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PENGARUH SUPLEMENTASI VITAMIN D TERHADAP NILAI PENGUKURAN FEV1/ FVC PADA PENDERITA ASMA TERKONTROL SEBAGIAN
Adyan Donastin;
Arief Bakhtiar;
Daniel Maranatha
Jurnal Ilmu Kesehatan dan Kesehatan Vol 1 No 1 (2017): FEBRUARY
Publisher : UNUSA Press
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DOI: 10.33086/mhsj.v1i1.617
Background:Airflow resistance in asthma caused by changes in the airways that is bronchoconstriction,airway edema, airway hyperresponsiveness and airway remodeling. Vitamin D supplementation is expectedto raise the value of the measurement of FEV1/ FVC in patients with asthma controlled in part through therole of vitamin D in terms of antiviral effects, atopic response, response improvement steroid and preventairway remodeling process.Objective:Comparing the measurement values of FEV1/ FVC in patients withasthma controlled most of which do not get supplemental vitamin D than getting supplemental vitaminD.Methods:This study is a randomized experimental simple study. This research was conducted in drSoetomo Hospital from June to July 2015. The sampling technique using consecutive sampling. Sampleswere divided into two groups each consisting of 14 samples which have earned a combined therapy ofinhaled corticosteroids and LABA. The control group that was not given additional vitamin Dsupplementation and the treatment group were given supplements of vitamin D for 1 month. Measurementand main result:Testing of data distribution using the ShapiroWilk method because the sample size is lessthan 50. The result of the difference in FEV1 / FVC with a paired sample t - test is known that in the controlgroup (not given additional vitamin D supplements) did not occur significant difference (p = 0.219> 0.05),while the treatment group (given additional vitamin supplements D) proved significant difference (p = 0.020<0.05) where the value of FEV1 / FVC after being given additional vitamin D supplements increased to96.071% of the initial conditions is 84.786%.Conclusions:The measurement values of FEV1/ FVC in patientswith asthma controlled most of which get vitamin D supplementation are the most significant increasecompared to the control group who did not receive supplementation ofvitamin D.
PENGARUH PEMBERIAN JUS BUAH BELIMBING WULUH (AVERRHOA BILIMBI L.) TERHADAP KADAR TRIGLISERIDA DARAH TIKUS PUTIH (RATTUS NORVEGICUS) JANTAN GALUR WISTAR YANG DIBERI DIET TINGGI LEMAK
Fatichasari, Hilda Dwi
Jurnal Ilmu Kesehatan dan Kesehatan Vol 3 No 2 (2019): AUGUST
Publisher : UNUSA Press
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DOI: 10.33086/mhsj.v3i2.865
ABSTRAK Latar Belakang: Hipertrigliseridemia merupakan suatu keadaan yang terjadi karena peningkatan kadar trigliserida ≥150 mg/dl. Pencegahan hipertrigliseridemia sangat diperlukan secara non farmakologi dengan mengubah gaya hidup sehari – hari, apabila hal ini tidak berhasil dibutuhkan farmakoterapi menggunakan obat konvensional dan atau obat tradisional. Salah satu obat tradisional yang secara empiris digunakan untuk menurunkan trigliserida adalah buah belimbing wuluh (Averrhoa bilimbi L.). Tujuan: Tujuan penelitian untuk menilai efek pemberian jus buah belimbing wuluh terhadap kadar trigliserida tikus Wistar jantan. Metode: Desain penelitian eksperimental laboratorik. Hewan coba 24 ekor tikus Wistar jantan, dibagi secara acak kedalam 3 kelompok (n=8). Kelompok kontrol negatif hanya diberikan pakan biasa. Kelompok kontrol positif diberikan pakan tinggi lemak selama 28 hari. Kelompok perlakuan diberikan pakan tinggi lemak 28 hari dan jus buah belimbing wuluh dengan dosis 4ml/200grBB pada hari ke 15 selama 14 hari. Analisis data persentase penurunan kadar trigliserida menggunakan One-Way ANOVA, yang dilanjutkan uji Post Hoc dengan teknik LSD. Hasil: Pada kelompok kontrol negatif menunjukkan rerata kadar trigliserida sebesar 66,13 mg/dl. Sedangkan pada kelompok kontrol positif, hasil penelitian menunjukkan adanya peningkatan rerata kadar trigliserida sebesar 96,13 mg/dl. Pada data penelitian didapatkan nilai p = 0,048 (p < 0,05), sehingga dapat disimpulkan bahwa terdapat kenaikan kadar trigliserida yang bermakna. Kenaikan ini menunjukkan bahwa diet tinggi lemak dapat meningkatkan kadar trigliserida darah. Kesimpulan: Jus Buah Belimbing Wuluh dapat menurunkan kadar trigliserida namun tidak signifikan secara statistik. Kata Kunci: Trigliserida, diet tinggi lemak, Belimbing wuluh (Averrhoa bilimbi L.)
PENGARUH PEMBERIAN JUS BUAH APEL MANALAGI (MALUS SYLVESTRIS) TERHADAP KADAR TRIGLISERIDA DARAH TIKUS PUTIH (RATTUS NORVEGICUS) JANTAN GALUR WISTAR YANG DIBERI DIET TINGGI LEMAK
Rahmat, Reni Rabiatul;
Suyono, Bambang;
Risma, Risma
Jurnal Ilmu Kesehatan dan Kesehatan Vol 3 No 2 (2019): AUGUST
Publisher : UNUSA Press
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DOI: 10.33086/mhsj.v3i2.866
Manalagi apples (Malus sylvestris) have long been believed to have the effect of lowering blood cholesterol levels. Where the main content is quercetin class of flavonoids as antioxidants and pectin which functions as fat absorption. This study was an experimental study with a randomized post test only control group design study conducted for 28 days and using 30 rats divided into 3 groups. In all groups given a high fat diet with treatment, control (-) was given a high fat diet, control (+) was given simvastatin and KP1 was given Manalagi apple juice (Malus sylvestris) dose of 10 ml/day. One-Way ANOVA test results from measurements of triglyceride levels showed p = 0.139 (p> 0.05) so that Manalagi apple juice (Malus sylvestris) did not significantly affect blood triglyceride levels of male Wistar strains (Rattus norvegicus) given high fat diet. Keywords: Apple Fruit Juice, Triglycerides, High fat Buah apel Manalagi (Malus sylvestris) telah lama dipercaya memiliki khasiat menurunkan kadar kolesterol darah. Dimana Kandungan utamanya adalah quercetin golongan flavonoid sebagai antioksidan dan pektin yang berfungsi sebagai penyerapan lemak. Penelitian ini bertujuan untuk mengetahui apakah ada pengaruh jus kulit dan daging buah apel Manalagi(Malus sylvestris) terhadap kadar trigliserida darah tikus putih jantan galur wistar (Rattus norvegicus) yang diberi diet tinggi lemak sebelumnya. Penelitian ini merupakan penelitian eksperimental dengan rancangan penelitian randomized post test only control group design yang dilakukan selama 28 hari dan menggunakan 30 ekor tikus yang dibagi menjadi 3 kelompok. Pada semua kelompok diberi diet tinggi lemak dengan perlakuannya, kontrol (-) diberi diet tinggi lemak, kontrol (+) diberi simvastatin dan KP1 diberi jus buah apel Manalagi (Malus sylvestris) dosis 10 ml/hari. Hasil uji One-Way ANOVA dari pengukuran kadar trigliserida menunjukan p = 0,139 (p > 0,05) sehingga pemberian jus buah apel Manalagi (Malus sylvestris) tidak berpengaruh secara signifikan terhadap kadar trigliserida darah tikus putih (Rattus norvegicus) jantan galur wistar yang diberi diet tinggi lemak. Kata kunci: Jus Buah Apel, Trigliserida, Diet tinggi lemak.
PENGGUNAAN PENANDA BIOLOGIS ANGIOGENIK RASIO s-Flt1 DAN PIGF SEBAGAI PREDIKTOR PREEKLAMSIA
Levani, Yelvi
Jurnal Ilmu Kesehatan dan Kesehatan Vol 3 No 1 (2019): FEBRUARY
Publisher : UNUSA Press
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DOI: 10.33086/mhsj.v3i1.920
Preeclampsia is a leading cause of maternal death worldwide. Preeclampsia involves multi-organ and characterized by hypertension and proteinuria. One of the hypothesis pathogenesisin preeclampsia is placental insufficiency. Its causing imbalance between angiogenic and antiangiogenic factors in maternal circulation. This imbalance factors are responsible for systemic vasoconstriction. However, until now, there is no predictor for preeclampsiain high risk pregnancy. Therefore, this review briefly describes the recent studies about utility of biologic angiogenesis marker, such as s-Flt1 and PIGF as predictor in preeclampsia
PENGARUH EKSTRAK DAUN PEPAYA (Carica papaya) TERHADAP KEMATIAN LARVA NYAMUK Aedes agypti INSTAR III
Payangka, Jonathan;
Risma, Risma;
Wibowo, Prajogo
Jurnal Ilmu Kesehatan dan Kesehatan Vol 3 No 1 (2019): FEBRUARY
Publisher : UNUSA Press
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DOI: 10.33086/mhsj.v3i1.921
Background: Papaya leaves (Carica papaya) extract is a natural larvacide that contains papain and alkaloid karpain so its usage is safe for the environment. The larvacide properties can also be used to reduce the amount of Aedes aegypti mosquito larvae. This mosquito species is the main vector for the virus that causes dengue fever which incident number increases over the years. There have been a few methods used to control the mosquito’s amount, one of which is by decreasing the number of Aedes aegypti’s larvae using the organophosphate insecticide chemical known as temefos. Temefos is really effective in killing the Aedes aegypti larvae but it has a lot of side effects especially towards the environment. By controlling the number of the Aedes aegypti’s larvae, hopefully the number of the dengue fever case can also be reduced. Objective: To prove that the papaya leaves (Carica papaya) extract have effects on the death of Aedes aegypti’s instar III larvae. Method: This is an experimental research what uses a post test only control group design. The study consists of seven groups, which are positive control that is given abate powder, negative control that is given only aquadest, and five groups treated with concentrations of 0.5%, 1%, 1.5%, 2%, and 2.5%; repeated for four times. The calculation of the amount of dead larvae is done within the first 24 hours. Result: Based on the Kruskal-Wallis test, p’s value is <α with p value being 0.000 and α being 0.05. It proves the significance of the experiment. Conclusion: The papaya leaves (Carica papaya) extract have effects on the death of Aedes aegypti’s instar III larvae
PENGARUH EKSTRAK BUAH MENGKUDU (MORINDA CITRIFOLIA) TERHADAP KADAR KOLESTEROL TOTAL DARAH PADA TIKUS PUTIH (RATTUS NORVEGICUS) JANTANGALUR WISTARYANG DIBERI DIET TINGGI LEMAK
Priadna, Astrid Ika;
Adiwinoto, Budiarto;
Handajani, Fitri
Jurnal Ilmu Kesehatan dan Kesehatan Vol 3 No 1 (2019): FEBRUARY
Publisher : UNUSA Press
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DOI: 10.33086/mhsj.v3i1.922
Background: High cholesterol dietinduced hypercholesterolemia. Noni fruit extracthas flavonoids which are expected to reduceblood total cholesterol levels.This study aims to determine the effect of noni fruit extract (Morinda citrifolia) on total blood cholesterol levels in wistar strain male rats (Rattus norvegicus) given a high-fat diet. Method: Experimental study using post test only control group design. A total of 24 wistar strain male rats were divided into 3 groups: negative controlgroup given standard feed; positive control group of experimental animals who were given a high-fat diet; the experimental group treated with a high-fat diet for 14 days and given noni fruit extractat a dose of 200 mg / Kg BB. On the 29th day total blood cholesterol levels were measured for all groups of experimental animals. Results: The Mann Whitney UTest showed a significant increase in total blood cholesterol levels in the positive group of experimental animals given a high-fat diet (68.13 mg/dl) compared to the negative control group of experimental animals given standard feed (51.25 mg/dl). There was a significant decrease in total blood cholesterol levels in the experimental group treated with a high-fat diet and noni fruit extract (61mg/dl) compared to the average positive control group of experimental animals given a high-fat diet (68.13 mg/dl). Conclusion: Provision of a high-fat diet in wistar strain male ratscan significantly increase total blood cholesterol levels. The administration of noni fruit extract in wistar strain male ratscan significantly reduce total blood cholesterol levels
PENINGKATAN PENGETAHUAN GURU TENTANG P3K MELALUI PROMOSI KESEHATAN DI SMK KAL 1 SURABAYA
Rinarto, Nisha Dharmayanti;
Priyantini, Dwi;
Fitriastuti, Annisa Nurayu
Jurnal Ilmu Kesehatan dan Kesehatan Vol 3 No 1 (2019): FEBRUARY
Publisher : UNUSA Press
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DOI: 10.33086/mhsj.v3i1.923
Health promotion is an effort planned to influence other people, whether individuals, groups or communities, so that they do what is expected by health promotion actors. Health promotion of P3K in schools has an effect on the level of knowledge that teachers have about P3K on emergencies. This study aims to see the effect of health promotion on increasing teacher knowledge about first aid at Surabaya KAL-1 Vocational School. Sampling technique with Simple Random Sampling, a total sample of 39 respondents. The research method is Pre Experimental with the One Group Pretest-Posttest approach. Data collection using questionnaires. Data analysis techniques using the Wilcoxon Signed Rank Test. The results of the study showed that the teacher's knowledge before being given a health promotion with an average value of 1.38 and after being given a health promotion obtained an average value of 2.54. The results of statistical tests obtained the results of Asymp. Sig 0.001> α 0.05, which means that there are significant differences. Further analysis found that there was an effect of health promotion on the level of teacher knowledge, so it was hoped that the school would propose to the relevant UPTD for the provision of first aid training in schools
GAMBARAN INDEKS LARVA AEDES AEGYPTI DI BUFFER WILAYAH KERJA BANDARA SEPINGGAN BALIKPAPAN
Abdurrakhman, Abdurrakhman
Jurnal Ilmu Kesehatan dan Kesehatan Vol 3 No 1 (2019): FEBRUARY
Publisher : UNUSA Press
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DOI: 10.33086/mhsj.v3i1.924
The House index and Container Index in the buffer area of the working area of Balikpapan Sepinggan Airport is still above 1%, so the potential for the spread of dengue disease. Mobilization of people, goods and transportation equipment will increasingly affect the transmission of disease in ports and airports, especially for vector-borne diseases. This study aims to analyze the risk factors associated with larvae density of Aedes aegypti and describe the larvae index in the buffer zone of the Sepinggan Balikpapan Airport This study was a descriptive study with a cross sectional design. The sample in this study was 121 houses with a proportionate stratified random sampling, the research location was in the buffer zone of Sepinggan Balikpapan Airport in November 2018. The variables studied were houses with positive larvae containers, breeding sites and PSN behavior and larvasidation. The data was analyzed using the chi square test. There was a relationship between houses with larvae positive Aedes aegypti, behavior of Mosquito Nest Eradication (PSN) and larvasidation with larvae density of Aedes aegypti but not for breeding sites (p =0.00and95%CI=0.64),and (p=0.00and95%CI=0.34).Thedescription of several Aedes aegypti larvae index, namely House Index (HI) = 57.02%, Container Index (CI) = 24.36%, Bruteau Index (BI) = 148.76, and Flick Free Numbers (ABJ) = 42.98 %. Houses with larvae of Aedes aegypti larvae and PSN and larvasidation behavior were associated with larvae density of Aedes aegypti. The index of HI, CI and BI larvae is of high value so there is a risk of DBD transmission
THE RELATIONSHIP OF NUTRITIONAL STATUS TO URIC ACID LEVEL IN COMMUNITY OF PONDOK PESANTREN AL-HIDAYAH, NGAWI
Lestari, Marselli Widya;
Bintarti, Tri Wahyuni
Jurnal Ilmu Kesehatan dan Kesehatan Vol 3 No 1 (2019): FEBRUARY
Publisher : UNUSA Press
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DOI: 10.33086/mhsj.v3i1.925
Gout or Gouty Arthritis is a degenerative disease. Gouty arthritis is a clinical syndrome that is caused by deposition of purine crystals in the tissues, due to levels of uric acid (hyperuricemia) in the extracellular fluid that passes through saturation. The etiology of gout arthritis included age, sex, history of medication, obesity, consumption of purine and alcohol. Aging is an important risk factor for men and women. This study uses an analytical-descriptive approach with cross-sectional design. This study was conducted to obtain a relationship between nutritional status and uric acid levels in the community in the area of Al-Hidayah Islamic Boarding School, Ngawi. This research was conducted in Majasem Village, Kendal District, Ngawi Regency, starting from 7 June - 31 August 2018. The results showed that there was a relationship between nutritional status and uric acid levels in the community in the area of Al-Hidayah Islamic Boarding School, Ngawi (p=0,008). Suggestions for further research are bivariate analysis based on gender, knowledge and attitude to response to diet so that other factors that influence can be seen clearly.
IMUNOHISTOKIMIA PADA KONDILOMATA AKUMINATA
Widyaswari, Meidyta Sinantryana;
Lumintang, Hans;
Soemarno, Troef
Jurnal Ilmu Kesehatan dan Kesehatan Vol 3 No 1 (2019): FEBRUARY
Publisher : UNUSA Press
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DOI: 10.33086/mhsj.v3i1.926
Background: Condylomata Acuminata (CA) is a sexually transmitted disease caused by the Human Papilloma Virus (HPV) type-specific and may be simultaneously co-infected with other HPV types associated with malignancy. Purpose: To differentiate between CA and histopathological of malignancy by immunohistochemistry. LiteratureReview: CA refers to benign epidermal proliferation caused by the HPV types 6 and 11, but co-infection with high- risk HPV types are common. The clinical presentation of CA can’t differentiate between benign or preneoplastik diplasia lesions. Koilocytes considered pathognomonic for HPV lesions, these findings sometimes don’t appear on CA, and histopathology was not accurate, that immunohistochemistry with MIB-1 (Ki-67) and p16 can beused. Conclusion: Immunohistochemistry examination can help differentiate the diagnosis between malignancy or non- malignancy in the case of CA.