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Journal of Pharmaceutical and Health Research
Published by Forum Kerjasama Pendidikan TInggi
ISSN : -     EISSN : 27210715     DOI : https://doi.org/10.47065/jharma.v3i1.1322
Core Subject : Health,
Health Professions Medicine & Pharmacology Nursing Public Health
Journal of Pharmaceutical and Health Research memiliki bidang kajian, yaitu: 1. Bidang Gizi Klinis 2. Bidang Gizi Masyarakat 3. Pangan dan Gizi 4. Inovasi Pangan 5. Hematologi 6. Parasitologi 7. Biokimia 8. Laboratorium Kesehatan 9. Teknologi Laboratorium 10. Farmakologi 11. Farmasi 12. Keperawatan Jiwa 13. Keperawatan Anak 14. Keperawatan Maternitas 15. Keperawatan Medikal Bedah 16. Keperawatan Keluarga 17. Keperawatan Komunitas 18. Kesehatan Masyarakat 19. Teknologi Kesehatan
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 174 Documents
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Perbandingan Aktivitas Antioksidan Ekstrak Biji Mangga Arumanis (Mangifera indica L.) Segar dan Kering dengan Metode DPPH (1,1 Diphenyl-2-picrylhidrazyl) Ifmaily, Ifmaily; Juli Fendri, Sandra Tri; Husyalam, Mifta; Rahmawati, Annisa
Journal of Pharmaceutical and Health Research Vol 5 No 2 (2024): June 2024
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v5i2.4669

Abstract

In previous research, the arumanis mango plant was proven to have antioxidant properties, because it contains secondary metabolites of flavonoids and tannins. Based on this research, arumanis mango seeds also contain flavonoids and have the potential to act as antioxidants. Arumanis mango seeds are a form of organic waste that is often thrown away after we eat arumanis mango fruit and have the potential to be used as a basic ingredient for making antioxidant products. The aim of this research was to determine the antioxidant activity and compare the antioxidant of fresh and dried arumanis mango seed extract samples using the DPPH (1,1-diphenyl-2-picryhydrazyl) method. The results obtained from the maximum absorption wavelength of DPPH are 518 nm, with an absorbance of 0.647. The results of comparative antioxidant activity for gallic acid obtained IC50 = 2.8997 µg/mL, and a sample of fresh arumanis mango seed extract with an IC50 value = 20.4806 µg/mL, and dried mango seed extract IC50 = 21.1501 µg/mL. Based on the research results obtained, the antioxidant activity of fresh and dried arumanis mango seed extract samples was classified as very strong (<50 µg/mL). The antioxidant activity of fresh extracted seed samples was higher than that of dried arumanis mango seed samples, because if IC50 higher, its mean antioxidant activity is lower.
Penentuan Kadar Alkaloid Total Ektstrak Akar Bajakah (Spatholobus Littoralis Hassk) dengan Metode Spektofotometri Uv-Vis Hanifah, Nur; Daulay, Anny Sartika; Rahman, Fatur; Nasution, Haris Munandar
Journal of Pharmaceutical and Health Research Vol 5 No 1 (2024): February 2024
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v5i1.4788

Abstract

The Bajakah tampala tree (Spatholobus littoral hassk) is a native plant from the interior of the forests in Kalimantan, especially Central Kalimantan. This plant is a plant that stretches or grows and grows abundantly in the interior of the forest. The Bajakah plant is known to the people of Kalimantan as a medicinal plant and can cure various diseases, including diarrhea, rheumatism, and cancer. The aim of this research was to determine the alkaloid content of bajakah root extract in various concentrations. The research method was carried out experimentally, with the independent variable being an ethanol extract of bajakah roots with concentrations of 50, 70, and 96%. Meanwhile, the dependent variables are the characteristics of simplicia, the secondary metabolite content of Bajakah root ethanol extract, and the determination of the total alkaloid content of Bajakah root extract. Bajakah root simplicia extract is made with 96, 70, and 50% ethanol solvents. The parameters used in this study include water content, total ash content, acid insoluble ash content, water soluble extract content, ethanol soluble extract content, and secondary metabolite content, including alkaloids, tannins, flavonoids, saponins, steroids, and terpenoids, by conducting phytochemical screening. , making a standard caffeine solution, determining the maximum wavelength of caffeine, measuring the caffeine calibration curve, and determining the total alkaloid content of Bajakah root extract. The results of the phytochemical screening showed that Bajakah root was positive for containing alkaloid compounds, saponins, tannins, flavonoids, steroids, and terpenoids. And the results obtained from Bajakah root plants obtained from Central Kalimantan were a 96% ethanol concentration of 1.66797 ± 0.7088 mg/gram, a 70% ethanol concentration of 1.6679 ± 0.1124 mg/gram, and a 50% ethanol concentration of 0.46981 ± 1.0656 mg/gram
The Effect of Non-pharmacological Therapy with Soy Milk on the Reduction of Primary Dysmenorrhea Pain in Adolescent Girls Fitriani, Rani; Setiana, Eva Mesi
Journal of Pharmaceutical and Health Research Vol 5 No 1 (2024): February 2024
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v5i1.4821

Abstract

Dysmenorrhea is a detrimental condition for many women, significantly impacting the health-related quality of life. Non-pharmacological interventions, such as warm compress, balanced nutrition, and adequate rest, play a crucial role as strategies. Particularly, the consumption of high-calcium foods, such as soy, is recognized as an effective solution. This research adopts a Quasi-Experimental design with a Pretest Posttest approach and Control Group Design, involving 10 female students in each group. Statistical analysis employs Paired Sample T-Test and Independent T-test. The research findings reveal a p-value of 0.000, rejecting the null hypothesis (H0), indicating a significant difference in the reduction of dysmenorrhea pain scale after the administration of soy milk and health education intervention (HEI) in adolescent girls at MA Walisongo, North Lampung. The discussion emphasizes the role of calcium in alleviating muscle tension, including the uterine muscles, and the presence of isoflavones in soy that can reduce dysmenorrhea. In conclusion, soy milk has a positive influence on reducing primary dysmenorrhea pain in adolescent girls at MA Walisongo, North Lampung.
The Influence of the Combination of Acupressure on the Meridian Point P6 and Peppermint Aromatherapy Inhalation on the Reduction of Nausea and Vomiting Frequency in First-Trimester Pregnant Women Sari, Atika Kurnia; Setianingsih, Setianingsih
Journal of Pharmaceutical and Health Research Vol 5 No 1 (2024): February 2024
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v5i1.4823

Abstract

Nausea and vomiting disorders during pregnancy, particularly in the first trimester, often impact the quality of life for pregnant women, with 50-90% of cases occurring during this period. Besides affecting maternal health, these disorders also influence fetal growth and development. Management can be achieved through pharmacological and non-pharmacological methods, including the combination of acupressure at Meridian Point P6 and inhalation of peppermint aromatherapy.This research aims to evaluate the impact of this combination on reducing the frequency of nausea and vomiting in first-trimester pregnant women at RSHM Yusuf Kalibalangan in North Lampung. Utilizing a quasi-experimental method, involving 12 first-trimester pregnant women experiencing nausea and vomiting at the mentioned hospital, the study results demonstrate that the combination of acupressure and peppermint aromatherapy significantly reduces the frequency of these symptoms. Statistical analysis using the paired t-test yields a p-value of 0.012. In conclusion, this combination proves effective in addressing nausea and vomiting issues in first-trimester pregnant women at RSHM Yusuf Kalibalangan in North Lampung, offering new insights into non-pharmacological options for improving the well-being of pregnant women.
The Combination of Pakcoy Juice (Brassica Rapa L.) and Antihypertensive Medication in Reducing Blood Pressure in Pregnant Women with Hypertension Ardini, Weda Ayu; Irayani, Fahrul
Journal of Pharmaceutical and Health Research Vol 5 No 1 (2024): February 2024
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v5i1.4834

Abstract

Hypertension in pregnant women ranks as the second highest cause of Chronic Kidney Disease (CKD). Hypertension is defined as a minimum diastolic blood pressure of 90 mmHg and a minimum systolic blood pressure of 140 mmHg, with an increase in diastolic and systolic pressure of at least 15 mmHg and 30 mmHg, respectively. This study aims to evaluate the impact of a combination of Pakcoy juice (Brassica rapa L) and antihypertensive medication on blood pressure in pregnant women with hypertension.Using a quasi-experimental design with a One Group Pre-Test – Post-Test without a control group, the study involved 14 pregnant women with hypertension at the Gunung Sugih Community Health Center from January to June 2023 as the population. The results of data analysis indicate a significant influence (p value 0.000 < α: 0.05) on the reduction of blood pressure after the administration of antihypertensive medication and Pakcoy juice.The discussion emphasizes that Pakcoy juice is effective as a supplement to antihypertensive medication due to its natural content of potassium, calcium, and magnesium, which can reduce blood pressure. Consuming 4,700 milligrams of potassium per day is known to lower blood pressure caused by high sodium intake. In conclusion, the combination of Pakcoy juice and antihypertensive medication has a positive effect of 19% on reducing blood pressure in pregnant women with hypertension at the Gunung Sugih Community Health Center, with a recommendation for health education outreach to prevent hypertension cases in pregnant women.
Analisis GC-MS Minyak Atsiri dan Uji Antioksidan Kulit Jeruk Manis (Citrus sinensis) Sebagai Lip Balm Nurmala, Nurmala; Syarifah, Syarifah; Nilsya, Nilsya; Melisa, Melisa; Dina, Dina; Ayu, Ayu; Chairunnisa, Chairunnisa
Journal of Pharmaceutical and Health Research Vol 5 No 1 (2024): February 2024
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v5i1.4850

Abstract

Antioxidants are chemicals that can inhibit or stop other molecules from oxidizing. Antioxidants can be found in the fruit known as sweet orange (Citrus sinensis). Orange peel essential oil is utilized in processed foods, medicines, cosmetics, and aromatherapy in the medical field. Therefore, the objective of this study was to identify the chemical content and antioxidant potential of sweet orange peel to be used as a lip balm. Processing sweet orange peel, steam distillation of essential oil, GC-MS analysis, formulating lip balm preparation, assessing lip balm preparation, and measuring antioxidant activity using a spectrophotometer and DPPH technique, were part of this study. Essential oil from sweet orange peel (Citrus sinensis L.) was analyzed using GC-MS (Gas Chromatography - Mass Spectroscopy), and the results obtained in this study were 1.4 - Cyclohexadiene, 1 - methyl. The lip balm formulation containing essential oil was evaluated as the most preferred formulation. The IC50 value of sweet orange peel essential oil was determined to be 85.2595386 ppm, which converts the antioxidant to strong.
Uji Cemaran Coliform Menggunakan Uji MPN pada Air Sumur Gali, Sumur Bor dan PDAM Fatimah, Cut; Safriana, Safriana; Andriani, Sindy
Journal of Pharmaceutical and Health Research Vol 5 No 1 (2024): February 2024
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v5i1.4955

Abstract

Physical, biological, and chemical parameters form the environmental health quality standards for water media used for sanitary hygiene needs. These parameters must be checked periodically by the laws and regulations contained in the Minister of Health Regulation Number 32 of 2017. One of these requirements is the MPN limit, which is a maximum total Coliform count of 50 colonies per 100 milliliters and requires the absence of Escherichia coli. This study was to ascertain whether PDAM water, borehole, and dug well water in the Cinta Rakyat Village area of Percut Sei Tuan Deli Serdang were contaminated by Escherichia coli and the MPN Coliform index. A 3:3:3 tube series consisting of a prediction test using Lactose Broth (LB) media, a confirmation test using Brilliant Green Lactose Broth (BGLB) media, and a complementary test using Eosin media was used to conduct a microbiological contamination test using the Most Probable Number (MPN) Coliform method. Gram stain with methylene blue agar (EMBA). Six water samples from dug wells, six from boreholes, and one PDAM water sample from the homeowner's residence were used for testing. The samples were randomly selected. The findings showed that two well water samples - ASGD 1 with 75 colonies/100 mL and ASGD 6 with 75 colonies/100 mL - exceeded the total Coliform limit. Six samples taken from dug wells were positive for fecal coliform. The colony count for ASGD 1 was 15/100 mL, ASGD 2 was 7/100 mL, ASGD 3 was 7/100 mL, ASGD 4 was 15/100 mL, ASGD 5 was 4/100 mL, and ASGD 6 was 20/100 mL. Two samples from boreholes were positive for fecal coliform. There were 4 colonies/100 mL for ASBD 2 and 7 colonies/100 mL for ASBD 4. PDAM water samples did not contain non-fecal coliforms and fecal coliforms.
Formulasi dan Uji Aktivitas Antioksidan dengan Metode DPPH dari Minuman Sari Buah Cempedak (Artocarpus Integer) Menggunakan Spektrofotometri UV-Vis Sumardi, Sumardi; Zebua, Nilsya Febrika; Ulpah, Ulpah
Journal of Pharmaceutical and Health Research Vol 5 No 1 (2024): February 2024
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v5i1.4966

Abstract

As chempedak fruit is only used fresh in the community, it is easily affected by mechanical, chemical, and microbiological factors and decays quickly. Therefore, fruit processing becomes very important to extend the shelf life of the fruit. Making juices, syrups, and juice products with a long shelf life is one of the selected ways of fruit utilization. The preparation of cempedak fruit juice as an antioxidant is the objective of this study. This is a summary of the article to help the reader quickly ascertain the purpose of the study according to the research needs. Fruit juice is a drinkable liquid obtained by squeezing or filtering the pulp. Cempedak juice drink formulas were tested for antioxidant activity in water, sugar, and CMC as part of the formula optimization process using SLD (simple lattice design) and respondent polling. Seven cempedak juice drink formulas with concentrations of 80 µg/mL, 60 µg/mL, 40 µg/mL, and 20 µg/mL were shown to have antioxidant capacity based on the results. The IC50 readings of the seven cempedak juice drink formulas are as follows: 7.948 µg/mL, 2.048 µg/mL, 3.085 µg/mL, 0.435 µg/mL, 11.057 µg/mL, 3.388 µg/mL, and 2.726 µg/mL, all of which were considered very strong. The audience found high popularity in the optimal formula made with a mixture of water, sugar, and CMC addition in the hedonic test, which measured responses to taste, aroma, and color. The highest pH of 4 was achieved in the pH 7 test of the Cempedak juice drink recipe. The homogeneity and cycling test results showed that the beverage formulation could be integrated into the drink.
Uji Efektivitas Analgetik Ekstrak Etanol Buah Kundur (Benincasa hispida (Thunb.) Cogn.) Terhadap Tikus Putih Jantan (Rattus norvegicus L.) yang Diinduksi Asam Asetat Gunawan, Muhammad; Fatimah, Cut; Santika, Dewi
Journal of Pharmaceutical and Health Research Vol 5 No 2 (2024): June 2024
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v5i2.5015

Abstract

The class of drugs known as analgesics work by reducing or inhibiting pain. This can be achieved in several ways, such as by preventing the synthesis of prostaglandins, which are mediators of pain perception, or by reducing the sensitivity of pain receptors to mechanical, thermal, electrical stimuli. Interest in using natural-based medicine for therapy is increasing in Indonesian society. Kundur fruit is one of the medicinal plants that can be used as an analgesic. It has been empirically proven that kundur fruit (Benincasa hispida (Thunb.) Cogn.) can reduce pain. The purpose of this study was to ensure that the preparation of simplisia, macroscopic and microscopic analysis, phytochemical screening of simplisia, and analgesic efficacy tests were carried out experimentally in this study. Acetic acid 0.5% was injected intraperitoneally under the abdomen of male white rats to stimulate the male white rats. oral administration of ethanol extract solution of kundur fruit at doses of 100 mg/kgBB, 200 mg/kgBB, 400 mg/kgBB, CMC 0.5% (blank) and metampirone 45 mg/kgBB For one hour the number of writhing animals was counted every ten minutes. In addition, the collected data were statistically examined using Tukey test and SPSS ver. 20 One Way ANOVA. Analysis of simplisia and ethanol extracts of kundur fruit had phytochemical screening for the presence of alkaloids, flavonoids, tannins, saponins, steroids and glycosides. The percentage of writhing reduction increased with increasing doses of bamboo randu herb decoction, indicating an increase in analgesic potential and efficacy. Based on the results of the Tukey test and One Way ANOVA test, a dose of 400 mg/kgBB has the best analgesic potential at the 50th minute and is not statistically different from metampirone 45 mg/kgBB.
Potensi Buah Rimbang (Solanum torvum Sw.) sebagai Analgetik dengan Metode Induksi Asam Asetat dan plantar test Utami, Dinda Sari; Nasution, Melvi Ariati; Fauzi, Ziza Putri Aisyia; Sari, Syilvi Rinda; Hartini, Putri Tri; Rawitri, Kiki
Journal of Pharmaceutical and Health Research Vol 5 No 2 (2024): June 2024
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v5i2.5057

Abstract

Abstract is Solanum torvum is a traditional medicine plant ingredient for treating stomach disease, relieving pain (analgesic), initiating blood circulation, removing cough (anti-tussing) and anti-inflammatory. At this examination, a phytochemical screening of powder and fruit extracts has been carried out. Simplicity characteristic tests and analgesic effect tests with acetate acid induction method and plantar tests with suspensions of ethanol extract are given in doses of 500, 1000 and 2000 mg/kgBB, metampiron suspense 2% positive ontrol, CMC suspense 0.5% as negative control as well as gland data are analyzed with ANOVA method. Results of screening of phytomia powder and ethanole extract contains secondary metabolite compounds of the classes of alkaloids, tannins, saponins, flavonoids, steoids and glycosides. Characteristic results of simplisia powder are 8% water content, 5.3% total ash content, 29.6% water-soluble sulphur content, 18.9% ethanol-solubility, 0.48% acid-insoluble ash content. Ethanol extract with 2000 mg/kgBB acetate acid induction method has the highest analgesic strength and effectiveness percentage of 55.9% and 86.04% for plantar test methods with hight analgetic values with 29,3±1,7 second.

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