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Maulana Yusuf Alkandahri
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Pharma Xplore : Jurnal Sains dan Ilmu Farmasi
Published by Universitas Buana Perjuangan Karawang
ISSN : 25275801     EISSN : 25809601     DOI : https://doi.org/10.36805/farmasi
Core Subject : Health,
Medicine & Pharmacology
Biologi Farmasi, Farmakoekonomi, Farmakologi dan Toksikologi, Farmasetika dan Teknologi Farmasi. Farmasi Klinik, Farmasi Sosial, Kimia Farmasi
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Farmakologi
Articles 111 Documents
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ANALISIS POTENSIAL Alpinia galanga MENGGUNAKAN JEJARING FARMAKOLOGI MELALUI ANALISIS PENGAYAAN GENE ONTOLOGY DAN KEGG (KYTO ENCYCLOPEDIA OF GENE AND GENOMES) SEBAGAI ANTIDIABETES Fath, Dwi Hanif Muluqul; Muchlisin, Muhammad Artabah; Jamil, Ahmad Shobrun
Pharma Xplore : Jurnal Sains dan Ilmu Farmasi Vol 9 No 1 (2024): Pharma Xplore : Jurnal Sains dan Ilmu Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jpx.v9i1.6627

Abstract

Alpinia galanga L., is a family of Zingiberaceae that has been used traditionally in various medicinal practices due to its therapeutic properties. With this, this research aims to identify the potential content of Alpinia galanga metabolite compounds as one of the potential alternative therapies in cases of diabetes mellitus and several other disorders. In this study, in silico methods were used, namely pharmacological networks and also Gene Ontology and KEEG pathway enrichment analysis which revealed 28 metabolite compounds that have links to plants and diseases to be studied and also revealed the enrichment of key molecular functions such as catalytic activity, protein kinase activity, and small molecule binding, indicating their regulatory and catalytic properties. In addition, KEGG (Kyto Encyclopedia of Genes and Genomes) pathway analysis highlighted its involvement in signaling pathways associated with glucose homeostasis, cancer, and hormone response. Examination of cellular component terms revealed the subcellular localization and potential interactions of A. galanga compounds in cellular compartments such as the cytoplasm, plasma membrane, and cell periphery. The results showed that out of 28 metabolite compounds, 1 metabolite compounds in A. galanga, namely 1'S-1'- acetosxychavicol, have the potential for treatment in diabetes mellitus cases and show the diverse pharmacological properties of A. galanga, which has implications for its potential in the development of new therapies targeting various diseases and disorders.
PENGARUH EDUKASI NUTRISI KEPADA IBU OBESITAS DENGAN ANAK STUNTING TERHADAP PENURUNAN BEBAN GANDA MALNUTRISI DI KECAMATAN SERANG BARU-KABUPATEN BEKASI Arifianti Essen, Amanda; Bambang Sutjiatmo, Afifah; Hermanto, Faizal
Pharma Xplore : Jurnal Sains dan Ilmu Farmasi Vol 9 No 1 (2024): Pharma Xplore : Jurnal Sains dan Ilmu Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jpx.v9i1.6815

Abstract

The double burden of malnutrition (obese mothers with stunted children) has become an important focus in the field of public health both in Indonesia and the world. Serang Baru District, Bekasi Regency, is one of the areas in Indonesia that has a significant prevalence of stunting and obesity. This study aims to determine the effectiveness of nutritional education interventions for obese mothers of stunted children on changes in the status of the double burden of malnutrition in the household. The research began with collecting sociodemographic, anthropometric and food intake data for the past 2x24 hours. Respondents who met the inclusion criteria were then given a face-to-face nutrition education intervention every week for 3 months. In the third month, all respondents had their data collected again in the form of anthropometric data and food intake data. The results of the study showed that after the nutritional education intervention was carried out there was a change in the child's HAZ score from -2.87 ± 0.56 to -2.61 ± 0.62, while the mother's BMI was originally 32.52 ± 2.48 to 31.72 ± 2.16 which was significantly different when compared to before the intervention (P<0.05). It can be concluded that nutrition education interventions can reduce the double burden of malnutrition in Serang Baru District, Bekasi Regency.
UJI MUTU SIMPLISIA DAN EKSTRAK ETANOL 96% RIMPANG JAHE (Zingiber officinale Roscoe) Efrilia, Mega; Chandra, Pra Panca Bayu; Endrawati, Santi
Pharma Xplore : Jurnal Sains dan Ilmu Farmasi Vol 9 No 1 (2024): Pharma Xplore : Jurnal Sains dan Ilmu Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jpx.v9i1.6817

Abstract

Ginger (Zingiber officinale Roscoe) has long been commonly consumed as a spice and traditional medicine. The aim of the research was to test the quality of simplicia and ginger rhizome extract. The testing procedure consists of preliminary quality testing, testing specific and non-specific parameters. Fresh ginger rhizomes are processed to become simplicia powder. The simplicia was extracted using the maceration method using 96% ethanol solvent, then concentrated until a thick extract was obtained. Simplicia and extracts are subjected to quality testing. The results showed that the level of foreign organic matter of simplicia was 1.34%, the fine degree of simplicia was 4/18 through mesh sieve number 4 100% and number 18 was 96%. Identity of the research sample Zingiber officinale Roscoe. The levels of compounds in simplicia that are soluble in water and ethanol are 16.86 ± 0.45% and 6.81 ± 0.23%. The levels of compounds in the extract that were soluble in water and ethanol were 13.55 ± 0.21% and 13.72 ± 0.16%. Drying loss of simplicia is 0.80 ± 0.52% and extract is 9.53 ± 0.25%. The water content for simplicia is 9.03 ± 0.64% and extract is 12.33 ± 1.53%. The specific gravity of the simplicia is 0.7849 ± 0.06 g/mL and the extract is 0.85 ± 0.09 g/mL. The total ash content of simplicia was 4.09 ± 0.97% and the extract was 3.63 ± 0.44%. The water-soluble ash content in simplicia is 2.17 ± 0.31% and the extract is 2.6 ± 0.26%. The insoluble ash content of simplicia acid was 1.11 ± 0.32% and the extract was 0.5 ± 0.46%. Testing the quality of simplicia and ginger rhizome extract met the requirements, namely all specific parameters as well as non-specific parameters (drying loss, total ash and acid insoluble ash).
PEMANFAATAN SENYAWA METABOLIT SEKUNDER KAWISTA (Limonia acidissima) UNTUK PENGELOLAAN DIABETES: TINJAUAN ANALISIS JEJARING FARMAKOLOGI Hentu, Dina Siti Rahma M.; Muchlisin, M. Artabah; Jamil, Ahmad Shobrun; Astuti, Engrid Juni; Rafikayanti, Agustin
Pharma Xplore : Jurnal Sains dan Ilmu Farmasi Vol 9 No 1 (2024): Pharma Xplore : Jurnal Sains dan Ilmu Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jpx.v9i1.6964

Abstract

This study aims to explore the potential of secondary metabolite compounds from the kawista plant (Limonia acidissima) as antidiabetic agents through an in silico approach. We utilized pharmacological network analysis and analysis of the most important proteins to identify potential protein targets and signaling pathways involved in diabetes regulation. The analysis revealed that secondary metabolite compounds from kawista have the potential to affect various crucial aspects of glucose and lipid metabolism in the body, including through interactions with key proteins such as AKT1. These findings provide new insights into the development of additional therapies for diabetes treatment, and demonstrate the potential of in silico methods in accelerating the discovery and development of new drugs.
AKTIVITAS ANTIBAKTERI EKSTRAK ETANOL JAHE MERAH (Zingiber officinale var. Rubrum) TERHADAP BAKTERI Streptococcus mutans SECARA IN VITRO Nugraha, Yogi Rahman; Sujana, Dani; Dewi, Risma Anugrah
Pharma Xplore : Jurnal Sains dan Ilmu Farmasi Vol 9 No 2 (2024): Pharma Xplore : Jurnal Sains dan Ilmu Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jpx.v9i2.8019

Abstract

Infections remain a major public health challenge in Indonesia, including infections of the oral cavity caused by microorganisms such as Streptococcus mutans. Red ginger is known to contain flavonoids, phenols, essential oils, and tannins that have the potential to inhibit bacterial growth. This study aims to test the antimicrobial activity of red ginger ethanol extract against Streptococcus mutans using the agar diffusion method. The results showed that at concentrations of 10 and 20%, there was a slight increase in the zone of inhibition. However, starting from 40% concentration, the increase in concentration resulted in a larger zone of inhibition. At 60% concentration, the results were close to the positive control, and at the highest concentration of 80%, the inhibition zone reached 28.04 mm with an inhibition rate of 62.24%. Overall, the inhibitory activity showed a positive relationship as the concentration of red ginger extract increased.
KESESUAIAN RESEP BERDASARKAN ASPEK ADMINISITRATIF DAN FARMASETIK PADA PASIEN RAWAT JALAN DI PUSKESMAS WANARAJA GARUT Nurul, Nurul; Sujana, Dani; Rahayu, Sri
Pharma Xplore : Jurnal Sains dan Ilmu Farmasi Vol 9 No 2 (2024): Pharma Xplore : Jurnal Sains dan Ilmu Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jpx.v9i2.8020

Abstract

Completeness of administration and pharmacology in prescriptions can minimise or reduce the occurrence of medication errors. This study aims to look at the description of the suitability of administrative and pharmaceutical aspects in prescriptions by looking at the percentage of completeness of administrative and pharmaceutical aspects in prescriptions at the Wanaraja Garut Health Centre. This research is quantitative descriptive. The sampling method is random sampling which is calculated using the Slovin formula. The sample used was 308 prescription sheets in January 2021. Based on the results of the description of the completeness of prescriptions at the Wanaraja Garut Health Centre, of the 308 prescription sheets studied administratively, it was found that 60.90% were complete and 39.10% were incomplete, and studied pharmaceutically, it was found that 93.33% of the prescriptions were appropriate and 6.67% of the prescriptions were not appropriate. It can be concluded that the prescription sheet at the Wanaraja Garut Health Centre almost entirely meets the aspects of the completeness of the prescription in accordance with applicable laws and regulations, but it is still found that 11 out of 16 aspects of the completeness of the prescription do not contain information, namely the patient's age 2.27%, gender 30.51%, patient weight 98.51%, patient address 8.76%, doctor's name 47.7%, doctor's initials 64.28%, prescription date 3.57%, doctor's room or unit of origin 43.83%, doctor's SIP No. 0%, dosage form 11.3%, drug dosage 28.88%. This shows that the completeness of prescriptions at the Wanaraja Garut Health Centre is still incomplete, in writing prescriptions that trigger medication errors. It needs to be improved so that it meets the standards in accordance with applicable laws and regulations.
INDENTIFIKASI PERMASALAHAN TERKAIT PENGOBATAN PADA PASIEN DISLIPIDEMIA KOMORBID DIABETES MELITUS DENGAN TERAPI STATIN DI SALAH SATU RUMAH SAKIT KOTA BANDUNG TAHUN 2023 Rahayu, Siti Nurhaliza Nadya; Simanjuntak, Nela
Pharma Xplore : Jurnal Sains dan Ilmu Farmasi Vol 9 No 2 (2024): Pharma Xplore : Jurnal Sains dan Ilmu Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jpx.v9i2.8037

Abstract

ABSTRACT Dyslipidemia and type II diabetes mellitus (DM) can occur simultaneously and can mutually worsen the patient's condition. The complexity of treatment in patients with such comorbidities potentially increases the risk of treatment-related problems. This study aims to determine the demographics of patients with type II DM comorbid dyslipidemia in one of the hospitals in Bandung City in 2023 and describe the incidence of treatment problems. This descriptive study reviewed 92 patient medical records that met the research criteria. The classification method for identifying problems related to treatment refers to Basger et al. 2015. The results showed that patients with type II DM comorbid dyslipidemia on statin therapy were dominated by women (55.43%) and elderly (59.78%). The most frequent incidence of treatment-related problems was in the subcategory of inappropriate drug combinations. There were 78 cases resulting in increased therapeutic effect and the most common was related to the prescription of lansoprazole with atorvastatin; 55 cases of interactions resulting in reduced therapeutic effect, of which the most common was related to the prescription of clopidogrel with atorvastatin. There were 4 cases that resulted in hypersensitivity reactions involving allopurinol and antihypertensive drugs. It can be concluded that clinical pharmacists intervene in reviewing patient care by considering the risks and benefits of such a combination for the patient.
STUDI SURVEI KEPUASAN PASIEN: PERAN PELAYANAN KEFARMASIAN DI PUSKESMAS AIR DINGIN DALAM MENINGKATKAN KUALITAS LAYANAN KESEHATAN Elvionita, Cindy; Marsellinda, Elsa
Pharma Xplore : Jurnal Sains dan Ilmu Farmasi Vol 9 No 2 (2024): Pharma Xplore : Jurnal Sains dan Ilmu Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jpx.v9i2.8084

Abstract

Puskesmas (Community Health Center) is one of the primary health facilities that is the front line in providing health services to the community. One of the important pillars in improving the quality of health services in the Community Health Center is pharmaceutical services. The intended pharmaceutical services include the provision of drugs, information on drug use, and counseling to patients. Patient satisfaction is an important indicator used in evaluating the quality of health services. This study aims to determine the level of satisfaction felt by patients with pharmaceutical services and evaluate pharmaceutical services at the Air Dingin Community Health Center as a form of improving the quality of health services. This study used a quantitative survey conducted cross-sectionally in September 2024 at the Air Dingin Community Health Center in Padang City with 45 respondents. This study obtained results, namely the level of patient satisfaction in the reliability aspect of 82.78% (very satisfied), the responsive element of 91.81% (very satisfied), the assurance aspect of 98.44% (very satisfied), the empathy aspect of 91.68% (very satisfied), and the tangible aspect of 85.85% (very satisfied). Based on the results of the research that has been conducted, it was concluded that patient satisfaction in all aspects, namely 90.11%, is included in the very satisfied category.
INOVASI SEDIAAN SABUN PADAT TRANSPARAN DENGAN EKSTRAK ETANOL BUAH RIMBANG (Solanum torvum Swartz) SEBAGAI ANTISEPTIK Aulia, Syafitri; Safriana; Andilala; Tanjung, Siti Aisyah
Pharma Xplore : Jurnal Sains dan Ilmu Farmasi Vol 9 No 2 (2024): Pharma Xplore : Jurnal Sains dan Ilmu Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jpx.v9i2.8098

Abstract

Di pasaran banyak beredar sabun antiseptik mengandung antibakteri sintetis, namun sering menimbulkan efek samping, maka perlu dibuat sabun mengandung antiseptik alami contohnya buah rimbang yang mengandung senyawa metabolit sekunder dan mempunyai aktivitas antibakteri. Tujuan dari penelitian ini adalah untuk membuat formulasi sabun padat transparan sebagai antiseptik dari ekstrak etanol buah rimbang. Formulasi sabun padat transparan tanpa bahan uji (Blanko) dan ekstrak etanol buah rimbang konsentrasi 1,5%, 2% dan 2,5% dilakukan uji evaluasi mutu pada sediaan. Kemudian dilakukan uji efektivitas pada ekstrak etanol buah rimbang dan sediaan sabun padat transparan. Hasil uji skrining fitokimia pada simplisia dan ekstrak etanol buah rimbang memenuhi syarat mutu fisik pada senyawa metabolit sekunder. Hasil aktivitas antibakteri konsentrasi 2,5% diameter hambatan terhadap Staphylococcus aureus 19,47 ± 0,85 menunjukkan diameter hambatan sangat kuat. Angka lempeng total terhadap spesimen cuci tangan sukarelawan, EEBR 1,5% telah terjadi pengurangan koloni bakteri sebesar 73,32%, EEBR 2,5% diperoleh pengurangan bakteri paling besar yaitu 98,51%, hampir sama dengan sabun padat yang beredar di pasaran yaitu 98,75%. Dari penelitian ini dapat disimpulkan bahwa sediaan sabun padat transparan ekstrak etanol buah rimbang sebagai antiseptik memenuhi syarat dalam pembuatan sabun mandi.
KAJIAN PENGGUNAAN ANTIRETROVIRAL PASIEN HIV DI PUSKESMAS KOTA SEMARANG Sulistiyanto, FX; Anggoro, A. Barry
Pharma Xplore : Jurnal Sains dan Ilmu Farmasi Vol 9 No 2 (2024): Pharma Xplore : Jurnal Sains dan Ilmu Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jpx.v9i2.8146

Abstract

HIV is a human immunodeficiency virus that causes AIDS. ARV administration aims to reduce the number of viruses so that it will improve the immune status of HIV patients and reduce deaths due to opportunistic infections. This study aims to determine the characteristics of HIV patients who use antiretrovirals based on age, gender, and occupation as well as CD4 values ​​and to determine the description of antiretroviral use in HIV patients at the Semarang City Health Center in 2023. This research is a non-experimental study using retrospective data collection techniques. The research objects used were medical record data and laboratory values ​​(CD4) of HIV patients. Based on the research results, it is known that the majority of HIV patients are male with a percentage of 85%, while women make up 15%. Patients aged 26-35 years mostly suffer from HIV with a rate of 39%. Most patient jobs are in the private sector with a percentage of 92%. The CD4 value of most HIV patients is below 350 cells/mm³ with a rate of 37%, which shows that the HIV patient's immunodeficiency is in the moderate-severe category. Most antiretroviral therapy is given using KDT (Tenofovir + Lamivudine + Efaviren) with a percentage of 70%.

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