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Jl. JA Suprapto No. 2 Kec. Klojen Malang 65112, Indonesia. Laboratory of Internal Medicine, Department of Internal Medicine, Faculty of Medicine, dr. Saiful Anwar General Hospital, IRNA 1 Building 2nd Floor
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CRJIM (Clinical and Research Journal in Internal Medicine)
Published by Universitas Brawijaya
ISSN : 27235130     EISSN : 27235122     DOI : https://doi.org/10.21776/ub.crjim
Core Subject : Health, Science, Education,
Education Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Other
Clinical and Research Journal in Internal Medicine is the official open access journal of Internal Medicine Research Center, Department of Internal Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia. It publishes articles two times per year. It is a peer reviewed publication of Indonesian Internal Medicine journals and accepting articles for publication from around the world. CRJIM only publishes articles in the English version. The objective of this journal is to publish the selected clinical and basic research relevant to Internal Medicine. It covers the following topics, nephrology, endocrinology, metabolic, and diabetes, rheumatology, geriatrics, tropic infection, hematology oncology. CRJIM publishes original researches, reviews, brief reports, editorial, case series, case reports, and commentary. Additionally, it also considers publishing animal studies relevant to Internal Medicine topic. It is an international journal dedicated to providing new information that could give new insight for alternative solutions, diagnosis, therapy and prevention for researchers and practitioners in Internal Medicine.
Arjuna Subject : Kedokteran - Kedokteran Internal
Articles 93 Documents
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Fibromuscular Dysplasia: Renal Artery Dissection and Infarction in a Young Male Bdiwi, Mustafa; Dayco, John; Uddin , Mohammed; Afonso, Luis
Clinical and Research Journal in Internal Medicine Vol. 5 No. 1 (2024): Volume 5 No 1, May 2024
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.crjim.2024.005.01.11

Abstract

Fibromuscular dysplasia is an abnormal cell growth of the arterial wall that usually affects the renal and carotid arteries. It may lead to stenosis, tortuosity, aneurysm, or dissection of the artery and can potentially compromise the circulation from ensuing total occlusion and infarction of the recipient area. We report a case of a young male who presented with severe acute abdominal pain in the right side of the abdomen associated with nausea, vomiting, and constipation. Computed tomography of the abdomen with intravenous contrast showed acute renal infarction of a focal area at the lower pole of the right kidney, subsequent computed angiography showed dissection of a segmental branch of the right renal artery associated with fibromuscular dysplasia and beading appearance of the right renal artery. The renal function test and urinalysis were both normal. The patient was treated with unfractionated heparin infusion, with the resolution of abdominal pain, he was subsequently discharged home uneventfully on oral aspirin.
Seroprevalence of Chikungunya virus infection in a Tertiary Care Hospital, Warangal, Telangana, South India: Seroprevalence of Chikungunya virus infection Krishna, Gudikandula; Sreedevi, S; Khan, Abdul
Clinical and Research Journal in Internal Medicine Vol. 4 No. 2 (2023): Volume 4 No 2, November 2023
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.crjim.2023.004.02.05

Abstract

Introduction: The Chikungunya virus, an Alpha virus belongs to the Togaviridae family which infects via the vector Aedes spp. mosquitoes, is the cause of the Chikungunya sickness. The most prevalent symptoms are an abruptly rising temperature, rash, and acute arthralgia. Similar to other arboviral diseases such as Dengue and Japanese B encephalitis infections, it is a serious public health issue. Methods: A total of 3027 blood samples were received from suspected cases of Chikungunya in the Tertiary Care Hospital, Warangal, Telangana. Over a period of 17 months, this study was conducted. Nearly 5-10ml of blood was collected from the patients after 5 days of fever, and the serum was separated. Using an IgM antibody capture ELISA kit manufactured by NIV (NIV, Pune, India). Results: In our study population of 3027 during 12 months, 313 Chikungunya cases (10.34%) were found to be seropositive for Chikungunya by IgM ELISA. Most cases were from 0-10 Years (24.60%), followed by 11-20 years (17.25%). Regarding the sex ratio of the total affected cases, 53.35% were males, and 46.64% were females. A maximum number of positives were seen in September, November, and October, which were found to be 35.46%, 18.84%, and 17.57%. Conclusion: The study found a seroprevalence rate of 23.06% for Chikungunya, with a notable increase in frequency during the monsoon season. Additionally, the virus was found to disproportionately affect individuals in the productive age range of the population.
Failure Of Second Line ART Demands Third -Line Options For HIV-Infected Patients In Telangana, India g, krishna; Pandharpurkar, Deepak; Mallikarjun, P.
Clinical and Research Journal in Internal Medicine Vol. 5 No. 1 (2024): Volume 5 No 1, May 2024
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.crjim.2024.005.01.03

Abstract

Back ground: The research was carried out with the aim of detecting instances of second-line antiretroviral therapy (ART) failure and exploring the potential of third-line ART treatment for individuals with HIV, incorporating the utilization of HIV viral load (VL) testing. Beginning in 2016-17, individuals living with HIV are directed to government ART centers and ART plus centers for treatment. Patients who have experienced treatment failure with second-line therapy and have been exposed to multiple NRTIs, in accordance with the Indian National ART Guidelines, are referred to the SACEP Clinic for further evaluation. If deemed eligible according to the Indian National 3rd Line ART Guidelines, these patients are enrolled and followed up for the initiation of 3rd Line ART at our center. Throughout the duration of the study, a collective of 55 individuals diagnosed with Human Immunodeficiency Virus (HIV) were identified as potentially experiencing a lack of efficacy with regards to their secondary line antiretroviral therapy (ART). Two patients in the cohort were diagnosed with both HIV and multi drug resistant tuberculosis (MDR-TB). Method: Fifty-four and a half percent of the patient sample was classified as being in WHO stage I, while 32.8% were categorized as being in stage II, and the remaining 12.7% were identified as being in WHO stage IV. Fifty-five patients who were suspected of experiencing second-line treatment failure were transitioned to third-line antiretroviral therapy. Results: All 55 patients underwent VL follow-up, with 53 of them attaining viral suppression within a median period of 6 months. However, two patients were unable to achieve viral suppression. Conclusion: However, this study describes HIV-positive patients who need third-line ART due to probable second-line ART failure.
Correlation Of Albumin Levels With Glucose Levels in Hypoglycemic Patients After The Use Of Insulin Therapy Fajari, Nanang Miftah; Kholifah, Rika; Rosida, Azma
Clinical and Research Journal in Internal Medicine Vol. 5 No. 1 (2024): Volume 5 No 1, May 2024
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.crjim.2024.005.01.04

Abstract

Background: Most of the incidence of hypoglycemia in hospital (11.29%) is caused by administering insulin therapy as a therapeutic modality in diabetes mellitus patients during hospitalization. The bond between albumin and insulin using the help of fatty acids makes insulin control the body's glycemic levels. Aim: The purpose of this study was to determine and analyze the correlation between albumin levels and glucose levels in hypoglycemia patients after the administration of insulin therapy at the Ratu Zalecha General Hospital. Methods: This study was an analytic observational study with a cross-sectional approach. A total of 32 samples were obtained by purposive sampling Results: The patient's mean glucose level was 48.95 ± 11.5 mg/dL and the patient's mean albumin level was 2.4 ± 0.6 g/dL. Bivariate analysis using Pearson's correlation test showed a correlation between albumin levels and glucose levels (p = 0.045 <0.05; r = 0.356). Conclusion: The conclusion is that there is a significant correlation between albumin levels and blood glucose levels, the direction of the positive correlation with the strength of the weak correlation in the endocrine internal medicine ward of the Ratu Zalecha Martapura Hospital.
Correlation of serum Uric Acid levels with Blood Pressure and Glycated Hemoglobin in Prediabetes and Diabetes patients: Correlation of serum Uric Acid in prediabetes and diabetes AHMAD, AFZAL; Zahra, Nadia Az; Rochlani, Dimpal
Clinical and Research Journal in Internal Medicine Vol. 5 No. 1 (2024): Volume 5 No 1, May 2024
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.crjim.2024.005.01.05

Abstract

Background: Increased serum uric acid (SUA) through a series of pathophysiological sequelae like oxidative strain, inflammation and endothelial vascular impairment causes different diseases. Aim: Evaluate association between serum uric acid levels and hypertension, blood sugar and glycated hemoglobin in prediabetes, diabetes and healthy control. Methods: Cross sectional study conducted in 120 subjects, divided equally into three groups: 40 prediabetes, 40 type 2 Diabetes (T2DM) and 40 healthy controls. Data was collected using a proforma, covering particulars related to hypertension, fasting blood sugar (FBG), glycated hemoglobin (HbA1c) and the levels of SUA. SPSS software was used for analysing the data. Results: The age- and sex-matched prediabetic and diabetic groups had significantly higher systolic and diastolic blood pressures compared to control group. Diabetes markers FBG and HbA1c were recorded highest in the T2DM group, which shows a significant difference in mean compared to prediabetes and the control group. SUA levels were highest in diabetes but found an insignificant difference with prediabetes, whereas the control group showed significant differences (4.4±0.5, p<0.05) with prediabetes (7.1±2.4) and diabetes (7.6±1.5). A significant and positive correlation was recorded between SUA and blood pressure, FBG and HbA1c in the diabetes group. In prediabetes, SUA was found to have a positive association with only systolic blood pressure (SBP) and FBG.  Conclusion:  Severity of disease progression in patients with hypertension and diabetes, SUA can probably be used as an early biochemical marker. So, assessment of serum uric acid as a routine investigation may be recommended for evaluating disease progress.
Best Recommended Exercise for patients with Hypertension Tri Tjahjono, Cholid; Lestari, Defyna; Arthamin, Maimun
Clinical and Research Journal in Internal Medicine Vol. 4 No. 2 (2023): Volume 4 No 2, November 2023
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.crjim.2023.004.02.07

Abstract

Hypertension is known as a fatal yet preventable risk factor for cardiovascular disease and is responsible for majority of cardiovascular mortality. Hypertension is closely associated with sedentary lifestyle. Physical activity and/or exercise are shown to retard development of hypertension. Exercise, combined with other measures of lifestyle behaviour and pharmacologic treatments, is recommended as an effective lifestyle behaviour for adults to prevent and treat hypertension. The current exercise prescription for the treatment of hypertension is: cardiovascular mode, for 20-60 minutes, 3-5 days per week, at 40-70% of maximum oxygen uptake (VO2(max)).. Both aerobic and resistance exercise, should be performed simultaneously by hypertensive patients. Aerobic activity could include walking, jogging, cycling, rowing swimming. While dynamic resistance training could include free weights, resistance machines, and resistance bands. Functional exercises should be comprised of step-ups, bodyweight exercises, and balance training. After an exercise session, BP decreases, and this decline continues for up to 24 h; which is called post-exercise hypotension. Overall 5 mmHg decrease in BP with regular exercise may be encouraged. With a decrease of 5 mmHg in systolic BP, mortality due to coronary artery disease decreases by 9%, mortality due to cerebrovascular accident decreases by 14% and all-cause mortality decreases by 7%. Regular exercise should therefore be recommended for all individuals including normotensives, pre-hypertensives, and hypertensives.
Clinical Characteristics of Rheumatoid Arthritis Patients in Malang: Where Are We Now According to the Treat-to-Target Strategy? Pratama, Mirza Zaka; Suryana, Bagus; Megawanto, Nurhandi
Clinical and Research Journal in Internal Medicine Vol. 4 No. 2 (2023): Volume 4 No 2, November 2023
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.crjim.2023.004.02.04

Abstract

Background: Rheumatoid arthritis (RA) is the most frequent type of systemic inflammatory arthritis. Aim: to observe RA patients' clinical characteristics in Malang and assess the adherence of the clinical data to the existing guideline for the treat-to-target (T2T) strategy. Methods: This survey included 111 RA patients who visited the Rheumatology Clinic at Saiful Anwar Hospital in Malang. Patient's demographic information, medical and drug history, body mass index (BMI), tender joint count (TJC), swollen joint count (SJC), visual analogue scale (VAS) for pain, erythrocyte sedimentation rate (ESR), anti-cyclic citrullinated protein (CCP), and rheumatoid factor (RF) were all collected. The disease activity score for 28 joints - ESR (DAS28-ESR) was used to assess disease activity and remission. Results: The mean duration of the disease was 2.9±1.6 years. Among those patients, four patients (3.6%) got disease remission, and two patients (1.8%) had low activity. Methotrexate (MTX) was given to all subjects for an average of 78.4±11.7 months at a dose of 9.5±2.8 mg/week. Six patients (5.4%) received the DMARD combination of MTX+LEF (4.5%) and MTX+SSZ (0.9%). Most subjects had delayed MTX initiation (mean duration 6.0±2.2 months after the first onset); 77 patients (69.3%) initiated their MTX after >6 months since the first onset. Most subjects got 7.5 mg/weeks (45.0%), while only 11.7% of patients had ≥15 mg/weeks of MTX. Conclusion: The remission rate of RA patients in Malang is still low, which can be caused by inadequate adherence to the relevant guidelines and T2T strategy in clinical practices.
Increasing Adolescents' Knowledge in Indonesia of HIV and STD in Leading-Up Three Zero HIV/AIDS 2030 Indiastari, Dewi; Setyowati, Lita; Sutanto, Heri; Budiarti, Niniek; Rosandi, Millanitalia; Dwitarahma, Marshandyar
Clinical and Research Journal in Internal Medicine Vol. 5 No. 1 (2024): Volume 5 No 1, May 2024
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.crjim.2024.005.01.06

Abstract

During the transition period of puberty, adolescents experience physical, psychological, and ways of thinking, which social and environmental changes will have a significant impact on adolescents. Improper self-control becomes a threat that can damage the morale and future of adolescents, including choosing the wrong environment resulting in drug abuse, unwanted pregnancies, abortions, sexually transmitted infections, HIV, and AIDS. This community service activity aims to increase the knowledge and importance of youth awareness in Malang about HIV and STIs. This activity is an online lecture-based activity (webinar) and live event assisting teenagers in Malang area. It is held for seven weeks by providing education about what HIV is, why it must be avoided—the dangers of sexually transmitted infections online followed by a discussion session. The activity was attended by 763 participants aged 10-20 years and 114 guardians of students and laypeople. The results obtained during the activity showed an increase in the post-test scores compared to the values before getting the webinar. A long-term evaluation still needs to be carried out to assess the absorption rate of the material that has been carried out on the quality of life of webinar participants. The conclusion obtained from this activity is that the knowledge of webinar participants, especially teenagers, about HIV/AIDS has increased, and knowledge is a fundamental thing that must be instilled in adolescents as early as possible to prevent HIV transmission in adolescents.
Postoperative Hormonal and Water Balance Disturbances After Non-Functioning Pituitary Macroadenoma Surgery Yudha, Nyoman; Setiabudi, Patan; Abellia, Gaby
Clinical and Research Journal in Internal Medicine Vol. 5 No. 1 (2024): Volume 5 No 1, May 2024
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.crjim.2024.005.01.12

Abstract

Non-functioning pituitary adenomas (NFPAs) are common sellar region tumors. Certain pituitary adenomas are categorized as functional, as they arise from specific cell types that excessively secrete hormones. In contrast, non-functional adenomas do not secrete hormones but can potentially compress the surrounding regions. The lack of hormonal activity in NFPAs often leads to a delayed diagnosis. It becomes clinically significant when the adenoma gets larger and starts causing symptoms. A 52-year-old man presented with visual field impairment since two years ago and throbbing headaches for the last three months. He was found to have pituitary macroadenoma and no hormonal excess was detected. He was diagnosed with non-functioning pituitary macroadenoma, then underwent endonasal endoscopic transsphenoidal hypophysectomy as a surgical procedure in our institute. A surgical procedure to remove pituitary adenomas can lead to high chance of complications in pituitary hormone regulation due to the manipulation of the pituitary gland and its stalk, such as water balance imbalance and hormonal disturbances. Endonasal endoscopic transsphenoidal hypophysectomy as a surgical procedure in treating pituitary macroadenoma has proven effective, resulting in good outcomes. A multidisciplinary approach involving specialists in endocrinology, ophthalmology, and neurosurgery is essential for the comprehensive evaluation of patients with pituitary adenoma.
Tailored CML Treatment in Indonesia, Let’s See More Wardhani, Shinta Oktya
Clinical and Research Journal in Internal Medicine Vol. 4 No. 2 (2023): Volume 4 No 2, November 2023
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.crjim.2023.004.02.01

Abstract

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