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JURNAL FARMASIMED (JFM)
Published by Institut Kesehatan Medistra Lubuk Pakam
ISSN : -     EISSN : 26550814     DOI : -
Core Subject : Health,
Medicine & Pharmacology
Jurnal FARMASIMED (JFM) Volume I Nomor 1 Periode Mei - Oktober Tahun 2018. Jurnal ini memberikan ruang bagi akademisi, peneliti dan pengguna hasil penelitian dan pengabdian untuk mendiseminasikan, menginformasikan, mendiskusikan dan menggunakan hasil penelitian dan pengabdian sebagai upaya meningkatkan kualitas kebijakan di bidang farmasi yang berbasis ilmiah dan dapat dipertanggung jawabkan. Jurnal ini menyajikan hasil penelitian, pengabdian masyarakat serta artikel ilmiah di bidang farmasi.
Arjuna Subject : -
Articles 314 Documents
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Anti-Inflammatory Potential of Combined Turmeric Rhizome Extract (Curcuma longa L.) and Hydroxyapatite in Male White Mice (Mus musculus) Ritonga, Ahmad Hafizullah; Amelia, Fatma; Herlina, Herlina; Aritonang, Barita; Harefa, Karnirius
Jurnal FARMASIMED (JFM) Vol 8 No 2 (2026): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/garnbm90

Abstract

Inflammation is a protective response of the body to tissue injury that needs to be controlled to prevent further damage. The use of nonsteroidal anti-inflammatory drugs is effective; however, it has the potential to cause side effects, so safer alternatives are needed. Turmeric rhizome (Curcuma longa L.) is known to have anti-inflammatory activity, while hydroxyapatite (HA) is biocompatible and has the potential to enhance the effectiveness of the combination. This study aims to evaluate the anti-inflammatory potential of the combination of turmeric rhizome ethanolic extract and HA in male white mice (Mus musculus). This research method uses an experimental design with an acute inflammation model induced by intraplanar injection of 1% carrageenan. A total of 25 mice were divided into five groups: negative control (0.5% Na-CMC), positive control (diclofenac sodium), and three treatment groups at 0.5%, 1%, and 1.5%. Edema volume was measured every 1 hour for 6 hours and analyzed using the Kruskal-Wallis test followed by a post hoc test. The results of this study showed that all treatment groups exerted anti-inflammatory effects compared to the negative control, as indicated by decreases in edema volume and the percentage of inflammation and increases in the percentage of inhibition of inflammation, with the 1.5% concentration showing the most optimal effect. These findings indicate that the combination of turmeric rhizome ethanolic extract and HA has potential as an effective anti-inflammatory agent in male white mice.
The Role of Umbilical Cord-Derived Mesenchymal Stem Cells (UC-MSC) in Rheumatoid Arthritis: A Literature Review and Bibliographic Study Bastian, Bastian; Radiyati Umi Partan; Krisna Murti; Ayeshah Augusta Rosdah
Jurnal FARMASIMED (JFM) Vol 8 No 2 (2026): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/6mrp2h76

Abstract

Umbilical Cord-derived Mesenchymal Stem Cells (UC-MSCs) are promising candidates for innovative therapy in rheumatoid arthritis (RA) due to their immunomodulatory and regenerative properties. RA is a chronic autoimmune disease characterized by persistent synovial inflammation, progressive joint destruction, and immune dysregulation involving T cells, B cells, and pro-inflammatory cytokines such as TNF-α, IL-1β, and IL-6. This study aims to analyze the research development and therapeutic potential of UC-MSCs in RA through a bibliometric approach and literature review. Data were collected from PubMed, Dimensions, ScienceDirect, and Google Scholar databases covering the period 2016–2025 using relevant keywords related to UC-MSC and RA. Bibliometric analysis was performed using VOSviewer to map publication trends, scientific collaborations, and research topic clusters, while the literature review was used to evaluate the underlying mechanisms and therapeutic effectiveness. The results indicate a significant increase in UC-MSC research in recent years, with a primary focus on immunomodulatory mechanisms and clinical applications. Biologically, UC-MSCs have been shown to suppress synovial hyperplasia, inhibit pro-inflammatory cytokine production, and increase regulatory T cell (Treg/FOXP3) populations, thereby promoting immune tolerance and tissue repair. Preclinical and clinical studies have reported reductions in disease activity scores and improvements in joint function. However, the limited number of large-scale clinical trials and insufficient exploration of specific molecular mechanisms remain major challenges. Therefore, further studies are required to optimize the clinical application of UC-MSCs as a regenerative and immunomodulatory therapy for RA.
Effectiveness of Dapavin Concentration as a Fertilization Inhibitor in Productive-Age Mice (Mus musculus L.) Effendi, Mikaila Radisti; Prayogo, Habsari Shavina; Kusmianto, Arif
Jurnal FARMASIMED (JFM) Vol 8 No 2 (2026): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/w4na9k48

Abstract

Background: The rat population in Indonesia, both in agricultural areas and urban settlements, is relatively high with a rapid reproductive rate, thereby impacting the agricultural sector and public health. On the other hand, the physiological similarities between rats and humans make them important model animals in biomedical research, including antifertility studies. Aim: This study aims to examine the effectiveness of various concentrations of Dapavin, a combination of bael leaf extract (Aegle marmelos) containing flavonoids, tannins, and alkaloids, as well as the papain enzyme derived from papaya latex (Carica papaya L.), in inhibiting fertilization in productive-age mice (Mus musculus L.).Methods: The research employed a laboratory experimental method using a post-test only control group design consisting of four treatment groups: control (0%), and Dapavin at concentrations of 10%, 20%, and 30%, each consisting of five female mice. Result: Primary data were obtained through direct observation of pregnancy rates, number of embryos, body weight changes, and mating behavior after oral administration of Dapavin for 14 days. The data were then analyzed statistically to determine differences among treatment groups. The results showed that Dapavin administration significantly reduced fertilization success compared to the control group. A decrease in embryo number and birth weight was observed with increasing doses, with the 30% concentration showing the highest inhibitory effect. Conclusion: These findings indicate that Dapavin has potential as an effective, safe, and environmentally friendly natural phytocontraceptive agent.
Biosynthesis of Zinc Oxide Nanoparticles Using Annona Muricata L. Leaf as Antimicrobial Husna Humaira; Juwita, Nur Aira; Muhammad Fauzan Lubis
Jurnal FARMASIMED (JFM) Vol 8 No 2 (2026): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/661yzr29

Abstract

Nanotechnology enables the development of materials at the nanometer scale (1–100 nm) with unique physicochemical properties relevant to pharmaceutical applications. Zinc oxide nanoparticles (ZnO NPs) have attracted significant interest due to their semiconductor properties, high catalytic activity, and broad-spectrum antimicrobial potential. However, conventional chemical and physical synthesis methods are often energy-intensive and involve hazardous reagents, necessitating environmentally friendly alternatives. This study aimed to synthesize ZnO NPs via a green biosynthesis approach using Annona muricata L. leaf extract as a natural reducing and stabilizing agent, and to evaluate their physicochemical characteristics and antimicrobial activity. The synthesized ZnO NPs were characterized using UV–Vis spectroscopy, Fourier-transform infrared (FTIR) spectroscopy, X-ray diffraction (XRD), scanning electron microscopy–energy dispersive X-ray (SEM–EDX), particle size analysis (PSA), zeta potential analysis, and differential scanning calorimetry (DSC). The results confirmed the successful formation of ZnO NPs with a hexagonal wurtzite crystal structure and an average crystallite size of 26.43 nm. The average hydrodynamic diameter was 489.3 nm, and a zeta potential value of −18.1 mV indicated moderate colloidal stability. DSC analysis revealed endothermic peaks at 162.40 °C and 275.38 °C, corresponding to the removal of residual organic compounds from the plant extract. Antimicrobial evaluation using the disk diffusion method demonstrated concentration-dependent inhibitory activity against Staphylococcus aureus, Staphylococcus epidermidis, and Candida albicans, with the highest inhibition observed at 25 µg/mL. Overall, these findings indicate that ZnO NPs biosynthesized using A. muricata leaf extract possess promising potential as eco-friendly antimicrobial agents for pharmaceutical applications.
Antidiarrheal Activity Test of a Combination of Guava Leaf Extract (Psidium guajava  L.) and Kencur Rhizome (Kaempferia galanga) on Male Mice (Mus musculus) Salmah Handayani Lubis; Muharni Saputri; Ika Julianti Tambunan; Adilla Apriliani; Della Aisyah Syah Fitri
Jurnal FARMASIMED (JFM) Vol 8 No 2 (2026): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/m2vf9674

Abstract

Background Diarrhea is the leading cause of high morbidity and mortality in children in developing countries such as Indonesia. Diarrhea can be caused by bacterial infections. Guava leaves and kencur have astringent properties that can help reduce the frequency of bowel movements and stop diarrhea. Aim: The study aims to determine the most effective dose concentration of a combination of guava leaf ethanol extract (PGEE) and kencur rhizome ethanol extract (KGEE) as an antidiarrheal medicine. Methods: The study used an experimental method with stages of simplisia preparation, extract preparation by maceration, simplisia characteristics, phytochemical screening, and antidiarrheal efficacy testing using 25 male mice divided into 5 groups, namely F1 = negative control (NaCMC); F2 = positive control (Loperamide); F3, F4, and F5 were combinations (PGEE:KGEE) with 3 different dose concentrations, namely (25%:75%); (50%:50%), and (75%:25%), where the base doses used were (PGEE=400mg/kg/BW) and (KGEE=27.5mg/kgBW). Results: The parameters observed included the onset time of diarrhea, duration, frequency of bowel movements, and stool consistency. Statistical data analysis was performed using ANOVA and Tukey's post hoc test with the help of SPSS software. Statistical analysis with Tukey's post hoc test showed that there was a significant difference (p < 0.05) in fecal weight between the treatment group and the negative control group. Conclusion: The dose concentration (50%:50%) showed the most significant effect in reducing fecal weight comparable to loperamide, so that the combination of PGEE and KGEE at that dose concentration proved to be the most effective in reducing fecal weight and overcoming diarrhea, both visually (graph) and based on statistical analysis results.
Cytotoxic Effects of Extract and Fractions of African Leaves (Vernonia amygdalina Delile.) Against WiDr Cells Simanjuntak, Ezra; Satria, Denny; Hasibuan, Poppy
Jurnal FARMASIMED (JFM) Vol 8 No 2 (2026): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/tf07jx42

Abstract

Background: Colon cancer remains a major unresolved health problem worldwide, ranking as the third leading cause of death. African leaf (Vernonia amygdalina) is one of the plants widely used in traditional medicine. Several studies have identified phytoconstituents, including flavonoids, sesquiterpene lactones, and bactericidal saponins, with diverse pharmacological properties, including anticancer effects. Objective: This study aimed to determine cytotoxic activity of the extract and fraction of African leaf against WiDr cells. Method: African leaf extract was produced by reflux extraction with methanol, then fractionated using n-hexane, chloroform, and ethyl acetate. The analysis of total flavonoid and phenolic contents was carried out using a colorimetric method with AlCl3 and Folin-Ciocalteu reagent. Antioxidant activity was assessed using the DPPH method. Cytotoxic activity was tested using the MTT method against WiDr cells. Then, the data were analysed using the IC50 value. Results: The cytotoxicity test shows that the chloroform fraction has the strongest activity, with an IC50 value of 78.45 ± 8.95 μg/mL, followed by the n-hexane fraction of (119.07 ± 3.98 μg/mL), ethyl acetate fraction of (126.39 ± 3.28 μg/mL), methanol extract of (430.70 ± 31.92 μg/mL), and water fraction of (1607.71 ± 89.85 μg/mL). Conclusion: The chloroform fraction of African leaves shows strong cytotoxic activity against WiDr cells.
The Influence of Activated Carbon Produced from Duck Eggshells as an Adsorbent for Free Fatty Acid Content of Used Cooking Oilc Aritonang, Barita; Ritonga, Ahmad Hafizullah; Harefa, Karnirius; Herlina, Herlina; Wiratma, Dicky Yuswardi
Jurnal FARMASIMED (JFM) Vol 8 No 2 (2026): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/r6vzyw08

Abstract

The repeated use of cooking oil can lead to a decline in oil quality and an increase in free fatty acid (FFA) levels, which may pose adverse health effects when consumed continuously. Therefore, an effective, safe, and sustainable purification method is required to improve the quality of used cooking oil. This study aims to evaluate the effectiveness of activated carbon derived from duck eggshell waste in reducing FFA levels in used cooking oil. The research employed a laboratory experimental method with a post-test only control group design. Samples of used cooking oil were selected purposively based on a level of degradation representative of real conditions. The preparation of activated carbon began with the carbonisation of duck eggshells, followed by chemical activation using a 3 M phosphoric acid (H₃PO₄) solution to enhance surface area and adsorbent porosity. The resulting activated carbon was then applied in the adsorption process of used cooking oil. FFA levels were analysed using the alkalimetric titration method. The results showed that the activated carbon significantly reduced FFA levels from 1.57% to 0.22%, with a reduction efficiency of 75%. This final value complies with the quality standard for cooking oil according to SNI 3741:2013 (≤0.3%). Furthermore, the produced activated carbon exhibited favourable characteristics, as indicated by a high iodine adsorption capacity and well-developed pore structure. In conclusion, activated carbon derived from duck eggshells is effective as an adsorbent for reducing FFA levels in used cooking oil and shows strong potential as an environmentally friendly and economically valuable solution.
Formulation of Ethanol Extract Lotion from Snake Fruit (Salacca zalacca) as an Antioxidant Purba, Novandi; Aminah; Intan
Jurnal FARMASIMED (JFM) Vol 8 No 2 (2026): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/vy39nj40

Abstract

The skin is the outermost layer of the body that functions as the main protector from environmental exposure, including free radicals that can cause cell damage such as premature aging, dry skin, and various other skin disorders. Efforts to maintain healthy skin can be done through the use of appropriate cosmetic products, one of which is in the form of lotion. Lotion is a topical preparation that is easy to apply and can increase moisture and provide protection to the skin. Snake fruit (Salacca zalacca), a plant native to Indonesia that grows in tropical areas, is known to contain various bioactive compounds such as anthocyanins, flavonoids, flavonols, polyphenols, and β-carotene which have potential as antioxidants. This study aims to formulate and evaluate body lotion preparations based on ethanol extract of snake fruit (Salacca zalacca) as an antioxidant. The research methods include the preparation of simple drugs, extraction with ethanol solvents, body lotion formulations with varying extract concentrations (3%, 6%, and 9%), as well as physical quality evaluations including organoleptic tests, homogeneity, spreadability, pH, and irritation tests on volunteers. Antioxidant activity was tested using the DPPH (2,2- diphenyl-1-picrylhydrazyl) method. The results showed that all body lotion formulations met the physical evaluation requirements, with stable, homogeneous characteristics, good spreadability, and a pH that matched the skin's pH. The  irritation test showed that the preparation was safe to use because it did not cause irritation reactions on the volunteers' skin. Antioxidant activity testing showed that the ethanol extract of snake fruit had relatively strong antioxidant activity, with activity increasing along with increasing extract concentration in the preparation. Based on the results of the study, it can be concluded that the ethanol extract of snake fruit (Salacca zalacca) has the potential to be formulated into a stable, safe, and effective body lotion as an antioxidant to protect the skin from damage caused by free radicals.
Cytotoxic Potential of Extract Methanol and Fraction of African Leaf (Vernonia amygdalina Del.) on B16F10 Cell Line in Melanoma Cancer Risqina Lubis, Sahwani; Hasibuan, Poppy Anjelisa Zaitun; Satria, Denny
Jurnal FARMASIMED (JFM) Vol 8 No 2 (2026): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/dyf31640

Abstract

Melanoma is a highly aggressive malignancy derived from melanocytes and is considered the most severe form of skin cancer. Natural products have increasingly attracted attention as potential sources for the discovery of novel anticancer agents. The purpose of this study is to assess the cytotoxic activity of Vernonia amygdalina Delile leaf methanol extract and chloroform fraction against B16F10 melanoma cells. Vernonia amygalina Del. Leaves extracted using reflux method and liquid-liquid fractionation. Identification of the contained compounds were identified using thin layer chromatography. B16F10 cells were cultured under standard conditions and treated with various concentrations of the chloroform fraction and methanol extract of Vernonia amygdalina Delile leaves and the cytotoxicity assay was performed using the MTT method to determine cell viability and IC₅₀ values. The analysis revealed IC₅₀ values of chloroform fraction (81.80±4.18) and followed by n-hexane fraction (187.33±12.48), etil acetate fraction (204.35±8.39), methanol extract (344.37±25.12) and residual fraction (4032.38±921.22). All fraction and the methanol extract demonstrated dose-dependent cytotoxicity, with the chloroform fraction exhibiting a more pronounced inhibitory effect. These results suggest that Vernonia amygdalina leaves contain bioactive constituents with significant anticancer potential against melanoma. Future studies should focus to the isolation of active compounds and comprehensive in vivo validation to strengthen the therapeutic prospects.
Anticancer Potential of Methanol Extract and Fractions of African Leaf (Vernonia amygdalina Del.) Against HeLa Cervical Cancer Cells Suryati Cintia Gultom; Poppy Anjelisa Zaitun Hasibuan; Denny Satria
Jurnal FARMASIMED (JFM) Vol 8 No 2 (2026): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/yd7znx87

Abstract

Globally, cervical cancer is one of the leading causes of cancer-related mortality among women. African leaves (Vernonia amygdalina Del.) are known to contain active terpenoid compounds, such as sesquiterpene lactones, which can be utilized for cancer therapy. The aim of this study is to evaluate the cytotoxic potential of methanol extracts and leaf fractions from the African plant as anticancer agents against the HeLa cervical cancer cell line in vitro. The crude African leaf extract was prepared using a reflux method with methanol, followed by liquid-liquid fractionation to obtain n-hexane, chloroform, ethyl acetate, and residual fractions. Cytotoxicity testing was performed using the MTT Assay on HeLa cervical cancer cell lines; samples exhibiting the strongest cytotoxic activity underwent further testing, including cell cycle analysis and apoptosis assays using flow cytometry. The cytotoxicity test results showed that the methanol extract and fractions from African leaves exhibited cytotoxic effects with IC50 values ranging from 25.45 to 4163.63 μg/mL, with the chloroform fraction (IC50 = 25.45 ± 0.97 μg/mL) demonstrating the strongest cytotoxic activity. Cell cycle assay results showed that the chloroform fraction could inhibit HeLa cell proliferation in the G0-G1 phase. Cell apoptosis results indicated that the chloroform fraction could increase total apoptosis by 3.4%. Therefore, African leaves have potential as anticancer candidates, with anticancer active compounds tending to be concentrated in the chloroform fraction. Therefore, African leaves show potential as anticancer agents, with the active anticancer compounds tending to be concentrated in the chloroform fraction. Further studies are urgently needed to isolate and identify the pure compounds from the chloroform fraction of African leaves.

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