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Pharma Xplore : Jurnal Sains dan Ilmu Farmasi
Published by Universitas Buana Perjuangan Karawang
ISSN : 25275801     EISSN : 25809601     DOI : https://doi.org/10.36805/farmasi
Core Subject : Health,
Medicine & Pharmacology
Biologi Farmasi, Farmakoekonomi, Farmakologi dan Toksikologi, Farmasetika dan Teknologi Farmasi. Farmasi Klinik, Farmasi Sosial, Kimia Farmasi
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Farmakologi
Articles 111 Documents
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ANALISIS EFEKTIVITAS BIAYA PENGGUNAAN OBAT PADA PASIEN RAWAT INAP PENYAKIT COVID-19 KATEGORI SUSPEK NON-COMORBID DENGAN TERAPI OBAT KOMBINASI ANTIVIRUS DAN ANTIBIOTIK DI SALAH SATU RUMAH SAKIT KOTA BANDUNG PERIODE JULI – DESEMBER 2021 M. Hilmi Fathurrahman; Nela Simanjuntak; Neng Siti Sopiah
Pharma Xplore : Jurnal Sains dan Ilmu Farmasi Vol 8 No 1 (2023): Pharma Xplore : Jurnal Sains dan Ilmu Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jpx.v8i1.5251

Abstract

COVID-19 is an infectious disease caused by the SARS-CoV-2 virus. The cost of his treatment requires a large amount of money. This study aims to analyze the cost-effectiveness of drug use in hospitalized patients with COVID-19 in the category of non-comorbid suspects with combination antiviral and antibiotic therapy at the Bandung Hospital Period July – December 2021. This study uses a non-analytic descriptive method. Data collection was carried out retrospectively by accessing medical record data. Samples that met the inclusion criteria in this study were 48 patients. Cost-effectiveness analysis was carried out by calculating the Average Cost Effectiveness Ratio (ACER) and Incremental Cost Effectiveness Ratio (ICER), then a sensitivity analysis was carried out to determine the parameters that affect cost-effectiveness by increasing drug costs to 2.5%, 5%, 7.5%. . The results of the analysis show the use of combinations of antivirals and antibiotics in COVID-19 patients, namely there are 16 variables and the most cost-effective (cost-effective) treatment is the combination of ceftriaxone inj with oseltamivir obtained at ACER = Rp. 1.005.724, the combination of azithromycin with ceftriaxone inj. is obtained at ICER = Rp.-2.113,412. The results of the sensitivity analysis showed that there was no change in ACER and ICER even though the drug price was increased up to 7.5% and the combination of inj ceftriaxone with oseltamivir remained the most cost-effective.
KORELASI TINGKAT PENGETAHUAN PASIEN DIABETES TIPE- 2 DENGAN KEPATUHAN MINUM OBAT DIABETES DI KARAWANG KULON Lina Aliyani Mardiana; Sri Mulyanthy Tanuwidjaja; Ermi Abriyani
Pharma Xplore : Jurnal Sains dan Ilmu Farmasi Vol 8 No 2 (2023): Pharma Xplore : Jurnal Sains dan Ilmu Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jpx.v8i2.4435

Abstract

Type -2 Diabetes is a disease that is difficult to cure but can be controlled with lifelong medication and a healthy lifestyle. The aim of this study was to determine the effect of the relationship between knowledge of type-2 diabetes patients and patient adherence to taking diabetes medication in Karawang Kulon, West Java. The research method is descriptive correlation where the samples in this study were all type 2 diabetes patients in January 2023-February 2023 with a total of 311. The results showed that the level of knowledge of type -2 diabetes patients was good at 92.60%, and quite good at 7.4%. while the level of compliance is 13.83% compliance, 54.98% sufficient compliance and 31.19% disobedience. The results of the study based on the chi square test obtained a value of 0.00 <0.05, which means that there is a significant relationship between the level of knowledge of type 2 diabetes patients and adherence to taking diabetes medication in Karawang Kulon.
UJI SPF DAN AKTIVITAS ANTIBAKTERI SEDIAAN SUNSCREEN POWDER EKSTRAK ETANOL DAUN JAMBU BIJI (Psidium guajava L.) TERHADAP Propionibacterium acnes Nurul Halimah Amimi; Lina Rahmawati Rizkuloh; Susanti
Pharma Xplore : Jurnal Sains dan Ilmu Farmasi Vol 8 No 2 (2023): Pharma Xplore : Jurnal Sains dan Ilmu Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jpx.v8i2.5767

Abstract

Every human being has different skin problems. Skin problems caused by sun exposure and acne-causing bacteria can be overcome by using a sunscreen powder that contains anti-acne. Natural ingredients that can overcome these problems are guava leaves (Psidium guajava L.) because they contain flavonoid compounds that can absorb ultraviolet light and have antibacterial activity. This study aims to determine the ability of guava leaves as a sunscreen by determining the value of SPF (Sun Protection Factor) using a UV-Vis spectrophotometer and as an anti-acne by calculating the inhibition of Propionibacterium acnes bacteria using the well diffusion method. The preparation formulation uses a variation in the concentration of guava leaf extract of 2.5%, 5%, and 7.5%. The results showed that guava leaf extract can be formulated into a sunscreen powder that meets the requirements. Based on the data obtained, the SPF value and inhibition zone diameter increased according to the high concentration of guava leaf extract used. All three formulas have an SPF value in the maximum protection category. Formula 3 (7.5%) has the highest SPF value of 15.00. The results of bacterial inhibition zone activity in formulas 1 (2.5%) and 2 (5%) were included in the strong category, while formula 3 (7.5%) had an inhibition of 21.33 mm, which was included in the very strong category.
UJI AKTIVITAS ANTIBAKTERI FACE MIST EKSTRAK ETANOL DAUN ANDONG MERAH (Cordyline fruticosa (L) A. Chev.) TERHADAP Propionibacterium acnes Eko Sri Wahyuningsih; Melisa Puspitasari; Neni Sri Gunarti; Maulana Yusuf Alkandahri
Pharma Xplore : Jurnal Sains dan Ilmu Farmasi Vol 8 No 2 (2023): Pharma Xplore : Jurnal Sains dan Ilmu Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jpx.v8i2.5907

Abstract

This research is motivated by the problem of skin infection in the form of acne, one of the causes of which is the bacterium Propionibacterium acnes. Red andong leaves contain several secondary metabolites that have the potential as antibacterials such as flavonoids, tannin, saponins,and polyphenolic. The purpose of this study was to make a face mist preparation formula from red andong leaf extract which has the potential as an antibacterial for Propionibacterium acnes. The extraction method used was maceration with 70% ethanol solvent. Testing the inhibition of antibacterial activity was carried out using the well-diffusion method. Determination of the concentration of the extract needed for face mist preparation is taken from the results of the MIC test. Face mist preparations were made with 3 concentrations, namely formulas F3.12, F6.25, and F9.37. The face mist base was used as a negative control and the face mist base added with clindamycin powder was used as a positive control. Testing the face mist of red andong leaves extract included organoleptic, homogeneity, specific gravity, pH, spray spreadability, dry time, and hedonic tests. The results showed that the face mist of the ethanol extract of red andong leaves extract met the requirements for a good face mist preparation and had an inhibitory effect on the growth of Propionibacterium acnes bacteria in all formulas. Face mist Formulation 3.12% has an inhibition of 8.19 ± 0.22 mm, Formulation 6.25% has an inhibition of 10.59 ± 0.13 mm, and Formulation 9.37% has an inhibition of 11.75 ± 0.17 mm. From this study, it can be concluded that face mist containing 9.37% (F9.37) of red andong leaf extract was the most effective formulation against Propionibacterium acnes bacteria with the highest inhibition zone diameter of 11.75 ± 0.17 mm.
UJI AKTIVITAS ANTELMINTIK INFUSA DAN EKSTRAK ETANOL DAUN PEPAYA JEPANG (Cnidoscolus aconitifolius) TERHADAP CACING GELANG BABI (Ascaris suum) SECARA IN VITRO Asman Sadino; Dina Rosdiana; Anas Subarnas; Riza Apriani
Pharma Xplore : Jurnal Sains dan Ilmu Farmasi Vol 8 No 2 (2023): Pharma Xplore : Jurnal Sains dan Ilmu Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jpx.v8i2.5919

Abstract

Ascaris suum is a parasitic worm in pigs that is closely related to the worm in humans, A. lumbricoides. A literature search shows that A. suum can infect humans. Ascaris is thought to modulate host immune and inflammatory responses, which may lead to immune hyporesponsiveness during chronic infections. Treatment with anthelmintic drugs is considered to increase the risk of resistance. Thus, alternative medicines from natural ingredients are needed that are more effective and have minimal side effects, including Japanese papaya leaves (Cnidoscolus aconitifolius). This research aimed to analyze the anthelmintic activity of ethanol extract and Japanese papaya leaf infusion against A. suum worms and eggs in vitro. Testing was divided into 6 large groups, namely test group (extract and infusion concentrations of 3%, 6%, and 9%), comparison group (pyrantel pamoate 1% and piperazine citrate 2% for testing adult worms and mebendazole 0.25% for testing worm eggs), and control group (NaCl 0.9% and PGA 1%). The parameters looked at are the form of paralysis, death of adult worms, and the percent inhibition of worm eggs. The results of the research were the anthelmintic activity shown by Japanese papaya leaf extract (C.aconitifolius) against pig roundworms and their eggs at a concentration of 9% compared to test concentrations of 3% and 6%, pyrantel pamoate, piperazine citrate, and mebendazole. This research concludes that Japanese papaya (C.aconitifolius) leaf extract has anthelmintic activity against pork roundworms and their eggs.
EVALUASI EFEK ANTIPIRETIK AKAR PAKIS TANGKUR (Polypodium feei METT) PADA MENCIT YANG TERINDUKSI VAKSIN DTP-HB Hesti Renggana; Isye Martiani; Risa Susanti; Dani Sujana; Zakiah Nur Aeni
Pharma Xplore : Jurnal Sains dan Ilmu Farmasi Vol 8 No 2 (2023): Pharma Xplore : Jurnal Sains dan Ilmu Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jpx.v8i2.5928

Abstract

Fever is a state where the body's core temperature rises above normal levels. In healthy adults, the average oral temperature is around 37°C. Fever is not harmful but in certain circumstances this response is undesirable because it interferes with normal activities. The research method used is True Experimental with Posttest Only Control Group Design approach as the research design. The purpose of this study was to assess the antipyretic effect of tangkur fern root on mice induced by DTP-HB vaccine. The results showed that the extract and water fraction of tangkur fern root had antipyretic effects by reducing the fever temperature of mice during the observation time for 240 minutes. Overall, this study proves that the ethanol extract at a dose of 100 mg/kgBB is an effective dose as a candidate for antipyretic drugs.
ANALGESIC EFFECT OF INFUSA MIXTURE OF RED GINGER, TEMUKUNCI, KENCUR, LEMONGRASS AND TAMARIND ON FEMALE MICE BY WRITHING TEST METHOD. Dani Sujana; Nurul; Dadang Muhammad Hasyim; Yogi Rahman Nugraha; Diah Wardani; Mina Pertiwi; Hesti Renggana
Pharma Xplore : Jurnal Sains dan Ilmu Farmasi Vol 8 No 2 (2023): Pharma Xplore : Jurnal Sains dan Ilmu Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jpx.v8i2.5929

Abstract

Pain is an unpleasant sensory and emotional experience caused by actual or potential tissue damage. Based on systematic review studies it has been proven that red ginger, temukunci, kencur, lemongrass and tamarind have been shown to have analgesic effects both in vitro and in vivo. The purpose of this study was to determine the analgesic effect of IJTKSA. The method used in this study is a laboratory experiment with an analytical descriptive approach. The results showed that IJTKSA both concentrations of 0.02%, 0.04% and 0.08% were able to reduce the number of writhing mice. Overall, IJTKSA concentration of 0.02% has the most effective analgesic effect as evidenced by the low average total number of writhing mice during 60 minutes of observation.
FORMULASI DAN EVALUASI KRIM EKSTRAK DAUN PANDAN WANGI (Pandanus amaryllifolius Roxb.) DENGAN VARIASI KONSENTRASI ASAM STEARAT DAN TRIETANOLAMIN Laela Nurfitri; Nur Cholis Endriyatno
Pharma Xplore : Jurnal Sains dan Ilmu Farmasi Vol 8 No 2 (2023): Pharma Xplore : Jurnal Sains dan Ilmu Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jpx.v8i2.5932

Abstract

The fragrant pandan leaf (Pandanus amaryllifolius Roxb.) contains flavonoid compounds that can function as a sunscreen. Sunscreen preparations are generally in the form of creams. In cream formulations, emulsifiers play a crucial role in imparting physical properties to the cream. The objective of this research is to determine the influence of the combination of stearic acid and triethanolamine on the physical properties and stability of the cream and to identify the optimal emulsifier concentration. Cream formulations were prepared in three formulations with a combination of stearic acid and triethanolamine (TEA), namely F I (17%: 3.5%), F II (18%: 3%), and F III (19%: 2.5%). The cream formulations underwent physical evaluations such as organoleptic testing, homogeneity testing, viscosity testing, adhesion testing, pH testing, skin irritation testing, spreading power testing, and stability testing. The data obtained were analyzed using One Way ANOVA (analysis of variance) with a confidence level of 95%. The research data results showed that the addition of stearic acid and trietanolamin affected the viscosity, pH value, spreading power, and adhesion of the cream but did not affect the organoleptic properties, stability, homogeneity, and skin irritation. Based on the physical properties and statistical tests, the concentration of stearic acid and trietanolamin emulsifier (17%: 3.5%) was found to be the best.
FORMULASI DAN UJI AKTIVITAS ANTIBAKTERI SEDIAAN FOOTSPRAY ANTI BAU KAKI EKSTRAK TEH HITAM (Camellia sinensis) DAN DAUN JAMBU BIJI (Psidium guajava L.) Shalsadila, Rifani; Nuryanti, Mega; Siahaan, Nurbaiti Fentiani; Nurkamal, Elsa; Farhan, Dicky; Purwaeni
Pharma Xplore : Jurnal Sains dan Ilmu Farmasi Vol 9 No 1 (2024): Pharma Xplore : Jurnal Sains dan Ilmu Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jpx.v9i1.2939

Abstract

Increased release of apocrine infected by bacteria during the decay process will result in foot odor or bromhidrosis. Foot odor is caused by skin microbes. Some of the bacteria that cause foot odor are Staphylococcus epidermidis and Staphylococcus aureus. Black tea and guava leaves are natural ingredients that contain antibacterial compounds, namely flavonoids, saponins, tannins and alkaloids. The purpose of this study was to formulate footspray preparations from extracts of black tea and guava leaves and to determine the antibacterial activity of each formulation. This study uses an experimental method. Extracts of black tea and guava leaves are produced from the maceration extraction process, then the resulting extract is formulated into footspray with various concentrations. Footspray preparations were tested for evaluation of physical preparations and tested for antibacterial activity of Staphylococcus epidermidis and Staphylococcus aureus by the paper disc method. The results showed that black tea and guava leaf extracts could be formulated as active substances in footspray preparations which had antibacterial activity which was indicated by the presence of clear zones in formulas 1, 2 and 3. However, in the control formula there was no antibacterial activity which was indicated by the absence of clear zone.
AKTIVITAS ANTIOKSIDAN DAN KADAR TOTAL FENOL DARI EKSTRAK JAMU BERAS KENCUR DENGAN PENAMBAHAN RIMPANG KUNYIT Fitriansyah, Sani Nurlaela; Riasari, Hesti; Melati, Novi; Simanjuntak, Nela
Pharma Xplore : Jurnal Sains dan Ilmu Farmasi Vol 9 No 1 (2024): Pharma Xplore : Jurnal Sains dan Ilmu Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jpx.v9i1.6483

Abstract

Jamu is a traditional medicine from Indonesia. Jamu beras kencur is one of the most popular jamu in Indonesia. Jamu beras kencur are often added with other ingredients to increase the efficacy. Turmeric (Curcuma domestica) was a traditional medicinal plant that has high antioxidant and anti-inflammatory effects. Phenolic compound is the largest secondary metabolite in turmeric. The aimsf this research were to determine antioxidant activity and total phenolic content of extract jamu beras kencur wich was added of various concentrations of turmeric and the differences boiling time in processing jamu preparations. The processing of jamu beras kencur with the addition of turmeric with boiling time (15 minutes and 30 minutes). Variation of concentration of tumeric were 5%, 10% and 20%. The concentration of turmeric used addition 5%, 10% and 20. Each preparation was extracted using ethyl acetat. Aantioxidant activity of each extract was performed by DPPH method wich demonstrated as IC50 DPPH. Determination of total phenolic was performed by UV-Vis spectrophotometry and expressed in g GAE/100 g extract. The highest antioxidant activity (IC50 of 485 μg/mL) and the highest total phenolic (41.336 g GAE /100 g extract) was given by jamu beras kencur wich 20% turmeric and 15 min boiling time. Addition of turmeric and differences of boiling time in processing jamu preparations can affect antioxidant activity and total phenolic content.

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