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Mohammad Saifur Rohman
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Department of Cardiology and Vascular Medicine, Dr. Saiful Anwar General Hospital, 3rd Floor CVCU Jl. Jaksa Agung Suprapto No. 2, Malang, Indonesia
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Heart Science Journal
Published by Universitas Brawijaya
ISSN : 27219976     EISSN : 27219984     DOI : http://dx.doi.org/10.21776/ub.hsj.2020.001.01
Core Subject : Health, Science,
Health Professions Immunology & microbiology Medicine & Pharmacology
HEART SCIENCE is the official open access journal of Brawijaya Cardiovascular Research Center, Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia. The journal publishes articles three times per year in January, May, and September. The journal is a peer reviewed publication and accepts articles for publication from across the world. HEART SCIENCE accepts and publishes articles in the English language only. The primary goal of this journal is to publish clinical and basic research relevant to cardiovascular medicine. The journal covers the following topics: clinical cardiology, interventional cardiology, intensive and acute cardiovascular care, vascular diseases, non-invasive cardiology, pediatric cardiology, cardiac nuclear medicine imaging, arrhythmia, cardiac prevention and rehabilitation, and cardiac surgery. Animal studies are also considered for publication in HEART SCIENCE. To serve the interest of both practicing clinicians and researchers, the journal provides platform or forum for research scholars, intellectuals, and cardiologists to reveal their views and research work for dialogue, education, and interaction to the entire world. HEART SCIENCE publishes original research, reviews, brief reports, case reports, case series, editorial, and commentary. HEART SCIENCE also publishes the special issues and abstracts of papers presented at the annual meeting of the Cardiological Society of Malang.
Arjuna Subject : Kedokteran - Cardiology and Cardiovascular Medicine
Articles 344 Documents
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The role of N-terminal pro-brain natriuretic peptide as an early alert of pulmonary hypertension in chronic lung disease Hulaimi; Yanti, Budi; Ridwan, Muhammad; Arliny, Yunita; Nurrahmah
Heart Science Journal Vol. 7 No. 2 (2026): The Evolving Landscape of Heart Failure
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.hsj.2026.007.02.12

Abstract

BACKGROUND: One of the primary causes of illness and dying in worldwide was chronic lung disease (CLD). Pulmonary hypertension (PH) was among the most popular issues linked to CLD, often remaining undiagnosed in the early stages. N-terminal pro-brain natriuretic peptide (NT-proBNP) and electrocardiographic abnormalities could be early alert of pulmonary hypertension. OBJECTIVES: This study aims to ascertain the role of NT-proBNP as early markers of pulmonary hypertension in CLD. METHOD: This study used a cross-sectional design in 2024, and there where 35 patients with CLD were analyzed. A group of normal individuals without cardiac and pulmonary abnormalities was used as a control group. Data on patient characteristics, symptoms, typical electrocardiography (ECG) results of pulmonary hypertension, as well as serum NT-proBNP levels was measured at baseline before any intervention. RESULTS: Most patients were male (85.7%) and aged ≥60 years (51.4%), and Chronic Obstructive Pulmonary Disease (COPD) is the most popular CLD (65.7%). Prolonged QT (20%) was the most prevalent ECG abnormality, followed by right axis deviation (14.7%) and Right Bundle Branch Block (11.42%). The COPD group had the most elevated NT-proBNP levels (mean 90.22 pg/mL), then the Pulmonary Tuberculosis Lung Disease group at 74.34 pg/mL, and in normal individuals (57.89 pg/mL). The NTproBNP levels differed significantly amongst the groups (p = 0.0215). CONCLUSION: COPD, which is the most CLD, showed the highest prevalence of early pulmonary hypertension, characterized by increased NT-proBNP and QT prolongation. In CLD, NT-proBNP could be utilized as an indicator of the initial identification of pulmonary hypertension. 
A review of RUNX2 genetic interactions and their role in cardiovascular disease Christine, Anastasia; Rohman, Mohammad Saifur; Yogibuana, Valerinna
Heart Science Journal Vol. 7 No. 2 (2026): The Evolving Landscape of Heart Failure
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.hsj.2026.007.02.5

Abstract

Cardiovascular diseases (CVD) remain the leading cause of global mortality, with underlying factors such as genetics, environment, and lifestyle interacting in complex and multiple ways. Runt-related transcription factor 2 (RUNX2), traditionally associated with osteogenesis, has gained recognition for its critical role in cardiovascular health. RUNX2 contributes to vascular calcification (VC), endothelial dysfunction, and myocardial fibrosis, thereby accelerating CVD progression. Its expression is influenced by multiple upstream regulators relevant to vascular pathology, such as BMP2/SMAD, Wnt/β-catenin, and ERK signaling, along with epigenetic mechanisms and gene-environment interactions such as oxidative stress, hyperglycemia, and dyslipidemia. Genetic variants in RUNX2 and environmental variables including diet and physical inactivity, amplify its activation, worsening VC and cardiovascular risk. RUNX2 reduces endothelial nitric oxide bioavailability, enhances vascular inflammation, and activates profibrotic signaling in cardiac tissue, promoting vascular dysfunction and myocardial remodeling. Circulating RUNX2 levels and genetic variations exhibit potential as diagnostic and predictive indicators for cardiovascular disease. Severalpharmaceutical agents including metformin, empagliflozin, and statins,   as well as natural substances such green tea polyphenols and green coffee extract, have demonstrated partial modulatory effects on RUNX2 activity. Moreover, genome-editing tools such as CRISPR-Cas9 present future opportunities for selective RUNX2 targeting. Comprehensive understanding of RUNX2 regulation and its interaction with genetic and environmental factors offers novel opportunities for personalized CVD prevention and treatment approaches through lifestyle modification, pharmacotherapy, and gene-based interventions in the future.
Unrecognized major aortopulmonary collateral arteries in double outlet right ventricle-ventricular septal defect: A rare case report Siagian, Sisca Natalia; Panjaitan, Elsa Hedia; Wangsaputra, Vincent Kharisma
Heart Science Journal Vol. 7 No. 2 (2026): The Evolving Landscape of Heart Failure
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.hsj.2026.007.02.17

Abstract

BACKGROUND: Major aortopulmonary collateral arteries (MAPCAs) are aberrant vessels that typically form to compensate for cyanotic congenital heart disease (CHD) with restricted pulmonary blood flow. This often obscures clinical suspicion of MAPCAs in CHDs associ-ated with pulmonary overcirculation, making it potentially unrecognized. CASE ILLUSTRATION: We report the case of a 5-month-old girl presenting with dyspnea, recurrent respiratory infections, and failure to thrive. Echocardiography revealed double outlet right ventricle (DORV) with ventricular septal defect (VSD) and patent ductus arteriosus (PDA). After initial treatment for heart failure and pneumonia, she underwent pul-monary artery (PA) banding and PDA ligation. Ongoing poor postoperative status prompted a second surgery, where intraventricular tunnel repair failed due to inability to wean from cardiopulmonary bypass. An atrial septectomy and PA band retightening achieved hemodynamic improvement, but the patient remained ventilator-dependent with recurrent pneumonia. Further evaluation with multislice CT and catheterisation uncovered previously undiagnosed MAPCAs supplying the right lung and a hypoplastic right pulmonary artery (RPA), precluding embolisation. Since the MAPCAs and hypoplastic RPA were initially unrecognized, the PA banding procedure inadvertently exacerbated the right lung. CONCLUSION: This case highlights the importance of considering MAPCAs in various CHD morphologies and emphasizes the value of pre-procedural imaging selection to optimize surgical planning and outcomes.
Early intervention in asymptomatic external iliac artery stenosis: How important is it? Catelya, Laras Gaby; Kurnianingsih, Novi; Rohman, Mohammad Saifur
Heart Science Journal Vol. 7 No. 2 (2026): The Evolving Landscape of Heart Failure
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.hsj.2026.007.02.18

Abstract

Background: Aortoiliac occlusive disease (AIOD) represents a clinical manifestation of systemic atherosclerosis, which may progress into Chronic Limb-Threatening Ischemia (CLTI) and contribute to an increased risk of cardiovascular death. Case illustration: A 62-year-old male presented to the clinic for staged percutaneous coronary intervention without complaint of intermittent claudication. Higher pulsation was palpable in the right femoral artery, with an Ankle-Brachial Index (ABI) of 0.8. The PCI procedure was then carried out using left femoral artery access. Following the procedure, a Duplex ultrasound (DUS) evaluation of the lower extremity was done, with no remarkable stenosis found. CT angiography revealed severe stenosis of the right external iliac artery with a TASC II C lesion. Digital subtraction angiography (DSA) was then performed using right brachial artery access, revealing an 80% stenosis of the right medial external iliac artery. Based on the measurement, angioplasty was done, followed by stent implantation of the right external iliac artery using Abbott Vascular Omnilink Elite 7x39 mm 135 cm with a pressure of 11 atm for 30 seconds. Following the procedure, an improvement in distal arterial flow of the right lower extremity was observed, as indicated by ABI and DUS evaluation. The rest of the hospital stay was uneventful. The patient was discharged the next day after the procedure, without any residual symptoms. Conclusion: Patients with asymptomatic PAD are at very high cardiovascular risk. Early intervention of PAD may prevent its progression into CLTI. Endovascular revascularisation of the aortoiliac lesions in suitable patients grants satisfactory results with fewer drawbacks.
Beyond solely estrogen: Sex-based differences in platelet biology and antithrombotic response Salma, Zaskia Nafisa; Susilo, Hendri; Wungu, Citrawati Dyah Kencono; Tandecxi, Gabriel; Nugrahani, Annisa Salsabilla Dwi
Heart Science Journal Vol. 7 No. 2 (2026): The Evolving Landscape of Heart Failure
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.hsj.2026.007.02.6

Abstract

Despite increased awareness of sex differences in cardiovascular disease (CVD), disparities in sex-specific platelet biology and antithrombotic studies are still underexplored. Moreover, women are frequently underrepresented in clinical trials, with numerous research initiatives primarily focusing on estrogen while neglecting non-hormonal influences that contribute variations in thrombotic risk and treatment outcomes. We conducted a literature review to examine sex-related differences in platelet biology, such as elevated platelet counts and reactivity in females, along with distinct expression of receptors and signaling molecules. These variations influence responses to antiplatelet medications—including aspirin, P2Y12 inhibitors, and glycoprotein IIb/IIIa inhibitors, and dual antiplatelet therapy—leading to altered effectiveness and a heightened bleeding risk in women. This review emphasizes the importance of non-hormonal factors, such as transcriptomic and proteomic variations, and highlights the growing potential of omics and systems biology in identifying therapeutic targets specific to sex. Incorporating sex as a biological factor in preclinical and clinical research is crucial for enhancing risk assessment and treatment results.
Regulatory RNAs and coronary artery calcification: A systematic review of clinical associations and biological insights Tsuraya, Alfi; Raras, Tri Yudani Mardining; Lestari, Bayu; Ramadhani, Risa; Hose, Victor Alvianoes Guterez; Rohman, Mohammad Saifur; Waranugraha, Yoga; Fajar, Jonny Karunia
Heart Science Journal Vol. 7 No. 2 (2026): The Evolving Landscape of Heart Failure
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.hsj.2026.007.02.7

Abstract

BACKGROUND: Regulatory RNAs, including microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs), have emerged as key regulators of vascular remodelling and coronary heart disease. However, their specific roles in coronary artery calcification (CAC) remain fragmented across diverse clinical studies. OBJECTIVES: This review aims to systematically synthesize human observational evidence on differentially expressed regulatory RNAs associated with CAC and their underlying molecular mechanisms. METHODS: We included clinical observational studies (case-control, cross-sectional, or cohort designs) that compared regulatory RNA expression in patients with and without CAC. We searched PubMed, BioMed Central, Wiley, ScienceDirect, and Cochrane between January 2010 and June 2025. Risk of bias was assessed using the JBI Critical Appraisal Checklist for Observational Studies. Data were synthesized narratively with stratification by RNA type, direction of expression, and biological mechanism. RESULTS: A total of 10 eligible studies were included. Several regulatory RNAs demonstrated potential as biomarkers or modulators of CAC. However, the diversity of regulatory RNAs highlights the complex and multifactorial nature of CAC, while also revealing opportunities for future investigation. CONCLUSION: Notably, circSmad4 demonstrated a favourable trend with a high AUC and a reasonably balanced mix of sensitivity and specificity, despite with relatively larger sample sizes.
The association of CDKNB-AS1 gene polymorphism and coronary artery calcification: A systematic review Tsuraya, Alfi; Miasih, Dewi Sekar; Ramadhani, Risa; Rohman, Mohammad Saifur; Raras, Tri Yudani Mardining
Heart Science Journal Vol. 7 No. 2 (2026): The Evolving Landscape of Heart Failure
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.hsj.2026.007.02.8

Abstract

BACKGROUND: Coronary artery calcification (CAC) is a robust, heritable marker of subclinical atherosclerosis. Among genetic loci identified by genome-wide association studies (GWAS), 9p21 locus, particularly the CDKN2B-AS1 (ANRIL) region, has emerged as a key determinant of coronary artery disease (CAD). However, whether this signal generalizes to CAC across ancestries remains unresolved because the evidence is scattered and analytically heterogeneous, with certain populations underrepresented. OBJECTIVES: This systematic review was conducted to synthesize findings across studies that assessing CDKN2B-AS1 variants and CAC within populations. METHODS: We conducted a search in PubMed, BioMed Central, Wiley, ScienceDirect, and Cochrane from January 2010 to June 2025. Fourteen eligible studies were included in total. The JBI Critical Appraisal Checklist for Observational Studies was utilised to assess the risk of bias. Data were synthesised through a narrative approach. RESULTS: This systematic review integrates multi-ethnic evidence showing that rs1333049 and rs4977574 exhibit strong, reproducible associations with CAC severity in European and Admixed American populations, but weaker or absent effects in African and East Asian groups. In East Asia population, particularly Korean, rs10757272 shows the strongest influence. CONCLUSION: Overall, CDKN2B-AS1 functions as an important, ancestry-dependent in coronary calcification, emphasizing the need for fine-mapping and diverse cohort inclusion to achieve globally equitable genetic risk assessment.
Determining culprit lesion through the ECG pattern in wrapped LAD: A case series Suryono, Suryono; Ardhianto, Pipin; Tohari, Achmad Ilham; Utama, Riawati; Hidayat, Muhammad Rijal Fahrudin; Amien, Muhammad Irsyad; Ramadhan, Hazbina Fauqi
Heart Science Journal Vol. 7 No. 2 (2026): The Evolving Landscape of Heart Failure
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/10.21776/ub.hsj.2026.007.02.19

Abstract

Background: Wrapped left anterior descending (LAD) artery is defined as an LAD that supplies the apex and more than 25% of the inferior wall. Patients with wrapped LAD may have higher morbidity and mortality, and the culprit-lesion ECG pattern can differ from typical LAD occlusion, potentially leading to misinterpretation during primary percutaneous coronary intervention (PCI). Recognizing ECG patterns suggestive of wrapped LAD may help clinicians identify the culprit lesion and initiate appropriate therapy promptly.​ Case presentation: Four patients with ST-elevation myocardial infarction and angiographically confirmed wrapped LAD occlusion are presented, each demonstrating distinct culprit sites inferred from ECG patterns. The first was a 43-year-old Javanese man with mid-LAD occlusion; the second, a 40-year-old Javanese man with proximal LAD occlusion involving the first diagonal branch; the third, a 57-year-old Javanese man with isolated proximal LAD occlusion; and the fourth, a 59-year-old Javanese woman with mid wrapped LAD stenosis. All patients underwent successful primary PCI. Conclusion: Clinicians should consider wrapped LAD when ECG suggests combined anterior and inferior involvement, as the cardiac vector in wrapped LAD can produce patterns mimicking multivessel occlusion. In cases where the ECG appears to indicate two infarct territories, a single wrapped LAD occlusion rather than double-vessel disease should be suspected, which may refine culprit-lesion localization and procedural strategy during primary PCI.
Assessing left atrial function in acute decompensated heart failure: Insights from echocardiography Niazta, Nisa Amnifolia; Karolina, Wella; Rahimah, Anna Fuji; Prasetya, Indra
Heart Science Journal Vol. 7 No. 2 (2026): The Evolving Landscape of Heart Failure
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.hsj.2026.007.02.2

Abstract

Acute heart failure remains a major cause hospitalization, especially in older adults and is associated with mortality and frequent readmissions. Several factors associated with heart failure outcomes include left ventricular dysfuction, left atrial dysfunction, and LA enlargement. LA enlargement has been recognized as a dependable imaging marker, closely tied to adverse outcomes such as heart failure, stroke, atrial fibrillation, and mortality. LA is not merely a passive conduit for transport. LA plays an active role and responds to distension by releasing atrial natriuretic peptides. LA enlargement has been shown to correlate with poor cardiovascular prognosis. In patients experiencing acute heart failure, fluid overload and its reduction can alter LA mechanical performance. Decongestive treatment has been associated with improved LA reservoir function, which can be assessed through parameters like LA reservoir strain rate also peak atrial longitudinal strain. In more advanced heart failure—characterized by reduced left ventricular ejection fraction, increased filling pressures, then diminished cardiac output—both PALS and strain rate are often markedly impaired, reflecting significant dysfunction in LA reservoir. Evaluating left atrial function via echocardiographic techniques is proving to be a vital tool in predicting outcomes for individuals with acute decompensated heart failure. As the understanding of LA physiology evolves, its role is increasingly seen as dynamic rather than passive. Echocardiography is showing potential imaging biomarker for risk stratification and therapeutic guidance in heart failure management.
Acute cardiac care in rheumatic mitral stenosis Niazta, Nisa Amnifolia; Prasetya, Indra
Heart Science Journal Vol. 7 No. 2 (2026): The Evolving Landscape of Heart Failure
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.hsj.2026.007.02.4

Abstract

Rheumatic heart disease (RHD) is prevented, although productive-age people may develop consequences. Indonesia, as an endemic country of RHD, predominantly reported isolated mitral stenosis among RHD patients. Acute worsening of mitral stenosis can lead to acute heart failure and cardiogenic shock, arrhythmias, stroke, pulmonary hypertension, systemic embolic events, infective endocarditis, and pregnancy-related issues. The diagnosis of critical valvular emergency, especially rheumatic mitral stenosis in acute cardiac care, is often overlooked due to the clinical history potentially resembling other disease entities. This review highlights clinical emergency manifestation and comprehensive management of rheumatic mitral stenosis in acute cardiac care.  

Page 34 of 35 | Total Record : 344

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