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Journal of Pharmaceutical and Health Research
Published by Forum Kerjasama Pendidikan TInggi
ISSN : -     EISSN : 27210715     DOI : https://doi.org/10.47065/jharma.v3i1.1322
Core Subject : Health,
Health Professions Medicine & Pharmacology Nursing Public Health
Journal of Pharmaceutical and Health Research memiliki bidang kajian, yaitu: 1. Bidang Gizi Klinis 2. Bidang Gizi Masyarakat 3. Pangan dan Gizi 4. Inovasi Pangan 5. Hematologi 6. Parasitologi 7. Biokimia 8. Laboratorium Kesehatan 9. Teknologi Laboratorium 10. Farmakologi 11. Farmasi 12. Keperawatan Jiwa 13. Keperawatan Anak 14. Keperawatan Maternitas 15. Keperawatan Medikal Bedah 16. Keperawatan Keluarga 17. Keperawatan Komunitas 18. Kesehatan Masyarakat 19. Teknologi Kesehatan
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 173 Documents
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Hubungan Status gizi, Anemia, Faktor Stress dan Kualitas Tidur dengan Siklus Menstruasi Remaja di Pesantren Kartika Pibriyanti; Mardhatillah Mardhatillah; Lulu’ Luthfiya; Amilia Yuni Damayanti; Indahtul Mufida; Cut Kemala Handayani; Reni Indrayanti Fernandes
Journal of Pharmaceutical and Health Research Vol 4 No 1 (2023): February 2023
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v4i1.2918

Abstract

Infertility is a global health problem that affects millions of reproductive age worldwide. Infertility can be caused by menstrual cycle problems. Menstrual cycles altered often occur in adolescents with a prevalence of >65%. Changes in the menstrual cycle are influenced by several factors to avoid complications adolescents expected to monitor their menstrual cycle. This research was an observational quantitative research with cross-sectional method. The result of this research were most respondents aged 12 years as many as 62 respondents (64.6%). Most respondents had normal nutritional status of 76 respondents (79.2%) with the number of non-anemic respondents as many as 73 respondents (76%). Most of the respondents experienced stress as many as 83 respondents (86.5%) and poor sleep quality as many as 70 respondents (72.9%). Meanwhile, the most common menstrual cycle disorder was Amenorrhea with 70 respondents (72.9%). In this research it can be concluded that there was no relationship between nutritional status (p=1.000), stress factors (p=0.744), sleep quality (p=1.000) and menstrual cycle in adolescents at Boarding School but there was a relationshop between anemia and menstrual cycle in adolescents at Boarding School (p=0.022).
Uji Efek Nefroprotektif Ekstrak Kulit Buah Mangga Arumanis (Mangifera indica L) Secara In Vivo Diinduksi Gentamisin Ifmaily Ifmaily; Irwandi Irwandi; Essi Fadila Warni
Journal of Pharmaceutical and Health Research Vol 4 No 1 (2023): February 2023
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v4i1.3075

Abstract

Mango rind is one of the organic wastes after we eat the fruit. In previous studies, mango rind extract has been shown to have antihypertensive, antidiabetic, and antioxidant effects from its secondary metabolite flavonoids. The purpose of this study was to determine the effect of mango rind extract (EKBM) as a nephroprotector in male rats, and to determine the effect of varying doses of EKBM as a nephroprotector in male rats using creatinin level, ureum level, and weight ratio of rats’kidney. This study was purely experimental, using 25 white male rats with 5 groups of rats consisting of 5 rats per groups. The group was a negative control group, positive control, doses of 100 mg/kgbw, 150 mg/kgbw, 200 mg/kgbw, except for the negative control, all of which were induced with gentamicin for 5 days. On the 9th day, blood was taken through the orbital vein, then centrifuged, the serum was taken to check the creatinine level, then the rats were killed and weighed by the weight ratio of the rat kidneys. The results of this study were negative control, positive control, doses of 100 mg/kgbw, 150 mg/kgbw, and 200 mg/kgbw for creatinine levels in rats 0.74; 2.7; 0.76; 1,37; 1.4 (mg/dl), ureum levels; 28,7; 125,8; 28,9; 35,8; 43,5 ( mg/dl ) and for animal kidney weight 1,97 ; 2,74 ; 2,13 ; 2,15 ; dan 2,19 (%). The conclusion is that mango rind extract can provide a nephroprotector effect and the mango rind extract can provide a nephroprotector effect with an effective dose of 100 mg/kgbb with a p value = 0.047
Perbandingan Pertumbuhan Bayi dengan Pemberian ASI Ekslusif dan Non Ekslusif Nurbaiti Br. Singarimbun; Suharni Pintamas Sinaga; Selli M. Pasaribu
Journal of Pharmaceutical and Health Research Vol 4 No 1 (2023): February 2023
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v4i1.3107

Abstract

Nutrition is a nutritional intake that plays an important role during the period of growth and development in infants. The nutrition that babies aged 0-6 months need comes from exclusive breastfeeding. About 13% of infant mortality can be reduced through exclusive breastfeeding. The study aims to determine the comparison of infant growth with exclusive and non-exclusive breastfeeding. The research method used was a descriptive design with a population of 50 infants aged 6 months at the Bawomataluo Health Center. The results of the analysis showed that the average growth of babies who were given exclusive breastfeeding based on body weight was 6.11, body length was 65.68 and head circumference was 42.72. While the average growth of babies with non-exclusive breastfeeding based on body weight was 4.56, body length was 56.56 and head circumference was 37.96. Differences in infant growth based on body weight, body length and head circumference as well as infant development between exclusively and non-exclusively breastfed infants (p = 0.000 <0.05). The conclusion shows that the growth of babies at the Bawomataluo health center with exclusive breastfeeding is better than non-exclusive.
Gambaran Kejadian dan Manajemen Penatalaksanaan Dismenorea Primer Pada Mahasiswa Coas Fakultas Kedokteran Gigi Ayu Rosita Dewi; Dika Yanuar Frafitasari; Pety Merita Sari
Journal of Pharmaceutical and Health Research Vol 4 No 1 (2023): February 2023
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v4i1.3113

Abstract

Dysmenorrhea is pain that occurs before or during the menstrual cycle and is a gynecological problem in most adolescents. Dysmenorrhea is characterized by pain or cramps in the lower abdomen, the back, and the legs. To overcome the symptoms of dysmenorrhea, one can do so pharmacologically, non-pharmacologically, or in combination. The purpose of this study was to describe the incidence of primary dysmenorrhea and its management in students of the Faculty of Dentistry at the Bhakti Wiyata Institute of Health Sciences. This type of research is called descriptive research. Sampling technique using total sampling The population used in this study was new students in the odd semester 2022–2023 of the dental professional education program, with as many as 45 respondents. Methods of data collection using a questionnaire The results of this study described female students experiencing dysmenorrhea with mild pain intensity in 14 respondents (31%), moderate pain in 19 respondents (42%), and severe pain in 12 respondents (27%). Management of dysmenorrhea included 31 non-pharmacological respondents (69%), 4 pharmacological respondents (9%), and 10 respondents (22%), who used a combination of pharmacological and non-pharmacological methods. From the results of this study, researchers suggest female students who experience dysmenorrhea with moderate to severe pain levels see a doctor or health service and increase attention to reproductive health problems by seeking many sources of information related to the management of dysmenorrhea.
Pengaruh Prenatal Yoga Terhadap Pengurangan Keluhan Pada Ibu Hamil Dika Yanuar Frafitasari; Ayu Rosita Dewi; Pety Merita Sari
Journal of Pharmaceutical and Health Research Vol 4 No 1 (2023): February 2023
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v4i1.3129

Abstract

Women during their 9 months of pregnancy will experience many changes, both physical changes and psychological changes. Changes that occur often cause discomfort and complaints in pregnant women. Physical changes that occur may include breathing problems, sleep disturbances, gingivitis and redness of the gums, frequent urination, an uncomfortable feeling in the perineum, back pain, constipation, varicose veins, easy fatigue, false contractions, leg cramps, and ankle edemagivitis and redness of the gums, frequent urination, an uncomfortable feeling in the perineum, back pain, constipation, varicose veins, easy fatigue, false contractions, leg cramps, and ankle edema. This study aims to determine the effect of complementary therapy (pregnancy yoga or prenatal yoga) on reducing complaints experienced by mothers during pregnancy. 1 In this study, an analytic survey with a cross-sectional observational design was used. The sampling technique uses purposive sampling. The sample size in this study was 49 respondents. This research was conducted in September–November 2022. The statistical analysis used in this study was the linear regression test. Based on the results of statistical tests, more than two complaints of pregnant women can be reduced by the number of mothers who often do prenatal yoga, namely as many as 48% of respondents with p < (0.005). The conclusion in this study is that there is an effect of prenatal yoga on reducing complaints in pregnant women. It is recommended for pregnant women to empower themselves by doing prenatal yoga exercises to achieve a healthy and comfortable pregnancy and childbirth.
Pengaruh Terapi Kompres Hangat Terhadap Penurunan Nyeri Punggung Bawah pada Ibu Hamil Anggraini Dyah Setiyarini; Erna Rahmawati
Journal of Pharmaceutical and Health Research Vol 4 No 1 (2023): February 2023
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v4i1.3161

Abstract

Lower back pain in pregnant women is caused by hormonal changes. This causes changes in the supporting and connecting soft tissue. Result in decreased elasticity and flexibility muscle. One of the non-pharmacological therapies is warm water therapy. The benefits of a warm compress include increasing blood flow to areas of the body so that it can increase the flow of nutrients and relax muscles. The purpose of this study was to determine the effect of warm compresses on reducing low back pain in pregnant women at midwife Sri Wahyuni ​​Blitar. The research design used was Pre-Experimental. And the research design used is one group pre test-post test design. Sampling was carried out by means of non-probability sampling. The research sample consisted of 10 respondents who were selected using the Accidental Sampling technique. Collecting data with an observation sheet, using the NSR pain scale (Numeric Rating Scale). Data were analyzed using the Wilcoxon test to determine the effect of warm compresses on reducing low back pain. The Wilcoxon test results show a ρ value = 0.004, then <α (α = 0.05) then H₀ is rejected and H1 is accepted with an average difference between pretest and posttest which is 6.40 ± 4.50 so there is a decrease of 1.9 %. The conclusion from this study is that there is an effect of warm compresses on reducing pain in pregnant women. This study shows that warm water therapy can reduce lower back pain in pregnant women. It is hoped that warm compresses can be used as complementary therapy in pregnant women to reduce pain and can be combined with other therapies.
Hubungan Pendidikan dan Paritas dengan Keikutsertaan Ibu Hamil dalam Kelas Yoga di Desa Kalipang Kabupaten Kediri Elin Soya Nita; Lailaturrohmah Lailaturrohmah
Journal of Pharmaceutical and Health Research Vol 4 No 1 (2023): February 2023
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v4i1.3162

Abstract

Pregnancy is a natural method experienced by women and is not included in the pathological category except in special conditions, because pregnancy will experience both anatomical, physiological and biochemical adaptations which increase according to gestational age. During pregnancy there will be changes in all body systems both physically and psychologically One method that can be used to help and relieve pregnant women in preparing for a healthy pregnancy and physiological delivery is exercise. One good exercise for pregnant women is yoga for pregnant women / prenatal yoga. This research is a type of analytic quantitative research using a cross-sectional approach with the independent variables being Education and parity and the dependent variable being the participation of pregnant women in yoga classes with analysis using the Chi Square test. Total sampling data analysis. From the research data, the results of statistical analysis showed that there was no relationship between education and parity with the participation of pregnant women in yoga classes in Kalipang Village, Kediri Regency in 2023 with a P value of 0.463.
Formulasi Masker Peel-Off Ekstrak Biji Buah Pepaya (Carica papaya L.) Sebagai Antijerawat dengan Variasi Konsentrasi Polivinil Alkohol Vina Purnamasari M; Aztriana Aztriana; A Hasrawati
Journal of Pharmaceutical and Health Research Vol 4 No 1 (2023): February 2023
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v4i1.3175

Abstract

Papaya seeds have the ability to an antibacterial because they contain triterpenoid compounds, papain enzymes, and fatty acids such as oleic acid, palmitic acid, and linoleic acid which can moisturize the skin and shed dead skin cells so that they are suitable for making peel-off masks. The study aimed to obtain a peel-off mask formulation of papaya seed extract (Carica papaya L.) as a stable anti-acne and has good pharmaceutical properties. The research design used was laboratory experimental research. Papaya fruit seed extract peel-off masks are made in 2 formulas with variations in PVA concentrations, namely 10% and 12%. The peel-off masks obtained were tested for stability including organoleptic testing, homogeneity, viscosity, dispersion ability test, pH test, drying speed test, and primary irritation test. The results showed that papaya fruit seed extract can be made into a peel-off mask formula that meets the pharmaceutical stability test, but formula 2 shows the most optimal stability and good pharmaceutical properties compared to formula 1. In addition, the two formulas do not irritate the skin so they are safe to use when applied.
Mekanisme Antibakteri Ekstrak Etanol Daun Kemangi (Ocimum basilicum L.) terhadap Salmonella typhi Nasri Nasri; Vera Estefania Kaban; Denny Satria; Hariyadi Dharmawan Syahputra; Zulmai Rani
Journal of Pharmaceutical and Health Research Vol 4 No 1 (2023): February 2023
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v4i1.3176

Abstract

Infectious diseases are conditions that can be brought on by a variety of different organisms, including bacteria, viruses, fungi, and parasites. Typhoid fever is an example of an infectious disease that frequently causes the body's defenses to come under attack. The fever associated with typhoid is a leading cause of death around the world. Infection with the bacterium Salmonella typhi is considered to be one of the potential causes of typhoid fever. When antibiotics are used to treat bacterial infections, there is a risk that the bacteria will become resistant to the medication. In day-to-day life, basil leaves are utilized both as a cooked vegetable and as a fresh vegetable. The antibacterial properties of kemangi leaves have yet to be fully uncovered. The purpose of this study was to investigate the various mechanisms that are involved in antibacterial activity. These mechanisms include cell leakage, minimum inhibitory concentration, minimum killing concentration, and antibiofilm activity. The minimum inhibitory concentration (MIC) was determined with the agar diffusion method, the minimum biofilm forming concentration (MBC) was determined with the staining method, and cell leakage was determined with UV-VIS spectrophotometry at wavelengths of 260 nm (DNA) and 280 nm (protein). Additionally, the formation of anti-biofilms was determined with microtiter plates and gentian violet staining. In the moderate category, the MIC value tests showed a concentration of 0.3125% with an inhibition zone value of 6.80 0.05 mm. These results were obtained from the MIC value. Because there was no detectable bacterial growth on the streaked medium, KBM was obtained at a concentration of 10%. At wavelengths of 260 and 280 nanometers, leakage cells show absorbance absorption. The percentage of biofilm activity that is measured when the concentration is increased to 25% is 44.82%. In conclusion, the ethanol extract of basil leaves possesses a possible antibacterial mechanism against Salmonella typhi. This was discovered through testing.
Uji Aktivitas Antibakteri Ekstrak Daun Karenda (Carissa carandas Linn.) Terhadap Bakteri Propionibacterium acne dan Staphylococcus epidermidis Vera Estefania Kaban; Nasri Nasri; Hariyadi Dharmawan Syahputra; Muhammad Fauzan Lubis; Denny Satria
Journal of Pharmaceutical and Health Research Vol 4 No 1 (2023): February 2023
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v4i1.3181

Abstract

Karenda leaves contain flavonoids, steroids or triterpenoids, saponins, and tannins that act as antimicrobial compounds. The aim of the study was to determine the antibacterial activity of the ethanol extract of Karenda leaves against several acne-causing bacteria. The research method involved characterizing the simplicia of karenda leaves and extract preparation by maceration using 96% ethanol as a solvent. and test the antibacterial activity of the ethanol extract of Karenda leaves using the agar diffusion method. The bacteria used were Propionibacterium acnes and Staphylococcus epidermis. The extract concentrations used were 300, 150, 125, 100, 75, 50, 25, and 5 mg/mL. Based on tests carried out by the ethanol extract of karenda leaves, the diameters of the inhibition zones were 7.2 ± 0.12 respectively; 7.8±0.10; 9.7±0.15; 11.23±0.25; 12.43±0.06; 13.57±0.06; 14.20±0.10; 16.47 ± 0.21 for Propionibacterium acne and 8.17 ± 0.06; 9.37 ± 0.15; 9.80 ± 0.10; 10.73 ± 0.15; 11.27±0.12; 12.43±0.06; 13.77±0.06; 15.47 ± 0.12 for Staphylococcus epidermis. he test results proved that 300 mg/mL was the best concentration for inhibiting the growth of Propionibacterium acnes and Staphylococcus epidermis bacteria.

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