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Chairunisa Ayu Saputri
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Medfarm: Jurnal Farmasi dan Kesehatan
Published by Akademi Analis Farmasi dan Makanan Sunan Giri Ponorogo
ISSN : 23548487     EISSN : 27159957     DOI : -
Core Subject : Health, Science,
Chemistry Medicine & Pharmacology Public Health
Jurnal MEDFARM merupakan terbitan dari lembaga jurnal dibawah naungan Lembaga Penelitian dan Pengabdian Masyarakat (LP2M) Akademi Analis Farmasi dan Makanan Sunan Giri Ponorogo. Topik atau pembahasan dari Jurnal MEDFARM lebih terfokus pada bidang Farmasi, Obat Tradisional, Makanan, Minuman dan Kesehatan
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 183 Documents
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Burn Wound Healing Activity Of Ethanol Extract Gel Of Guava Peel (Psidium Guajava Linn.) In Rabbits (Oryctolagus Cuniculus). mohammad firdaus alshol; Mujtahid Bin Abdul Kadir; Datin An Nisa Sukmawati; Prayoga Fery Yuniarto; Herman Herman
MEDFARM: Jurnal Farmasi dan Kesehatan Vol 15 No 1 (2026): Medfarm: Jurnal Farmasi dan Kesehatan
Publisher : LPPM Akafarma Sunan Giri Ponorogo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.48191/medfarm.v15i1.790

Abstract

Traditional medicine using natural ingredients such as plants is becoming increasingly popular. Guava is a herbal plant used to treat various ailments, including burns. This study aims to evaluate the effectiveness of guava (Psidium guajava Linn.) peel extract gel in healing second-degree burns in rabbits (Oryctolagus cuniculus) and to determine the optimal dosage. This study used maceration and phytochemical screening methods, which identified alkaloids, triterpenoids, steroids, saponins, flavonoids, and tannins. Burns were induced using a hot metal on the rabbit's back. Twenty-five male rabbits weighing 1.5–2.5 kg were randomly divided into five groups (n = 5 per group). The experimental design was a Completely Randomized Design (CRD) consisting of a positive control (Bioplacenton gel), a negative control (no treatment), and guava peel extract gel at concentrations of 3%, 5%, and 7%. CRD ensured that each treatment was assigned randomly to minimize experimental bias. Burn wound diameter was measured periodically throughout the treatment period. Data were analyzed using one-way ANOVA followed by the LSD test. The results showed a significant difference between treatments (p = 0.000). 7% guava peel extract gel was the most effective treatment, showing the greatest reduction in burn diameter with an average reduction of 9.08 mm. These findings suggest that guava peel extract gel has potential as an alternative therapy for burn wound healing.
The Effect of Varying Concentrations of Mugwort Leaf Extract (Artemisia vulgaris L.) on SPF and Cream Physical Stability Umi Nafisah; Adeta Selvia Devi; Iin Suhesti
MEDFARM: Jurnal Farmasi dan Kesehatan Vol 15 No 1 (2026): Medfarm: Jurnal Farmasi dan Kesehatan
Publisher : LPPM Akafarma Sunan Giri Ponorogo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.48191/medfarm.v15i1.793

Abstract

Mugwort (Artemisia vulgaris L.) has antioxidant activity that can neutralize free radicals on the skin and also has sunscreen activity to protect the skin from UV exposure. This study highlights the benefits of the mugwort plant, which are currently unknown to the general public, requiring investigation into the formulation of its topical cream. This research aims to determine the stability of mugwort leaf extract cream and its SPF value. The extraction process uses the maceration method with 96% ethanol as the solvent. This study employed variations in mugwort leaf extract concentrations across formulas, starting from the control at 0% extract and increasing to 0.5%, 1%, 1.5%, and 2%. The organoleptic test results of the cream in the control formula showed a white color and green color in F1 to F4, with a characteristic smell and a semi-solid texture. The physical quality test for homogeneity indicates that all formulas are homogeneous. The pH test results of the formulation obtained values of 4,74-5,49, which meet the skin pH standard. The spreadability results obtained values of 6,15-6,38 cm. The cream's viscosity was in the range of 4,870-4,950 cPs. The hedonic test results showed that panelists preferred F1 with an extract concentration of 0.5%. The SPF test yielded scores ranging from 6,45 to 14,71. All formulations were able to preserve the physical quality stability of the preparations, according to the findings of the stability test conducted using the cycling test.
Evaluation of Papaya (Carica papaya L.) Seed Oil's α-Linolenic Acid and Linoleic Acid Compounds in-Silico as Antidiabetic Agents Against PPAR-γ Kadar Ismah; Yanulia Handayani; Claudia Dinda Safitri
MEDFARM: Jurnal Farmasi dan Kesehatan Vol 15 No 1 (2026): Medfarm: Jurnal Farmasi dan Kesehatan
Publisher : LPPM Akafarma Sunan Giri Ponorogo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.48191/medfarm.v15i1.797

Abstract

Despite it’s widespread usage in medical practice, conventional medicine is thought to cause unfavorable pharmacological reactions in the body. This is a therapy issue that is getting worse every year, particularly for people with diabetes mellitus. This study used pre-experimental computational techniques based on traditional Chinese medicine to offer a safer alternative therapy. Determining if substances in papaya seeds (Carica papaya L.) are effective against the PPAR-γ receptor is the goal of this study. The chemicals α-linolenic acid and linoleic acid served as test ligands in this study, while rosiglitazone was utilized as a positive control to measure binding affinity using molecular docking with Autodock Tools 4 software. By getting an RMSD value of 1,110 Å, the study's findings demonstrated that the validation procedure had satisfied the requirements. Papaya seeds (Carica papaya L) contain active chemicals that may have antidiabetic properties. Of these, α-linolenic acid had a stronger affinity (docking score of -6,82) than linoleic acid (docking score of -6,07). Each compound's highest score is known as the docking score. The SPSS paired T test was then used to evaluate the results. Data analysis using the paired T test reveals that there is a significant difference between the binding activity values of α-linolenic acid and linoleic acid because the p value is less than 0.05. Based on data interpretation, the binding activity values of α-linolenic acid and linoleic acid show that the data is normally distributed because the p value is >0.05..
Phytochemical Profile, Antioxidant Activity, and Cell Viability of Aegle marmelos Fruit Pulp Ethanolic Extract on SKOV-3 Ovarian Cancer Cells Sri Wahyuni; EM Sutrisna; Maryati Maryati; Sari Haryanti; Rona Nasywa Mahira
MEDFARM: Jurnal Farmasi dan Kesehatan Vol 15 No 1 (2026): Medfarm: Jurnal Farmasi dan Kesehatan
Publisher : LPPM Akafarma Sunan Giri Ponorogo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.48191/medfarm.v15i1.798

Abstract

Ovarian cancer remains a leading cause of cancer related mortality among women, emphasizing the need for safer more effective therapeutic strategies. Natural products are increasingly explored due to their diverse bioactive compounds. This study evaluated the phytochemical profile, total phenolic content (TPC), antioxidant activity, and cytotoxic effects of the ethanolic extract of Aegle marmelos fruit pulp on SKOV-3 ovarian cancer cells. Phytochemical screening was conducted using standard qualitative methods. TPC was determined by Folin-Ciocalteu Assay, antioxidant activity by the DPPH method, and cytotoxic using MTT assay. The extract contained flavonoids, alkaloids, tannins, and triterpenoids. The TPC was 8.22 mg GAE / g extract, indicating relatively low phenolic content. Consistently, antioxidant activity was week, with an IC50 value of approximately 712 ppm. The extract did not significantly reduce SKOV-3 cell viability, which remained above 90% at all tested concentrations. However, morphological changes, including cell shrinkage dan reduce adhesion, were observed at higher concentrations, suggesting sublethal cellular stress responses. In conclusion, the ethanolic extract of Aegle marmelos fruit pulp exhibits the presence of bioactive compounds and limited biological activity but lacks strong cytotoxic effects against SKOV-3 cells. These findings indicate its potential role as chemopreventive or supportive agent rather than a primary anticancer compound. Further studies are required to identify active constituents and clarify underlying mechanism.
The Rational Use of Human Serum Albumin and its Clinical Outcomes in Hospitalized Hypoalbuminemic Patients Zida Naswa Febriana; Fitria Wahyuning Wulan; Shofiatul Fajriyah; Ade Giri Ayu Anjani; Lelly Winduhani Astuti; Erni Anika Sari
MEDFARM: Jurnal Farmasi dan Kesehatan Vol 15 No 1 (2026): Medfarm: Jurnal Farmasi dan Kesehatan
Publisher : LPPM Akafarma Sunan Giri Ponorogo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.48191/medfarm.v15i1.803

Abstract

Background: Hypoalbuminemia is defined as a serum albumin level <3.5 g/dL, with clinically significant levels <2.5 g/dL associated with increased morbidity and mortality. Human Serum Albumin (HSA) is administered to increase serum albumin levels; however, its use requires evaluation to ensure rational prescribing and optimal therapeutic outcomes. Objective: This study aimed to evaluate the pattern of HSA use, analyze changes in serum albumin levels, and determine the relationship between the rationality of HSA use and albumin level achievement in hospitalized patients with hypoalbuminemia at Bhayangkara Hospital Kediri. Methods: This observational retrospective study used medical records of patients hospitalized from January to December 2025. A total of 32 patients meeting the inclusion criteria were selected using total sampling. Data were analyzed using the Paired t-test and Chi-Square test. Results: Most patients were male (59.37%), aged >60 years (65.63%), and hospitalized for <10 days (78.13%). Among patients receiving 20% HSA therapy, 28 patients (87.50%) received rational therapy, while 4 patients (12.50%) received irrational therapy based on the 2023 National Formulary criteria. Paired t-test analysis showed a significant increase in serum albumin levels after HSA administration (p<0.05). However, Chi-Square analysis showed no significant association between the rationality of HSA use and achievement of albumin level improvement (p>0.05). Conclusion: HSA therapy significantly increased serum albumin levels, although rationality of use was not significantly associated with albumin target achievement
Plasmodium vivax Malaria: A Case Review and Therapeutic Considerations in an Adult Patient Cindy Elvionita; Aulia Azzahra; Muhammad Aldy Dermawan
MEDFARM: Jurnal Farmasi dan Kesehatan Vol 15 No 1 (2026): Medfarm: Jurnal Farmasi dan Kesehatan
Publisher : LPPM Akafarma Sunan Giri Ponorogo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.48191/medfarm.v15i1.810

Abstract

Plasmodium vivax malaria remains a major health problem in tropical countries due to its high relapse rate and various hematological manifestations that may worsen the patient’s condition. This case report aimed to describe the clinical manifestations, laboratory findings, and evaluation of therapeutic rationality in a patient with Plasmodium vivax malaria during hospitalization. The study was conducted using a case report method involving a 22-year-old male patient who presented with periodic fever accompanied by chills for one week after traveling from a malaria-endemic area. Laboratory examination revealed microcytic hypochromic anemia, leukopenia, mild thrombocytopenia, and malaria parasites identified on peripheral blood smear examination. The patient received supportive therapy including intravenous Ringer Lactate fluid, paracetamol, omeprazole, domperidone, and ferrous sulfate, as well as definitive therapy consisting of dihydroartemisinin-piperaquine (DHP) for three days and primaquine for 14 days. The evaluation showed that most of the therapies administered were in accordance with national guidelines and WHO recommendations for uncomplicated P. vivax malaria. However, the absence of glucose-6-phosphate dehydrogenase (G6PD) enzyme activity testing prior to primaquine administration was considered one of the limitations in patient management. During hospitalization, the patient showed clinical improvement without severe complications. The management of P. vivax malaria requires a comprehensive approach including early diagnosis, rational therapy, clinical monitoring, and patient education to prevent relapse and improve therapeutic outcomes.
Analysis of National Hospital Quality Indicator Achievement among Hospitals in Karawang Regency, Indonesia Dian Agnesa Sembiring; Iha Nursolihah; Muhammad Irfan
MEDFARM: Jurnal Farmasi dan Kesehatan Vol 15 No 1 (2026): Medfarm: Jurnal Farmasi dan Kesehatan
Publisher : LPPM Akafarma Sunan Giri Ponorogo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.48191/medfarm.v15i1.812

Abstract

The National Hospital Quality Indicators (NHQI) are a set of indicators used to assess the quality of hospital services at the national level. However, the implementation of NHQI in Indonesia still shows variations in quality indicator achievements among hospitals, both in terms of reporting compliance and the attainment of specific indicator targets, including in Karawang Regency. This study aimed to analyze the achievement of thirteen NHQI indicators in Karawang Regency. This study employed a cross-sectional design with a descriptive quantitative approach through secondary data analysis. The research sample consisted of 24 hospitals that had reported NHQI achievements in April 2026 and had completed the NHQI reporting comprehensively, which were then analyzed using univariate analysis. In general, the characteristics of hospitals in Karawang Regency were predominantly private hospitals, Class B hospitals, and General Hospitals. Most NHQI indicators showed high levels of achievement, with the highest mean score observed for complaint response time (Mean ± SD: 99.9 ± 0.6). However, compliance with fall risk prevention measures (Mean ± SD: 94.1 ± 16.3) and compliance with physician ward visit schedules (Mean ± SD: 79.8 ± 18.8) remained below their respective national targets. Complaint response time demonstrated the highest level of compliance, with 100.0% of hospitals meeting the established standard, followed by compliance with the National Formulary (91.7%). In contrast, PPE compliance showed the highest proportion of hospitals failing to meet the target (58.3%), while compliance with patient identification and fall risk prevention measures also showed unmet proportions of 41.7% each. Therefore, targeted improvement strategies are needed, particularly for indicators with a high proportion of unmet targets and those with N/A data. From a policy perspective, the Karawang District Health Office and hospital management should strengthen monitoring systems, standardize reporting procedures, and provide regular performance feedback to ensure more complete, accurate, and consistent NHQI reporting across hospitals.
Molecular Docking Study of Pongamia pinnata Phytochemicals as Phosphodiesterase-4 Inhibitors for Atopic Dermatitis Adinda Salsabila; Riska Arini; Tantri Liris Nareswari; Naura Nurnahari
MEDFARM: Jurnal Farmasi dan Kesehatan Vol 15 No 1 (2026): Medfarm: Jurnal Farmasi dan Kesehatan
Publisher : LPPM Akafarma Sunan Giri Ponorogo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.48191/medfarm.v15i1.815

Abstract

Atopic dermatitis is a chronic inflammatory skin disease characterized by recurrent itching, eczematous lesions, and associated with significant impairment in quality of life. Current therapies for AD, including corticosteroids and calcineurin inhibitors, are often associated with adverse effects, highlighting the need for safer alternatives. Pongamia pinnata is widely used in traditional medicine and has demonstrated anti-inflammatory and antioxidant properties. Therefore, this study aimed to explore the potential of P. pinnata phytochemicals as phosphodiesterase-4 inhibitors for atopic dermatitis through molecular docking analysis. Molecular docking analysis was conducted against phosphodiesterase-4 to evaluate their binding affinities and key amino acid residues compared to the native ligand and roflumilast as the reference drug. Subsequently, Lipinski’s Rule of Five was applied to assess the oral drug-likeness properties of the selected compounds. Karanjachromene exhibited the highest binding affinity toward PDE4 (ΔG = −8.17 kcal/mol), exceeding both the reference drug roflumilast (ΔG = −6.47 kcal/mol) and the native ligand (ΔG = −7.81 kcal/mol). Interaction analysis demonstrated that karanjachromene shared several key amino acid residues with the native ligand, indicating similar binding interactions with phosphodiesterase-4. In addition, karanjachromene fulfilled Lipinski’s Rule of Five and favorable ADMET properties, suggesting oral administration potential. However, further in vitro and in vivo evaluations are required to validate its pharmacokinetics, bioavailability, and pharmacological activity against phosphodiesterase-4.
Overview of Pharmaceutical Personnel's Knowledge of Good Compounding Practices in Community Pharmacies Sri Bintang Sahara Mahaputra Kusuma Negara; Devi Ristian Octavia; Asmaul Fitri Natasia; Andini Suryani
MEDFARM: Jurnal Farmasi dan Kesehatan Vol 15 No 1 (2026): Medfarm: Jurnal Farmasi dan Kesehatan
Publisher : LPPM Akafarma Sunan Giri Ponorogo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.48191/medfarm.v15i1.660

Abstract

Compounding is a process of preparing medications tailored to the individual needs of patients by pharmaceutical personnel, due to the limited availability of ready-made drug formulations. Knowledge of drug compounding is essential for pharmaceutical personnel to ensure the availability of quality medications that are safe and effective in achieving therapeutic goals. This study aimed to assess the level of knowledge of pharmaceutical personnel regarding proper compounding practices in pharmacies in Lamongan. The study employed a descriptive design. Data were collected using a questionnaire distributed to pharmacies from February to April 2024. The sampling method used was simple random sampling with a total of 70 respondents. The data were processed and analyzed through editing, coding, scoring, and tabulating. The results showed that out of 70 respondents, the majority (58 respondents; 83%) had good knowledge, 7 respondents (10%) had moderate knowledge, and 5 respondents (7%) had poor knowledge. Knowledge of good compounding practice among pharmaceutical personnel indicated that the highest percentage of correct answers was in the category of compounding definition (97%), while the moderate level of answers was found in the category of compounding aspects (75%). Based on these findings, it can be concluded that pharmaceutical personnel working in pharmacies in Lamongan have, in general, good knowledge of compounding. Keywords: Pharmacy, Compounding, Knowledge, Pharmaceutical Personnel.
Anti-Inflammatory Activity of White Radish Tuber Ethanol Extract (Raphanus sativus L.) Induced by Carrageenan Evi Kurnia Ningsih; Wahyu Yuliana Solikah; Rizal Fauzi; Daru Estiningsih
MEDFARM: Jurnal Farmasi dan Kesehatan Vol 15 No 1 (2026): Medfarm: Jurnal Farmasi dan Kesehatan
Publisher : LPPM Akafarma Sunan Giri Ponorogo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.48191/medfarm.v15i1.725

Abstract

Indonesia possesses abundant natural resources with significant potential for the development of nutraceutical foods and traditional medicines. However, many local plants remain insufficiently studied regarding their efficacy and safety. One promising plant is the white radish tuber (Raphanus sativus L.), which offers various health benefits and potential as a functional food ingredient. This study aims to evaluate the anti-inflammatory effect of the ethanol extract of white radish tubers on paw edema in male Wistar rats (Rattus norvegicus) induced with 1% carrageenan. The research employed a laboratory experimental design, producing ethanol extracts using three solvent concentrations—50%, 70%, and 96%—followed by phytochemical screening. Anti-inflammatory activity was tested using five treatment groups: a negative control (1% CMC-Na), a positive control (diclofenac sodium 2.25 mg/kgBW), and three extract groups administered at 300 mg/kgBW according to the respective ethanol concentrations. The primary parameter measured was the volume of edema formed in the rats’ paws. Phytochemical screening revealed that the ethanol extract contained secondary metabolites such as alkaloids, flavonoids, saponins, and tannins, all known to possess anti-inflammatory properties. The extracts produced edema inhibition rates of 31.02% (50%), 21.80% (70%), and 18.44% (96%), comparable to diclofenac sodium at 18.63%. Statistical analysis using one-way ANOVA indicated an overall difference among the treatment groups. However, post-hoc Tamhane T2 analysis demonstrated that the anti-inflammatory activities of the 50%, 70%, and 96% ethanol extracts were not significantly different (p > 0.05), although all extract groups exhibited anti-inflammatory activity comparable to diclofenac sodium.

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