani, Firdha Aprillia
Jurnal FARMASIMED (JFM) Vol 7 No 2 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v7i2.2645

Abstract

Pioglitazone and vildagliptin combination is one of the recommended alternatives as antidiabetic therapy to achieve the therapeutic target. This combination with complementary mechanisms of action can improve lipid profiles. This study aims to evaluate lipid profile achievement for outpatients with Type II DM on administering pioglitazone/vildagliptin combination therapy. Methods of the study were an observational prospective study in outpatients with Type II DM who use pioglitazone/vildagliptin combination at RS. Bhayangkara Surabaya during November 2021 – April 2022. Patients were included if aged between 18-80 y.o, used this combination ? 3 months before the study, HbA1C >7%, and were voluntarily involved by signing the informed consent. Laboratory examination of HbA1c, HDL-C, and triglycerides was done initially when patients were voluntarily involved as baseline data and after 3 months as post-data. The final sample in this study consisted of 25 patients who met the inclusion and exclusion criteria. The results of the study show mean value of HDL-C significantly increases from baseline to endpoint (p < 0.05). At the end of 3 months, the lipid profile of HDL-C and triglyceride increases by 30% and 4%, respectively, in patients who achieve the target compared to baseline conditions. The combination therapy of pioglitazone and vildagliptin improved lipid profile control in patients with type 2 diabetes mellitus after 3 months of treatment.
Formulation of Body Scrub Containing Ethanol Extract of Temulawak Rhizome (Curcuma xanthorrhiza Roxb) as a Skin Moisturizer H, Herlina; Melda Astrika Sianipar; Yaturramadhan Harahap, Hasni; Aritonang, Barita; Yosi Darmirani
Jurnal FARMASIMED (JFM) Vol 7 No 2 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v7i2.2650

Abstract

A body scrub is a cosmetic formulation intended to exfoliate dead skin cells and enhance skin hydration. One promising natural ingredient for body scrub formulations is the rhizome of Java turmeric (Curcuma xanthorrhiza Roxb.), which contains curcumin, a potent antioxidant known to support skin moisture retention. This study aims to evaluate the moisturizing efficacy of a body scrub formulated with Java turmeric rhizome extract. Methods: The rhizome was extracted through maceration using 96% ethanol and incorporated into body scrub formulations at concentrations of 10%, 15%, and 20%. The formulations were assessed for organoleptic characteristics, homogeneity, pH, spreadability, adhesion, oisturizing effect, and potential skin irritation on human volunteers. A commercial body scrub served as the comparator in a study involving 12 volunteers over four weeks, with applications performed once per week. Results: All Java turmeric body scrub formulations remained physically stable at room temperature and did not induce skin irritation. The physical characteristics of the formulations met standard cosmetic criteria, including consistent appearance, pH range of 6–7, spreadability between 5–7 cm, adhesion time above 4 seconds, and absence of irritation. Moisturizing effectiveness was evaluated using a skin analyzer, and data were statistically analyzed using SPSS. The p-value of 0.046 indicates that there is a significant difference between F1 and the commercial product, while for F2 and F3, there is no significant difference in moisturizing effectiveness between the temulawak formulations and the commercial product.. Among the tested formulations, the body scrub containing 20% Java turmeric extract exhibited the highest moisturizing effect. Conclusion: The body scrub formulated with Java turmeric rhizome extract, particularly at a concentration of 20%, is safe for use and shows potential as a natural moisturizing product comparable to commercial products on the market.
Formulation of Nanoemulgel Preparation from Jernang Resin Extract (Daemonorops draco (Wild.)) for Healing Burn Wounds in Male White Rats (Rattus norvegicus) Yulia Sari, Ersa; Cut Mutia; Fitri, Zahwa Syuhada; R.A. Talitha Nabila Sakhi; Indri Maharini; Elisma
Jurnal FARMASIMED (JFM) Vol 7 No 2 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v7i2.2651

Abstract

Background: Jernang resin (Daemonorops draco) contains secondary metabolite compounds, namely flavonoids, alkaloids, triterpenoids and steroids that play a role in the healing process of burns. Objective: The development of jernang resin into a pharmaceutical dosage form can be done in the form of nanoemulgel. Nanoemulgel is easy to apply to the skin, and can be specifically targeted to the site of treatment, avoiding first metabolism, and reducing gastric or systemic side effects. Method: the method used is experimental using a Completely Randomized Design (CRD) with a Post Test Only Control Group Design approach using 25 male white rats consisting of 5 treatment groups: positive control (bioplacenton), negative control (vaseline flavum) F1 1%, F2 3%, F3 5%. The parameters observed were the physical properties of nanoemulgel and the effectiveness of burns on male white rats, namely burn diameter, wound healing percentage, collagen density and fibroblast cells through histological observations. Results: each treatment has effectiveness, The best burn healing effectiveness is in F3 5% with a healing percentage of 93.32% and very dense collagen and fibroblast cells among other treatment groups, followed by F1 1% with a healing percentage of 90.65% and dense collagen density, the effectiveness produced is the same as the positive control (bioplacenton) which is with a burn healing percentage of 90.77%, and the concentration with the lowest effect is in F2 3% with a burn healing percentage of 84.14%. Conclusion: Nanoemulgel with different concentrations does not affect the physical properties of nanoemulgel but has different burn healing effects, with the best concentration being 5% jernang resin extract.
Potential of Flavonoids from Cat's Whiskers Plant (Orthosiphon Stamineus) as Antidiabetic Candidates through Inhibition of Tyrosine Phosphatase 1B and Aldose Reductase Proteins Adi Budi Ramadhan, Adi Budi Ramadhan; Galih Hamdani Riansyah; Saeful Amin
Jurnal FARMASIMED (JFM) Vol 7 No 2 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v7i2.2654

Abstract

Diabetes mellitus is a chronic metabolic disorder characterized by impaired regulation of blood glucose levels. The enzymes Protein Tyrosine Phosphatase 1B (PTP1B) and Aldose Reductase are known to play significant roles in the development of insulin resistance and diabetes-related complications. This study aims to evaluate the potential of flavonoid compounds from Orthosiphon stamineus as dual inhibitors of these enzymes through an in silico approach. The research involved phytochemical screening of flavonoids reported in O. stamineus, followed by molecular docking and validation using PyRx software on the crystal structures of PTP1B (PDB ID: 1AAX) and Aldose Reductase (PDB ID: 1AH3). Docking validation was performed via redocking of native ligands, yielding RMSD values < 2 Å. Ligand-protein interactions were analyzed using Discovery Studio, while pharmacokinetic and toxicity predictions were carried out using SwissADME, pkCSM, and ProTox-II. Docking results revealed that sinensetin and salvigenin exhibited the highest binding affinities to PTP1B and Aldose Reductase, with binding energies of -9.4 and -8.4 kcal/mol, respectively. These compounds formed strong interactions with key residues at the active sites of the enzymes, indicating their potential as effective inhibitors. Pharmacokinetic evaluation showed that most compounds complied with Lipinski’s rule of five and demonstrated favorable ADME profiles, including good absorption and potential blood-brain barrier penetration. Toxicity analysis indicated that the candidate compounds were non-toxic (toxicity class III–IV) and safe for oral administration. Flavonoid compounds from O. stamineus, particularly sinensetin and salvigenin, demonstrated strong potential as dual inhibitors of PTP1B and Aldose Reductase. This study supports further development of O. stamineus flavonoids as natural multitarget therapeutic agents for the management of diabetes mellitus.
Isolation and Structural Elucidation of Flavonoid Compounds from Ciplukan (Physalis angulata L.) Leaf Extract Cahya, Cucu Arum Dwi; Sinurat, Jhon Patar; Br Turnip, Nur Ulina M.; Br Karo, Reh Malem
Jurnal FARMASIMED (JFM) Vol 7 No 2 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v7i2.2667

Abstract

The exploration and utilization of herbal medicines continue to expand due to the presence of plant-derived secondary metabolites, which have been proven to prevent and treat various diseases with minimal side effects. One plant widely recognized for its medicinal properties is Physalis angulata L. (commonly known as ciplukan). Despite its frequent use in traditional medicine, particularly its leaves, limited studies have focused on the isolation of flavonoid compounds from this part of the plant. The isolation and structural elucidation of these flavonoids are essential to identify the bioactive compounds responsible for the plant's pharmacological effects. This study aimed to isolate and elucidate the chemical structure of flavonoid compounds from P. angulata leaf extract. The powdered leaves were subjected to maceration, solvent partitioning, phytochemical screening, thin-layer chromatography (TLC), and compound isolation using column chromatography. The isolated compounds were then characterized using UV-Visible (UV-Vis) spectroscopy, Fourier-transform infrared spectroscopy (FT-IR), nuclear magnetic resonance (NMR), and mass spectrometry (MS). The flavonoid compound isolated in this study was identified as quercetin (C??H??O?), a member of the flavonol subclass. It exhibited a molecular mass of 302 g/mol and showed maximum absorbance at wavelengths of 372.5 nm and 305.5 nm. Spectroscopic analyses revealed the presence of functional groups including C–O, C=C, C=O, CH, and OH, as well as 10 hydrogen and 15 carbon atoms in the NMR spectra. Based on these data, the isolated compound was confirmed to be 3,3',4',5,7-pentahydroxyflavone, commonly known as quercetin, with the molecular formula C??H??O?.
Acute Toxicity Evaluation of Mango (Mangifera indica L.) Leaf and Peel Extracts on Zebrafish (Danio rerio) Embryos Lusi Agus Setiani; Zaldy Rusli; Dinda Sabina Oktavia
Jurnal FARMASIMED (JFM) Vol 7 No 2 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v7i2.2682

Abstract

Mangiferin is the main flavonoid compound found in Mangifera indica L. (mango), known for its antioxidant and anti-inflammatory activities. In addition to the leaves, secondary metabolites such as alkaloids, flavonoids, and triterpenoids are also present in mango peels, contributing to their antibacterial properties. This study aimed to evaluate the acute toxicity of mango leaf and peel extracts using the Zebrafish Embryo Acute Toxicity Test (ZFET). The test was conducted over a 96-hour post-fertilization (hpf) period using zebrafish (Danio rerio) embryos exposed to five different concentrations of the extracts: 50 ppm, 100 ppm, 150 ppm, 200 ppm, and 250 ppm, along with an internal control using embryo water. Observed parameters included mortality rate and morphological abnormalities such as pericardial edema, yolk sac edema, spinal deformities, and tail malformations. Probit regression analysis revealed LC?? values of 156.133 ppm for mango leaf extract and 160.353 ppm for mango peel extract at 96 hpf. According to the EPA toxicity classification, both extracts fall into the practically non-toxic category. These findings provide preliminary evidence that mango leaf and peel extracts are relatively safe and have potential for further development into natural product-based formulations. However, additional research is required to support their clinical applications and long-term toxicological profiles.
Testing The Effectiveness of An Ethanol Extract Gel Preparation of Kelakai Leaves (Stenochlaena palustris (Burm.F.) Bedd.) on Reducing The Extent of Burns in Male White Rats (Rattus novergicus) Syarifuddin, Aminah; Novandi Purba; Yayuk Rahayu Suyudi; Elliya Siswanti; Syahfitri, Wilda Dani
Jurnal FARMASIMED (JFM) Vol 7 No 2 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v7i2.2685

Abstract

The wound healing process is essential for restoring body tissue to its original integrity or normal function. This process involves several stages, including the inflammatory, proliferative, and maturation phases. Both internal and external factors play a role in accelerating wound healing. Kelakai leaves are traditionally used as a topical treatment for burns in gel form, as they are safe for use, non-toxic, and do not cause harmful side effects. The most significant effect was observed with the gel formulation containing 15% w/w kelakai leaf extract, which was able to reduce burn wound area by 13.75%. This demonstrates the effectiveness of kelakai leaf extract gel (Stenochlaena palustris (Burm. F.) Bedd.) in the wound healing process. Therefore, the gel has the potential to reduce the extent of burn injuries.The aim of this study was to analyze the effect of various concentrations of ethanol-based kelakai leaf extract gel. As an effort to reduce burn wound area, this research included several stages, starting from the collection of materials and equipment, plant identification, research procedures, to the extraction process of kelakai leaf simplicia using maceration. This was followed by phytochemical screening and gel formulation at concentrations of 5%, 10%, and 15%, which were then tested for effectiveness on male white rats. The data were analyzed using ANOVA with a significance level of p < 0.050. The findings indicate that the gel containing kelakai leaf extract has a significant effect in reducing the burn wound area in rats.
Reduction of BOD, COD, and TSS in Textile Wastewater Using Bentonite Activated Charcoal Adsorbent Aritonang, Barita; Ritonga, Ahmad Hafizullah; Harefa, Karnirius; H, Herlina
Jurnal FARMASIMED (JFM) Vol 7 No 2 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v7i2.2699

Abstract

Wastewater generated by the textile industry contains a variety of hazardous contaminants, including complex organic compounds, synthetic dyes, surfactants, heavy metals, and critical pollution indicators such as biochemical oxygen demand (BOD), chemical oxygen demand (COD), and total suspended solids (TSS). This study evaluates the efficacy of a dual-adsorbent system comprising hydrochloric acid-activated bentonite and phosphoric acid-activated carbon for the removal of BOD, COD, and TSS from textile effluents. The activation processes significantly altered the physicochemical properties of both adsorbents. The moisture content of activated carbon decreased from 18% to 3.10%, while ash content was reduced from 15% to 3.05%. The iodine number, indicative of adsorption capacity, increased from 650 mg/g to 810 mg/g. Additionally, the fixed carbon content improved from 55% to 80%. Surface characterization via Fourier Transform Infrared Spectroscopy (FTIR) and Scanning Electron Microscopy (SEM) confirmed substantial structural modifications, which enhanced the adsorption performance of the materials. Application of the combined adsorbent system resulted in substantial pollutant removal efficiencies, with reductions of 70.23% in BOD, 70.11% in COD, and 74.88% in TSS. These findings demonstrate that acid-activated bentonite and phosphoric acid-treated activated carbon represent a promising and efficient adsorptive treatment strategy for the remediation of textile wastewater.

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