cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
Beny Irawan
Contact Email
benyirawan77@gmail.com
Phone
-
Journal Mail Official
benyirawan77@gmail.com
Editorial Address
-
Location
Kab. deli serdang,
Sumatera utara
INDONESIA
JURNAL FARMASIMED (JFM)
Published by Institut Kesehatan Medistra Lubuk Pakam
ISSN : -     EISSN : 26550814     DOI : -
Core Subject : Health,
Medicine & Pharmacology
Jurnal FARMASIMED (JFM) Volume I Nomor 1 Periode Mei - Oktober Tahun 2018. Jurnal ini memberikan ruang bagi akademisi, peneliti dan pengguna hasil penelitian dan pengabdian untuk mendiseminasikan, menginformasikan, mendiskusikan dan menggunakan hasil penelitian dan pengabdian sebagai upaya meningkatkan kualitas kebijakan di bidang farmasi yang berbasis ilmiah dan dapat dipertanggung jawabkan. Jurnal ini menyajikan hasil penelitian, pengabdian masyarakat serta artikel ilmiah di bidang farmasi.
Arjuna Subject : -
Articles 314 Documents
 28   29   30   31   32 
Formulation and Antibacterial Activity Evaluation of a Mouthwash Containing a Combination of Ethanolic Extracts of Basil Leaves (Ocimum sanctum L.) and Mint Leaves (Mentha piperita L.) against Streptococcus mutans Turnip, Nur Ulina M. Br.; Sunariati; Rosminar Hasibuan
Jurnal FARMASIMED (JFM) Vol 8 No 2 (2026): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/phftxp74

Abstract

Background: Dental caries was a tooth decay characterized by the progressive destruction of enamel and dentin caused by the metabolic activity of Streptococcus mutans. The prevention of dental caries could be achieved by using mouthwash. However, many commercial mouthwashes contained alcohol, which might cause side effects with long-term use. Therefore, a natural-based mouthwash formulation using basil leaves (Ocimum sanctum L.) and mint leaves (Mentha piperita L.) was needed, as both contained secondary metabolites with potential antibacterial activity. Objective: This study aimed to determine whether the combination of basil leaf extract and mint leaf extract could be formulated as a mouthwash and to evaluate its antibacterial activity against Streptococcus mutans. Methods: This study used an experimental design. Basil and mint leaves were extracted by maceration using 70% ethanol. The extracts were formulated into mouthwash preparations with concentrations of 20%:0% (F1), 0%:20% (F2), and 20%:20% (F3). The formulations were evaluated through pH, stability, and clarity tests. Antibacterial activity was assessed using the disc diffusion method. Results: The results showed that the combination of basil and mint leaf extracts met the requirements for pH, stability, and clarity tests. The antibacterial activity test showed inhibition zone diameters of 14.9 mm (moderate), 15.8 mm (strong), and 16.35 mm (strong) for F1, F2, and F3, respectively. The positive control showed an inhibition zone of 25.2 mm (very strong), while the negative control showed no inhibition zone. Conclusion: The combination of basil and mint leaf extracts could be formulated as a mouthwash, met the required evaluation parameters, and exhibited antibacterial activity against Streptococcus mutans.
Cellophane Membranes In In Vitro Permeation Studies Using Franz Diffusion Cells: A Review Jamin, Nessa Ramawati; Astuti, Novia Tri; Pratiwi, Puspa Dwi
Jurnal FARMASIMED (JFM) Vol 8 No 2 (2026): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/4kesna66

Abstract

Transdermal drug delivery systems require permeation evaluation to ensure the effectiveness and safety of formulations before clinical application. In vitro permeation testing using the Franz diffusion cell is a widely used method in the early stages of formulation development, as it can describe the drug release and diffusion profile in a controlled manner. One of the synthetic membranes commonly utilized in this system is the cellophane membrane, which is semipermeable, easily obtainable, and provides more reproducible testing conditions compared to biological membranes. This article aims to review the use of cellophane membranes in in vitro permeation studies using Franz diffusion cells and to analyze the parameters reported in the results. The method employed is a literature review conducted through Google Scholar using keywords related to cellophane membranes, Franz diffusion, and in vitro permeation within the period of 2021–2026. The review results indicate that cellophane membranes are used in various dosage forms such as gels, transdermal patches, emulgels, vesicular systems, nanosponges, and solid lipid nanoparticles, with testing conditions generally involving phosphate buffer pH 6.8–7.4 at temperatures of 32–37°C and sampling times up to 24 hours or longer. The most frequently reported parameters include percentage of cumulative drug release, cumulative amount of drug permeated, and flux values. Permeation enhancement is generally influenced by formulation composition, the addition of enhancers, and the type of delivery system used.
Effect of Tocotrienol Rich Fraction (TRF) Administration on Blood Glucose and Cholesterol in Streptozotocin Induced and High Fat Diet Rats Simangunsong, Irene; Pertiwi, Dewi; Dalimunthe, Aminah; Asfianti, Vivi
Jurnal FARMASIMED (JFM) Vol 8 No 2 (2026): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/139epr61

Abstract

Diabetes mellitus (DM) is a chronic metabolic disorder with a continuously increasing global prevalence and remains a major health problem, characterized by hyperglycemia and dyslipidemia, including elevated Low Density Lipoprotein (LDL) and decreased High Density Lipoprotein (HDL) levels. This study aimed to evaluate the effect of tocotrienol rich fraction administration on blood glucose levels and lipid profile in rats induced with streptozotocin and a high fat diet. The study used 24 white rats divided into six groups: a negative control group, a positive control group treated with glibenclamide, and four treatment groups receiving tocotrienol rich fraction at doses of 50, 100, 200, and 400 mg/kg body weight. The measured parameters included blood glucose, HDL, and LDL levels. The results show that tocotrienol rich fraction significantly reduces blood glucose levels and improves the lipid profile compared to the negative control group. The highest dose demonstrates the most optimal effect and approaches that of the positive control. Tocotrienol rich fraction increases HDL levels and decreases LDL levels in a dose dependent manner. These findings indicate that tocotrienol rich fraction significantly lowers blood glucose levels and improves lipid profile in streptozotocin induced and high fat diet rats in a dose dependent manner. Therefore, tocotrienol rich fraction has potential as an alternative therapeutic agent for diabetes mellitus with dyslipidemia.
Formulation and Evaluation of a Pandanus amaryllifolius Leaf Ethanol Extract Ointment for Burn Wound Healing in Male Rats Harahap, Mawandha; Heppy Nova Jayanti; Bunga Salsabila Gunawan
Jurnal FARMASIMED (JFM) Vol 8 No 2 (2026): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/a2nwpp71

Abstract

Background: Burn injuries are a form of tissue trauma that remain a global health problem, with significant morbidity and mortality, especially in developing countries. Objectives: This study aims to design and evaluate the effectiveness of an ointment containing ethanol extract of Pandanus amaryllifolius Roxb. leaves as a topical agent for the healing of second-degree burns. Specifically, this research is intended to assess the pharmaceutical characteristics of the resulting formulation, including homogeneity, stability, and physical properties, to ensure product quality and consistency. Methods: Pandan leaves were selected due to their bioactive compounds, including flavonoids, tannins, alkaloids, and saponins, which possess anti-inflammatory and antibacterial properties. The ointment formulation was developed using ethanol extract of pandan leaves and its efficacy was evaluated in treating second-degree burns in male white rats induced by a heated metal plate. The investigation began with the preparation of pandan leaf extract using the maceration method with 96% ethanol as the solvent. The ointment was formulated in three concentrations: 10%, 15%, and 20%, and subsequently evaluated for physical stability. The most stable formulation was then tested on male white rats with second-degree burns. The positive control used bioplacenton ointment, while the negative control used a base ointment. Data were analyzed using normality, homogeneity, and one-way ANOVA tests. Results: The study showed that the ethanol extract of pandan leaves contains active compounds including alkaloids, flavonoids, saponins, tannins, and polyphenols. The resulting ointment had a distinctive aroma, green color, semi-solid form, and homogeneous consistency. The efficacy test results indicated a significant effect of the pandan leaf extract ointment on burn wound healing (sig. 0.000 < 0.05). Conclusion: The 20% concentration demonstrated superior efficacy in accelerating the reduction of burn wound diameter compared to the 10% and 15% concentrations. The ethanol extract of pandan leaves can be developed into an effective ointment for the treatment of second-degree burns. This ointment formulation demonstrates therapeutic effects on second-degree burn wounds in the dermis of male white rats.
Moracin N as a Potential Anti-Obesity Agent via Modulation of Steroid Hormone Metabolism: A Network Pharmacology and Docking Study Rizqy Prabhata, Wimzy; Yogi Pratama, Galuh; Anggun Tiara Kaldella, Shilvia
Jurnal FARMASIMED (JFM) Vol 8 No 2 (2026): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/gnmer592

Abstract

Background: Obesity is a global health problem with a rapidly increasing prevalence, while available pharmacological therapies remain limited and are often associated with adverse effects. Although bioactive compounds from Morus alba have been widely investigated, the anti-obesity potential of Moracin N remains largely unexplored, creating a knowledge gap regarding its molecular mechanisms and protein targets. Objectives: This study aimed to evaluate the anti-obesity potential of Moracin N using network pharmacology and molecular docking approaches. Methods: Potential targets of Moracin N were predicted using SwissTargetPrediction, TargetNet, and Super-PRED, while obesity-related targets were obtained from OMIM and GeneCards. Network analysis was performed using STRING and Cytoscape, followed by enrichment analysis (gene ontology biological process and KEGG). Docking studies were conducted on HSD17B13, HPGD, and STS using PLANTS and visualized with PyMOL. Results: The analysis identified 62 overlapping targets (4.8%), mainly involved in steroid hormone biosynthesis, metabolism, and inflammatory regulation. Key proteins, including CYP19A1, CYP17A1, CYP11B2, pro-inflammatory cytokines (IL1B, TNF, IL6), and metabolic enzymes (HSD17B13, STS, HPGD), occupied central positions in the protein–protein interaction network. Docking results demonstrated strong binding affinity of Moracin N, particularly toward STS, with amino acid residue interaction patterns comparable to those in reference ligands. Conclusion: Overall, Moracin N shows potential as a multi-target anti-obesity agent, primarily through modulation of steroid hormone metabolism. However, these findings remain predictive and require further experimental validation.
Effectiveness Test of a 96% Ethanolic Extract Cream of Sambung Nyawa Leaves (Gynura procumbens L.) on Incision Wounds in Male White Rats Pranata, Chandra; Harahap, Hasni Yaturramadhan; Herlina, Herlina; Silitonga, Anissa Jelita
Jurnal FARMASIMED (JFM) Vol 8 No 2 (2026): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/fh42gn18

Abstract

Background: A major challenge in wound care is the high risk of infection and the relatively prolonged healing process. Synthetic antiseptics such as povidone iodine remain widely used as first-line therapy; however, prolonged use has been reported to cause adverse effects, including tissue irritation and the potential to delay epithelialization under certain conditions. Therefore, alternative therapies that are safer, more effective, and accessible to the community are needed. One promising approach involves the use of traditional medicinal plants known to possess antiseptic, anti-inflammatory, astringent, and antibacterial properties. Sambung Nyawa leaves (Gynura procumbens L.) have been empirically used in Indonesia to treat various health conditions, including skin wounds. This study aimed to evaluate the wound healing effect of an ethanol extract cream of Sambung Nyawa leaves and to determine the most effective concentration for incision wound healing. Methods: A true experimental method with a post-test only control group design was employed. The study subjects were male white rats (Rattus norvegicus) with standardized incision wounds. The animals were treated with Sambung Nyawa leaf extract cream at concentrations of 5%, 10%, and 20%, along with a positive control group (povidone iodine) and a negative control group. The observed parameter was wound diameter following treatment. Results: The findings indicated that the 20% cream concentration demonstrated the fastest healing time, followed by the 10% and 5% concentrations, the positive control, and the negative control. Differences in wound diameter among treatment groups suggest that Sambung Nyawa leaf extract has the potential to accelerate the wound healing process. Conclusion: Cream formulations containing 5%, 10%, and 20% extract exhibited effectiveness relatively comparable to povidone iodine, indicating their potential for development as a natural alternative therapy for incision wounds.
Association between Medication Adherence, Anxiety, and Quality of Life in Pulmonary Tuberculosis Patients: A Cross-Sectional Study Gelmeyfia; Afriani, Tika; Jannah, Miftahul
Jurnal FARMASIMED (JFM) Vol 8 No 2 (2026): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/wpk19m04

Abstract

Background: Tuberculosis (TB) remains a major public health problem in Indonesia with a high disease burden. Treatment success is strongly influenced by medication adherence; however, psychological factors such as anxiety and aspects of quality of life often interact in complex ways and have not been extensively examined simultaneously, particularly in primary healthcare settings. Objective: This study aimed to analyze the relationship between medication adherence, anxiety levels, and quality of life among patients with pulmonary tuberculosis. Methods: A quantitative analytic study with a cross-sectional design was conducted among 107 pulmonary TB patients using a total sampling technique. Variables were measured using standardized instruments, including the MMAS-8, GAD-7, and WHOQOL-BREF. Data were analyzed using Spearman’s rank correlation test. Results: Most respondents demonstrated a moderate level of medication adherence (62.6%), with anxiety predominantly at a minimal level (98.1%). Correlation analysis revealed a strong negative relationship between adherence and anxiety (rₛ = −0.729; p < 0.001), indicating that higher adherence is associated with lower anxiety levels. Furthermore, adherence was significantly positively associated with quality of life in the psychological (rₛ = 0.454; p < 0.001), social (rₛ = 0.461; p < 0.001), and environmental domains (rₛ = 0.600; p < 0.001), but not in the physical domain (p = 0.058). Conclusion: These findings highlight that medication adherence plays an important role not only in clinical outcomes but also in patients’ psychological well-being and quality of life. Integrating adherence-based interventions with psychosocial approaches is essential to improve treatment outcomes holistically.
Physicochemical Characterization of Goroho Banana (Musa acuminafe sp.) Starch and Its Potential as a Binder in Tablet Formulation Rindengan, Elvie Rifke; Maramis, Rilyn Novita; Nahor, Evelina Maria
Jurnal FARMASIMED (JFM) Vol 8 No 2 (2026): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/5534ds72

Abstract

Starch is a commonly used excipient in pharmaceutical formulations due to its favorable physicochemical properties. Bananas represent a promising natural source of starch. One potential source is Goroho banana (Musa acuminata), an endemic plant from North Sulawesi that remains underexplored as a pharmaceutical excipient. This study aimed to characterize the physicochemical properties of starch isolated from unripe goroho banana and to evaluate its potential as a binder in tablet formulation. The starch was isolated and subsequently subjected to physicochemical characterization. Chemical characterization included proximate analysis (moisture, ash, fat, and protein content) and determination of amylose and amylopectin content. Physical characterization involved the observation of starch granule morphology using scanning electron microscope (SEM) and the analysis of gelatinization profile using rapid visco analyzer (RVA). The obtained starch yield was 7.66%, with a slightly brownish-white appearance. The gelatinization temperature was recorded at 74.35 °C, and the pH of 1% starch dispersion was 7.76. Morphological analysis revealed that the starch granules were oval to spherical in shape with relatively smooth surfaces. Tablet formulation evaluation showed that all formulations met the requirements for weight uniformity and disintegration time (<15 minutes). Formulations F3 and F4 complied with the hardness requirement, while all formulations exhibited friability values >1%, indicating that they did not meet the acceptable friability standard. These findings suggest that goroho banana starch possesses suitable physicochemical characteristics for use as a pharmaceutical excipient, particularly as a binder. However, further formulation optimization is required to improve the mechanical strength of the resulting tablets.
Formulation and Stability Evaluation of Antioxidant Sunscreen Gel Containing Green Tea Leaf (Camellia sinensis) Extract Using the DPPH Method Sinurat, Jhon Patar; Fitria, Zahara; Br Karo, Reh Malem; Syarifuddin, Shofian
Jurnal FARMASIMED (JFM) Vol 8 No 2 (2026): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/f66vym74

Abstract

Sunscreen formulations are designed to protect the skin from exposure to ultraviolet (UV) radiation; however, excessive use of synthetic ingredients may lead to adverse effects on the skin. The utilization of natural ingredients as alternatives has gained increasing attention, one of which is green tea leaves (Camellia sinensis), known for their rich antioxidant content. This study aimed to formulate and evaluate the stability and antioxidant activity of a sunscreen gel based on green tea leaf extract. This research was a laboratory-based experimental study employing a quantitative approach with a post-test only control group design. The gel formulations were prepared in four variations of extract concentration, namely 0% (F0), 5% (F1), 10% (F2), and 15% (F3). The preparations were then evaluated for physical characteristics, irritation potential, and antioxidant activity using the DPPH method. The results showed that 392 g of extract was obtained from 3.8 kg of dried simplicia, yielding a 10.32% extraction yield. Phytochemical screening indicated the presence of flavonoids, tannins, saponins, and alkaloids. All formulations exhibited a semi-solid form, good homogeneity, and stable pH values ranging from 6.0 to 6.3, which are compatible with skin pH. Furthermore, no irritation reactions were observed among the 12 volunteers. Antioxidant activity increased with higher extract concentrations, with IC₅₀ values of 28.86 ppm (F0), 22.11 ppm (F1), 21.25 ppm (F2), and 20.72 ppm (F3). In addition, the percentage of inhibition for F0–F3 also showed an increasing trend, namely 8.24–17.50%, 15.79–26.28%, 13.30–24.89%, and 14.82–26.25%, respectively. In conclusion, green tea leaf extract demonstrates strong potential as an active ingredient in sunscreen gel formulations that are safe, stable, and possess significant antioxidant activity.
Formulation and Evaluation of Bioactive Gelatin from Tilapia (Oreochromis niloticus) Scales as an Antioxidant-Based Anti-Aging Cream Herlina, Herlina; Wulandari, Suci; Barita Aritonang; Amelia Putri Eflynia; Lasmaryna Sirumapea
Jurnal FARMASIMED (JFM) Vol 8 No 2 (2026): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/nnzg2676

Abstract

The increasing demand for sustainable, bioactive cosmetic ingredients has driven the use of marine by-products as alternative raw materials. Tilapia (Oreochromis niloticus) scales, an abundant aquaculture waste, are rich in collagen that can be converted into gelatin with potential dermatological applications. This study aimed to develop and evaluate bioactive gelatin derived from tilapia scales as an antioxidant-based anti-aging cream. Gelatin was extracted with 15% acetic acid and characterized by physicochemical parameters, including yield (4.6%), moisture content (12%), and ash content (2.2%), all of which met SNI standards. Antioxidant activity was determined using the DPPH method, yielding an IC₅₀ value of 139.46 ppm, indicating moderate to weak antioxidant activity. The gelatin was formulated into cream preparations at concentrations of 1%, 1.5%, and 2%, and the formulations were evaluated for stability, homogeneity, pH, spreadability, and irritation. Anti-aging efficacy was assessed using a skin analyzer, showing improvements in skin moisture and sebum balance, with the 1% formulation demonstrating optimal performance. Although the antioxidant activity was relatively low, topical application of gelatin contributed to measurable anti-aging effects. These findings highlight the potential of tilapia scale-derived gelatin as a sustainable bioactive ingredient for cosmeceutical applications.

Page 31 of 32 | Total Record : 314

 28   29   30   31   32 

Filter by Year

2018 2026


Reset
Filter By Issues
All Issue Vol 8 No 2 (2026): Jurnal Farmasimed (JFM) Vol 8 No 1 (2025): Jurnal Farmasimed (JFM) Vol 7 No 2 (2025): Jurnal Farmasimed (JFM) Vol 7 No 1 (2024): Jurnal Farmasimed (JFM) Vol 6 No 2 (2024): Jurnal Farmasimed (JFM) Vol 6 No 1 (2023): Jurnal Farmasimed (JFM) Vol 5 No 2 (2023): Jurnal Farmasimed (JFM) Vol 5 No 1 (2022): Jurnal Farmasimed (JFM) Vol 4 No 2 (2022): Jurnal Farmasimed (JFM) Vol 4 No 1 (2021): Jurnal Farmasimed (JFM) Vol 3 No 2 (2021): Jurnal Farmasimed (JFM) Vol 3 No 1 (2020): Jurnal Farmasimed (JFM) Vol 2 No 2 (2020): Jurnal Farmasimed (JFM) Vol 2 No 1 (2019): Jurnal Farmasimed (JFM) Vol 1 No 2 (2019): Jurnal Farmasimed (JFM) Vol 1 No 1 (2018): Jurnal FARMASIMED (JFM) More Issue