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Jurnal Insan Farmasi Indonesia
Published by Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin
ISSN : 26213184     EISSN : 26214032     DOI : https://doi.org/10.36387/jifi
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Medicine & Pharmacology Physics
Focus and Scope Jurnal Insan Farmasi Indonesia (JIFI) is a broad-based primary journal covering all branches of pharmacy and its sub-disciplines that contains complete research articles, short communication and review articles. JIFI is a forum for the publication of quality and original works that open discussions in the field of pharmacy and health sciences.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 358 Documents
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FORMULASI DAN UJI MUTU FISIK SEDIAAN LOTION DARI EKSTRAK DAUN NANAS (Ananas comosus (L).Merr) Cikra Ikhda Nur Hamidah Safitri; Qholindah Qumairo Vidya Zahra
Jurnal Insan Farmasi Indonesia Vol 9 No 1 (2026): Jurnal Insan Farmasi Indonesia
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jifi.v9i1.2888

Abstract

Pineiapplei leiaveis (Ananas comosuis (L.) Meirr) is known as a natuiral ingreidieint that contains variouis bioactivei compouinds with thei poteintial for antioxidant activity, so it has thei opportuinity to bei uiseid in thei deiveilopmeint of topical cosmeitic preiparations. This reiseiarch aims to deiveilop a lotion formuilation that contains pineiapplei leiaf eixtract and asseiss thei physical quiality of thei reisuilting preiparation. Thei eixtraction proceiss is carrieid ouit by maceiration meithod uising 70% eithanol solveint and produiceis a yieild of 7,028%. Lotion is formuilateid in threiei variations, nameily F0 withouit thei addition of eixtract as a control, F1 with 1% eixtract conceintration, and F2 with 3% conceintration. Physical quiality teisting incluideis pH eivaluiation, organoleiptic propeirtieis, spreiadability, viscosity, and homogeineiity. Phytocheimical screieining reisuilts show thei preiseincei of flavonoid compouinds, alkaloids, and tannins in pineiapplei leiaf eixtract. Thei eintirei formuila meieits thei physical quiality reiquiireimeints of topical preiparations, shown by a pH valuiei that is suiitablei for thei skin condition, spreiading poweir and viscosity that meieits thei standard, as weill as good homogeineiity withouit phasei seiparation. Thei addition of pineiapplei leiaf eixtract doeis not reiduicei thei physical stability of thei preiparation, so it has thei poteintial to bei fuirtheir deiveilopeid as a natuiral activei ingreidieint in skin carei lotion formuilations.
KAJIAN INTERAKSI OBAT PASIEN DIABETES MELITUS TIPE 2 DENGAN KOMORBID HIPERTENSI RAWAT JALAN DI RUMAH SAKIT AREA KOTA YOGYAKARTA Ginanjar Zukhruf Saputri; Siti Anisya Rahayu; Endang Darmawan; Prita Anggraini Kartika Sari; Woro Supadmi
Jurnal Insan Farmasi Indonesia Vol 9 No 1 (2026): Jurnal Insan Farmasi Indonesia
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/07k2bp37

Abstract

Patients with type 2 diabetes mellitus and hypertension comorbidity generally receive more than one medication, increasing the risk of drug interactions that may affect therapeutic outcomes. This study aimed to determine the potential drug interactions in outpatients with type 2 diabetes mellitus and hypertension at PKU Muhammadiyah Gamping Hospital during January–December 2024. This research employed a descriptive-retrospective observational method using 44 medical records selected through purposive sampling based on inclusion and exclusion criteria. Drug interactions were assessed using the MedFacts Pocket Guide of Drug Interactions, Stockley’s Drug Interactions (2009), and drug interaction checkers from Medscape and Drugs.com based on interaction mechanisms and severity levels. The results showed 129 cases of drug interactions, with the most common combination being metformin–amlodipine (10 cases; 7.7%). The most frequent interaction mechanism was pharmacodynamic interaction (68 cases; 52.71%), while the severity level was predominantly moderate according to Medscape (65 cases; 50.38%) and Drugs.com (79 cases; 61.24%). Major interactions were identified in the bisoprolol fumarate–clonidine combination (4 cases; 5.3%). This study indicates the potential for drug interactions in antidiabetic and antihypertensive therapy, highlighting the need for therapeutic monitoring and dose adjustment to improve treatment safety and effectiveness.
FORMULASI LOTION TABIR SURYA EKSTRAK ETANOL DAUN ANDONG MERAH (Cordyline Fruticosa (L.) A. Chev) Weni Puspita; Heny Puspasari; Ika Ristia Rahman; Dian Kartika Sari; Inderiyani
Jurnal Insan Farmasi Indonesia Vol 9 No 1 (2026): Jurnal Insan Farmasi Indonesia
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/m82fby98

Abstract

Ethanol extract of the of red andong leaves has strong antioxidant activity and has the potential to be a  sunscreen with maximum protection. This study aims to formulate and evaluate the sunscreen activity of a lotion preparation made from ethanol extract of red andong leaves. The sunscreen activity test was carried out using the UV-Vis spectrophotometer method with a wavelength of 290-320 nm. The ethanol extract of the red andong leaves is formulated in lotions with various concentrations (F1: 5%, F2: 10%, F3: 15%). The lotion was tested for physical properties including organoleptic, viscosity, dispersibility, pH, homogeneity, type of lotion, and protection ability. The results showed that the ethanol extract of red andong leaves can be formulated into lotion preparations, where the three lotion formulas with variations in the concentration of 5%, 10%, and 15% of the red andong leaf extract ethanol produce light brown, the distinctive odor, semi-solid, a homogeneous, M/A type emulsion, meets the requirements of pH, viscosity, dispersibility, and provides protection. The results of the sunscreen activity test were respectively 9,81±0,10; 12,15±0,25; 14,03±0,53, with the highest SPF value being 14,03±0,53 in formula III (15% red andong ethanol extract) which is included in the maximum protection category.
UJI PENANGKAPAN RADIKAL DPPH  DAN PENETAPAN KADAR FLAVONOID DARI DAUN KALANGKALA (Litsea garciae S. Vidal) EKSTRAK METANOL Najwa Rahmadina; Rizka Aulia Ramadani; Samsul Hadi; Nahdiati Ulfah; Noor Rahmi Febriani; Nor Khadijah; Erika Indriani; Nanda Hesti Rahmawati
Jurnal Insan Farmasi Indonesia Vol 9 No 1 (2026): Jurnal Insan Farmasi Indonesia
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/j4mds879

Abstract

Excessive free radicals the body can induce oxidative stress, which plays a significant role the development of various degenerative diseases. Therefore, the search for natural sources antioxidants essential to mitigate detrimental effects free radicals on health. This study aimed determine flavonoid content and evaluate the free radical scavenging activity using DPPH method the methanolic extract Litsea garciae (kalangkala) leaves. Extraction was carried out using methanol as the solvent, followed by thin-layer chromatography (TLC) analysis flavonoid identification and determination total flavonoid content using a spectrophotometric method with quercetin the standard. Antioxidant activity was assessed using DPPH assay, with the IC₅₀ value used an indicator of free radical scavenging effectiveness. The TLC results showed similar Rf values between the extract and quercetin, indicating the presence flavonoids in kalangkala leaves. The total flavonoid content was recorded as 8.3364 ± 0.0023 mg quercetin equivalents/g extract, while the DPPH assay yielded an IC₅₀ value 141.144 μg/mL with RSD of 2.333%, which was higher than that quercetin (6.101 μg/mL with RSD of 1.450%). These findings indicate that methanolic extract of Litsea garciae leaves exhibits moderate antioxidant activity and has potential a natural antioxidant source. Therefore, kalangkala leaves may be further developed for prevention of oxidative stress.
UJI AKTIVITAS ANTIBAKTERI KOMBINASI EKSTRAK BUNGA ROSELLA (Hibiscus sabdariffa L.) DAN KULIT BATANG KAYU MANIS (Cinnamomum burmannii) TERHADAP Escherichia coli Muhammad Irsyad Ilham; Naomi Dwi Cahyanti
Jurnal Insan Farmasi Indonesia Vol 9 No 1 (2026): Jurnal Insan Farmasi Indonesia
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/1pbmdb49

Abstract

Escherichia coli is one of the main causes of diarrhea; therefore, alternative antibacterial agents derived from natural materials are needed. Roselle flowers (Hibiscus sabdariffa L.) and cinnamon bark (Cinnamomum burmannii) are known to possess antibacterial activity through different mechanisms of action. This study aimed to determine and compare the antibacterial activity of 30% roselle flower extract, 10% cinnamon bark extract, and their combination against Escherichia coli. The theoretical basis of this study was the flavonoid content in roselle and the cinnamaldehyde and eugenol compounds in cinnamon as antibacterial agents. This research was an experimental study using the disk diffusion method with three treatment groups and one negative control group. The observed parameter was the diameter of the inhibition zone after 24 hours of incubation at 37°C. The results showed that all treatment groups produced inhibition zones in the moderate category, while the negative control did not produce any inhibition zone. Statistical analysis using the Kruskal Wallis test showed a significant difference in antibacterial activity among the groups (Asymp.Sig = 0.000008). Further analysis using the Mann Whitney test showed that the combination extract had the highest antibacterial activity.
Metabolit Antibakteri dari Aspergillus nidulans DSP 20, Jamur Endofit Mangrove Asosiasi Sesuvium portulacastrum safwan safwan; Baiq Desti Isnanda Maolia; Yuli Fitriana; Abdul Rahman Wahid; Widayatul Khairi
Jurnal Insan Farmasi Indonesia Vol 9 No 1 (2026): Jurnal Insan Farmasi Indonesia
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/safz8j78

Abstract

Mangrove-associated endophytic fungi are promising producers of antibacterial secondary metabolites. This study evaluated the potential of Aspergillus nidulans DSP 20, isolated from leaves of Sesuvium portulacastrum collected from the Sekotong mangrove-associated ecosystem, as a producer of antibacterial metabolites. The isolate was obtained through surface sterilization of leaf tissue, colony purification, and morphological characterization. Metabolite production was performed by 21-day solid-state fermentation followed by ethyl acetate extraction. The metabolite profile was qualitatively analyzed using thin-layer chromatography, while antibacterial activity was tested against Staphylococcus aureus and Escherichia coli using the disc diffusion method. DSP 20 showed morphological characteristics supporting its identification as A. nidulans, produced an ethyl acetate extract with several chromatographic spots, and formed inhibition zones against both test bacteria. These findings indicate that A. nidulans DSP 20 is a potential preliminary source of antibacterial metabolites from mangrove-associated endophytic fungi.
OPTIMASI DAN EVALUASI FISIK FORMULA KAPSUL EKSTRAK SELEDRI DENGAN VARIASI BAHAN PENGISI Joko Kawiyanto; Alifah Asri Elina; Margaretha Harnanda Putri; Puji Hartati; Galuh Saras Sukmaningrum
Jurnal Insan Farmasi Indonesia Vol 9 No 1 (2026): Jurnal Insan Farmasi Indonesia
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jifi.v9i1.3007

Abstract

Celery has the activity as an antihypertensive. Celery extract contains apigenin which can lower blood pressure by preventing the narrowing of blood vessels. Celery extract can be formulated in capsule. One of the important components in making capsules is the filler. Filler can increase the mass of capsule and reduce the moisture of the extract in the capsule. The purpose of this study is to determine the optimal filler for celery extract capsules. In this study, a physical evaluation of celery extract capsules was carried out with 4 types of fillers, such as Manihot starch, Flocel 101, Lactose, and Corn starch amount 37% for each variation. The observed evaluations was the organoleptic properties, moisture content, disintegration time, uniformity and hygroscopicity. Each evaluation was analyzed by Graphpad ANOVA Tukey Multiple comparation. The optimum physical evaluation result was the corn starch capsule filler with a flow time of 20,0 grams/sec, the water content of 7,88% and the disintegration time of 9,26 minute, the weight uniformity met the requirements also the physical appearance with no lumps before an after exposure for 24 hours. Thus corn starch can be an optimal filler in celery extract capsule preparation. 
ANALISIS KESESUAIAN PENYIMPANAN COLD CHAIN PRODUCT DI INSTALASI FARMASI RUMAH SAKIT ISLAM BANJARMASIN Muhammad Fadhil Qadhafi; Amaliyah Wahyuni; Noor Aisyah; Hidayaturrahman
Jurnal Insan Farmasi Indonesia Vol 9 No 1 (2026): Jurnal Insan Farmasi Indonesia
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/1s92jd86

Abstract

CCPs are pharmaceutical preparations that require strict temperature control to maintain drug stability. Temperature deviations during storage cause degradation of pharmaceutical product quality. This study aims to analyze the compliance of the CCP storage system based on the five indicators of the CDOB standard as stipulated in BPOM Regulation No. 20 of 2025. The study used a descriptive observational design with a cross-sectional approach through direct observation using standardized observation sheets. Data were analyzed descriptively qualitatively and quantitatively by calculating the percentage of compliance, and the data were processed using Microsoft Excel 2021. The results showed that the compliance level of CCP storage in the Banjarmasin Islamic Hospital Pharmacy Unit was 90.48%, in accordance with the 2025 CDOB BPOM regulations. Temperature monitoring and human resource quality and capacity were fully compliant (100%), building and space systems (87.5%), facilities and infrastructure (75%), and documentation and reporting (87.5%). Non-compliance was influenced by several factors, including limited storage space, the absence of temperature alarms, refrigerator placement that did not meet standard distances, and evidence of equipment calibration. Overall, CCP storage in the pharmacy installation did not fully meet CDOB standards, requiring improvements in infrastructure, completeness of documentation, and optimization of storage space management.
ANALISIS HUBUNGAN TINGKAT KEPATUHAN PENGGUNAAN OBAT TERHADAP KUALITAS HIDUP PASIEN DIABETES MELLITUS TIPE II DI PUSKESMAS BAMBANGLIPURO BANTUL Mexsi Mutia Rissa; Machfudz Eko Arianto
Jurnal Insan Farmasi Indonesia Vol 9 No 1 (2026): Jurnal Insan Farmasi Indonesia
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/4678wd55

Abstract

Diabetes Mellitus is a degenerative disease that requires long-term management. Medication adherence plays an important role in treatment success, as it can influence the quality of life in patients with Type II Diabetes Mellitus. This study aimed to determine the relationship between medication adherence and quality of life among Type II Diabetes Mellitus patients at Bambanglipuro Primary Health Center, Bantul. This study used an analytical observational design with a cross-sectional approach. A total of 52 patients were included using total sampling technique. Medication adherence was measured using the Morisky Medication Adherence Scale (MMAS-8), while quality of life was assessed using the Short Form-36 (SF-36). Data were analyzed using the Chi-Square test. The results showed that most respondents had high medication adherence (86.54%) and good quality of life across most domains. The Chi-Square test showed a significance value of p = 0.000 (p < 0.05), indicating a significant relationship between medication adherence and quality of life. In conclusion, there is a significant relationship between medication adherence and quality of life in patients with Type II Diabetes Mellitus.
Analisis Kualitatif dan Kuantitatif Senyawa Polifenol dan Glikosida pada Fraksi Ekstrak Etanol Daun Jambu Mete (Anacardium occidentale L.) Menggunakan Spektrofotometri UV-Vis Rabiatul Adawiyah; Evita Wulandari; Nur Ani
Jurnal Insan Farmasi Indonesia Vol 9 No 1 (2026): Jurnal Insan Farmasi Indonesia
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/cjs1d853

Abstract

Cashew leaves (Anacardium occidentale L.) are known to contain secondary metabolites with potential medicinal properties, including polyphenols and glycosides. This study aimed to determine the qualitative and quantitative contents of polyphenol and glycoside compounds in the ethanol extract fractions of cashew leaves using the UV-Vis spectrophotometric method. Cashew leaves were extracted using 96% ethanol. Fractionation was carried out using n-hexane and ethyl acetate solvents. Glycoside content was determined using quercetin as the standard at a wavelength of 430 nm, while polyphenol content was determined using gallic acid as the standard at a wavelength of 700 nm. Qualitative test results showed that both n-hexane and ethyl acetate fractions were positive for glycosides, indicated by a green color, and positive for polyphenols, indicated by a greenish-purple color. Quantitative results showed that the glycoside content in the n-hexane fraction was 3.999 mgQE/g and in the ethyl acetate fraction was 8.043 mgQE/g. The polyphenol content in the n-hexane fraction was 2.138 mgGAE/g and in the ethyl acetate fraction was 3.198 mgGAE/g. The ethyl acetate fraction exhibited higher glycoside and polyphenol contents compared to the n-hexane fraction.

Page 35 of 36 | Total Record : 358

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