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Journal of Pharmaceutical and Health Research
Published by Forum Kerjasama Pendidikan TInggi
ISSN : -     EISSN : 27210715     DOI : https://doi.org/10.47065/jharma.v3i1.1322
Core Subject : Health,
Health Professions Medicine & Pharmacology Nursing Public Health
Journal of Pharmaceutical and Health Research memiliki bidang kajian, yaitu: 1. Bidang Gizi Klinis 2. Bidang Gizi Masyarakat 3. Pangan dan Gizi 4. Inovasi Pangan 5. Hematologi 6. Parasitologi 7. Biokimia 8. Laboratorium Kesehatan 9. Teknologi Laboratorium 10. Farmakologi 11. Farmasi 12. Keperawatan Jiwa 13. Keperawatan Anak 14. Keperawatan Maternitas 15. Keperawatan Medikal Bedah 16. Keperawatan Keluarga 17. Keperawatan Komunitas 18. Kesehatan Masyarakat 19. Teknologi Kesehatan
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 7 Documents
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Search results for , issue "Vol 6 No 1 (2025): February 2025" : 7 Documents clear
Analisa Fitokimia dan Aktivitas Antioksidan Sirup Herbal Ekstrak Buah Labu (Curcubita Moschata) dan Rimpang Kunyit (Curcuma Domestica) dengan Metode DPPH Kurniasih, Khamdiyah Indah; Fauziah, Fauziah; Misworo, Misworo; Prismadito, Hansen
Journal of Pharmaceutical and Health Research Vol 6 No 1 (2025): February 2025
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v6i1.6189

Abstract

Pumpkin is one of the natural ingredients with antioxidant properties, and it helps reduce symptoms of diabetes, hypertension, tumors, cholesterol, antibacterial, anthelmintic, and anti-inflammatory effects. The polyphenol and flavonoid contents in pumpkin are 97.4 mgGAE/gram and 28.6 mgQE/gram, respectively, with high antioxidant activity against DPPH radicals at 0.065 ± 0.010 mol TE/gram. Turmeric rhizome is also a plant with high antioxidant activity. Turmeric rhizome contains curcumin as the main active compound, with a content of 7.798%. The ethanol extract of turmeric rhizome exhibits antioxidant activity with an IC50 value of 41.95 µg/mL (DPPH). Studies on the composition and benefits of pumpkin and turmeric rhizome have been conducted. However, so far, there has been no standardization of the simplicia and extracts of these two plants from Central Java. The herbal syrup combining pumpkin and turmeric extracts is an herbal product that has not been scientifically proven regarding its metabolite compounds and antioxidant activity, which play a role in addressing various degenerative diseases. Therefore, standardization of the simplicia and verification of the phytochemical metabolites and antioxidant content are necessary. This study was conducted by comparing the IC50 values of three syrup formulas: turmeric rhizome syrup (F1), pumpkin syrup (F2), and a mixture of pumpkin and turmeric rhizome syrup (F3). The results showed that Formula 1 (F1) had the lowest IC50 value of 17.366 µg/mL, indicating the highest antioxidant potential, followed by F3 with an IC50 of 47.862 µg/mL, and F2 with the lowest antioxidant activity, with an IC50 value of 288.545 µg/mL.
Determination of Sunscreen Gel’s SPF (Sun Protecting Factor) Value Containing Cemba Leaf Extract (Acacia rugata (Lam.) Fawc. Rendle) Muzayyidah, Muzayyidah; Sukara, Muhammad Akmal A; Syahrianti, Andi
Journal of Pharmaceutical and Health Research Vol 6 No 1 (2025): February 2025
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v6i1.6239

Abstract

Excessive sun exposure can have negative effects on the skin. One way to reduce this impact is to use sunscreen. This study aims to formulate cemba leaf ectract into a stable sunscreem gel preparation and to determine the resulting sun-protecting factor (SPF) value. Using the laboratory experimental method, cemba leaves were extracted using the maceration method and the extract was made as an active ingredient in a gel preparation with concentrations of each formula including 0.5% (F1), 1% (F2), and 1.5% (F3). The gel preparation that had been made was then tested for stability using the cycling test method at temperatures of 4oC and 40oC. The research results of the cemba leaf extract gel preparations showed good stability and met the quality requirements in term of organoleptic, homogeneity, pH viscosity, spreadability, and adhesiveness with no significant difference before and after the cycling test (p<0.05). Determination of SPF value using UV-Vis spectrophotometry obtained the values of each formula respectively are 31.99 (F1), 43.23 (F2), and 43.24 (F3). The three formulas show activity as sunscreen seen from the SPF value > 15 which is included in the ultra-category.
Uji Aktivitas Analgesik Dari Ekstrak Daun Ara Sungsang (Asystasia gangetica L.) Terhadap Mencit Jantan dengan Metode Hot Plate Fujiko, Muflihah; Saputri, Muharni; Sofia, Vivi; Mauliza, Indah
Journal of Pharmaceutical and Health Research Vol 6 No 1 (2025): February 2025
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v6i1.6881

Abstract

Pain is a body response that indicates a disorder. The use of conventional drugs to treat pain is quite worrying because of its long-term effects. This causes people to use drugs derived from nature. Breech fig leaves contain flavonoids and alkaloids that are able to reduce pain. This study aims to see the potential of breech fig leaves as an analgesic induced to male mice using the hot plate method. This research began with plant identification, material collection, simplicia and extract, phytochemical screening, and testing on mice. This study was carried out in vivo using male mice. Twenty birds were divided into five groups, namely the negative control group (CMC-Na 0.5%), the positive control group (Ibuprofen 200 mg/kg BB), the breech fig leaf extract group (dosage 50 mg/kg BB, 100 mg/kg BB, 200 mg/kg BB). Then the analgesic activity test was carried out by looking at the responsse of mice who were given pain using the hot plate method with a temperature of 55ºC. Then the percent of analgesic power and percent of the effectiveness of the analgesic were calculated. The results of the study showed that flavonoid compounds, alkaloids, tannins, steroids, and saponins were contained in breech fig leaves (Asystasia gangetica L.). dose 200 mg/kg BB has the highest percent analgesic power and effectiveness percentage, which is 99.12% (p<0,05) and 99.67% (p<0,05). From dose 50 mg/kg BB, the analgesic effect can be seen, and the best analgesic effect is at a dose of 200 mg/kg BB. This shows that breech fig leaf extract has analgesic activity in male mice by hot plate method.
Cytotoxic Potential of Mangifera indica L var Arumanis Rind Extract and Fraction Against T47D Cells with Microtetrazolium (MTT) Method Ifmaily, Ifmaily; Oktafera, Oktafera
Journal of Pharmaceutical and Health Research Vol 6 No 1 (2025): February 2025
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v6i1.6984

Abstract

Breast cancer is a major problem in the health sector, one type of malignant cancer in Indonesia and the world. Medical therapy for cancer patients has had side effects such as nausea, vomiting, weakness, diarrhea and hair loss. The arumanis mango rind, in previous research, contains secondary metabolites of flavonoids, phenolics, saponins and tannins. Arumanis mango rind extract has been studied to have antioxidant activity with an IC50 of 18.29 µg/ml and a toxic, toxicity test with an LC50 of 169.04 µg /ml. The aim of the research was to determine the cytotoxic potential of arumanis mango rind extract and fractions against T47D cancer cells using the Microtetrazolium (MTT) method from the percentage of cancer cell viability, IC50, and cancer cell morphology. It was using ethanol extract, n-hexane fraction, ethyl acetate fraction, and n-butanol fraction, with concentrations of 1000, 100, 10, 1, 0.1 μg/ml against T47D cancer cells. Data were the life cell absorbance obtained from the ELISA reader, to calculate the percentage of T47D cell viability, obtain IC50, then observe the morphology of the cancer cells. The results of the percentages of cell viability ( μg/ml ) from the ethanol extract were 81.1: 103.5; 137.3; 163; 165.5, n-hexane fraction were 28.5; 82.7; 105.1; 130.5; 132.5, ethyl acetate fraction were 15.9; 27.2; 101.7; 134.1; 162.7, n-butanol fraction were 32.6; 75.6; 82.8; 122.3; 146.4, doxorubicin as a comparison were 22.6; 38.4; 45.4; 53.4; 56. The IC50 results of the ethanol extract, the n-hexane fraction, the ethyl acetate fraction, the n-butanol fraction, and doxoburicin were 32.21; 616.59; 90.57; 338.84, and 1.44. The best of cancer cell morphology was doxorubicin, ethanol extract, and ethyl acetate fraction. The conclusion that the extract and fraction of arumanis mango rind had cytotoxic potential against T47D cancer cells from the percentages of cell viability, IC50 and cancer cell morphology, and the best of result are ethanol extract, ethyl acetat fraction, also doxorubicin as comparison drug.
Formulasi Sediaan Body Scrub Pencerah Kulit Dari Serbuk Kopi Robusta (Coffea Robusta L) dan Lidah Buaya (Aloe Vera) Lidyawati, Lidyawati; Mardiana, Rosa; Pratiwi, Silvia Putri
Journal of Pharmaceutical and Health Research Vol 6 No 1 (2025): February 2025
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v6i1.6220

Abstract

Body scrub is one form of pharmaceutical preparation that functions to clean the skin from dirt, dead skin cells, dust, and oil with the help of scrub particles that act as abrasives. Currently, the use of natural body scrubs is more popular because of the minimal risks and side effects. Robusta coffee beans and aloe vera extract contain flavonoid compounds that function as free radical scavengers. This study aims to determine whether robusta coffee beans (Coffea Robusta) and aloe vera extract (Aloe vera) can be used as a body scrub preparation to ward off free radicals, and to evaluate their physical stability through organoleptic testing, pH testing, homogeneity, accompanied by irritation testing. This study used an experimental method in the laboratory. The body scrub formulation was developed in three variations of the proportion of coffee extract and powder, namely F0 (0%), F1 (4.6%), and F2 (6.13%). Evaluation of the body scrub preparation includes organoleptic testing, homogeneity testing, pH testing, and skin irritation testing. The results showed that robusta coffee beans and aloe vera extract can be formulated into a body scrub preparation. The results of the pH test show that the pH of the body scrub is 6, according to the pH of the skin, so it is safe when applied to the skin. The results of the volunteer skin irritation test are also safe, having no irritating effect on the skin.
Optimization of HPMC Aand Carbopol 940 Bases in the Formulation of Red Beet (Beta vulgaris L.) Gel Preparations as Hair Dye Hartini, Putri Tri; Fauzi, Ziza Putri Aisyia; Utami, Dinda Sari; Karo-Karo, Sry Ulina; Puteri, Cut Intan Annisa
Journal of Pharmaceutical and Health Research Vol 6 No 1 (2025): February 2025
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v6i1.6661

Abstract

Red beet (Beta vulgaris L.) is grass-shaped plant with short stems. Betacyianine is a red or purplish red pigment, while the betaxantin pigment has yellow colour and when diluted in water will form a red solution. This study aims to formulate hair dye gel with red beet juiceas colorant, evaluate the coloring capacity of the gel, and evaluate the stability of the formulation. 114.43 grams red beet juice was obtained using juicer, with yield percentage 55.76%. Phytochemical screening indicated alkaloid, tannin, flavonoid and saponin content. Hair dye gel is formulated in three different concentrations, F1 (10%), F2 (20%), F3 (30%) using combination of Carbopol 940 (0.5%) and HPMC (1%) as gel base. Hair dye gel obtained has beet distinctive smell. Evaluation results for the three-formulation showed that the color changed in all formulas. Color changing is influenced by pH degree of the formulation and temperature. The original color of the preparation only stable for 5 days, then the color changed due to oxidation at room temperature. Stability evaluation was conducted using Cycling Test method for 6 cycles in 12 days. All formula showed discoloration after 6 cycles from purple to brownish and they also showed viscosity change, F1 13673,34 cPs; F2 11826,67 cPs; dan F3 10673,34 cPs.
Evaluasi Sediaan Ekstrak Etanol Daun Sawi Langit (Cyanthillium cinereum (L) H.Rob) Sebagai Formulasi Krim Alas Bedak Tambunan, Ika Julianti; Sudewi, Sudewi; Nasyabila, Aura
Journal of Pharmaceutical and Health Research Vol 6 No 1 (2025): February 2025
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v6i1.6992

Abstract

Sky mustard leaf (Cyanthillium cinereum (L.) H.Rob) is a herbaceous plant that is used as a natural medicine in the community, especially in the treatment of irritation, intestinal diseases and febrile diseases. Sky mustard leaves are known to contain secondary metabolites such as flavonoids, alkaloids, saponins, tannins, phenolics and triterpenoids. Foundation cream is very popular among women as a powder base during the process of using makeup on the face but few foundation creams use natural ingredients compared to synthetic ingredients. This study aims to determine whether sky mustard leaf extract can be formulated in a foundation cream preparation that at certain doses has antioxidant activity and does not irritate facial skin. The sample used was sky mustard leaves, the research stages began, plant identification, ethanol extract preparation, phytochemical screening, selection of standard formulas, making foundation cream preparations with concentrations of 1%, 1.5%, 2%, blank physical quality assessment of preparations and antioxidant activity tests are some of the tests carried out. The results of this study indicate that the leaves of sky mustard (Cyanthillium cinereum (L.) H.Rob) The foundation cream preparation is homogeneous, stable and has an oil-in-water (M/A) emulsion type. The cream has a pH of 5.7-5.9 after cycle testing and can be applied up to 5-7 cm with an increase in moisture content of 36.86 which is included in the “moist” category, 2% preparation (F3) is the most preferred preparation, the IC50 value of the mustard leaf extract foundation cream formulation is in the “strong” category of 63.08 ppm “very strong” 47.37 ppm at a concentration of 1%, 1.5%. So it is concluded that mustard leaf extract IC50 value is in the “very strong” category of 14.75 ppm. The IC50 value of mustard leaf extract including the “very strong” category is 14.75 ppm. so it can be concluded that sky mustard leaves can be formulated as a foundation cream preparation without irritation.

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