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INDONESIA
JURNAL FARMASIMED (JFM)
Published by Institut Kesehatan Medistra Lubuk Pakam
ISSN : -     EISSN : 26550814     DOI : -
Core Subject : Health,
Medicine & Pharmacology
Jurnal FARMASIMED (JFM) Volume I Nomor 1 Periode Mei - Oktober Tahun 2018. Jurnal ini memberikan ruang bagi akademisi, peneliti dan pengguna hasil penelitian dan pengabdian untuk mendiseminasikan, menginformasikan, mendiskusikan dan menggunakan hasil penelitian dan pengabdian sebagai upaya meningkatkan kualitas kebijakan di bidang farmasi yang berbasis ilmiah dan dapat dipertanggung jawabkan. Jurnal ini menyajikan hasil penelitian, pengabdian masyarakat serta artikel ilmiah di bidang farmasi.
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Articles 314 Documents
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Association Between Drug Related Problems and Outcomes of Tuberculosis Patients at Citra Husada Hospital Jember Lutvi Anggraeni; Fifteen Aprila Fajrin; Afifah Machlaurin; Irma Prasetyowati; Angga Mardro Rahardjo
Jurnal FARMASIMED (JFM) Vol 8 No 2 (2026): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/4h3axm73

Abstract

Background: Tuberculosis (TBC) remains a major global challenge. In Indonesia, the success rate for Drug-Sensitive Pulmonary TB (DS-TBC) treatment is still below target, often linked to Adverse Drug Reaction (ADR) and Drug Related Problem (DRP). The complexity of regimens and polypharmacy increases the risk of DRPs, which are strong predictors of treatment failure. Objective: This study aimed to identify DRPs and analyze their relationship with the clinical outcomes of DS-TBC. Method: A retrospective cohort study was conducted on 281 DS-TBC patients recorded at Citra Husada Hospital Jember from January 2020 to December 2023. Data were collected from medical records and the TBC Information System (SITB). DRPs were identified using the PCNE V9.1 classification, focusing on dose inappropriateness, drug interactions, and ADR. Outcomes were categorized as successful (cured/treatment completed) or unsuccessful. Result: Data analysis included descriptive statistics, bivariate analysis using Chi-Square, and multivariate analysis using Binary Logistic regression with a significance p < 0,05. The result of this study is that patients were predominantly male (55.16%), aged 46-65 years, with a treatment completion rate of 82.21%. DRPs were found in 84.34% of patients, dominated by drug interactions (79%) and ADRs (35.23%), although the accuracy of anti-TB drug dosage was 100%. In multivariate analysis, age ≥65 years was associated with a decreased likelihood of successful treatment (aOR 0.367), while respiratory tract medication administration was associated with an increased likelihood of successful treatment (aOR 2.477). The overall relationship between DRPs and outcome was not statistically significant. Conclusion: Sociodemographic factors (age) and clinical symptom management (respiratory therapy) play the most crucial roles in determining the treatment outcome. Effective pharmaceutical intervention is suggested to mitigate the impact of DRPs on treatment failure. More aggressive clinical management is necessary for elderly patients.
Evaluation of Vaccine Cold Chain Storage at Karangrejo Public Health Center in Tulungagung Regency in 2025 Izzah, Fatiya Nurul; Sugihantoro, Hajar; Hakim, Abdul; Maulina, Novia; Muti'ah, Roihatul
Jurnal FARMASIMED (JFM) Vol 8 No 2 (2026): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/zdb8gq71

Abstract

Vaccine storage is an important aspect of vaccine cold chain management. If not done properly, it can cause vaccine damage, rendering the vaccine ineffective and unusable. This study aims to evaluate the suitability of vaccine storage at the Karangrejo Community Health Center in Tulungagung Regency based on the 2021 Guidelines for Vaccine Management in Health Care Facilities and Minister of Health Regulation No. 12 of 2017. This study used a descriptive qualitative method with an observational approach. Data were collected through direct observation using a checklist and interviews with personnel responsible for vaccine storage. The highest percentage of compliance was found in the vaccine storage condition indicator at 95% with 5% non-compliance, followed by the vaccine refrigerator condition at 89% with 11% non-compliance, storage facilities and infrastructure at 84% and 16% non-compliance, and vaccine refrigerator maintenance at 82% and 18% non-compliance. The conclusion of this study is that the cold chain management of vaccine storage at the Karangrejo Community Health Center in Tulungagung Regency achieved 87.5% compliance and 12.5% non-compliance with the 2021 Guidelines for Vaccine Management in Health Care Facilities and Minister of Health Regulation No. 12 of 2017.
The Influence of Perceived Usefulness and Perceived Ease of Use on the Utilization of Electronic Medical Records: A Systematic Literature Review Asih, Hastin Atas; Arifin, Syamsul; Musafaah; Mohammad Bakhriansyah
Jurnal FARMASIMED (JFM) Vol 8 No 2 (2026): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/sn46mj50

Abstract

The utilization of Electronic Medical Records (EMR) is a crucial component of digital transformation in the healthcare sector to improve efficiency, accuracy, and quality of services. However, the success of EMR implementation largely depends on acceptance by end users, particularly healthcare professionals. The Technology Acceptance Model (TAM) is widely used to explain technology acceptance through two main constructs, namely Perceived Ease of Use (PEOU) and Perceived Usefulness (PU). Nevertheless, empirical studies examining the influence of PEOU and PU on EMR utilization have reported inconsistent findings. This study aims to analyze the influence of PEOU and PU on EMR utilization across various healthcare service contexts based on recent empirical evidence. A systematic literature review was conducted following the PRISMA guidelines. Literature searches were performed in the Scopus, ScienceDirect, PubMed, and Google Scholar databases for publications from 2019 to 2024 using relevant keywords and Boolean operators. The article selection process involved screening titles, abstracts, and full texts based on PICOS criteria, resulting in 13 quantitative studies included from a total of 196 identified articles. The narrative synthesis revealed three main patterns. First, PEOU was found to have a more significant influence than PU, particularly during the early stages of EMR adoption. Second, PU emerged as a stronger predictor of sustained EMR utilization. Third, several studies indicated that PEOU and PU contributed relatively equally to EMR acceptance. These variations reflect the complexity of interactions among user characteristics, organizational factors, and implementation contexts. In conclusion, both PEOU and PU play important roles in EMR utilization, with their relative influence varying according to the adoption phase and healthcare service conditions.
Formulation and Evaluation Of Sunscreen Foundation Cream Containing Jackfruit Seed (Artocarpus heterophyllus L.) Extract As A Natural Uv Protective Agent Julianty, Siti Muliani; Salmah Handayani Lubis; Jenti Najira Siregar
Jurnal FARMASIMED (JFM) Vol 8 No 2 (2026): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/j505xc75

Abstract

Background:: The utilization of natural ingredients in the cosmetic industry has increased significantly as consumers tend to prefer products that are safe and environmentally friendly. Jackfruit seeds (Artocarpus heterophyllus L.) are known to contain various bioactive compounds, including alkaloids, flavonoids, saponins, and tannins, which are reported to have potential photoprotective properties against ultraviolet (UV) radiation. Objective: This study aimed to evaluate the potential of ethanol extract from jackfruit seeds as an active ingredient in the formulation of a foundation cream with sunscreen activity based on the Sun Protection Factor (SPF) value. Methods: This research employed a laboratory-based experimental approach. The jackfruit seed simplicia were first dried and then extracted using analytical grade ethanol (p.a.). The obtained extract was subjected to phytochemical screening to identify the presence of secondary metabolites. Furthermore, the extract was formulated into foundation cream preparations with concentrations of 2%, 4%, and 6%. The prepared formulations were evaluated through several parameters including homogeneity, pH, spreadability, adhesion, and  determination of SPF values using a UV-Vis spectrophotometer. Results: Phytochemical screening results indicated that the ethanol extract of jackfruit seeds contained alkaloids, flavonoids, saponins, and tannins. All formulations produced homogeneous preparations with pH values ranging from 4.5 to 6.5. The spreadability values were within the range of 6.0–6.7 cm, while adhesion ranged from 7.97 to 11.63 seconds, which met the standard requirements for topical preparations. The SPF values increased proportionally with the extract concentration, showing values of 0.816 for the blank formulation, 4.38 for F1, 5.92 for F2, and 6.52 for F3. Conclusion: The ethanol extract of jackfruit seeds demonstrated potential as an active ingredient in foundation cream formulations with sunscreen activity. These findings indicate an opportunity for the development of innovative natural-based cosmetic products that provide protective effects against ultraviolet radiation.
Effectiveness of the Use of Analgetic Drugs in Sectio Caesarea (SC) Patients at RSAL Mintoharjo Atisi; Fajar Amirulah; Rizky Farmasita Budiastuti; Rangki Astiani; Atisi, Atisi
Jurnal FARMASIMED (JFM) Vol 8 No 2 (2026): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/0jfgbm77

Abstract

Cesarean section (CS) is a common obstetric surgical procedure that is frequently associated with moderate to severe postoperative pain, which may delay early mobilization and prolong recovery. This study aimed to evaluate the effectiveness of analgetic use based on the type and number of analgetics on pain intensity and recovery time in post-cesarean section patients at RSAL Mintoharjo. This research was conducted as an observational analytic study with a prospective cohort design involving 80 post-CS patients. Data were collected through medical records, direct observation, and pain assessment using the Numeric Rating Scale (NRS) at 6 hours, 24 hours and on day 2 or 3 postoperatively. Statistical analysis was performed using univariate analysis, Chi-Square test, and one-way ANOVA. The results show that the type of analgesic significantly affects pain intensity at all measurement times (p < 0,05), with combination analgetic regimens providing better pain control that single analgetics. The number of analgetics does not affect pain intensity at 6 hours postoperatively but shows a significant effect at 24 hours and during follow-up interviews. Recovery time is not significantly influenced by the type or number of analgesics, with most patients discharged within three days. Patient age and comorbidities affect pain intensity, while cesarean history and smoking status do not. In conclusion, multimodal analgesia is effective for controlling acute postoperative pain following cesarean section, whereas recovery time is more strongly influenced by patient clinical factors
Phytochemical Screening and Antioxidant Activity Test of Puring Leaf Extract (Codiaeum variegatum (L.) Rumph. ex A. Juss.) in Various Solvents Using the DPPH (2,2-diphenyl-1-picrylhydrazil) Method Sanitha Jayanti, Putu; Puspita Apsari, Dewi; Gede Adi Purwa Hita, I Putu; Agung Dharma Randika Putra, I Gusti Ngurah
Jurnal FARMASIMED (JFM) Vol 8 No 2 (2026): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/w0x19h76

Abstract

Background: Free radicals are molecules or compounds that exist independently and possess one or more unpaired electrons. Free radicals may infiltrate the body and damage healthy cells, leading to degenerative disorders. The detrimental effects they induce can be mitigated using antioxidant substances. Antioxidants are substances that inhibit the oxidation of molecules and can neutralize free radicals, even in minimal quantities. The croton leaf (Codiaeum variegatum (L.) Rumph. ex A. Juss.) is a plant in Indonesia with putative antioxidant properties. Purpose: To ascertain the composition of secondary metabolite chemicals and the antioxidant activity present in croton leaf extract (Codiaeum variegatum (L.) Rumph. ex A. Juss.) using 96% ethanol, ethyl acetate, and n-hexane solvents. Methods: The antioxidant activity was assessed using the DPPH (2,2-diphenyl-1-picrylhydrazyl) technique and quantified via UV-Vis spectrophotometry at a peak wavelength of 516.5 nm. Results: The ethyl acetate extract of croton leaves exhibited the highest antioxidant activity, with an IC50 of 11.31 ppm, whereas the IC50 values ​​for the 96% ethanol and n-hexane extracts were 13.55 ppm and 13.16 ppm, respectively. Conclusion: This study's results indicate that croton leaf extract, derived with ethyl acetate as the solvent, displays significant in vitro antioxidant activity as proven by the DPPH assay, with IC₅₀ values ​​close to those of the positive control, vitamin C, highlighting its remarkable free radical scavenging capability relative to extracts obtained with 96% ethanol and n-hexane.
The Immunomodulatory Potential of Ethanolic Extract of Blue Butterfly Pea Flower (Clitoria ternatea) on Non-Specific Immune Mechanisms Fiskia, Ermalyanti; Karim, Muhammad Azhar A; Hi Yusuf, Muhammad Fakhrur Rajih; Azzahra, Rufaidah; Rahman, Ismail
Jurnal FARMASIMED (JFM) Vol 8 No 2 (2026): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/s67fbc03

Abstract

The immune system is a complex mechanism consisting of cells, tissues, and organs that work in coordination to protect the body from exposure to pathogens. However, pathogens also possess strategies to counteract immune defenses, thereby necessitating external substances to support immune enhancement. One such substance is antioxidants. Butterfly pea flower (Clitoria ternatea) is a potential candidate as an immunomodulator due to its high antioxidant content, which functions to prevent lipid peroxidation and combat free radicals. This study aims to investigate the immunomodulatory potential of the ethanol extract of butterfly pea flower using the carbon clearance test in mice. The research method was experimental, employing 30 BALB/c mice as test animals, which were divided into six groups: Butterfly Pea Flower Extract (EBTB) at doses of 150, 300, and 600 mg/kg BW, levamisole 25 mg and methylprednisolone 4 mg as comparison groups, and sodium CMC as the negative control group. The substances were administered orally for seven consecutive days, followed by intravenous induction of carbon ink on day 8. The obtained serum was measured for absorbance using UV-Vis spectrophotometry at 650 nm. Parameters observed included the phagocytic index (PI) and lymphoid organ index (liver, spleen, and thymus). Based on the phagocytic index calculation, EBTB at doses of 150 and 300 mg/kg BW yielded values of 2.990 and 2.929, respectively, indicating strong immunostimulant activity, while BPFE at 600 mg/kg BW showed moderate immunostimulant activity with a PI value of 1.423. Results for the lymphoid organ index in the BPFE 150 group did not show significant differences (P > 0.05) compared to the control group. In conclusion, the ethanol extract of butterfly pea flower demonstrates potential as an immunomodulator for nonspecific immune responses.
Cost-Effectiveness Analysis (CEA) of Adjunctive Hyperbaric Oxygen Therapy to Standard Wound Care Alone in Diabetic Foot Ulcer (DFU) Herdian Pradana; Afifah Machlaurin; Ayik Rosita Puspaningtyas; Fifteen Aprila Fajrin; Ainur Rokhmah
Jurnal FARMASIMED (JFM) Vol 8 No 2 (2026): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/8z370a41

Abstract

Background: Diabetic foot ulcer (DFU) is a chronic complication of diabetes mellitus that is associated with high treatment costs and an increased risk of amputation. Hyperbaric oxygen therapy (HBOT) has been used as an adjunctive therapy to improve wound healing, yet evidence regarding its cost-effectiveness in Indonesia remains limited. Aim: This study aimed to evaluate the cost-effectiveness of HBOT compared with standard care in patients with DFU. Methods: A retrospective observational analytic study was conducted involving 80 DFU patients treated at RS Paru Jember between January 2024 and September 2025, consisting of 37 patients receiving standard care with HBOT and 43 patients receiving standard care without HBOT. Result: Clinical outcomes assessed included wound status, pain status, duration of healing, and incidence of amputation. Cost analysis was performed from the hospital perspective using direct medical costs, and cost-effectiveness was evaluated using the Incremental Cost-Effectiveness Ratio (ICER). The results showed that the HBOT group had a significantly higher proportion of wound healing compared with the non-HBOT group (21.62% vs 4.63%) and a lower rate of wound deterioration (2.7% vs 20.93%) (p=0.001). Although the mean total treatment cost was lower in the HBOT group than in the non-HBOT group (IDR 11,737,388 vs IDR 14,177,692), the difference was not statistically significant (p=0.118). ICER analysis demonstrated negative values for all evaluated outcomes, including wound healing, pain improvement, healing within six months, and prevention of amputation, indicating cost savings. Conclusion:  HBOT as an adjunctive therapy for DFU provides better clinical outcomes with lower overall treatment costs and may be considered a cost-effective and economically favorable intervention.
Integrative Review of Indonesian Phytocosmetics: Resveratrol, Collagen, and Pachyrhizus erosus for Anti-Aging and Skin-Brightening in Multipurpose Serum Lathifah, Sofiani; Kintoko , Kintoko; Gulies Sentana, Pradanty Anaperta
Jurnal FARMASIMED (JFM) Vol 8 No 2 (2026): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/nqkd8678

Abstract

Background: The demand for natural-based cosmetic products has increased substantially, driven by consumer awareness of safety, efficacy, and sustainability, with facial serums being preferred for anti-aging and skin-brightening applications. Objective: This review aimed to synthesise scientific evidence on the potential of resveratrol, marine collagen, and jicama (Pachyrhizus erosus) extract as key actives in multipurpose facial serum formulations with antioxidant, anti-ageing, and skin-brightening claims. Methods: A narrative review was conducted using original research articles published between 2015 and 2025 retrieved from PubMed and Crossref databases, focusing on quantitative outcomes including antioxidant and antityrosinase IC₅₀ values, changes in skin elasticity and hydration, transepidermal water loss (TEWL), and molecular biomarkers of skin ageing. Results: Of 1,393 identified records, 20 studies met the inclusion criteria (resveratrol n=6; collagen n=8; P. erosus n=6). Resveratrol shows strong antioxidant and anti-inflammatory activities that mitigate UV-induced photoaging; marine collagen, particularly hydrolysates, improves skin hydration and elasticity; and jicama extract provides antioxidant activity, including phenolic- and flavonoid-rich compounds, with tyrosinase inhibitory effects. Conclusion: Integrating these three actives may offer synergistic multi-target benefits; however, further formulation studies and clinical evaluations are required to confirm stability, compatibility, and combined efficacy within a single serum product.
Unidentified Drug-Related Problems (DRPs) Associated with Self-Medication in Patients with Type 2 Diabetes Mellitus and CKD Natalia Christine Latjandu; Ida Sa’adah; Patonah
Jurnal FARMASIMED (JFM) Vol 8 No 2 (2026): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/cghtrs29

Abstract

Patients with type 2 diabetes mellitus (T2DM) complicated by chronic kidney disease (CKD) are particularly vulnerable to drug-related problems (DRPs) as a result of altered pharmacokinetics, polypharmacy, and declining renal function. In this population, the practice of self-medication using over-the-counter (OTC) drugs and complementary and alternative medicine (CAM) is common and often not disclosed to healthcare professionals, causing many DRPs to remain undetected in routine clinical care. This systematic review aims to summarize the scientific evidence regarding the prevalence of self-medication among patients with T2DM and CKD and to examine the relationship between self-medication behavior, patient perception, and the occurrence of unidentified DRPs. A comprehensive search of major scientific databases identified twenty-three observational studies published between 2020 and 2025 that met the inclusion criteria. The findings reveal a high prevalence of OTC and CAM use, particularly analgesics, non-steroidal anti-inflammatory drugs, dietary supplements, and herbal products. Frequently reported unidentified DRPs included inappropriate dosing adjustments for renal impairment, potential drug–drug and drug–herb interactions, the use of nephrotoxic agents, and instances of duplicate therapy. Contributing factors to these unidentified DRPs were non-disclosure of self-medication practices, low levels of medication literacy, polypharmacy, and the lack of structured medication review in clinical settings. Overall, self-medication with OTC drugs and CAM represents a significant and underrecognized source of DRPs in patients with T2DM and CKD, emphasizing the need for proactive medication reconciliation processes and pharmacist-led interventions to improve medication safety and patient outcomes.

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