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JURNAL FARMASIMED (JFM)
Published by Institut Kesehatan Medistra Lubuk Pakam
ISSN : -     EISSN : 26550814     DOI : -
Core Subject : Health,
Medicine & Pharmacology
Jurnal FARMASIMED (JFM) Volume I Nomor 1 Periode Mei - Oktober Tahun 2018. Jurnal ini memberikan ruang bagi akademisi, peneliti dan pengguna hasil penelitian dan pengabdian untuk mendiseminasikan, menginformasikan, mendiskusikan dan menggunakan hasil penelitian dan pengabdian sebagai upaya meningkatkan kualitas kebijakan di bidang farmasi yang berbasis ilmiah dan dapat dipertanggung jawabkan. Jurnal ini menyajikan hasil penelitian, pengabdian masyarakat serta artikel ilmiah di bidang farmasi.
Arjuna Subject : -
Articles 314 Documents
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Histopathology Test in Dyslipidemic Female White Rats (Rattus Norvegicus) Treated With Chitosan Nanoparticle Gel of Pineapple Peel Extract (Ananas Comosus (L.) Merr) as Anti-Cellulite Merista, Indri; Mitra, Aisa Dinda; Firira, Camila Putri
Jurnal FARMASIMED (JFM) Vol 8 No 2 (2026): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/ms60zx36

Abstract

Cellulite is considered a skin condition associated with aging appearance due to the accumulation of fat deposits beneath the skin. The use of natural-based skincare products, such as pineapple peel extract containing active compounds, offers an alternative solution for reducing cellulite. Pineapple peel contains beneficial bioactive compounds, including flavonoids, tannins, saponins, bromelain enzymes, and secondary metabolites such as quercetin, which act as lipolytic agents. This study aimed to determine the effect of varying concentrations of pineapple peel extract gel and chitosan nanoparticle–based pineapple peel extract gel on their anti-cellulite effectiveness and to identify the gel formulation that meets good physical quality requirements. The research employed an experimental method, beginning with sample collection, determination, simplicia preparation, extraction using maceration, phytochemical screening, nanoparticle solution formulation, and gel formulation with various concentrations (F0 0%, F1 2.5%, F2 5%, F3 2.5%, and F4 5%). The gel formulations were evaluated for their physical properties, including organoleptic characteristics, homogeneity, pH, spreadability, adhesiveness, and stability, followed by a histopathological test on the skin. The results show that all gel formulations exhibit physical characteristics that meet standard quality requirements. The variation in gel concentration influences the histopathological outcomes in female dyslipidemic white rats with cellulite, where an increased concentration of chitosan nanoparticle gel up to 5% significantly reduces the number of fat cells and improves skin tissue structure.
The Effect of Pharmacist Homecare Services on Medication Adherence, Drug-Related Problems, Clinical Outcomes, and Quality of Life of Hypertensive Patients at Sei Mencirim Public Health Center Fragilie, Dimas; Dalimunthe, Aminah; Khairunnisa, Khairunnisa
Jurnal FARMASIMED (JFM) Vol 8 No 2 (2026): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/d4bc3z22

Abstract

Background: Hypertension is one of the most prevalent chronic diseases in Indonesia (25.8%) and remains a leading cause of death globally, accounting for approximately three million deaths annually. Poor patient adherence to antihypertensive therapy continues to be a major challenge in achieving optimal blood pressure control and preventing cardiovascular complications. Objective: This study aimed to analyze the effect of pharmacist-led homecare interventions on medication adherence, drug-related problems (DRPs), clinical outcomes, and quality of life among hypertensive patients at Sei Mencirim Primary Health Center. Methods: A pre- and post-cohort study was conducted involving 38 hypertensive patients aged over 55 years between April and June 2024. Medication adherence was assessed using the MASES-R (Medication Adherence Self-Efficacy Scale-Revised) questionnaire, DRPs were identified according to the PCNE V9.0 classification, clinical outcomes were evaluated through blood pressure measurements, and quality of life was measured using the SF-36 (Short Form-36) questionnaire. Data were analyzed using the Wilcoxon Signed Rank test. Results: The majority of respondents were female (76.3%) and aged 56–66 years (71.0%). The mean adherence score significantly increased from 16.29 ± 2.35 to 40.97 ± 10.03 (p < 0.001), with adherence rates improving from 0% to 76.3%. A significant reduction was observed in drug-related problems, dropping from 14 to 2 cases, while adverse drug reactions decreased from 18 to 4 cases. The patients’ systolic blood pressure declined from 166.13 ± 17.85 mmHg to 129.07 ± 5.39 mmHg, and diastolic pressure decreased from 86.28 mmHg to 79.26 mmHg (p < 0.001). Furthermore, the average quality-of-life scores increased across all dimensions, including physical function (19.74–87.76), general health (2.19–90.46), and social functioning (4.28–94.41). Conclusion: Pharmacist-led homecare interventions involving continuous education, counseling, and patient support were proven effective in significantly improving medication adherence and quality of life among hypertensive patients. These findings suggest that such interventions should be implemented routinely in primary healthcare settings.
Analysis of The Implementation of Pharmaceutical Service Standards at Granmed Lubuk Pakam Hospital Sumitra, Jhoti; Miftahul Jannah; Yosi Darmirani
Jurnal FARMASIMED (JFM) Vol 8 No 2 (2026): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/v82hvz23

Abstract

Background: Pharmaceutical care involve direct interaction and responsibility of pharmacists to patients regarding pharmaceutical products with the aim of achieving clear outcomes to improve patients' quality of life. To enhance the quality of pharmaceutical care in hospitals, the Minister of Health Regulation No. 72 of 2016 on Standards of Pharmaceutical Services in Hospitals was established. Pharmacists have the duty to provide advice, information, and education related to the medications received by patients, as well as assist patients in implementing a healthy lifestyle to ensure the success of the treatment. They also monitor the outcomes of the therapies that patients have undergone and collaborate with other healthcare professionals with the goal of improving patients' quality of life. Objective: To analyze the implementation of the Minister of Health Regulation No. 72 of 2016 on Standards of Pharmaceutical care Hospital in relation to patient satisfaction. Method: cross-sectional in nature. The collected data were compared with standards listed in the literature and analyzed using the Chi-Square method. Results: it was found that 25 individuals (42.4%) who responded felt that clinical pharmacy services were unsatisfactory, while 34 individuals (57.6%) felt that the clinical pharmacy services were quite good. Conclusion: the implementation of PMK No. 72 of 2016. There is a relationship between clinical pharmacy care and patient satisfaction at Granmed Lubuk Pakam Hospital (p value = 0.007).
Implementation of Pharmaceutical Care to Improve Therapeutic Outcomes and Quality of Life in Type 2 Diabetes Mellitus Patients at Batubara Public Health Center Damanik, Citra Syahriani; Khairunnisa, Khairunnisa; Wiryanto, Wiryanto
Jurnal FARMASIMED (JFM) Vol 8 No 2 (2026): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/bym4fr96

Abstract

Background: Pharmacists have a significant function in delivering pharmaceutical care services aimed at maximizing therapeutic success for individuals with type 2 diabetes mellitus. Objective: The objective of this research was to evaluate the impact of pharmaceutical care practices on medication adherence, therapeutic outcomes, quality of life, and the frequency of drug-related problems (DRPs) in patients diagnosed with type 2 diabetes mellitus at Batubara community health centers. Methods: This research employed a comparative experimental approach with a prospective cohort design, assessing 66 participants across three community health centers during a three-month period before and after the intervention. Medication adherence was measured using the MARS-5 questionnaire, while DRPs were identified with the PCNE V9.1 instrument. Therapeutic outcomes were determined from random blood glucose (RBG) and HbA1c levels, and the Diabetes Quality of Life Clinical Trial Questionnaire (DQLCTQ) was used to assess quality of life. Data analysis was conducted using the Wilcoxon Signed Rank Test and Friedman Test via SPSS version 22.0. Results: The mean medication adherence score improved substantially from 5.21±0.90 to 23.39±1.78 following pharmaceutical care intervention. The average number of DRPs per patient declined from 1.26±0.44 to 0.12±0.48. Moreover, mean RBG levels decreased from 305.79±82.86 mg/dl to 194.62±67.67 mg/dl, and HbA1c levels reduced from 9.37±1.52% to 8.69±1.48%. The mean quality of life score also showed an increase from 7.20±0.90 to 11.14±0.77. Conclusion: The provision of structured pharmaceutical care significantly improved medication adherence, optimized therapeutic outcomes, minimized drug-related problems, and enhanced the overall quality of life of type 2 DM patients in Batubara community health centers.
Comparative Study of Antioxidant Test of Combination Pomegranate Peel and Rice Husk Extract in Body Scrub Formula Tsurayya, Nadya; Wulandari, Risca
Jurnal FARMASIMED (JFM) Vol 8 No 2 (2026): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/467hrw03

Abstract

Background: Antioxidant molecules have the ability to convert free radicals into harmless molecules. Antioxidants can be formed in the body or obtained from external sources, either in the form of enzymes, minerals, or non-enzymatic compounds such as vitamins A, C, and E. Pomegranate peel contains bioactive compounds in the form of phenolics, flavonoids, and tannins. The use of rice husks is relevant because, as a natural exfoliator, they also contain phenolic/flavonoid antioxidants. Research objective: To assess and compare the antioxidant activity of body scrubs made from rice husk extract and pomegranate peel. Research method: The methods used were maceration, antioxidant testing using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) method, and physical stability testing of the preparations. The antioxidant activity test results showed that the IC50 value of pomegranate peel extract was 7.65 ppm. Results: The antioxidant activity test results of preparations combining the extract with rice husks showed an IC50 value of 3.65 ppm. This indicates that F3 has very strong antioxidant activity. Based on organoleptic testing, homogeneity, pH, spreadability, adhesiveness, and cream type in Formulas 0, 1, 2, and 3. Conclusion: Pomegranate peel extract and rice husks can be successfully combined to produce a stable body scrub formula with sustained antioxidant activity
Antioxidant Activity Test of Black Rice (Oryza sativa L. Indica) Extract and Total Phenolic Test of Soybean Sprout (Glycine max L.) Extract Using 70%, 90%, and 96% Ethanol Variations. Maulizah, Rizlah; Kintoko; Nina Salamah; Elfi Anis Saati
Jurnal FARMASIMED (JFM) Vol 8 No 2 (2026): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/v5bg4116

Abstract

Background: The human body requires external antioxidants to neutralize free radicals that cause cellular damage and degenerative diseases. Black rice contains higher anthocyanin levels than red rice, while soybean germination increases flavonoids, phenolic compounds, and secondary metabolites.Objective: This study aimed to determine the total phenolic content of germinated soybeans extracted using three ethanol solvent concentrations (70%, 90%, and 96%) and to valuate the antioxidant activity of soybean and black rice extracts as copigmentation agents. Methods: Soybean extracts were obtained by maceration using different ethanol concentrations, followed by analysis of total phenolic content and antioxidant activity. Black rice extract was evaluated for antioxidant activity using the DPPH method to obtain a stable antioxidant with a very strong IC₅₀ value. Results: The total phenolic content of germinated soybean extracts varied with solvent concentration: ethanol 70% yielded 2.24 mg GAE/g, ethanol 90% yielded 7.14 mg GAE/g, and ethanol 96% yielded 3.36 mg GAE/g. The total anthocyanin content of black rice extract determined by the pH differential method was 8.182 mg/100 g, with an antioxidant activity IC₅₀ of 82.24 ± 3.6 ppm, categorized as strong. The IC₅₀ value of the non-copigmented sample was 83.71 ± 1.6 ppm (moderate), while copigmentation ratios of 1:1, 1:2, and 1:3 resulted in IC₅₀ values of 70.83 ± 0.8 ppm (strong), 62.97 ± 1.2 ppm (strong), and 38.53 ± 0.3 ppm (very strong), respectively. Conclusion: Extraction of germinated soybeans using ethanol 90% significantly increased total phenolic content (p < 0.05). Copigmentation of black rice anthocyanin flavylium with germinated soybean polyphenols at a 1:3 ratio produced very strong antioxidant activity (p < 0.05), indicating its potential as a copigmentation agent in functional food products.
The Relationship Between Knowledge Level and Attitudes of the Sanding Gianyar Community Toward the Use of Traditional Medicines for Self-Medication Megawati, Fitria; Ni Putu Dewi Agustini; Luh Santhi Utami Wiryani
Jurnal FARMASIMED (JFM) Vol 8 No 2 (2026): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/c9grej48

Abstract

Background: Knowledge is defined as an individual's ability that serves as the basis for decision-making and can influence attitudes. The self-medication process often involves the use of traditional medicine, where its utilization is strongly influenced by the individual's level of knowledge and attitude. Objective: This study aims to determine the relationship between the level of knowledge and community attitudes toward the use of traditional medicine for self-medication in Banjar Dinas Sanding, Gianyar. Methods: This study used a cross-sectional research design with an accidental sampling technique. The sample size was determined using the Slovin formula, resulting in 247 respondents from a population of 649 people who met the inclusion and exclusion criteria. The data used were primary data collected through questionnaires, consisting of a knowledge questionnaire using the Guttman scale and an attitude questionnaire using the Likert scale. Results: Data analysis in this study was conducted using univariate and bivariate analyses. The results showed that in the knowledge aspect, 153 respondents (61.94%) had good knowledge, while 94 respondents (38.06%) had poor knowledge. In the attitude aspect, 152 respondents (61.55%) showed a positive attitude, while 95 respondents (38.46%) had a negative attitude. The analysis of the influence of knowledge level on community attitudes was performed using SPSS with the Chi-Square test, which produced a p-value of 0.001 (p < 0.05).Conclusion: There was a significant relationship between the level of knowledge and attitudes toward the use of traditional medicine in Banjar Dinas Sanding, Gianyar.
The Effect of Pharmacist Education Using the Brief Counseling Method on Improving Medication Adherence in Hypertensive Patients Fauzana, Cut Alfaini Rahmah; Khairunnisa, Khairunnisa; Nasution, Azizah
Jurnal FARMASIMED (JFM) Vol 8 No 2 (2026): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/va7q5c96

Abstract

Background: The main problem in controlling hypertension is patients' low knowledge about the disease, complications, and the importance of adherence to long-term therapy. Objective: This study analyzes the effect of pharmacist education using brief counseling in improving the adherence of hypertensive patients. Methods: Quasi-experimental pretest and posttest with control group. The intervention took the form of brief counseling with leaflets using the 5A technique on hypertensive patients who met the inclusion criteria during July–October 2025. Compliance data were analyzed using the Wilcoxon test to determine the differences in the results of each group and the Mann-Whitney test to determine the differences between groups before and after the intervention. A total of 190 patients were followed up for one month, consisting of 96 control groups and 94 intervention groups. The intervention group was followed up in months 1 and 2 after the intervention. Results: The characteristics of respondents were dominated by women (86.8%), aged ≥65 years (36.8%), unemployed (62.1%), and high school education (45.2%). The results showed that in the intervention group there was an increase in compliance from 14.77 ± 3.817 to 24.67 ± 0.847 (p < 0.001). Meanwhile, in the control group, compliance increased from 15.31 ± 4.107 to 15.65 ± 4.063 (p = 0.083). Although compliance decreased in the first (24.64 ± 0.828) and second (24.61 ± 0.779) months of follow-up, there was no statistically significant difference from the posttest results. Conclusion: Education using brief counseling method can increase adhererence hypertension patients and effective in maintaining adherence for to two months.
The Impact of Implementation of Electronic Prescription on Patient Satisfaction in Primary Health Centers Medan Tampubolon, Frengki Daniel; Azizah Nasution; Urip Harahap
Jurnal FARMASIMED (JFM) Vol 8 No 2 (2026): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/4ecn4s52

Abstract

Background: The digital transformation of primary care services necessitates the implementation of electronic prescriptions to optimize productivity, performance, accuracy, service quality, and patient satisfaction. Objectives: This study analyzed the impact of the quality of pharmacy care on patient satisfaction levels and identified the dimensions with the highest to the satisfaction. Methodology:  The quantitative phase involved a patient survey using the Service Quality (SERVQUAL) which consits of tangible facilities, reliability, responsiveness, assurance, and empathy along with satisfaction indicators. Data were analyzed using Structural Equation Modeling – Partial Least Squares (SEM-PLS) to determine the influence of each dimension. The qualitative phase consisted of in-depth interviews with ten pharmacy personnel to clarify and enrich the quantitative findings, followed by a comprehensive integration of both datasets. Results: Most (65.8%) of the participants were female. All SERVQUAL dimensions significantly influenced patient satisfaction. Responsiveness showed the strongest contribution with an Original Sample (O) value of 0.302, followed by empathy (O = 0.254) and assurance (O = 0.185). Reliability and tangibles had a negative yet significant effect. The qualitative findings revealed that real-time prescription input accelerated service delivery. Limited human resources, inadequate infrastructure, network instability, and irregular polyclinic workflows weakened perceptions of service consistency and physical service quality. Conclusion: Patient satisfaction is primarily determined by service speed, quality of interaction, and clarity of information, as reflected in the strong dimensions of responsiveness, empathy, and assurance. The reliability and tangibles dimensions were affected by weakness of infrastructure weaknesses and workflow issues.
The Activity of Facial Serum from Essential Oil of Nutmed Seed (Myristicae fragrans Houtt.) as an Antiacne Agent Rina Kurniaty; Dewi, Resmila Dewi; Risa Nursanty
Jurnal FARMASIMED (JFM) Vol 8 No 2 (2026): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/920b6t08

Abstract

Acne is a chronic inflammatory dermatological condition affecting the pilosebaceous unit and is influenced by multiple etiological factors, one of which is bacterial colonization by Propionibacterium acnes. Nutmeg seeds have been recognized as a natural source of antibacterial agents, exhibiting stronger inhibitory activity against Gram-positive bacteria than Gram-negative strains. This antimicrobial potential is attributed to the presence of bioactive constituents, including essential oils, saponins, and alkaloids. The essential oil content of nutmeg seeds has been reported to range from approximately 2% to 16%, with an average value of around 10%.This study aimed to develop an optimized cosmetic formulation in the form of a facial serum incorporating nutmeg seed essential oil as an anti-acne agent. The quality of the formulated serum was assessed through a series of physicochemical evaluations, including organoleptic properties, homogeneity, pH, viscosity, adhesion capacity, emulsion type, and spreadability. Antibacterial efficacy was evaluated against P. acnes using the agar well diffusion method, with essential oil concentrations of 15%, 20%, 25%, and 30%. A serum base without essential oil served as the negative control, while a commercially available anti-acne serum containing erythromycin was used as the positive control.Statistical analysis using ANOVA demonstrated that all serum formulations were capable of inhibiting the growth of P. acnes.  The inhibition zone diameters observed for formulations containing 15% (F1), 20% (F2), 25% (F3), and 30% (F4) essential oil were 19.50±0.5000 mm (strong activity), 21.16±0.2887 mm, 22.33±0.2887 mm, and 24.33±0.5000 mm (very strong activity), respectively. According to standard criteria for inhibition zone interpretation, formulations with essential oil concentrations of 15%, 20%, and 25% were categorized as Intermediate (I), exhibiting inhibition diameters within the range of 14–22 mm, whereas the 30% formulation was classified as Susceptible (S) due to an inhibition zone diameter of ≥23 mm.

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