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INDONESIA
JURNAL FARMASIMED (JFM)
Published by Institut Kesehatan Medistra Lubuk Pakam
ISSN : -     EISSN : 26550814     DOI : -
Core Subject : Health,
Medicine & Pharmacology
Jurnal FARMASIMED (JFM) Volume I Nomor 1 Periode Mei - Oktober Tahun 2018. Jurnal ini memberikan ruang bagi akademisi, peneliti dan pengguna hasil penelitian dan pengabdian untuk mendiseminasikan, menginformasikan, mendiskusikan dan menggunakan hasil penelitian dan pengabdian sebagai upaya meningkatkan kualitas kebijakan di bidang farmasi yang berbasis ilmiah dan dapat dipertanggung jawabkan. Jurnal ini menyajikan hasil penelitian, pengabdian masyarakat serta artikel ilmiah di bidang farmasi.
Arjuna Subject : -
Articles 314 Documents
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Anti-Aging Activity Test and Physical Stability Evaluation of NanoCream  Containing Ethanolic Extract of Binara Herb (Artemisia vulgaris L.) Marbun, Romauli Anna; *, Yanna Rotua Sihombing; Ratih Anggraeni
Jurnal FARMASIMED (JFM) Vol 8 No 2 (2026): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/xecp6c81

Abstract

Background: Antioxidants are compounds that neutralize free radicals or prevent their formation by slowing oxidative reactions, thereby helping to inhibit premature skin aging. Binara herb (Artemisia vulgaris L.) is one of the plants with potential antioxidant properties. Previous studies have shown that binara herb contains flavonoids and exhibits moderate to strong antioxidant activity. Objective: This study aimed to formulate a stable and effective nanoCream  preparation containing binara herb extract (Artemisia vulgaris L.) as an anti-aging agent. Methods: This study employed an experimental research design. The pH test results met the acceptable range (4.5–7), and the viscosity test results complied with the required standard (2,000–5,000 cps). Results: The ethanolic extract of binara herb (Artemisia vulgaris L.) demonstrated very strong antioxidant activity with an IC₅₀ value of 40.36 ± 1.21 µg/mL. The nanoCream  formulation showed good physical stability during storage, as indicated by stable organoleptic characteristics, pH values within the skin-compatible range (6.6–6.8), and viscosity increasing with higher extract concentrations. The irritation test revealed that the 10% nanoCream  formulation was safe and did not cause irritation in volunteers. These findings indicate that the nanoCream  containing ethanolic extract of binara herb has potential for development as a herbal-based anti-aging preparation. Conclusion: The ethanol extract of binara herb showed very strong antioxidant activity (IC₅₀ 40.36 ± 1.21 µg/mL). The formulated nanoCream  was physically stable, had a skin-compatible pH (6.6–6.8), showed increased viscosity with higher extract concentrations, and caused no irritation up to a 10% concentration. Therefore, this nanoCream  has potential as a stable, safe, and effective herbal anti-aging formulation.
Evaluation of Drug Storage Systems Based on Good Distribution Practice in Pharmaceutical Wholesalers in Indonesia: A Systematic Review Martsom Putra Sulung S Langga; Teuku Nanda Saifullah Sulaiman; Satibi
Jurnal FARMASIMED (JFM) Vol 8 No 2 (2026): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/fnws3q19

Abstract

The pharmaceutical distribution system plays a crucial role in ensuring that medicines maintain their quality, safety, and efficacy throughout the supply chain. In Indonesia, Pharmaceutical Wholesalers (PBF) are required to implement Good Distribution Practice (CDOB), including proper storage systems; however, variations in compliance have been reported in several local studies. Purpose: This study aimed to identify the implementation of drug storage systems in PBF in Indonesia based on CDOB and to analyze the most frequent areas of non-compliance. Methods: A systematic review was conducted following PRISMA 2020 guidelines. Literature searches were performed in Google Scholar and Semantic Scholar for studies published between 2014 and 2024. Primary observational descriptive studies focusing on drug storage practices in Indonesian PBF were included, and seven eligible articles were analyzed. Result: The findings indicate that non-compliance most frequently occurs in the operational aspect, particularly in the inconsistent implementation of FEFO, medicines classification, and adherence to standard operating procedures. Issues related to building and equipment, such as unstable temperature control and inadequate ventilation, are also commonly reported. Weaknesses in documentation, stock verification, and managerial oversight further affect storage effectiveness. Conclusion: These recurring patterns suggest that challenges lie more in implementation consistency and internal control rather than regulatory absence. Overall, drug storage practices in Indonesian PBF generally refer to CDOB standards; however, compliance remains uneven. Strengthening operational discipline, documentation accuracy, and managerial supervision is essential to improve distribution quality and ensure patient safety.
The Effect of Variation in Polyvinylpyrrolidone (PVP) Concentration as a Binder in The Formulation of Curcumin Isolate Lozenges Putri, Yola Desnera; Dewantara, Annisa Putri; Sumirtapura, Yeyet Cahyati; Andriyannto, Adit
Jurnal FARMASIMED (JFM) Vol 8 No 2 (2026): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/tqs16n98

Abstract

Background: The pharmaceutical industry continues to develop user-friendly dosage forms to improve patient compliance, especially for individuals who have difficulty swallowing conventional tablets. Lozenges are an alternative oral dosage form that does not require water and allows drug absorption through the oral mucosa, making them more practical and convenient. In lozenge formulation, polyvinylpyrrolidone (PVP) as a binder plays an important role in determining physical characteristics such as hardness, friability, and disintegration time. Objective: This study aimed to evaluate the effect of varying PVP concentrations on the physical characteristics of curcumin isolate lozenges and to determine the optimal formulation. Methods: An experimental method using wet granulation was applied with PVP concentrations of 1%; 2%; 3%; 4% and 5%. Evaluations included granule properties (moisture content, flow rate, angle of repose, compressibility index) and tablet properties (organoleptic characteristics, weight and size uniformity, hardness, friability, and disintegration time). Results: Increasing PVP concentration influenced tablet characteristics, particularly hardness, friability, and disintegration time. All formulations met the physical quality requirements for lozenges. The formulation containing 3% PVP showed the most balanced characteristics compared to others. Conclusion: PVP concentration affects the physical properties of curcumin lozenges, with 3% identified as the optimal concentration, indicating its potential as a practical alternative oral dosage form.
Comparison of the SPF Values of 70% and 96% Ethanol Extracts of Bandotan Leaves (Ageratum conyzoides L.) Using the UV-Vis Spectrophotometric Method Dewianisya Arifatussholiha; Annie Rahmatillah; Rahmat Hidayat
Jurnal FARMASIMED (JFM) Vol 8 No 2 (2026): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/8gtb2161

Abstract

Indonesia, as a tropical country, has high exposure to ultraviolet radiation that can cause skin damage. Bandotan leaves (Ageratum conyzoides L.) contain flavonoids and tannins capable of absorbing UV radiation, thus having potential to be developed as a safer natural sunscreen agent. This study aimed to determine the Sun Protection Factor (SPF) values of 70% and 96% ethanol extracts of bandotan leaves using the UV-Vis spectrophotometric method and to evaluate the effect of different ethanol solvent concentrations on the SPF values of the extracts. The study used dried bandotan leaf simplicia extracted by maceration method with 70% and 96% ethanol. The obtained extracts were subjected to standardization and phytochemical screening. SPF values were determined in vitro using a UV-Vis spectrophotometer at a wavelength range of 290–320 nm with extract concentrations of 20, 40, 60, 80, and 100 ppm, and calculated using the Mansur method. The results showed that the SPF values of the 70% ethanol extract were 1.1550, 1.8349, 2.4004, 3.3868, and 4.5036, respectively, while the 96% ethanol extract produced SPF values of 1.0821, 2.0559, 2.9325, 3.8779, and 5.1098, categorized from no protection to moderate protection. The difference in ethanol solvent concentration (70% and 96%) had a significant effect on the SPF values of bandotan leaf extract (p < 0.05). Based on these findings, it can be concluded that the 96% ethanol extract of bandotan leaves (Ageratum conyzoides L.) is more effective than the 70% ethanol extract in producing photoprotective activity and therefore has potential to be developed as a natural ingredient in sunscreen formulations.
The Role of Medication Adherence Companions on the Pharmacotherapy Outcomes of Hypertensive Patients at Bambanglipuro Community Health Center Aprianto A, Diki; Eva Nurinda; Ari Susiana Wulandari; Ade Puspitasari; Ifa Aris Suminingtyas
Jurnal FARMASIMED (JFM) Vol 8 No 2 (2026): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/7r11af50

Abstract

Hypertension is a prevalent chronic condition in primary health care, particularly among geriatric patients requiring long-term therapy. Despite the availability of antihypertensive medications, achieving target blood pressure remains challenging and is often associated with poor medication adherence. Medication Adherence Companions (PMO) may improve adherence and enhance therapeutic outcomes. This study aimed to analyze the role of PMO in the pharmacotherapy outcomes of hypertensive patients at the Bambanglipuro Community Health Center. This analytic observational study with a cross-sectional design involved 101 geriatric patients diagnosed with hypertension. Data were collected using structured questionnaires covering patient characteristics, presence of PMO, medication adherence, and blood pressure control status. Data were analyzed descriptively and using multivariate logistic regression with a significance level of p < 0.05. The results showed that 64.4% of patients had a PMO, and 54.5% demonstrated high adherence. Patients with high adherence were more likely to achieve controlled blood pressure. Multivariate analysis revealed that the presence of PMO significantly increased the likelihood of controlled blood pressure (AOR = 2.77; 95% CI: 1.29–5.95; p = 0.009). Combination therapy was also significantly associated with blood pressure control (AOR = 2.25; p = 0.047). These findings suggest that Medication Adherence Companions can support successful hypertension pharmacotherapy among geriatric patients in primary health care settings.
Antibacterial Activity Test of an Ethanol Extract Toner Formulation from Water Apple Leaves (Syzygium aqueum) Against Propionibacterium acnes Darojatun Ni'mah; Yani’ Qoriati; Atika Nirmala
Jurnal FARMASIMED (JFM) Vol 8 No 2 (2026): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/fnzz4q83

Abstract

Background: Acne vulgaris is an inflammatory condition of the pilosebaceous unit, one of the contributing causes of which namely the bacterium Propionibacterium acnes. Long-term utilization of synthetic antibacterial agents may result in bacterial antibiotic resistance; therefore, alternative therapies based on natural ingredients are needed. Leaves from the water apple plant (Syzygium aqueum). Contain active compounds which consists of flavonoids, tannins, saponins, and alkaloids, which possess bacterial inhibition activity and can be formulated into skincare products such as toners. Toner refers to a liquid skincare preparation that is applied to assist in cleansing the skin from residual impurities, balance skin pH, control excess oil, and help manage acne problems. Aim: The purpose of this study was to evaluate the physical characteristics and antibacterial effect of an ethanolic extract toner formulation derived from water apple leaves active against Propionibacterium acnes. Method:  Inhibitory power test research method (agar diffusion – disk) with four variations of extract concentration, namely F0 (0%), F1 (1%), F2 (3%), and F3 (5%). Extraction was carried out by maceration using 96% ethanol. The toner To ensure quality, the prepared toner samples underwent several physical assessments, including observation of appearance, consistency, pH value, moisture content, andflow properties. Antibacterial activity was assessed using the agar diffusion method with paper discs. Results: The results showed that the water apple leaf extract toner formulations met the quality requirements in accordance with the Indonesian National Standard (SNI) for topical preparations, as indicated by acceptable organoleptic properties, homogeneity, pH, moisture content, and viscosity. Furthermore, the antibacterial activity test demonstrated that the ethanol extract toner formulation F3 at a concentration of 5% exhibited the strongest inhibitory effect against Propionibacterium acnes, with an average inhibition zone diameter of 15.03 mm. Conclusion: The ethanol extract toner preparation of guava leaves meets physical quality standards according to SNI and has fairly high effectiveness as an antibacterial agent in inhibiting the growth of bacteria that cause acne.
Gastrointestinal Adverse Effects of Elobixibat in Chronic Constipation: A Systematic Review and Meta-Analysis of Randomized Controlled Trials Citra Safitri Wirman; Kurniawan, Rudi Erwin; Darmawi; Benni Iskandar
Jurnal FARMASIMED (JFM) Vol 8 No 2 (2026): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/3rncke15

Abstract

Chronic constipation is a common gastrointestinal disorder that negatively affects quality of life and increases healthcare burden worldwide. Elobixibat, an ileal bile acid transporter inhibitor, has been introduced as a novel therapy to enhance intestinal fluid secretion and improve colonic motility in patients with chronic constipation. However, concerns remain regarding gastrointestinal adverse effects, particularly their potential relationship with dosage. Therefore, this study aimed to evaluate gastrointestinal adverse effects associated with elobixibat and to assess whether these events demonstrate a dose-dependent pattern. This systematic review and meta-analysis followed the PRISMA 2020 guidelines and was registered in PROSPERO (CRD420251155537). A literature search was conducted in PubMed and ScienceDirect to identify randomized controlled trials investigating elobixibat in chronic constipation patients published up to December 2025. Study eligibility was determined using the PICOS framework. Data on adverse effects, dosage, and treatment duration were extracted and analyzed using proportional meta-analysis with a random-effects model in R Studio, and risk of bias was assessed using the RoB2 tool. Five randomized controlled trials involving 922 participants are included in the analysis. The pooled proportion of diarrhea is 21%, abdominal distension is 26%, and abdominal pain is 16%, while unspecified gastrointestinal disorders represent the most frequently reported adverse events at 49%. Overall, gastrointestinal adverse events show a dose-dependent pattern, with higher doses associated with increased event rates. These findings indicate that elobixibat is associated with dose-dependent gastrointestinal adverse effects, highlighting the importance of individualized dosing and gradual titration to improve treatment tolerability.
Factors Associated with Reduced Blood Glucose Levels in Patients with Diabetes Mellitus: The Role of Oral Antidiabetic Therapyand Dietary Patterns Azrul Zuniarto, Ahmad; Pandanwangi TW, Siti; Deria, Deria
Jurnal FARMASIMED (JFM) Vol 8 No 2 (2026): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/as02jb48

Abstract

Background: Diabetes mellitus is a chronic disease that requires proper blood glucose control through appropriate dietary patterns and antidiabetic therapy. Objective: This study aims to analyze the association between dietary patterns and oral antidiabetic therapy with the effectiveness of blood glucose reduction in patients with diabetes mellitus in several health facilities in the Cirebon and Majalengka regions. Methods: This study used an observational cross-sectional design. Data were collected through medical records and the Food Frequency Questionnaire (FFQ). Results and Discussion: The results show that most patients had good dietary patterns, with 53 out of 69 patients (76.8%). In the oral antidiabetic therapy variable, 56 out of 69 patients (81.2%) who used oral antidiabetic drugs showed effective blood glucose reduction. The analysis of dietary patterns indicates that good dietary patterns are associated with a higher likelihood of effective glucose reduction in Cirebon City (OR 0.600; 95% CI: 0.058–6.213), Cirebon Regency (OR 2.500; 95% CI: 0.100–62.605), and Majalengka Regency (OR 0.826; 95% CI: 0.685–0.996). Regarding antidiabetic therapy, the use of Metformin shows a 3.5 times greater likelihood of achieving effective glucose reduction compared to Glibenclamide (OR 3.500; 95% CI: 0.435–28.138). Combination therapy is more favorable in Cirebon Regency (OR 0.100; 95% CI: 0.004–2.504), while in Majalengka Regency, the effectiveness between single and combination therapy is relatively similar (OR 1.167; 95% CI: 0.142–9.586). Conclusion: Overall, this study confirms that good dietary patterns and appropriate oral antidiabetic therapy regimens play an important role in improving the effectiveness of blood glucose control in patients with diabetes mellitus.
Antibacterial Activity Test Of Methanolic Extract Of Rambutan Leaves (Nephelium Lappaceum L.) Against Propionibacterium Acnes Growth Cahya, Cucu Arum Dwi; Desi Elmasari Manik
Jurnal FARMASIMED (JFM) Vol 8 No 2 (2026): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/92bkef26

Abstract

Background: Diseases caused by bacterial infections remain one of the leading health problems in Indonesia. Infections are among the most common illnesses suffered by the population, including skin infections such as acne (acne vulgaris). Therefore, alternative solutions are needed to address this issue by utilizing antimicrobial compounds derived from plants. One commonly used medicinal plant comes from the Sapindaceae family. A species from this family, the rambutan leaf (Nephelium lappaceum L.), has been reported to inhibit the growth of Propionibacterium acnes. Objective: To determine whether methanol extract of rambutan leaves (Nephelium lappaceum L.) contains tannins, flavonoids, saponins, and terpenoids; to assess its ability to inhibit the growth of Propionibacterium acnes; and to identify the most effective concentration among 15%, 35%, and 50% for antibacterial activity. Methods: The antibacterial activity was tested using the disc diffusion method to evaluate the potential of rambutan leaf extract as an antibacterial agent. Results: The study showed that the methanol extract of rambutan leaves inhibited the growth of Propionibacterium acnes, with inhibition zone diameters of 7.4 mm (15%), 9.53 mm (35%), and 11.53 mm (50%). The positive control showed an inhibition zone of 15.3 mm, while the negative control showed no antibacterial activity. Conclusion: The results indicate that the methanol extract of rambutan leaves exhibits antibacterial activity that increases with concentration, with the highest effectiveness observed at 50%. This activity is presumed to be due to the presence of secondary metabolite compounds that inhibit the growth of Propionibacterium acnes.
The Effect of Administering Ethanol Extract of Tempuyung Leaves(Sonchus arvensis L.) on Decreasing Uric Acid LevelsIn Mile Mice Situmorang, Novidawati Boru; Azahra Salsabila Mahriza
Jurnal FARMASIMED (JFM) Vol 8 No 2 (2026): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/ak6ez231

Abstract

Background: When serum uric acid levels are higher than normal, this condition is known as hyperuricemia. This condition is caused by increased breakdown of nucleic acids, decreased excretion, increased production of uric acid from purine-rich foods, or a combination of these. In traditional Indonesian medicine, tempuyung leaves (Sonchus arvensis L.) have traditionally been used to treat various diseases, including gout and kidney stones. Methods: Antihyperuricemic activity tests were conducted on 24 mice divided into six treatment groups. Hyperuricemia was induced by oral administration of chicken liver juice at a rate of 0.5 mL/20 gBW. Results: From days 1-6 after induction, uric acid levels in the test group increased progressively. In addition, the groups treated with allopurinol, 0.5% Na-CMC, and ethanol extract of tempuyung leaves (EEDT) at doses of 100, 300, and 500 mg/kgBW showed a decrease in uric acid levels on days 7 to 13. At doses of 500 mg/kgBW, 300 mg/kgBW, and 100 mg/kgBW, the allopurinol group experienced the greatest reduction, followed by the EEDT group. Conclusion: After allopurinol, the 500 mg/kgBW dose had the best antihyperuricemic efficacy, based on the percentage reduction in uric acid levels. Because the extract contains a large number of secondary metabolites, increasing the extract dose decreased the increase in effectiveness.

Page 29 of 32 | Total Record : 314

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