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INDONESIA
JURNAL FARMASIMED (JFM)
Published by Institut Kesehatan Medistra Lubuk Pakam
ISSN : -     EISSN : 26550814     DOI : -
Core Subject : Health,
Medicine & Pharmacology
Jurnal FARMASIMED (JFM) Volume I Nomor 1 Periode Mei - Oktober Tahun 2018. Jurnal ini memberikan ruang bagi akademisi, peneliti dan pengguna hasil penelitian dan pengabdian untuk mendiseminasikan, menginformasikan, mendiskusikan dan menggunakan hasil penelitian dan pengabdian sebagai upaya meningkatkan kualitas kebijakan di bidang farmasi yang berbasis ilmiah dan dapat dipertanggung jawabkan. Jurnal ini menyajikan hasil penelitian, pengabdian masyarakat serta artikel ilmiah di bidang farmasi.
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Articles 314 Documents
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Pharmacoeconomic Analysis of Cost Comparison Between Calcium Channel Blocker (CCB) and Angiotensin II Receptor Blocker (ARB) Antihypertensive Drugs in Hospitalized Hypertensive Patients at RSU Royal Prima Simbolon, Cherryl A.M; Razoki; Asyrun Alkhairi Lubis
Jurnal FARMASIMED (JFM) Vol 8 No 2 (2026): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/y2fhvc35

Abstract

Hypertension is a global health problem that contributes substantially to morbidity and mortality, thus requiring therapeutic management that is both clinically effective and economically efficient. In clinical practice, Calcium Channel Blockers (CCB) and Angiotensin II Receptor Blockers (ARB) are commonly used, either as monotherapy or in combination, but they differ in terms of cost and effectiveness. This study aimed to conduct a pharmacoeconomic analysis by comparing the costs and effectiveness of antihypertensive therapy using CCB and ARB in hospitalized hypertensive patients at RSU Royal Prima Medan. The study employed a retrospective design with a pharmacoeconomic analysis approach. Data were obtained from the medical records of hospitalized hypertensive patients during the period October–December 2024 using a total sampling technique, resulting in 52 patients who received CCB therapy, ARB therapy, or a combination of CCB + ARB. The analysis included patient characteristics, treatment costs, therapeutic effectiveness based on achievement of target blood pressure <140/90 mmHg, and calculation of the Average Cost-Effectiveness Ratio (ACER) and Incremental Cost-Effectiveness Ratio (ICER). The results showed that the combination therapy of CCB + ARB had the highest total treatment cost, while the lowest average cost per patient was found in the ARB monotherapy group. In terms of effectiveness, CCB monotherapy demonstrated the highest effectiveness (75.0%). ACER analysis indicated that CCB monotherapy was the most cost-effective therapy, and ICER analysis confirmed that CCB dominated both ARB and the CCB + ARB combination. In conclusion, CCB monotherapy is the most cost-effective antihypertensive treatment option for hospitalized hypertensive patients at RSU Royal Prima Medan.
Antifungal Potential of Pineapple Rind and Foliage Crown (Ananas comosus L. Merr) Waste Extracts Against Dermatophyte and Non-Dermatophyte Fungi Riesti Retno Arimurti, Anindita; Kunsah, Baterun; Artanti, Dita; Azizah, Fitrotin; Eka Sispita Sari, Yety
Jurnal FARMASIMED (JFM) Vol 8 No 2 (2026): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/73e7qm59

Abstract

Background: Fungal infections (mycoses) are common health problems in Indonesia, where tropical climatic conditions favor fungal growth. These infections are generally classified into dermatophytosis and non-dermatophytosis and are commonly treated using synthetic antifungal agents such as ketoconazole, which may cause adverse effects. Therefore, safer natural alternatives are needed. Pineapple rind and foliage crown (Ananas comosus L. Merr), which are typically discarded as agricultural waste, contain bioactive compounds with potential antifungal activity, including flavonoids, alkaloids, saponins, and tannins. Purpose: This study aimed to evaluate the antifungal activity of ethanol extracts from pineapple rind and foliage crown waste against Trichophyton rubrum and Aspergillus niger. Methods: An experimental study was conducted using the Kirby–Bauer disc diffusion method with extract concentrations of 25%, 50%, and 75%, along with negative (0%) and positive (ketoconazole) controls. Results: Both pineapple rind and foliage crown extracts inhibited the growth of T. rubrum and A. niger. The 75% concentration exhibited the largest inhibition zones, indicating the highest antifungal effectiveness. Conclusion: These findings suggest that pineapple rind and foliage crown waste have potential as natural antifungal agents.
Evaluation of Telemedicine Access with Health Insurance: A Systematic Review Erlisa Irawati Putri; Diah Ayu Puspandari; Anna Wahyuni Widayanti
Jurnal FARMASIMED (JFM) Vol 8 No 2 (2026): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/bne7rx24

Abstract

Introduction: Telemedicine transforms healthcare through electronic Communication technologies and offers high-quality medical treatments from a distance. The COVID-19 pandemic is accelerating the adoption of telemedicine, making its integration with insurance financing a strategic step to increase access to healthcare, reduce the financial strain on patients, and ensure continuity of service. Some nations have extended the coverage of private insurance companies and health insurance programs like Medicare and Medicaid to include telemedicine services. Objectives: Assess the impact of implementing telemedicine technology in the context of insurance financing and formulate policy recommendations to improve the accessibility and effectiveness of health services. Methods: Following PRISMA guidelines, a comprehensive search was conducted in Scopus, ScienceDirect, and PubMed, covering studies from 2015 to 2024. The inclusion criteria described telemedicine or telehealth financed by health insurance written in English. Based on the inclusion criteria, seven articles were reviewed in this article. We then assessed the studies’ quality using different research evaluation tools based on the research methods. Results: Health insurance-backed telemedicine has been shown to increase access to healthcare, lessen individuals’ financial burdens, and enhance the standard of medical care. However, several issues, including inadequate infrastructure, low digital literacy, and unclear regulations, continue to impede the use of telemedicine in conjunction with health insurance programs. Adapting to telemedicine presents challenges for elderly populations and people with physical disabilities. Policies, training for healthcare professionals, and technical advancements are required for these services to be inclusive and sustainable. Conclusion: Health insurance-backed telemedicine can improve access and efficiency of care and reduce patients’ financial burdens. By implementing corrective measures, as some countries have successfully done, health systems can maximise the benefits of telemedicine and create more inclusive, efficient, and sustainable health services.
Evaluation Of Antibiotic Use In Diabetic Ulcer Patients Based On The Defined Daily Dose Method (Ddd) Widi, As Syifa Roidhotul Jannah Putri; Purwaningsih, Avianti Eka Dewi Aditya; Sari, Novita
Jurnal FARMASIMED (JFM) Vol 8 No 2 (2026): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/8nffcw16

Abstract

Diabetic ulcers are a complication of diabetes mellitus that manifest as open skin wounds on the feet due to blood vessel disorders and nerve damage. These ulcers are susceptible to infection because bacteria thrive in high glucose environments. Selecting the right antibiotic is crucial in treating these infections. This study aims to predict the pattern of antibiotic prescribing in patients with diabetic ulcer infection in Hospital X Semarang Regency in 2023 using the ATC (Anatomical Therapeutic Chemical) method and DDD (Defined Daily Dose) units. This study is a retrospective descriptive study that analyzes data on diabetic ulcer patients who received antibiotic therapy between January-December 2023. The data collection technique was carried out by purposive sampling, following the inclusion and exclusion criteria. The results of the study of 168 patients with Diabetic Ulcers were found to be more dominant in female patients 53.57% (90 patients) and male patients 46.43% (78 patients). The antibiotic research that was classified as having the highest DDD/100 patient-days value was Ceftriaxone 44.99 DDD, followed by Metronidazole 33.96 DDD and Levofloxacin 26.85 DDD. Meanwhile, antibiotics that were included in the DU 90% segment with the order of highest to lowest values ​​were Ceftriaxone (36.16%), Metronidazole (63.46%), and Levofloxacin (85.04%). The use of antibiotics in diabetic ulcer patients based on the ATC/DDD and DU 90% methods needs to be reviewed periodically because it has the potential to cause the risk of resistance in patients which will then prolong the healing process. Based on the evaluation of antibiotic consumption patterns in diabetic ulcer patients at Hospital X, Semarang Regency in 2023 using the ATC/DDD and DU 90% methods, the antibiotics with the highest DDD/100 patient-days were Ceftriaxone (44.99), followed by Metronidazole (33.96) and Levofloxacin (26.85). These three antibiotics are included in the DU 90% segment, therefore their use needs to be periodically evaluated to ensure the rationality of therapy and to prevent the occurrence of antibiotic resistance.
Evaluation of the Implementation of Minimum Pharmaceutical Service Standards in Indonesian Hospitals: A Systematic Review Kurniati, Yarnida; Sukandar, Elin Yulinah
Jurnal FARMASIMED (JFM) Vol 8 No 2 (2026): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/cpap3x61

Abstract

Pharmaceutical services play a crucial role in ensuring patient safety and healthcare. Evaluation of the implementation of Minimum Service Standards (SPM) for pharmacy is an instrument for measuring the performance of healthcare institutions in providing quality and efficient services. This systematic review aims to evaluate the implementation of SPM for pharmacy in Indonesian hospitals based on four main indicators, influencing factors, and suggested intervention strategies. The systematic review method adopted the PRISMA guidelines through the Google Scholar electronic database. The evaluation results show variations for each indicator: waiting time 4-38.1 minutes, waiting time for compounded medication 8-≥60 minutes, no medication errors 90-100%, formulary compliance 89.3-100%, and patient satisfaction 53.6-94%. In conclusion, SPM for pharmacy has not been fully implemented in Indonesian hospitals. The main factors causing non-compliance with established standards include limited number of pharmacists, incompletely integrated information systems, and suboptimal drug inventory management. Intervention strategies can be implemented through recruitment of qualified pharmacists; ongoing training programs; implementation of an integrated management information system in the form of electronic prescriptions; and digital queuing system, the formation of a quality team to evaluate the Minimum Service Standards for pharmacies in hospitals, and multi-professional collaboration between pharmacists, doctors and management to ensure optimal service delivery.
Narrative Review: Expired Medicines in Public Health Services and Exploration of Causal Factors and Prevention Strategies Cicillia Debora Melissa Sumardi; Diah Ayu Puspandari; Anna Wahyuni Widayanti
Jurnal FARMASIMED (JFM) Vol 8 No 2 (2026): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/kjr6pf92

Abstract

Background: Although medications are essential to healthcare, the issue of expired medicines in public health institutions continues to be a significant obstacle. Various studies show high rates of expired medicines, such as in Jimma Zone (4.87%), Dire-Dawa (3.07%), Hadiya Zone (5.24%), and Arsi Zone (7.66%). The leading causes include delivery of drugs close to expiry, inaccurate quantity planning, weak stock management systems, and limited clinician involvement in the procurement process. Expired drugs cause economic losses, reduced healthcare quality, and environmental impacts. Objectives: to critically appraise, synthesize, and present available evidence on the possible causal factors associated with expired drugs, their impacts, and preventive mitigation or reduction strategy recommendations. Methods: Narrative literature review: content analysis. Results: The main factors leading to expired drugs include delivery of drugs close to the expiration date, inaccurate stock planning, weak inventory management systems, sudden changes in therapeutic protocols, and lack of clinician involvement in the drug procurement process. The impact of this problem is not only significant economic losses and increased waste disposal costs, but also a decrease in the quality of pharmaceutical services, potential environmental pollution, and a negative impact on the distribution of health budgets. Various strategies have been implemented, such as stock management training, the use of digital systems, and coordination among related units, which are expected to reduce the drug expiration rate. Conclusion: expired drugs remain a serious issue that requires collaborative efforts and innovation in the drug management system to achieve optimal budget efficiency and quality of health services.
The Effectiveness of Red Ginger (Zingiber officinale var. rubrum) Extract Administration on Weight Reduction in Obese Mice (Mus musculus) Muhammad Erlangga Dewantara djoharam; Andi Alamanda Irwan; Asrini Safitri; Sigit Dwi Pramono; Irna Diyana Kartika Kamaluddin
Jurnal FARMASIMED (JFM) Vol 8 No 2 (2026): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/d4pdxz92

Abstract

Background: Obesity is a complex condition influenced by various factors, including an imbalance between caloric intake and energy expenditure. Red ginger contains bioactive compounds such as gingerol, flavonoids, and essential oils that have the potential to reduce body weight through mechanisms related to fat metabolism regulation and anti-inflammatory activity. However, studies on the effectiveness of red ginger in reducing body weight in obese mice (Mus musculus) are still limited, thus further research is needed to confirm its benefits. Objective: To evaluate the effectiveness of red ginger extract in reducing body weight in obese mice (Mus musculus). Methods: This study employed a true experimental research design with full control over research variables, allowing direct observation of cause-and-effect relationships. The treatment was administered to obese mice to determine the impact of red ginger extract on body weight reduction. Results: The results showed that red ginger extract was effective in reducing the body weight of obese mice. The bioactive compounds in red ginger act through anti-obesity mechanisms, particularly by regulating fat metabolism, indicating its potential use as a phytotherapeutic agent in managing obesity. Conclusion: Administration of red ginger extract (Zingiber officinale var. rubrum) proved effective in reducing the body weight of obese mice, evidenced by a significant difference between body weight before and after treatment, with greater weight reduction observed in the treatment groups compared to the control group.
The Effect of Genjer Leaf Extract Ointment (Limnocharis flava) on Incision Wounds in Male New Zealand White rabbits Megawati, Sefi; Saru Noliqo Rangkuti; Ilmi Hidayat; Avianti Eka Dewi Aditya Purwaningsih
Jurnal FARMASIMED (JFM) Vol 8 No 2 (2026): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/tfpm7z77

Abstract

Background: Incision wounds are a common type of open wound that require proper treatment to prevent infection and accelerate the healing process. The use of natural products as alternative wound therapy has been increasingly developed, one of which is yellow velvetleaf (Limnocharis flava), known to contain active compounds such as flavonoids, tannins, and saponins that have anti-inflammatory and wound healing properties. Objective: This study aimed to determine the effect of ethanol extract ointment of Limnocharis flava leaves on incision wound healing in male New Zealand White rabbits and to identify the most effective extract concentration. Methods: Limnocharis flava leaves were extracted using 70% ethanol by maceration with a ratio of 1:10, then formulated into ointments with concentrations of F1 (5%), F2 (7.5%), F3 (10%), F4 (negative control), and F5 (positive control using povidone-iodine). Results: The evaluation results showed that all ointment formulations met the physical requirements, including good homogeneity, stable form and color, pH compatible with skin pH, as well as optimal spreadability and adhesion. Observation of wound healing indicated an increase in the percentage of wound closure with higher extract concentrations and longer treatment duration. Statistical analysis using Two-Way ANOVA showed a p-value < 0.05, indicating a significant effect of extract concentration and duration of treatment on incision wound healing. Conclusion: Quantitatively, the 10% concentration group (F3) showed the highest percentage of wound closure and the fastest healing time compared to other groups, with effectiveness approaching the positive control. The 10% Limnocharis flava leaf extract ointment is the most effective formulation for accelerating incision wound healing.
A Systematic Review of Healthcare Professionals' Knowledge, Attitudes, and Practices Regarding Adverse Drug Reaction Reporting in Southeast Asia Manek, Maria Sintia; Chairun Wiedyaningsih; Dwi Endarti
Jurnal FARMASIMED (JFM) Vol 8 No 2 (2026): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/c3t2v738

Abstract

Background: Adverse drug reaction (ADR) reporting is a crucial component of ensuring patient safety within a pharmacovigilance system. ADR reporting plays an essential role in detecting, assessing, and preventing adverse effects related to medications in clinical practice. However, ADR reporting practices in Southeast Asia remain low. Objective:  The purpose of this systematic review was to evaluate and synthesize evidence regarding healthcare professionals' knowledge, attitudes, and practices (KAP) regarding ADR reporting in Southeast Asia. This review aims to provide a comprehensive overview of current evidence and identify key gaps that may affect reporting practices. Methods: We conducted a literature search using PubMed, Scopus, EBSCOhost, and Web of Science for studies published between 2015 and 2025. Studies meeting the inclusion criteria were assessed for quality and analyzed using the PRISMA approach. This systematic review examined 16 studies from six Southeast Asian countries. Results: Most healthcare professionals have positive attitudes toward reporting ADRs, but knowledge varies, and actual reporting practices are low. Training, education, and incentive support were the most frequently cited factors facilitating reporting. Time constraints, unavailability of reporting forms, lack of awareness, uncertainty about the causality of drugs with adverse reactions, and lack of incentives were the main barriers to reporting. Conclusion: Healthcare professionals in Southeast Asia generally show positive attitudes toward ADR reporting, but knowledge remains varied, and reporting practices are low. Continuous education, system integration, and stronger national pharmacovigilance policies are needed to improve reporting.
Identification of Gene Variations and Gene Expression in Allergic Diseases Using a Bioinformatics Approach Naila Ismatun Hasanah; Ilham Alifiar; Rahmawati
Jurnal FARMASIMED (JFM) Vol 8 No 2 (2026): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/0y6eqw75

Abstract

Background: Allergy is an abnormal or excessive immune response to allergens involving complex interactions between genetic and environmental factors. Identification of genetic variations contributing to allergy susceptibility is important to understand molecular mechanisms and support the development of personalized biomarkers and therapies. Objective: This study aimed to identify genetic variations and gene expression profiles associated with allergic diseases using a bioinformatics approach. Research Methods: The study was conducted using a bioinformatics approach by analyzing data from GWAS Catalog, HaploReg v4.2, SNPnexus, GTEx Portal, and Ensembl Genome Browser. Results: A total of 18 missense single-nucleotide polymorphism variants are associated with allergic diseases. Three variants, namely rs1805009 (MC1R), rs183884396 (TESPA1), and rs59039403 (NLRP10), show the highest prediction score (1.000), indicating the most significant biological impact. Gene expression analysis shows dominant expression in whole blood, EBV-transformed lymphocytes, and skin (sun-exposed). Conclusion: The identified missense variants potentially contribute to the pathogenesis of allergic diseases and may serve as a basis for the development of genetic biomarkers and personalized therapeutic approaches.

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