cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
Novena Yety Lindawati
Contact Email
novena_yl@yahoo.com
Phone
+62271-572339
Journal Mail Official
ojs.stikesnas@stikesnas.ac.id
Editorial Address
LPPM STIKES Nasional Jl. Raya Solo-Baki, Kwarasan, Grogol, Sukoharjo, Jawa Tengah 57552
Location
Kab. sukoharjo,
Jawa tengah
INDONESIA
Jurnal Farmasi
Published by Sekolah Tinggi Ilmu Kesehatan Nasional
ISSN : 23027436     EISSN : 26568950     DOI : https://doi.org/10.37013/jf
Core Subject : Health,
Dentistry Health Professions Medicine & Pharmacology Nursing Public Health
JURNAL FARMASI (Journal Of Pharmacy) adalah jurnal ilmiah resmi yang dikeluarkan oleh Sekolah Tinggi Ilmu Kesehatan Nasional dengan nomor p-ISSN 2302-7436 e-ISSN 2656-8950. JURNAL FARMASI (Journal Of Pharmacy) berisikan jurnal-jurnal ilmiah dalam semua aspek ilmu pengetahuan dan teknologi di bidang Farmasi dan kesehatan antara lain: Farmakognosi dan Fitokimia meliputi Pengembangan Simplisia, Budidaya Tanaman Obat, Isolasi, Skrining Fitokimia, dan Identifikasi Obat Bahan Alam Indonesia. Biologi meliputi Biologi Molekuler, Bioteknologi, Mikrobiologi, Immunologi, Parasitologi, Biomedisinal Teknologi Farmasi meliputi Farmasetika, Teknologi dan Formulasi Sediaan Obat, Teknologi dan Formulasi Sediaan Obat Bahan Alam Indonesia. Ilmu Kimia meliputi Kimia Analisa, Kimia Organik, Sintesa Obat, Kimia Medisinal, Pemodelan Molekul, Biokimia, dan Kimia Lingkungan. Farmakologi meliputi Farmakologi, Farmakokinetik, Farmakoterapi, dan Toksikologi. Farmasi Klinik dan Komunitas meliputi Farmakoekonomi, Farmakovigilan, Analisis dan Evaluasi Penggunaan Obat, Monitoring Efek Samping Obat, Analisa Kebijakan Kefarmasian, Evaluasi kegiatan Kefarmasian, Evaluasi Efektifitas Penggunaan Obat, Evaluasi Kualitas Hidup Pasien.
Arjuna Subject : Profesi Kesehatan - Profesi Kesehatan (Lain-Lain)
Articles 189 Documents
 1   2   3   4   5 
GAMBARAN PENGGUNAAN OBAT PADA HEPATITIS A PASIEN RAWAT INAP DI RUMAH SAKIT UMUM DAERAH dr. SOEDIRAN MANGUN SUMARSO WONOGIRI PERIODE JANUARI 2017 – JUNI 2019 Listiana Noor Hidayati; Truly Dian Anggraini
Jurnal Farmasi (Journal of Pharmacy) Vol 9, No 1 (2020): Maret
Publisher : SEKOLAH TINGGI ILMU KESEHATAN NASIONAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37013/jf.v9i1.97

Abstract

Hepatitis A adalah penyakit infeksi pada hati yang disebabkan oleh virus hepatitis A. Jumlah kasus hepatitis A pasien rawat inap di Rumah Sakit Umum Daerah dr. Soediran Mangun Sumarso Wonogiri selama tahun 2017 - Juni 2019 sebanyak 110 pasien. Tujuan penelitian ini untuk mengetahui gambaran penggunaan obat pada pasien hepatitis A meliputi karakteristik dan pengobatan pasien. Penelitian ini merupakan penelitian non eksperimental dengan rancangan analisis deskriptif, dengan mengumpulkan informasi data melalui catatan rekam medik pasien hepatitis A yang didiagnosa periode Januari 2017 - Juni 2019. Parameter yang digunakan adalah persentase dari karakteristik pasien hepatitis A dihitung berdasarkan usia, jenis kelamin, jenis penyakit penyerta dan gambaran pengobatan pasien hepatitis A meliputi jenis dan jumlah obat yang digunakan, jenis dan jumlah cairan infus yang digunakan. Hasil Penelitian menunjukan bahwa persentase berdasarkan usia pasien penderita terbanyak rentang usia ≥ 56 tahun (30,91%), persentase berdasarkan jenis kelamin terbanyak laki-laki (55%), persentase berdasarkan jenis penyakit penyerta terbanyak jenis penyakit thypoid (53,33%), persentase berdasarkan penggunaan obat yang banyak digunakan yaitu curcuma (12,37%), dan persentase berdasarkan penggunaan cairan infus terbanyak yaitu ringer asetat (58,78%).
HUBUNGAN KARAKTERISTIK DENGAN PENGETAHUAN TENAGA TEKNIS KEFARMASIAN DALAM REKONSTITUSI INJEKSI ANTIBIOTIK DI RAWAT INAP RS UNS Dwi Utari, Septiyani; Adiningsih, Retnowati
Jurnal Farmasi (Journal of Pharmacy) Vol. 11 No. 2 (2022): Jurnal Farmasi (Journal of Pharmacy), October 2022
Publisher : Sekolah Tinggi Ilmu Kesehatan Nasional & Pengurus Cabang Ikatan Apoteker Indonesia (IAI) Sukoharjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.373013/j5ww7h55

Abstract

Reconstitution is the process of mixing the solvent medium into a dry powder mass to produce suspended or dissolved substances. Mixing injection drugs, including reconstitution of antibiotic injections, should be formulated by pharmacists, in fact all of them are still made by non-pharmaceutical health workers, apart from lack of correlation, it also gives the impression that the hospital is violating the rules. To prevent errors in compounding, pharmaceutical staff attend aseptic technique training to minimize contamination during compounding. The purpose of this study was to examine the relationship between characteristics and knowledge of pharmaceutical technicians in reconstitution of antibiotic injections at UNS Hospital inpatients. Descriptive research with correlation studies the relationship between two or more variables. Data collection is done.total.sampling. Retrieval of data used a questionnaire and processed with SPSS 21.0 For.Windows application. The results of this study indicate that the characteristics include gender, p value = 0.014, at = 0.05 (p<α), education p value = 0.961, at = 0.05 (p>α), length of work p value = 0.719, at =0.05 (p>α). The conclusion obtained is that there is no significant relationship between education and length of work. There is a significant relationship between gender in the knowledge of pharmaceutical technicians in reconstitution of antibiotic injections at UNS Hospital inpatients.
Uji Antibakteri Fraksi Aktif Ekstrak Aseton Kulit Batang Shorea acuminatissima terhadap Staphylococcus aureus dan Pseudomonas aeruginosa Multiresisten antibiotik Prayitno, Imam; Saroyobudiyono, Haryoto; Indrayudha, Peni
Jurnal Farmasi (Journal of Pharmacy) Vol. 2 No. 1 (2013): Jurnal Farmasi (Journal of Pharmacy), October 2013
Publisher : Jurnal Farmasi (Journal of Pharmacy)

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Infection disease has a serious problem in Indonesia, including antibiotic resistance of microorganisms. One of the tropical forest plant in Indonesia is Shorea accuminatissima which included in Dipterocarpaceae and reported to have compound content of phenolic with biological activity like antibacterial, antioxidant and antifungi. This research aim to know the antibacterial activities of acetone extract and active fraction of acetone extract to S. aureus and P. aeruginosa multiple resistance antibiotic.Acetone extract obtained with maceration method, then tested the antibacterial activity. Later, acetone extract fractioned use Vacuum Liquid Chromatography (VLC). Each fraction tested by bioautographic to determine the antibacterial activities using a filter paper disc method with S. aureus and P. aeruginosa. Fraction with the biggest radical zone is an active fraction, then tested the antibacterial activity. The lowest concentration that kills bacterial growth conceived as Minimum Bactericidal Concentration (MBC).Research show that acetone extract of Shorea accuminatissima stembark have the MBC values at 0,25% to S. aureus multiple resistance antibiotic and 1% to P. aeruginosa multiple resistance antibiotic. Active fraction is fraction C. Active fraction have the MBC values at 0,125% to S. aureus multiple resistance antibiotic and 0,25% to P. aeruginosa multiple resistance antibiotic.
Uji Aktivitas Antioksidan Kombinasi Ekstrak Sarang Semut ( Myrmecodia Pendans) dan Daun Sirsak (Annona muricata) dengan Metode DPPH (2,2-diphenyl-1-picrilhidrazyl) Wimpy; Suharyanto
Jurnal Farmasi (Journal of Pharmacy) Vol. 3 No. 1 (2014): Jurnal Farmasi (Journal of Pharmacy), October 2014
Publisher : Jurnal Farmasi (Journal of Pharmacy)

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Free radicals are highly reactive molecules containing one or more unpaired electrons in its outer orbital Free radicals attackelectron binding molecules in the surrounding areas. Malfunctioning cells, damage cell structures, and even mutations are the effects of free radical. Antioxidants can inhibit reactive oxygen and free radicals in the human body. The compound flavonoid, which is contained in thesoursop’s leaf and sarang semut act as anti-oxidants. This researchaimsto test the antioxidant activity of the combination of extracted sarang semut (Myrmecodia pendans) and Soursop’s leaf (Annona muricata) with DPPH (2,2-diphenyl-1-picrilhidrazyl) method. This researchwas conducted by plant extraction Sarang semut and soursop’s leaf with maceration The results showed that ultrasonic extraction techniqueall fractions are detected such as alkaloids, flavonoids, saponins and tannins, water fraction of sarang semut has76.64 ppm IC50 and the butanol fractions has 76.82 ppm IC50, the combination of extracted sarang semut and extracted soursop’s leaf (1: 1) have 71.09 ppm IC50, the water fraction soursop leafhas 73.48 ppm IC50, and butanol fraction has 99.70 ppm so we can conclude that the water fraction of sarang semut is better than butanol fraction of sarang semut extract. The combination between extracted soursop’sleaf and extracted sarang semut with a ratio of 1: 1 has a better antioxidant activity than the singular.
EVALUASI PENGARUH KESESUAIAN TERAPI HIPERTENSI DENGAN GUIDELINE JNC 7 TERHADAP TERCAPAINYA TARGET TEKANAN DARAH PASIEN DI RS PANTI WALUYO SURAKARTA PERIODE JANUARI-DESEMBER 2013 Dian Anggraini, Truly; Puspita Sari, Ika; Probosuseno
Jurnal Farmasi (Journal of Pharmacy) Vol. 5 No. 1 (2016): Jurnal Farmasi (Journal of Pharmacy), October 2016
Publisher : Jurnal Farmasi (Journal of Pharmacy)

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Hypertension is a major public health problem worldwide and is the most common risk factor for cardiovascular disease. The prevalence of hypertension in the population aged 18 years and above at 29.8%. Epidemiological data indicates that an increase of blood pressure would improve cardiovascular events. Therefore, hypertension should be treated appropriately by controlling blood pressure. This research aims to evaluate the effect of appropriateness of therapy hypertension based on JNC7 guideline in order to gain targeted blood pressure in RS Panti Waluyo Surakarta during January-December 2013. This study conducted using cohort retrospectively in inpatients medical record in RS Panti Waluyo Surakarta. A total of 116 samples were analyzed with descriptive-analytic method. Both monotherapy and combination of anti-hypertension drug were analyzed with JNC 7 guideline while the target blood pressure were statistically analized using Chi-square test. This research result showed that 50 patients exhibited the appropriate anti-hypertension therapy, while 66 patients showed the inappropriate anti-hypertension therapy. The pattern of anti-hypertension was that 38 patients prescribed single anti-hypertension medicine, 34 patients prescribed combination of 2 anti-hypertension medicine. Like the patients in appropriate group (66%), there were (47%) patients in inappropriate group could achive the target of blood pressure. In conclusion, there is a significant relationship between appropriateness of anti-hypertension use and target blood pressure (p <0.05).
DETERMINATION of TOTAL FLAVONOID LEVELS on LEAF STALKS ETHANOL EXTRACT of TARO (Colocasia esculenta[L.]Schott) Novena Yety Lindawati
Jurnal Farmasi (Journal of Pharmacy) Vol 1, No 1 (2018): PROCEEDINGS ICHC
Publisher : SEKOLAH TINGGI ILMU KESEHATAN NASIONAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37013/jf.v1i1.65

Abstract

Taro is plant that has a pseudostalk,cylindrical and light brown bulbs. The shape of leaf is the heart in length. Leaf stalk of taro contains are saponins, flavonoids, tanins, alkaloids, steroids and terpenoids. Leaf stalk of taro can be used as an alternative medicines wound and antioxidants. Flavonoids have an important role in the biological activity of taro leaf stalk. This research aims to determine the flavonoid and total flavonoids content in the taro leaf stalk extract. The extraction is done using maceration method with 70% ethanolas solvent. The extract which is got is used for qualitative and quantitative analysis. Quercetin used as a standard solution. Quantitative analysis using UV-Vis Spectrophotometry on a wavelength of 435.5 nm and operating time at the 29th minute. The results of qualitative test showed that the extract was positive flavonoids. The average concentrations of total flavonoids was 10,2223mg QE/gram extract with %CV value of 0,3051%.
Keragaman dan Kelimpahan Plankton di Perairan Rawa Pening Ambarawa Kabupaten Semarang Yovita Widya Asmara
Jurnal Farmasi (Journal of Pharmacy) Vol 3, No 1 (2014): Oktober
Publisher : SEKOLAH TINGGI ILMU KESEHATAN NASIONAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37013/jf.v3i1.23

Abstract

Keberadaan bahan-bahan anorganik dan organik yang berasal dari sungai, sisa pakan, sisa metabolisme ikan, dan sisa pembusukan makrofita air dapat menjadi sumber nutrien. Salah satu organisme yang hidup di Rawa Pening Ambarawa adalah plankton yang dapat digunakan untuk mengevaluasi kestabilan komunitas pada perairan dengan mengkaji keragaman dan kelimpahannya. Penelitian yang bertujuan untuk mengetahui keragaman dan kelimpahan plankton perairan Rawa Pening Ambarawa Jawa Tengah ini dilakukan dari bulan Juli sampai September 2006. Metode yang digunakan adalah metode survei dan pengambilan sampel dibagi menjadi 3 zona (zona hulu, tengah, dan hilir) dengan 3 stasiun pada setiap zona. Data yang dikumpulkan adalah jumlah spesies dan jumlah individu serta parameter fisika kimia air perairan Rawa Pening. Analisis data yang digunakan adalah analisis secara deskriptif dan aturan 50%. Hasil penelitian menunjukkan keragaman plankton yang ditemukan pada zona hulu sebanyak 30 genera dengan kelimpahan plankton 2.227 ind/l, pada zona tengah sebanyak 31 genera dengan kelimpahan plankton 2.753 ind/l, dan pada zona hilir sebanyak 29 genera dengan kelimpahan plankton 1.215 ind/l. Berdasarkan hasil penelitian, keragaman dan kelimpahan plankton pada zona hulu, tengah, dan hilir adalah sama
Pengaruh Rasionalitas Penggunaan Antihipertensi dengan Standart Guideline JNC 8 Terhadap Keberhasilan Terapi Hipertensi di RS Panti Waluyo Surakarta Truly Dian Anggraini; Eka Wisnu Kusuma; Deswinda Diandari
Jurnal Farmasi (Journal of Pharmacy) Vol 6, No 1 (2017): Oktober
Publisher : SEKOLAH TINGGI ILMU KESEHATAN NASIONAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37013/jf.v6i1.39

Abstract

AbstrackHipertensi merupakan masalah utama kesehatan publik di seluruh dunia dan merupakan faktor resiko penyakit kardiovaskuler tersering. Prevalensi hipertensi pada penduduk umur 18 tahun ke atas sebesar 29,8%. Data epidemiologi menunjukkan bahwa peningkatan tekanan darah akan meningkatkan kejadian kardiovaskuler, sehingga hipertensi harus diobati dengan tepat. Penelitian ini bertujuan untuk mengetahui pengaruh rasionalitas penggunaan antihipertensi dengan standar guideline JNC 8 terhadap keberhasilan terapi hipertensi di RS Panti Waluyo Surakarta tahun 2016.  Penelitian ini merupakan penelitian cohortdimana pengambilan data dilakukan secara retrospektif dari catatan rekam medik pasien hipertensi rawat inap pada tahun 2016. Setelah diperoleh sampel maka akan dianalisis pola penggunaan antihipertensi serta rasionalitas penggunaan antihipertensi dengan standar guideline JNC 8 dianalisis secara diskriptif, pengaruh rasionalitas penggunaan antihipertensi dengan standar guideline JNC 8 terhadap keberhasilan terapi (dilihat dari tercapainya target tekanan darah pasien) dianalisis secara statistik menggunakan Chi-square.  Hasil penelitian, 84 pasien mendapatkan terapi hipertensi yang rasional sesuai dengan guideline JNC 8 dan 16 pasien mendapatkan terapi hipertensi yang tidak rasional dengan guideline JNC 8. Pola obat antihipertensi, 52 pasien diresepkan obat antihipertensi tunggal, 43 pasien kombinasi 2 obat antihipertensi, selebihnya pasien diresepkan lebih dari 2 antihipertensi. Keberhasilan terapi, 65 pasien dari 84 pasien yang mendapatkan terapi hipertensi yang rasional mampu mencapai target tekanan darah sehingga terapi dikatakan berhasil. Ada hubungan yang signifikan antara rasionalitas terapi hipertensi dengan guideline JNC 8 terhadap ketercapaian keberhasilan terapi (p<0,05). 
Pengaruh Pemberian Sediaan Creambath Ekstrak Daun Kembang Sepatu (Hibiscus Rosa-Sinensis) pada Pertumbuhan Rambut Kelinci (New Zealand) Widyastuti, Lita; Ningsih, Dwi; Aisiyah, Siti
Jurnal Farmasi (Journal of Pharmacy) Vol. 8 No. 1 (2019): Jurnal Farmasi (Journal of Pharmacy), October 2019
Publisher : Jurnal Farmasi (Journal of Pharmacy)

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Hibiscus rosa-sinensis is contains flavonoids, saponins and polyphenols that play a role in accelerating the growth of hair.This research aims to know the influence of the variation of concentration of ethanol extracts of hibiscus leaves in preparation creambath against rabbit hair growth. Of ethanol extracts of hibiscus leaves are obtained with the method remaseration using ethanol 70%. Creambath preparation made in 4 formula with the concentration of the extract of hibiscus in 10%, 15%, 20% and a negative control. Applied to the backs of rabbits that had been shaved and then given the preparations-2 times a day for 15 days. To test the activity of rabbit hair growth by measuring the length of the hair and rabbit hair, weight and physical test performed which include odor, color, pH, spread power, power protection, the ability to say, type, viscosity and stability of creams, creambath. Physical quality test data, weight, and hair is analyzed with the Saphiro-Wilk, then using ANOVA and Post Hoc Tests. The results showed that preparations creambath hibiscus leaves ethanol extract with a concentration of 10%, 15%, and 20% have good physical stability. The higher the concentration of the extract in preparations creambath hair growth activity differences produce rabbits. The results views of the parameter weights and lengths of hair, but not yet as effective as comparison control formula that delivers results-effective against the growth of rabbit hair creambath is with a concentration of 20%.
Perbandingan Kadar Flavonoid Total Seduhan Daun Benalu Cengkeh (Dendrophthoe Petandra L.) pada Bahan Segar dan Kering Susilowati; Nurlinda Sari, Iin
Jurnal Farmasi (Journal of Pharmacy) Vol. 9 No. 2 (2020): Jurnal Farmasi (Journal of Pharmacy), October 2020
Publisher : Jurnal Farmasi (Journal of Pharmacy)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.373013/7sk16r03

Abstract

Dendrophthoe petandra L. is a plant that attaches itself to cloves. in society, this plant is often considered a pest, even though this parasite plant can be used as a medicinal plant because it contains phytochemicals including flavonoids, terpenoids, tannins, alkaloids and saponins. Flavonoids are marker compounds that are responsible for the antioxidant and anticancer potential of clove parasite leaves. In the use of medicinal plants, people usually use simple extraction techniques with infusion. The aim of this study was to determine of total flavonoid levels ini leaf infusion of fresh and dry clove parasite leaves so as to provide information to the public on the proper preparation of ingredients before use. Identification of flavonoids using the alkaline test with NaOH, acid test with H2SO4 and willstater test. Determination of total flavonoid levels was carried out by UV-Vis spectrophotometry using AlCl3 and expressed as quercetin equivalent. The results showed that clove parasite leaves contained flavonoids with total flavonoid levels of 8,1977 ppm QE of fresh leaf infusion and 5,4407 ppm QE of dry leaf infusion. Comparison analysis of levels with One Way Anova showed that the total flavonoids of fresh clove parasite leaves were significantly greater than the dry leaves.

Page 2 of 19 | Total Record : 189

 1   2   3   4   5 

Filter by Year

2012 2025


Reset
Filter By Issues
All Issue Vol. 14 No. 2 (2025): Jurnal Farmasi (Journal of Pharmacy), October 2025 Vol. 14 No. 1 (2025): Jurnal Farmasi (Journal of Pharmacy), April 2025 Vol 14, No 1 (2025) Vol. 13 No. 2 (2024): Jurnal Farmasi (Journal of Pharmacy), October 2024 Vol. 13 No. 1 (2024): Jurnal Farmasi (Journal of Pharmacy), April 2024 Vol 13, No 2 (2024) Vol 13, No 1 (2024) Vol. 12 No. 2 (2023): Jurnal Farmasi (Journal of Pharmacy), October 2023 Vol. 12 No. 1 (2023): Jurnal Farmasi (Journal of Pharmacy), April 2023 Vol 12, No 2 (2023) Vol 12, No 1 (2023) Vol. 11 No. 2 (2022): Jurnal Farmasi (Journal of Pharmacy), October 2022 Vol. 11 No. 1 (2022): Jurnal Farmasi (Journal of Pharmacy), April 2022 Vol 11, No 2 (2022) Vol 11, No 1 (2022) Vol. 10 No. 2 (2021): Jurnal Farmasi (Journal of Pharmacy), October 2021 Vol. 10 No. 1 (2021): Jurnal Farmasi (Journal of Pharmacy), April 2021 Vol 10, No 2 (2021): Oktober Vol 10, No 1 (2021): Maret Vol 2, No 1 (2021): PROCEEDINGS ICHC Vol 2, No 1 (2021): PROSIDING SEMINAR NASIONAL KEFARMASIAN Vol. 9 No. 2 (2020): Jurnal Farmasi (Journal of Pharmacy), October 2020 Vol. 9 No. 1 (2020): Jurnal Farmasi (Journal of Pharmacy), April 2020 Vol 9, No 2 (2020): Oktober Vol 9, No 1 (2020): Maret Vol 9, No 1, Maret (2020) Vol. 8 No. 1 (2019): Jurnal Farmasi (Journal of Pharmacy), October 2019 Vol. 7 No. 1 (2018): Jurnal Farmasi (Journal of Pharmacy), October 2018 Vol 1, No 1 (2018): PROCEEDINGS ICHC Vol. 6 No. 1 (2017): Jurnal Farmasi (Journal of Pharmacy), October 2017 Vol 6, No 1 (2017): Oktober Vol. 5 No. 1 (2016): Jurnal Farmasi (Journal of Pharmacy), October 2016 Vol. 4 No. 1 (2015): Jurnal Farmasi (Journal of Pharmacy), October 2015 Vol 4, No 1 (2015): Oktober Vol. 3 No. 1 (2014): Jurnal Farmasi (Journal of Pharmacy), October 2014 Vol 3, No 1 (2014): Oktober Vol. 2 No. 1 (2013): Jurnal Farmasi (Journal of Pharmacy), October 2013 Vol 2, No 1 (2013): Oktober Vol. 1 No. 1 (2012): Jurnal Farmasi (Journal of Pharmacy), October 2012 Vol 1, No 1 (2012): Oktober More Issue