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Pharma Xplore : Jurnal Sains dan Ilmu Farmasi
Published by Universitas Buana Perjuangan Karawang
ISSN : 25275801     EISSN : 25809601     DOI : https://doi.org/10.36805/farmasi
Core Subject : Health,
Medicine & Pharmacology
Biologi Farmasi, Farmakoekonomi, Farmakologi dan Toksikologi, Farmasetika dan Teknologi Farmasi. Farmasi Klinik, Farmasi Sosial, Kimia Farmasi
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Farmakologi
Articles 111 Documents
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FORMULASI DAN UJI AKTIVITAS ANTIBAKTERI SALEP EKSTRAK ETIL ASETAT BATANG KECOMBRANG (Etlingera elatior (Jack) R.M.Sm.) TERHADAP BAKTERI Pseudomonas aeruginosa Linda Nur Azizah; Galih Samodra
Pharma Xplore : Jurnal Sains dan Ilmu Farmasi Vol 7 No 2 (2022): Pharma Xplore : Jurnal Sains dan Ilmu Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jpx.v7i2.2946

Abstract

Kecombrang stems contain flavonoid compounds, alkaloids, saponins and tannins that have the potential to inhibit bacterial growth. This study aims to determine the physical properties, stability and antibacterial activity of the ethyl acetate extract of kecombrang stem ointment.This type of research is an experimental laboratory. Extraction using maceration method with ethyl acetate solvent. The concentrations of the extracts used were F1 (10%), F2 (15%) and F3 (20%). Testing of physical properties seen from organoleptic, homogeneity, pH, adhesion and spreadability. The results were analyzed by One Way Anova and there were significant differences in the pH value, adhesion and dispersion. Formulas 1, 2 and 3 can inhibit Pseudomonas aeruginosa bacteria with an average inhibition zone of (F1) 8.02 mm, (F2) 9.34 mm and (F3) 11.00 mm. Based on this research, it can be concluded that F3 is the best formula with a strong inhibition zone, while F1 and F2 have moderate inhibition.
FORMULASI SEDIAAN SALEP ANTIJERAWAT EKSTRAK ETANOL DAUN TEH HIJAU (Camellia sinensis (L.) (Kuntze) DENGAN KOMBINASI BASIS PEG 400 DAN PEG 4000 TERHADAP BAKTERI Propionibacterium acnes Dewi Rahmawati; Galih Samodra
Pharma Xplore : Jurnal Sains dan Ilmu Farmasi Vol 7 No 2 (2022): Pharma Xplore : Jurnal Sains dan Ilmu Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jpx.v7i2.2947

Abstract

Ointment is semisolid preparations used by topical. Leaf tea green contain beneficial flavonoid compounds, tannins and catechins as antibacterial. On research this extract leaf tea green made preparation ointment using a watersoluble base i.e combination of PEG 4000 and PEG 400 with comparison (2:3) on formula 1, (1:1) on formula 2 and (3:2) on formula 3. Research this aim for see nature physique preparation ointment as well as power resistor to bacteria Propionibacterium acnes. Test results nature physique from the three formulas include color, odor, shape, homogeneity, pH have good result during the storage period, while power spread and power sticky have less result good. The results of the One Way ANOVA analysis show that existence significant difference in the value of power spread and power sticky. The results of the paired test t test analysis show existence influence During storage to pH and power spread ointment. Test antibacterial conducted use method well. Antibacterial test results show the three formulas have zones of inhibition categorized strong.
FORMULASI SEDIAAN SALEP DAN UJI AKTIVITAS ANTIBAKTERI EKSTRAK ETANOL DAUN BIDARA ARAB (Ziziphus spina-christi (L.) Desf) TERHADAP BAKTERI Staphylococcus Epidermidis alviony trista hapsari; Galih Samodra
Pharma Xplore : Jurnal Sains dan Ilmu Farmasi Vol 7 No 2 (2022): Pharma Xplore : Jurnal Sains dan Ilmu Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jpx.v7i2.2952

Abstract

Ointment is a semi-solid preparation that is used topically. Arabic bidara leaves contain secondary metabolites in the form of saponins, tannins, alkaloids, polyphenols and flavonoids which can inhibit the antibacterial growth of Staphylococcus epidermidis so that it can be made in ointment preparations. The purpose of thi study was to determine the physical properties and zone of inhibition of the formulation of the ethanol extract of bidara arabic leaf ointment. Extraction using remaceration method with 70% ethanol solvent was formulated using a water-soluble ointment base in the from of PEG 400 and PEG 4000. Made in 3 variations of extract concentration 40%, 50%, 60%. Furthermore, the evaluation of the preparation include: organoleptic test, homogeneity, pH, disperbility, adhesion. The results of the One Way ANOVA analysis showed that there werw differences in the pH test, dispersion and adhesion with a p-value of <0,05 the homogeneity test showed differences during storage for 6 cycles, while the organoleptic test was in a stable state during storage. The results obtained showed that the preparation of bidara arabic leaf extract ointment was able to inhibit the growth of Staphylococcus Epidermidis bacteria, namely the FI of 9.16±0.76 mm, FII of 8.56±1.01 mm and FIII of 10.08±0.10 mm is included in the medium category.
PENGARUH KOMBINASI BASIS PEG 400 DAN PEG 4000 PADA PEMBUATAN SEDIAAN SALEP EKSTRAK ETANOL BIJI MAHONI (Swietenia mahagoni (L). Jacq SEBAGAI ANTIBAKTERI TERHADAP Propionibacterium acne Umi Hanifatun Nikmah; Galih Samodra
Pharma Xplore : Jurnal Sains dan Ilmu Farmasi Vol 7 No 2 (2022): Pharma Xplore : Jurnal Sains dan Ilmu Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jpx.v7i2.2955

Abstract

Ointment preparations are semisolid preparations intended for topical use. Mahogany seeds (Swietenia mahagoni (L) Jacq) contain saponin compounds that have antibacterial activity, so they can be made into ointment formulations. This study aims to determine the stability of the physical properties as well as the antibacterial inhibition zone produced from the ointment preparation with the active ingredient of mahogany seed extract (Swietenia mahagoni (L)). Jacq) based on PEG 400 and PEG 4000. Physical properties were tested for 6 cycles of storage at a temperature of 5 C and at a temperature of 45 C, seen from the organoleptic, homogeneity, pH, spreadability, adhesion and viscosity. The results were analyzed using One ­Way ANOVA and paired t -test. The results of the One_ Way ANOVA test showed a significant difference <0.05 in the adhesion, spreadability and viscosity tests. The results of the paired t_test analysis showed that there was an effect of storage on the pH test with a value of <0.05, while the organoleptic test, homogeneity, viscosity, spreadability and adhesiveness had no effect during storage. Antibacterial tests on different formulas showed antibacterial activity on Propionibacterium acne. Before stability had an average inhibition zone at F1 (60%:40%) 12.76 mm, F2 (50%:50%) 10.58 mm and F3 (40%:60%) 8.74 mm, while after stability at F1 (60%:40%) 14.20 mm F2 (50%:50%) 12.44 mm, and F3 (40%:60%) 8.90 mm.
ETNOBOTANI TUMBUHAN OBAT OLEH WARGA DAYAK MERATUS DI DESA GUNUNG RIUT KABUPATEN BALANGAN KALSEL Nashrul Wathan; Rina Rina; Nadia Rahmah; Hilya Aulia; Nita Pujianti
Pharma Xplore : Jurnal Sains dan Ilmu Farmasi Vol 8 No 1 (2023): Pharma Xplore : Jurnal Sains dan Ilmu Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jpx.v8i1.2904

Abstract

Traditional knowledge about the use of medicinal plants owned by various indigenous Dayak tribes in Kalimantan reflects that people's lives cannot be separated from the surrounding natural resources, especially medicinal plants. The purpose of this study was to determine the types of medicinal plants, the percentage of medicinal plant parts used and to determine how to process and use medicinal plants by traditional healers of the Dayak Meratus tribe in Gunung Riut Village. Informants are determined by purposive sampling technique. The result of the interview showed 28 species and divided into 18 families of medical plants used to treat toothache, back pain, skin diseases, fever, influenza, syphilis, fractures, wounds, hypertention, jaundice, malaria, hemorrhoids, increase stamina, laxative, asthma and indigestion. The percentage of plant parts that are widely used are leaves (26.67%), roots (23.33%), and stems (13.33%). Processing methods by soaking, boiling, pounding, without processing, squeezing, heating, cutting and burning. How to use by applying, massaging, sticking, drinking, pinching, bathing, and eating.
FORMULASI SEDIAAN HAIR TONIC EKSTRAK ETANOL DAUN KELOR (Moringa oleifera Lamk.) DAN DAUN RAMBUTAN (Nephelium lappaceaum L.) TERHADAP PERTUMBUHAN RAMBUT Siti Hindun; Nopi Rantika; Aji Najihudin; Acep Indra
Pharma Xplore : Jurnal Sains dan Ilmu Farmasi Vol 8 No 1 (2023): Pharma Xplore : Jurnal Sains dan Ilmu Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jpx.v8i1.3008

Abstract

Moringa olifera lamk and Nephelium lappaceaum L leaves are empirically widely used to stimulate hair growth. The purpose of this research is to combine the kelor leaf extract and rambutan leaf extract formulated in hair tonic. The hair tonic preparations made were evaluated by performing a physical test of the preparation and knowing the best concentration of kelor leaf extract and rambutan leaf extract on rabbit hair growth. The hair tonic were orepared in 3 formulations with the ratio of kelor leaf exract and rambutan leaf extract (1:3 , 1:1 and 3:1)% w/v. the positive control used is hair tonic Minoxidil 2%. Physical tests of the preparation include organoleptic test, pH test, homogeneity test and Viscosity test. Hair growth activity on the 3 rabbits shaved hair and hair growth measurements until the 28 st day. The data of growth measurements were tested statistically by ANOVA test metode. Based on the reseach result, in can be concluded that hair tonic combination of kelor leaf extract and rambutan leaf extract with ratio (1:1)%, has average hair length 3 cm and hair weight 0,236 g is the optimum concentration in stimulating hair growth aktivity with positive control has average hair length 2,025 cm and hair weigth 0,207 g. Test statistically there was no significant difference between extract and positif control (P < 0,05).
ANALISIS PERSEPSI PENYAKIT TERHADAP KUALITAS HIDUP PASIEN DIABETES MELITUS TIPE II DI RUMAH SAKIT UMUM DAERAH TORABELO Amelia Rumi; Adifa Salsabila
Pharma Xplore : Jurnal Sains dan Ilmu Farmasi Vol 8 No 1 (2023): Pharma Xplore : Jurnal Sains dan Ilmu Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jpx.v8i1.3847

Abstract

Diabetes mellitus is a disorder that occurs in heterogeneous metabolism due to chronic glycine. Diabetes mellitus also occurs due to disorders in insulin secretion or impaired insulin effect or both factors. Based on the results of the research of the Central Sulawesi Health Office, especially in Sigi Regency, the number of people with type II diabetes mellitus is 15,244 people suffering from type II diabetes mellitus. The purpose of this study was to determine the relationship of the perception of disease in the quality of life of patients with type II diabetes mellitus in the Torabelo regional hospitals. This study used a cross sectional method with the number of respondents, namely 100 respondents, data collection using disease perception questionnaires and live quality questionnaires provided to respondents directly. The results of the study that were obtained from disease perception questionnaires for positive categories, namely 70%, the neutral category of 20% and the negative category of 10%, while the result of life quality cakes are obtained by the category of good 12%, and 88% poor. The results of the chi square test received p = 0.028 or < a (0.05), Ha accepted was rejected meaning to having a relationship between illness perception of the disease of patients with the type II diabetes mellitus. The conclusion was obtained from this study, namely there is a relationship between the perception of disease with the quality of life. The occurrence of increased quality of life due to good disease perceptions.
UJI STABILITAS SEDIAAN AMPISILLIN SULBAKTAM SETELAH REKONSTITUSI I Gede Edy Sagitha; Suharjono Suharjono; Yulistiani Yulistiani; Isnaeni Isnaeni
Pharma Xplore : Jurnal Sains dan Ilmu Farmasi Vol 8 No 1 (2023): Pharma Xplore : Jurnal Sains dan Ilmu Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jpx.v8i1.4333

Abstract

Repeated use of antibiotic ampicillin sulbactam after reconstitution, therefore in storage various many factor can affect it stability such as type of solvent used, storage temperature and storage time. Objective of study is to analyze the chemical stability product of ampicillin sulbactam in repeated use with the parameters of the solvent and storage temperature Sample products were weighed and reconstituted using WFI and NS solvents, diluted ad 20 ppm and put into sterile vials. Then stored at room temperature (25-30 ° C) and refrigerator temperature (4-8 ° C). Storage is carried out for 24 hours which is divided into 4 -time series, namely 0, 1, 4 and 24 hours. Each time series is microbiological tested and after 18 hours incubation the inhibition zone is observed and its diameter measured using calipers. Result of study is at 0th hour showed a significant difference in different solvents. Samples dissolved with NS solvents have a greater inhibition zone than those dissolved using WFI. This happens because there is a primary salt effect that occurs with the influence of electrolytes (salt) or variations in the strength of ions can affect the coefficient of activity that affects the reaction rate. From the statistical analysis at the 1st and 4th hours, the storage temperature that provides significant result, storage in the refrigerator produces better results compared to storage at room temperature. At 24 hours the temperature and solvent did not give the significant result on the stability of the sulbactam ampicillin sample. Conclusion is NS solvents give better results than WFI solvents. Samples are more stable if stored in a refrigerator. After 4 hours based on the above study the sample no longer meets the requirements of Indonesian Pharmacopoeia 5th edition
IDENTIFIKASI SENYAWA AKTIF EKSTRAK DAUN JARAK KEPYAR (Ricinus communis) DENGAN ANALISIS FITOKIMIA DAN GC-MS SEBAGAI KANDIDAT SENYAWA OBAT Sulwiyatul K Sani; Baiq Erna; Atri Sri Ulandari
Pharma Xplore : Jurnal Sains dan Ilmu Farmasi Vol 8 No 1 (2023): Pharma Xplore : Jurnal Sains dan Ilmu Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jpx.v8i1.5115

Abstract

As a tropical country with biodiversity, Indonesia is rich with flora especially those with potential as medicinal plants such as Jarak Kepyar (Ricinus communis). Leaves of jarak kepyar (Ricinus communis) are used as a medicine for wounds, rash, abscess, and fever. Therefore, the purpose of this study was to determine the active compound in ethanol and n-hexane extract of jarak kepyar (Ricinus communis) leaves using phytochemical analysis and GC-MS. The research method used is the experimental method in the laboratory. The steps of the research were extraction of jarak kepyar (Ricinus communis) leaves using 96% ethanol and n-hexane with the maceration method. Furthermore, jarak kepyar (Ricinus communis) leaves extract was analyzed qualitative and quantitatively by phytochemical screening and GC-MS analysis. The results of the phytochemical screening showed that the chemical compounds contained in the ethanol extract of jarak kepyar (Ricinus communis) leaves were flavonoids, alkaloids, terpenoids, tannins and phenolics. While the chemical compounds contained in the n-hexane extract of jarak kepyar (Ricinus communis) leaves are alkaloids. GC-MS analysis of the ethanol and n-hexane extracts of jarak kepyar (Ricinus communis) leaves showed that several compounds that are found in the extract of jarak kepyar (Ricinus communis) leaves such as 2-ethoxycarbonyl-5-oxo-pyrolidine, delta-octalactone, trimethyl ester or trimethyl citrate, quinic acid, 2,3- Dihydro-3,5-dihydroxy-6-methyl-4H-pyran-4-one and methyl oleate have potential as medicinal compounds.
ANALISIS POTENSI DAUN TORBANGUN (Plectranthus amboinicus) SEBAGAI ANTIBAKTERI TERHADAP Klebsiella pneumoniae SECARA IN SILICO Nabila Nur Nafiati; Rini Madyastuti Purwono; Nurhidayat Nurhidayat; Laksmi Ambarsari
Pharma Xplore : Jurnal Sains dan Ilmu Farmasi Vol 8 No 1 (2023): Pharma Xplore : Jurnal Sains dan Ilmu Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jpx.v8i1.5190

Abstract

Antibiotic-resistant is a global issue. Klebsiella pneumoniae has high priority to find its antibiotic because it has extended-spectrum beta-lactamase (ESBL) enzyme that makes the bacteria easy to resist the antibiotic. The study of phytochemicals in medicinal plants is one of the efforts to find antibiotics. Indrulizia is one of the empirical medicinal plants containing flavonoids used to treat disease. The aim of this study was to analyze the potential of borage as an antibacterial agent against Klebsiella pneumoniae in silico. Docking is the method for this study using AutoDock Vina. This is an application for docking the enzyme ESBL from K. pneumoniae, referred to as SHV (sulfhydryl variable), and the metabolite second from plants. The parameters analyzed were binding free energies, inhibition constants and visualization in 3D and 2D. The free energy of binding and the inhibition constant of the native ligand are -6.7 kcal/mol and 12.118 μM. The binding free energy values ​​of apigenin 7-glucuronide and rosmarinic acid show higher potencies than the native ligand of SHV-1 (1,4-thiazepine).

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