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All Journal Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya CURRENT INTERNAL MEDICINE RESEARCH AND PRACTICE SURABAYA JOURNAL Sewagati Folia Medica Indonesiana
Wungu, Citrawati Dyah Kencono
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Arts Humanities Biochemistry, Genetics & Molecular Biology Education Engineering Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Neuroscience Public Health Social Sciences Other

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Efficacy of Ozoralizumab vs. Golimumab for Rheumatoid Arthritis: A Systematic Review Fithriyah, Nathania Elma; Rahmadhani, Khafiyah Hikmah; Susanti, Luthfiana Rofhani; Mustika, Arifa; Lita Diah Rahmawati; Wungu, Citrawati Dyah Kencono
Current Internal Medicine Research and Practice Surabaya Journal Vol. 6 No. 2 (2025): CURRENT INTERNAL MEDICINE RESEARCH AND PRACTICE SURABAYA JOURNAL
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/cimrj.v6i2.66406

Abstract

Introduction: Rheumatoid arthritis, a systemic autoimmune disease, affects 13% of the world population. As a well-established therapy, golimumab provides a key benchmark for assessing novel biological treatments. In contrast, ozoralizumab represents an innovative therapeutic approach. This study aimed to comprehensively elucidate the efficacy of golimumab and ozoralizumab in reducing rheumatoid arthritis disease activity. Methods: Literature searches were conducted throughout PubMed, Cochrane, and Web of Science using Boolean operators, covering available records from database inception until October 2024. The literature search was performed in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The included studies were randomized controlled trials (RCT) evaluating the efficacy of ozoralizumab or golimumab for rheumatoid arthritis. Five studies from 2015 to 2022 were obtained and assessed using the Cochrane Risk of Bias 2 (ROB2) tool. Results: The five studies consisted of two ozoralizumab trials and three golimumab trials conducted in Japan and the United States, involving 2,305 participants. All included studies exhibited a low risk of bias based on assessments undertaken using the ROB2 tool. The differences in Disease Activity Score-28 (DAS28) remission rates between ozoralizumab and placebo were 42.6% in one study and 6.3% in the other, whereas golimumab mainly showed smaller differences versus placebo across three studies (4.6%, 5.9%, and 10.4%). Conclusion: This study demonstrates DAS28 remission in rheumatoid arthritis patients receiving either ozoralizumab or golimumab therapy. Nonetheless, further direct statistical studies are essential to determine which therapy is superior and under what circumstances it should be administered.   Highlights: 1. This study provides robust evidence that establishes ozoralizumab as a novel tumor necrosis factor-alpha (TNF-α) inhibitor for rheumatoid arthritis. 2. According to the findings, ozoralizumab may be a clinician's choice due to its comparable efficacy and potential advantages over golimumab.
Osteopontin and Its Clinical Correlation to Type 1 Cardiorenal Syndrome: A Literature Review Welliam, Yongki; Wungu, Citrawati Dyah Kencono; Susilo, Hendri
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 9 No 01 (2025): Qanun Medika Vol 09 No 01 January 2025
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v9i01.20878

Abstract

Cardiorenal syndrome (CRS) is a spectrum of disorders involving both the heart and the kidneys, either acutely or chronically, in one organ that can lead to dysfunction in the other. Type 1 CRS, the most common CRS, is when acute heart dysfunction impacts acute kidney dysfunction, commonly known as acute kidney injury. Comorbidities involving these two significant organs contribute to a high patient mortality rate that requires a new potential diagnostic method. Biomarkers are one of the diagnostic modalities widely used in various diseases. Osteopontin (OPN) is a phosphorylated glycoprotein found primarily in bones and teeth that regulates mineralization. Osteopontin is known to be involved in describing various pathological changes in the body, including cardiovascular diseases. This review aims to evaluate the clinical correlation of OPN level changes with the occurrence of Type 1 CRS. The results indicate that OPN also plays a role in detecting the progression of cardiovascular disease towards renal injury. The imbalance in the function of OPN as a pro-inflammatory and anti-inflammatory agent increases the progression of kidney disease in patients. Further findings suggest that, more specifically, urinary OPN describes renal injury events in type 1 CRS patients.
The Improvement of Community Knowledge, Attitudes and Practices After Covid-19 Socialization Khaerunnisa, Siti; Syafa'ah, Irmi; Wungu, Citrawati Dyah Kencono; Prabowo, Gwenny Ichsan; Handajani, Retno; Safitri, Indri; Notopuro, Harianto; Qurnianingsih, Ema; Lukitasari, Lina; Humairah, Ira; Bakhtiar, Arief; Suwandito, Suwandito; Asih, Susi Wahyuning; Anggraeni, Zuhrotul Eka Yulis; Adi, Ginanjar Sasmito; Nugrahani, Ely Rahmatika; Zulka, Ayesie Natasha; Soetjipto, Soetjipto
Folia Medica Indonesiana Vol. 57, No. 2
Publisher : Folia Medica Indonesiana

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Abstract

This study determined community knowledge, attitudes, and practices after COVID-19 socialization in Rambipuji and Suci Village, Jember District, East Java, Indonesia. This study used the analytic observational design study. As many as 40 people were given socialization about COVID-19 by gathering and online. The questionnaires were completed in two parts included before-socialization and after-socialization. The questionnaire data were analyzed descriptively by calculating frequency, percentage, and inferential statistics by t-test, Spearman correlation, and chi-square test. The data analysis used IBM SPSS version 23 software. The mean and standard deviation of percentage of knowledge pre-test, knowledge post-test, high attitude, moderate attitude, low attitude, very high practice, high practice, sufficient practice, and low practice were 58.33 ± 30.97, 77.70 ± 22.52, 62.5±21.7, 31±22.2, 6.5±17.1, 65±13.8, 32.3±13.8, 1.25±2.4, 1.25±1.8, respectively. Knowledge pre-test and post-test correlated 0.819 (p=0.001) and a t-test with p=0.003. Attitudes and practices correlated with p=0.001. Socialization of COVID-19 was useful to improve the community knowledge, attitudes, and practices in Rambipuji and Suci Village, Jember District, East Java, Indonesia that could prevent the transmission and inhibit the spread of the COVID-19 pandemic in Indonesia. Furthermore, continuous encouragement of COVID-19 socialization in wide areas was recommended.
PRELIMINARY LABORATORY EVALUATION OF RAPID DIAGNOSTIC TEST PROTOTYPE TO DETECT HBsAg IN WHOLE BLOOD AND SERUM Qurnianingsih, Ema; Wungu, Citrawati Dyah Kencono; Amin, Mochammad; Setyawati, Dewi; Yasan, Yanna Debby Restifanny; Lukitasari, Lina; Lusida, Maria Inge; Soetjipto, Soetjipto
Folia Medica Indonesiana Vol. 61, No. 2
Publisher : Folia Medica Indonesiana

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Abstract

Chronic hepatitis B virus (HBV) remains a major global health issue,[-10pc]AU: Please provide ORCID ID for all authors.[-7pc]AU: Please provide affiliation’s for all authors. with over 250 million people affected worldwide. In Indonesia, HBV prevalence has declined from high to moderate endemicity, but challenges persist due to regional disparities, risk of mother-to-child transmission, and the predominance of B3 and C1 sub-genotype. Despite available preventive measures and diagnostic tools, approximately 90% of cases remain undiagnosed, particularly in low-resource settings, indicating the need for improved screening and control strategies. Therefore, this study aims to conduct preliminary performance tests of KODC hepatitis B surface antigen (HBsAg) (rapid diagnostic test (RDT) prototype) produced by Konimex on serum and whole blood samples. Performance was assessed through sensitivity, precision, specificity, and comparative testing against commercial RDT. The results obtained were visually interpreted by 2 independent readers. KODC HBsAg RDT demonstrated a detection limit of 50 IU/ml in serum and 400 IU/ml in whole blood. Precision testing showed high reproducibility (RSD <3.02%), with no cross-reactivity against other pathogens. Compared with a commercial RDT, it showed equivalent performance in serum and superior specificity in whole blood. In addition, predictive value analysis confirmed excellent accuracy, with Positive predictive value (PPV) and negative predictive value (NPV) >99% in both sample types. Therefore, KODC HBsAg RDT prototype showed comparable performance to commercial tests with good sensitivity, precision, and specificity, indicating its potential as a practical tool for HBV screening in resource-limited settings.
Upaya peningkatan pola pengasuhan guru dan orang tua penyandang disabilitas di Pendidikan Khusus dan Layanan Khusus (PK-LK) Shafa Mojokerto Rimbun, Rimbun; Yuliawati, Tri Hartini; Faizah, Zakiyatul; Hamidah, Berliana; Amanda, Bella; Prasetiowati, Lucky; Sari, Dewi Ratna; Purwantari, Kusuma Eko; Wungu, Citrawati Dyah Kencono; Darsini, Ninik; Fepiosardi, Raihenette Amirasanti; Fathimatuzzahroh; Parmanto, Christian Melka
Sewagati Vol 9 No 5 (2025)
Publisher : Pusat Publikasi ITS

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12962/j26139960.v9i5.8095

Abstract

Anak Berkebutuhan Khusus (ABK) adalah anak yang mengalami keterbatasan ataukeluarbiasaan, baik fisik, mental-intelektual, sosial, maupun emosional. Keberadaanpendamping bagi siswa ABK memiliki makna yang berarti bagi proses perlindungandan tumbuh kembangnya. Kegiatan pengabdian kepada masyarakat ini bertujuanuntuk meningkatkan pengetahuan guru dan orang tua mengenai pola asuh bagi siswapenyandang disabilitas di Sekolah Shafa Mojokerto. Sebanyak 23 siswa berkebutuhankhusus diberikan asesmen kognitif, sosioemosional dan psikomotor lengkapdengan saran bagi stimulasi tumbuh kembangnya, yang dilakukan oleh psikologklinis dari Layanan Psikologi Rumah Kumbang. Diantaranya, sebanyak 4 siswapenyandang tuna daksa (cerebral palsy) diberikan asesmen fisik yang dilakukan olehDokter Spesialis Kedokteran Fisik dan Rehabilitasi dari RSUD Dr. Soetomo. Selainitu juga diberikan penyuluhan mengenai cerebral palsy, pemeriksaan genetik danpola pengasuhan yang tepat bagi guru dan orang tua siswa. Luaran dari kegiatanPkM yang telah tercapai antara lain tersedianya laporan asesmen psikologis siswadan peningkatan pengetahuan guru dan orang tua yang dibuktikan dengan peningkatanrerata nilai posttest test (80, 63 ± 14, 36) dibanding pretest (61, 88 ± 20, 07)secara signifikan ( ? = 0, 010). Kesiapan dan kesiagaan guru dan orang tua siswaABK merupakan kunci sukses penanganan, ditambah dukungan dari masyarakat danpemerintah dalam menyediakan lingkungan dan fasilitas yang ramah terhadap ABK.
Co-Authors Adi, Ginanjar Sasmito Amanda, Bella Amin, Mochammad Anggraeni, Zuhrotul Eka Yulis Arifa Mustika Bakhtiar, Arief Darsini, Ninik Dewi Ratna Sari Ely Rahmatika Nugrahani, Ely Rahmatika Faizah, Zakiyatul Fathimatuzzahroh Fepiosardi, Raihenette Amirasanti Fithriyah, Nathania Elma Hamidah, Berliana Harianto Notopuro Humairah, Ira Indri Safitri, Indri Khaerunnisa, Siti Kusuma Eko Purwantari Lucky Prasetiowati Lukitasari, Lina Maria Inge Lusida Parmanto, Christian Melka Prabowo, Gwenny Ichsan Qurnianingsih, Ema Rahmadhani, Khafiyah Hikmah Rahmawati, Lita Diah Retno Handajani Rimbun, Rimbun Setyawati, Dewi SOETJIPTO . Susanti, Luthfiana Rofhani Susi Wahyuning Asih, Susi Wahyuning Susilo, Hendri Suwandito, Suwandito Syafa'ah, Irmi Welliam, Yongki Yasan, Yanna Debby Restifanny Yuliawati, Tri Hartini Zulka, Ayesie Natasha