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Medica Hospitalia
Published by RSUP Dr. Kariadi Semarang
ISSN : 23014369     EISSN : 26857898     DOI : https://doi.org/10.36408/mhjcm
Core Subject : Health,
Dentistry Health Professions Medicine & Pharmacology Nursing Public Health
Medica Hospitalia: Journal of Clinical Medicine adalah jurnal ilmiah yang diterbitkan RSUP Dr. Kariadi dan menerima artikel ilmiah dalam bahasa Indonesia dan bahasa Inggris yang diharapkan dapat menjadi media untuk menyampaikan temuan dan inovasi ilmiah dibidang kedokteran atau kesehatan kepada para praktisi dan akedemisi di bidang kesehatan dan kedokteran.
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Articles 21 Documents
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Search results for , issue "Vol. 10 No. 2 (2023): Med Hosp" : 21 Documents clear
Correlation Between Visceral Fat And Lipid Profile in Myocardial Infarction Patients Yuniari, Dwi; Puruhita, Niken; Probosari, Enny; Subagyo, Hertanto Wahyu; Nugrohowati, Annta Kern
Medica Hospitalia : Journal of Clinical Medicine Vol. 10 No. 2 (2023): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36408/mhjcm.v10i2.797

Abstract

BACKGROUND : Previous studies reported that visceral fat plays an important role in cardiovascular disease, even in non-obese individuals. Bioelectrical impedance analysis (BIA) is a non-invasive and radiation-free method for assessing visceral fat. Not much is known whether visceral fat correlates with lipid profile in myocardial infarction (MI) patients in Indonesian population. PURPOSE : To analyze the correlation between visceral fat and serum lipid profile in MI patients. METHODE : This is a correlational study on 32 MI patients hospitalized at the ICCU of RSUP Dr. Kariadi Hospital recruited with consecutive sampling. Visceral fat was measured by BIA SECA mBCA 525 series, data regarding levels of total cholesterol, triglycerides, low density lipoprotein (LDL), and high density lipoprotein (HDL) were gathered from medical record. The data were normally distributed, then the hypothesis was tested with the Pearson. RESULT : The mean age of the subjects was 55 ± 9.88 years, with 87.5% being male. As many as 81.3% of subjects experienced ST-elevation myocardial infarction (STEMI). The average body mass index (BMI) was 26.2 ± 3.68 kg/m², in which 40.6% of subjects were classified as grade 1 obesity. The majority of subjects (93.8%) had high visceral fat. As many as 68.8% of subjects had high LDL levels with an average of 120.5 ± 38.84 mg/dL. HDL average was 35±13.55 mg/dL with 62.5% of subjects having low HDL levels. More than half of the subjects (56.3%) experienced hypertriglyceridemia with an average of 157.4 ± 55.84 mg/dL. Visceral fat was significantly related to total cholesterol and triglycerides (r=0.40; p=0.02 and r=0.36; p=0.04). CONCLUSION : There is a significant correlation between visceral fat and total cholesterol and triglycerides in MI patients.
Analgesic Potency Of Ibuprofen, Paracetamol, And Mephenamic Acid: A Randomized Controlled Trial Nayoan, Christin Rony; Syamsi, Nur
Medica Hospitalia : Journal of Clinical Medicine Vol. 10 No. 2 (2023): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36408/mhjcm.v10i2.842

Abstract

BACKGROUND: Analgesics are a group of drugs to relieve pain. The use of analgesics is quite high, around 22.8% is used per year. Selection of analgesic drugs having adequate potency and minimal side effects is needed. Common analgesics publicly known involve paracetamol 500 mg, mefenamic acid 500 mg, and ibuprofen 400 mg. This study aims to compare the analgesic potency of paracetamol 600 mg, ibuprofen 600 mg and mefenamic acid 500 mg. METHODS: This study used a double blind randomized control trial. The study population was healthy subjects. The study sample consisted of 30 subjects with the inclusion criteria involve normal vital signs, while the exclusion criteria involve history of allergy to NSAID class drugs. This study consisted of three  groups namely group 1 (K1)= paracetamol 600 mg, group 2 (K2)= mefenamic acid 500 mg, group 3 (K3)= ibuprofen 600 mg. Each subject was given medication according to the group and their pain latency (the time of onset of constant and unbearable pain) was measured every 30 minutes RESULTS: The repeated ANOVA test shows P= 0.1507 meaning that no significantly different analgesic potency  was found between groups. CONCLUSION: Paracetamol 600 mg, mefenamic acid 500 mg and ibuprofen 600 mg have equal analgesic potency.
The Effect of 1% Povidone Iodine Mouthwash on The Incidence of Oral Mucositis and Odynophagia in Patients with Head and Neck Malignancy Handayani, Peny; Budiarti, Rery; Yusmawan, Willy; Antono, Dwi; Dewi, Anna Mailasari Kusuma; Widodo , Pujo
Medica Hospitalia : Journal of Clinical Medicine Vol. 10 No. 2 (2023): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36408/mhjcm.v10i2.854

Abstract

BACKGROUND: Oral mucositis is an injury of normal mucosal tissue with an acute inflammation of the oral, tongue, and pharyngeal mucosa after exposure to chemo-radiotherapy. Post chemoradiotherapy oral mucositis is commonly accompanied by painful swallowing or odynophagia. Povidone iodine 1% is an antiseptic mouthwash that widely used to prevent infections in the oral cavity. OBJECTIVE: The aim of this study was to determine the effect of 1% povidone iodine mouthwash on the incidence of oral mucositis in patients with head and neck malignancy at Dr. Kariadi General Hospital Semarang.    METHOD: This study was single random blinded experimental study, with total samples of 44 patients with head and neck malignancy after chemoradiotherapy. The samples divided into treatment group of 22 samples with 1% povidone iodine mouthwash and control group of 22 samples with NaCl 0.9% recruited using single random sampling at Dr. Kariadi Semarang General Central Hospital in 2022. The effect of 1% povidone iodine mouthwash on the incidence of oral mucositis and odynophagia was analyzed using the Fischer Exact and Mann Whitney test. RESULT: In the 1% povidone iodine mouthwash group day 15th, 21 patients (95.5%) were found without mucositis and 1 patient (4.5%) with mucositis oral grade I. In the 1% povidone iodine mouthwash group, 21 people (4.5%) were found without odynophagia and 1 people (4.5%) had odynophagia. There was an association between oral mucositis and odynophagia on povidone iodine 1% group (p < 0.05).        CONCLUSION: Povidone iodine 1% mouthwash can affect the incidence of oral mucositis in patients with head and neck carcinoma. Povidone iodine 1% mouthwash can reduce the incidence of oral mucositis and odynophagia compared to placebo in patients with head and neck carcinoma.
Effect of Fixed‐Dose Combinations Antituberculosis and Separate Formulations on Clinical Symptoms, Weight Gain, Adverse Effect and Plasma Concentration in Tuberculosis and HIV Coinfection Cases Sundari, Titi; Mariana, Nina; Permatasari, Debby Intan; Rusli, Adria; Sitompul, Pompini Agustina; Rosamarlina, Rosamarlina; Widiantari, Aninda Dinar; Maemun, Siti; Lisdawati, Vivi
Medica Hospitalia : Journal of Clinical Medicine Vol. 10 No. 2 (2023): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36408/mhjcm.v10i2.867

Abstract

BACKGROUND: Fixed Dose Combination (FDC) was aimed to simplify TB therapy and facilitate physician and patient compliance. OBJECTIVE: We aimed to evaluate the effect of FDC antituberculosis and separate formulations (SF) on clinical symptoms, weight gain, adverse effect and plasma concentration in TB/HIV cases during the intensive phase. METHOD: Prospective cohort study was conducted in public hospital, Jakarta. We recruited TB-HIV patients in May 2018-May 2019. Patients (over than 18 years old) diagnosed with TB-HIV who consumed either FDC or SF and had not received antiretroviral. A total of 36 subjects were included in this study, 20 subjects in FDC group and 16 subjects in SF group. RESULT:  There was not significant different between FDC and SF groups with an improvement of clinical symptoms (P = 0.70) and weight gain (P = 1.00). Gastrointestinal syndrome was 75% in FDC group; 62.5 % in SF group. Mean (±SD) of rifampicin, isoniazid, pyrazinamide plasma concentration after 2 weeks therapy in FDC group were 5.49 mg/L (±3.40 mg/L), 1.35 mg/L (±1.20 mg/L), 19.87 mg/L (±17.00 mg/L), respectively. Mean (±SD) of rifampicin, isoniazid, pyrazinamide plasma concentration in SF group were 6.42 mg/L (±4.80mg/L), 0.87 mg/L (±0.70 mg/L), 5.03 mg/L (±7.60 mg/L), respectively. CONCLUSION: There was not significant different between FDC and SF groups on improvement of clinical symptoms and weight gain in intensive phase of therapy, the highest of adverse effects was gastrointestinal syndrome, and all subjects had normal reference ranges of rifampicin concentrations, and isoniazid and pyrazinamide below the normal range.
The Effect Of Giving A Vibrator With A Cooler On Pain Level In Childhood With Venipuncture In Tidore Kepulauan Hospital Abdullah, Fadila; Anwar, Nursanti
Medica Hospitalia : Journal of Clinical Medicine Vol. 10 No. 2 (2023): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36408/mhjcm.v10i2.870

Abstract

BACKGROUND : Atraumatic care is therapeutic care that is carried out as part of an intervention to remove or suppress psychological or physical stress suffered by a child. The act of minimizing pain, stress and trauma to children when given at the time of blood collection is part of the principle of atraumatic care. One of the atraumatic actions that can be performed on children is the use of a vibrator with a cooler to minimize pain when stabbing a vein AIMS : to determine the effectiveness of giving a vibrator accompanied by a cold compress against pain in children when taking venous blood. METHODS : The design of this research is true experimental with a post-test only control group design. Researchers divided into 2 groups, namely the intervention and control groups were taken randomly. Then the researcher made a vibrator with a cooler that had been previously tested on 30 adults, then after being declared to have passed the ethical study it would be applied to children when taking venous blood, assessing children's pain using the FLACC instrument (face, legs, activity, cry and controllability). The study was conducted at the Tidore Islands Hospital. Data processing was carried out previously by testing the homogeneity and normality test, if normally distributed it will use the independent t-test to assess the difference in the average of the two groups, while if it is not normally distributed it will be tested with Mann-Whitney. RESULT : The results of this study indicate that the characteristics of respondents according to age are mostly 4 years old. In the control group the average age of children is 3.87 while in the intervention group the average age of children is 3.93. Most of the experience of having blood drawn in both groups had blood drawn before. Based on gender characteristics, most of the control and intervention groups were women. There are differences in pain scores in the control and intervention groups. The mean pain score in the intervention group was 3.13 and the mean pain score in the control group was 7.87. The results of statistical tests using Mann Whitney showed that there was a significant difference in pain during venipuncture in the intervention group and the control group (p=0.013). CONCLUSION : The results of the statistical test show that there was a significant difference in pain in the intervention group and the control group (p=0.013). The use of a cooling vibrator can be an alternative to reduce pain in children during venipuncture.
PERBANDINGAN PROGRAM LATIHAN OTAGO MODIFIKASI DAN LATIHAN BERJALAN TERHADAP PHYSICAL PERFORMANCE PADA LANSIA PRE-FRAIL Vikawati, Nura Eky; Julianti, Hari Peni; Dewi, Novita Sari; Mariani, Endang Sri
Medica Hospitalia : Journal of Clinical Medicine Vol. 10 No. 2 (2023): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36408/mhjcm.v10i2.874

Abstract

Background: Multicomponent training program like OTAGO is considered to improve the physical performance of pre-frail elderly, thereby reducing risk of fall. The Short Physical Performance Battery (SPPB) is a combination test that assesses physical performance and becomes a fall risk screening test for pre-frail elderly. This study aimed to compare the modified OTAGO to walking training on physical performance as measured by SPPB in the pre-frail elderly. Methods: This was an observational study with a cross-sectional design. The data were taken from the previous study including pre-frail subjects in Prolanis, Gunung Pati area, Semarang before and after giving intervention (modified OTAGO vs walking training) for 6 weeks. The SPPB score was measured from balance function test, chair stand test, and 4-meter walking test before and after the intervention. Data analysis was using SPSS ver 20.0. Paired sample T-test and Wilcoxon signed ranks test were used to analyze the SPPB score before and after interventions in the modified OTAGO and walking training group, respectively. Mann-Whitney U was used to analyze the difference in the average improvement of SPPB score. Results: There was a significant improvement in SPPB score before and after interventions either in modified OTAGO (p=0.013) or walking training (p=0.013). No significant difference was found in the average improvement of SPPB score in both groups (p=0.826). Conclusion: Both modified OTAGO and walking training intervention can improve the physical performance of pre-frail elderly. The modified OTAGO training is not superior in improving physical performance compared to walking training.
Strategi Koping dan Skor DASS pada Perawat yang Bertugas di Ruang Isolasi COVID-19: Sebuah studi cross-sectional Adinoto, Septo Pero; Fitrikasari, Alifiati; Wardani, Natalia Dewi; Noerhidajati, Elly
Medica Hospitalia : Journal of Clinical Medicine Vol. 10 No. 2 (2023): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36408/mhjcm.v10i2.875

Abstract

BACKGROUNDS: Nurses are at risk for mental health problems while caring for Corona Virus Disease 2019 (COVID-19) patients. The COVID-19 pandemic had impacted not only on emotions but also nurses' coping strategies. The difference between this study and previous research in this study adds up the total DASS 42 (Depression Anxiety Stress Scale) scores as parameter to assess mental health problems of the subjects. OBJECTIVE: To determine the association between coping strategies and the DASS score among nurses on duty in the COVID-19 isolation room of Dr Kariadi Hospital. METHODS: This cross-sectional study involved nurses who treated patients in the COVID-19 isolation ward, the COVID-19 intensive room, and the COVID-19 emergency room. All participants were involved by the consecutive sampling method. The research instrument used a sociodemographic questionnaire, the Brief COPE, and the DASS 42. Inclusion criteria included nurses who served in the COVID-19 isolation room and aged 22-60 years. Higher DASS score indicates that the subject is experiencing general psychological distress compared to subjects with a lower score. RESULTS: Most of the respondents in this study (n=112 subjects) had problem-focused coping strategies. The mean DASS score on the subjects is 14.29 ± 13.25. There was an association between coping strategies (p=0.048), sex (p < 0.001), place of work (p = 0.041), and DASS score. CONCLUSION: There was a relationship between coping strategies and the DASS score of nurses on duty in the COVID-19-19 isolation room. Further research needs to explore environmental factors and social support, also examine physical illnesses in more detail.
Association Of Neuropathic Pain Improvement And hs-CRP Changes Among Trigeminal Neuralgia Patients Experienced Radiofrequency Ablation 60o and 65o Celcius: 6 months follow up Arlina, Yani; Budisulistyo, Trianggoro; Pudjonarko, Dwi; Tugasworo, Dodik; Suryawati, Herlina; Diah Pasmanasari, Elta
Medica Hospitalia : Journal of Clinical Medicine Vol. 10 No. 2 (2023): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36408/mhjcm.v10i2.876

Abstract

INTRODUCTION: Trigeminal neuralgia (NT) is a neuropathic pain that involves the trigeminal nerve in the face. The first-line medical management of patients with NT is Carbamazepine (CBZ). Radiofrequency ablation (RFA) procedure is a minimally invasive procedure using a high-frequency current-generating device that produced heat ablate of C-fibers with effectiveness around 76% for 10 yeas follow-up. Inflammed trigeminal nerve (TG) or the branch(es) might be one of the underlying mechanisms unless vascular compression is a common etiology. The heat effects might be according to the temperature set up varies recently from 60°C to 95°C. METHOD: This observational study enrolled 75 severe NT subjects without satisfactory improvement of treatments, divided into 3 groups: analgesics prescription (Control), RFA 60, and RFA 65 Groups. The LANSS scores and hs-CRP levels were followed-up before (baseline), 2 weeks, 3, and 6 months experienced the treatments. Subjects ages in the range of 48.32 + 12.73 to 50.88 + 14.59 years old, and the duration of illness from 4.48 to 10.32 months. RESULT: The LANSS score >12 before treatments showed significance improvements (p<0.001), as in the Control (64% with neuropathic pain), RFA 60 (100% with neuropathic pain), and RFA 65 group (92% with nociceptive pain) at 2 weeks followed-up. At 3 and 6 months observed 100% subjects with nociceptive pain but without significancies. Even though the hs-CRP levels observed reduced for all groups, especially RFA 60 and RFA 65, but have no significances. CONCLUSION: The LANSS scores changes observed significant improvement in all groups, which mentioned if the neuropathic pain syndromes might be better under each treatment. The Hs-CRP levels improvement is better in the neuro ablation groups than analgesic drugs treatment. Even though the Hs-CRP are following of systemic nonspecific inflammation, NT is a focal inflammation.
Fetal Growth Cut-Off Point To Predict Neonatal Outcome In Pregnancy With Normal And Deficient Vitamin D Levels: Intergrowth-21, World Health Organization Fetal Growth Curve, And Hadlock’s Estimated Fetal Weight Dewantiningrum, Julian; Kristanto, Herman; Pudjonarko, Dwi; Mexitalia, Maria; Ediati, Annastasia; Soejoenoes, Ariawan; Hadisaputro, Suharyo
Medica Hospitalia : Journal of Clinical Medicine Vol. 10 No. 2 (2023): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36408/mhjcm.v10i2.877

Abstract

Purpose : Analyze the cut-off point of fetal growth based on the Intergrowth-21, World Health Organization (WHO), and Hadlock’s estimated fetal weight (EFW) in pregnant women with normal or deficient vitamin D levels to predict neonatal outcomes. Method: This cross sectional study to develop a diagnostic test, included 120 of pregnant women who completed follow up until children aged 2 years, divided into normal and deficient vitamin D group. Ultrasound and maternal vitamin D level examined during the second trimester of pregnancy. EFW was calculated using Hadlock’s formula and plotted on the Intergrowth-21 and WHO curves. The reference standards were the neonatal outcome, LBW, stunting, and neurocognitive impairment. Significant odds ratio (OR) value and area under the curve (AUC) of 0.6 are used to determine the cut-off point to be used. Result: Fetal growth curve was based on the WHO at the 5th percentile to predict LBW to have an AUC of 0.6 and OR of 6, 95% confidence interval (CI) of 1.36–26.45. The AUC for predicting LBW based on Intergrowth and Hadlock were 0.45 and OR not significant. As well as the AUC estimated stunting based on Hadlock, the Intergrowth-21 and the WHO fetal growth curves is <0.6 with OR not statistically significant. The AUC predicted neurocognitive impairment based on WHO’s chart was 0.6 but OR not statistically significant. Conclusion: The WHO fetal growth curve can be used to predict LBW. The cut-off point of the fetal growth curve and which percentile is determined by the neonatal outcome.
The Wistar Rat Parietal Lobe Cell And Pain Perception Changes After Frequent Of Mobile Phone Electromagnetic Wave Expose Tamad, Fatiha Sri Utami; Budisulistyo, Trianggoro; Husni, Amin; Retnaningsih, Retnaningsih; Suryawati, Herlina; Suryadi, Suryadi
Medica Hospitalia : Journal of Clinical Medicine Vol. 10 No. 2 (2023): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36408/mhjcm.v10i2.884

Abstract

Background: The increasing number of mobile phone users raises concerns about the effects. Mobile phone electromagnetic wave radiation harms pain perception due to granular cell changes in the cerebral parietal cortex. Objective: To determine the effect of exposure to electromagnetic waves mobile phone on pain perception due to changes in the granular cells of the cerebral parietal cortex Wistar rats. Methods: Experimental research using randomized posttest with control group design. Samples were 28 rats divided into 4 groups. The control group was not exposed, the treatment group was exposed to 2100 MHz electromagnetic waves for 2 hours/day with a distance of 3 cm for 15 days in treatment group 1, for 30 days in treatment group 2, and 45 days in treatment group 3. Measurement of pain onset using the hot method. Changes in pain threshold were taken from the difference in pain onset after exposure to before exposure. Granular cell changes in the cerebral parietal cortex were assessed from the total score with the provisions of normal cells (sumx0), hydropic degenerated cells (sumx1), and necrotic cells (sumx2). Results: The longer the exposure to mobile phones, the higher the pain threshold and the cerebral parietal cortex granular cell damage score. There was a significant difference in pain threshold and changes in cerebral parietal cortex granular cells between groups (p=0.000). There was a significant relationship between changes in the parietal cerebral cortex granular cells and pain threshold in Wistar rats exposed to electromagnetic waves (p=0.000). Conclusion: Exposure to mobile phone electromagnetic waves affects pain perception due to changes in the granular cells of the cerebral parietal cortex in wistar rats.

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