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Jurnal Farmasi dan Sains Indonesia (JFSI)
Published by Sekolah Tinggi Ilmu Farmasi Nusaputera
ISSN : 26219360     EISSN : 26863529     DOI : https://doi.org/10.52216
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Medicine & Pharmacology Neuroscience
Focus and Scope Jurnal Farmasi & Sains Indonesia is an open-access journal that published twice a year by Sekolah Tinggi Ilmu Farmasi Nusaputera. This journal is a media of research publication on all aspects of pharmaceutical & science that is innovative, creative, original and based on scientific. Articles published in this journal about drug discovery, drug delivery systems and drug development with specific field include: 1. Medicinal chemistry 2. Pharmacology 3. Pharmacokinetics 4. Pharmacodynamics 5. Pharmaceutical analysis 6. Drug delivery systems 7. Pharmaceutical technology 8. Pharmaceutical biotechnology 9. Herbal medicines and active components 10. Clinical evaluation of the medicine
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 12 Documents
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Search results for , issue "Vol 5 No 2 (2022)" : 12 Documents clear
UJI AKTIVITAS ANTIINFLAMASI KOMBINASI EKSTRAK DAUN SALAM (Syzygium polyanthum (Wight) Walp) dan EKSTRAK DAUN PEPAYA (Carica papaya L.) TERHADAP UDEMA KAKI TIKUS PUTIH JANTAN YANG DIINDUKSI KARAGENIN Syahputra, Dhika Adhil; Samodra, Galih; Prabandari, Rani
Jurnal Farmasi & Sains Indonesia Vol 5 No 2 (2022)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol5no2p1-6

Abstract

Inflammation or inflammation is the body's normal response to tissue damage caused by physical trauma, chemical and microbial damage. Plants that are thought to have anti-inflammatory properties are bay leaves (Syzygium polyanthum (Wight) Walp). Which acts as an anti-inflammatory in bay leaves and papaya leaves are flavonoids. Bay leaf and papaya leaf extracts were extracted using 70% ethanol by maceration method. The test animals were divided into 7 groups, namely a negative control group (Na CMC), a positive group (Diclofenac Sodium 50 mg), a single dose group of 100 mg/kgBW bay leaf extract, a single dose group of 100 mg/kgBW papaya leaf extract, and a combination group of leaf extracts. salam and papaya leaf extract 50mg/kgBB: 50mg/kgBB, 150mg/kgBB: 100mg/kgBB, 250mg/kgBB: 200mg/kgBB. Treatment 1 hour after the hind legs of rats was induced by subplantar carrageenin. The results showed that the combination of bay leaf and papaya leaf extracts had anti-inflammatory activity. The results of the calculation of the inflammatory power in the combination group showed inflammatory activity.
Pengaruh Interaksi Simvastatin dan Perasan Buah Jeruk Bali (Citrus maxima Merr.) Terhadap Efek Antikolesterol Mencit Jantan Humaidah, Daffa; Widodo, Gunawan Pamudji; Widyasti, Jena Hayu
Jurnal Farmasi & Sains Indonesia Vol 5 No 2 (2022)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol5no2p7-13

Abstract

Consumption of drugs together with herbal medicine at the same time can affect its efficacy. Cholesterol can be treated with simvastatin and herbal medicine such as grapefruit (Citrus maxima Merr.) which contains phenols and flavonoids as anticholesterol and furanocoumarins. This study aims to determine whether the consumption of simvastatin and grapefruit together will affect the anticholesterol effect. Male mice of 35 Swiss strains were divided into 7 groups, each consisting of 5 mice. Without treatment, negative control Na-CMC 0.5%, positive control I simvastatin 5.2 mg/kgBW mice, positive control II grapefruit juice 26 mL/kgBW mice, interaction I, II and III simvastatin 5.2 mg/ kgBW of mice and grapefruit juice were 13 mL/kgBW, 19.5 mL/kgBW, and 26 mL/kgBW of mice, respectively. All groups except without treatment were given a high-fat diet consisting of lard, duck egg yolk, and chicken liver and were induced with 0.1% propylthiouracil solution for 28 days before treatment. Total cholesterol levels were measured after 28 days of induction and 35 and 42 days after treatment. The interaction of simvastatin and grapefruit juice can affect the anticholesterol effect in the form of increasing the effect of reducing total cholesterol levels in the blood of mice. The effective interaction dose was the interaction dose I (simvastatin 5.2 mg/kg BW of mice and grapefruit juice 13 mL/kg BW of mice) which had an anticholesterol effect compared to the single dose group of simvastatin and grapefruit juice.
UJI EFEK ANTIDIARE EKSTRAK ETANOL KULIT BUAH PISANG AMBON (Musa acuminata Colla) TERHADAP MENCIT JANTAN (Mus Musculus L.) YANG DIINDUKSI MINYAK JARAK (Oleum Ricini) Serang, Yithro; Wijayanti, Maria Widya Riska
Jurnal Farmasi & Sains Indonesia Vol 5 No 2 (2022)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol5no2p20-25

Abstract

Utilization of plants as a treatment for diarrhea is an alternative to traditional medicine. Ambon banana peel is one of the plants that can be used as an antidiarrheal because it contains flavonoid compounds, tannins and saponins. This study aimed to determine the antidiarrheal effect of the ethanol extract of Ambon banana peel on male mice induced by Oleum Ricini and to determine the dose of ethanol extract of Ambon banana peel that gave the best antidiarrheal effect. Ambon banana peel was extracted by maceration method. The research method used was a laboratory experimental study using 25 male mice which were divided into 5 groups, namely the negative control group (given CMC Na 1%), the positive control group (given Loperamide HCl 2 mg), the treatment group with ethanol extract of Ambon banana peel. with varying doses of 300 mg/KgBW, 600 mg/KgBW and 900 mg/KgBW. The antidiarrheal effect was observed every 30 minutes for 4 hours with the parameters used were diarrhea frequency, stool weight and stool consistency. Based on the results of the study, the ethanol extract of Ambon banana peel at a dose of 900 mg/KgBW showed diarrhea frequency and stool weight results which were almost the same as the Loperamide HCl treatment group. The results of statistical analysis using ANOVA obtained p<0.05, this indicates that there is a significant difference. The ethanol extract of Ambon banana peel at a dose of 900 mg/KgBW had the best antidiarrheal effect compared to the ethanolic extract of Ambon banana peel at a dose of 300 mg/KgBW and a dose of 600 mg/KgBW.
FORMULASI KRIM WAJAH EKSTRAK PELEPAH POHON AREN (Arenga pinnata Merr.) SEBAGAI ANTI ACNE Fauzi, Rizky Mohammad; Nugraha, Davit; Wahlanto, Panji
Jurnal Farmasi & Sains Indonesia Vol 5 No 2 (2022)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol5no2p26-31

Abstract

Aren (Arenga pinnata Merr.) is a biological resource believed to have antioxidant abilities and is easily found throughout Indonesia. It is widely used by the populace, for example in midrib flour as a traditional medicine to relieve itching and scars on the skin. The purpose of this study was to determine whether the palm leaf extract (Arenga pinnata Merr.) could be formulated into cream preparations and was of good quality. The research method used is experimental by formulating the extract into three formulations, namely the extract concentration of 1%, 3%, 5%. Data analysis was performed using qualitative analysis including organoleptic test, homogeneity test, and quantitative analysis including pH test, dispersion test, adhesion test, viscosity and using one-way ANOVA statistics. The results of the analysis showed that there was no significant difference in the concentration of palm midrib cream in pH with a sig value of 0.542 (sig. > 0.05), a dispersion of 0.504 (sig. > 0.05) and a Adhesion of 0.717 (sig. > 0.05) gave > 0.05) and the viscosity meets the standard of good cream viscosity which is between (2000 - 50000 cps). Data analysis of the results showed that the three variations of extracts could be formulated into cream preparations and had quality standards for cream preparations that met the requirements, there was no effect of variations in the concentration of arene (Arenga pinnata Merr.) on the physical quality of cream preparations. The best wording is found in F2 (3%). Further research is expected to modify the formula for preservatives and fragrance additives, create new dosage forms such as lotions.
Identifikasi Senyawa Sibutramin Hidroklorida Pada Jamu Pelangsing Fakhriah, Siti Nurintan; Rahmadani, Rahmadani; Mahdiyah, Dede
Jurnal Farmasi & Sains Indonesia Vol 5 No 2 (2022)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol5no2p32-37

Abstract

Dissatisfaction with the current body causes women to try to change their appearance by losing weight quickly which results in switching to slimming herbal products that can be trusted to lose weight instantly. With the current progress in the circulation of slimming herbal products, medicinal chemicals (BKO) are added. Slimming herbal products are prohibited from containing medicinal chemicals. Sibutramine Hydrochloride is one of the BKOs found in slimming herbs because Sibutramine HCl is a hard drug that works by inhibiting norepinephrine, serotonin and dopamine, which can suppress appetite so it can be used to lose weight. The study was conducted to identify the compound Sibutramine Hydrochloride in slimming herbs circulating in Tanah Grogot. The method used is pre-experimental with one shot case study. Sampling was done by purvosive sampling technique. The sample from the study was 10 slimming herbs circulating in Tanah Grogot. The results of the TLC method identified 10 samples, only 1 sample was positive for Sibutramine HCl because it had the same Rf value as the comparison standard, which was 0.95. The UV-Vis Spectrophotometry method obtained the sample results showing the levels of Sibutramine HCl exceeding the dose of 15mg with the sample content containing % Sibutramine HCl content, namely S4 0.59%. The results of this study are that there are slimming herbs with a BPOM permit that contain the medicinal chemical Sibutramine HCl.
FORMULASI DAN UJI AKTIVITAS KRIM ANTI AGING EKSTRAK DAUN SIRIH (Piper betle L.) DENGAN VARIASI KONSENTRASI GLISERIN DAN PROPILEN GLIKOL PADA KULIT PUNGGUNG KELINCI PUTIH NEW ZAELAND Wicaksono, Salsabila Melia Putri; Ekowati, Dewi; Handayani, Sri Rejeki
Jurnal Farmasi & Sains Indonesia Vol 5 No 2 (2022)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol5no2p38-47

Abstract

Aging is a natural event of living things caused by extrinsic factors, one of which is ultraviolet light. Aging causes human skin to become wrinkled. In this study, the formulation of an anti-aging cream preparation of betel leaf extract (Piper betle L.) and the anti-aging activity test on the back skin of white rabbits in New Zaeland will be carried out. In previous studies, researchers used extraction using methanol as a solvent. This study aims to determine the healing of wrinkles on the back skin of rabbits due to exposure to UV-A rays. The extraction method used is the maceration method. Betel leaf extract was tested for water content and chemical content. The betel leaf extract was made into a cream formulation and then tested for the physical quality of the cream, namely organoleptic, cream type, homogeneity, pH, spreadability, adhesion, viscosity, and stability. Primary and ocular irritation test and anti-aging activity test were perfomed on the backs of 5 rabbits with 5 treatments. The skin on the rabbit’s back was smeared with negative control cream, positive control cream, betel leaf extract cream with variations of glycerin 5% propylene glycol 15%, glycerin 10% propylene glycol 10%, glycerin 15% propylene glycol 5%. The results of the study obtained that the yield of betel leaf extract was 12.04%. For stability results on cream of betel leaf extract, it was found that all physical quality tests were stable. The results of the irritation test using the Draize method showed that the betel leaf extract cream did not irritate the skin. Anti-aging activity test showed that betel leaf extract cream with various concentrations of glycerin 10% propylene glycol 10% and glycerin 5% propylene glycol 15% was the most effective in reducing wrinkles on the rabbit’s back skin
HUBUNGAN POLIFARMASI DAN TEMUAN POTENSI INTERAKSI OBAT PADA PERESEPAN PASIEN ANAK DI APOTEK BUKIT SARI SEMARANG TAHUN 2021 Dariyati, Nita; Suwarni, Sri; Pitarisa, Agustina Putri; Serang, Yithro; Leki, Karol Giovani Battista
Jurnal Farmasi & Sains Indonesia Vol 5 No 2 (2022)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol5no2p14-19

Abstract

Polypharmacy is still frequent and very common in pediatric prescribing. Polypharmacy can increase the potential for drug interactions. Most of which have a detrimental impact on patient therapy. Drug interactions are considered clinically important when they result in increased toxicity or reduced therapeutic effectiveness. This study aims to determine the relationship between polypharmacy and the potential for drug interactions in the prescription of pediatric patients at Bukit Sari Pharmacy Semarang for the 2021 period. This research is a type of quantitative descriptive analysis research. Research data were obtained retrospectively in the period January - December 2021 which is based on the prescription data of pediatric patients at Bukit Sari Pharmacy Semarang for the 2021 period. The sampling technique used proportional random sampling method where samples were taken from pediatric patient prescriptions that met the inclusion criteria. Of the 270 prescription sheets analyzed, 160 prescription sheets experienced polypharmacy. Percentage of drug interaction events drug interaction was 36.7%. Statistical analysis using the Spearmans Test obtained a p value
PROMOSI KESEHATAN DENGAN METODE BEHAVIORAL CHANGE PADA ANGKA TEMUAN PASIEN SKABIES DI SEMUA CABANG KLINIK DERMA JAWA TENGAH Ernada, Nindya Widyani; Suwarni, Sri; Indrasari, Ferika; Leki, Karol Giovani Battista; Kusumaningtyas, Aprilia
Jurnal Farmasi & Sains Indonesia Vol 5 No 2 (2022)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol5no2p48-56

Abstract

Clinics as health care facilities also play a role in promotive and preventive. Scabies is an infectious skin disease caused by Sarcoptes scabei variant hominis which can be transmitted through direct human contact. This study aims to determine the effect of knowledge level and public health status to change patient behavior to live clean and healthy with behavioral change analysis of scabies rates in all branches of Kinik Derma Central Java. This type of research is observational with cross sectional design, purposive sampling technique. The population is all patients who come to the Derma clinic with a diagnosis of scabies in the January-April 2021 period. This research instrument uses a questionnaire sheet with the application of behavioral change measurement indicators, while for the diagnosis of scabies using the results of medical examination records. Data presentation is presented in the form of Histograms and percentages. The average knowledge of people with scabies answering about scabies disease is 78.02% answering correctly and for the average healthy and clean behavior (personal hygine) is 70.20%. Providing health promotion for the application of behavioral change methods used health promotion by providing brochures and IEC (Information Communication and Education) at the time of drug collection. When waiting for the medicine, it is also expected to see video shows on the Derma Clinic television screen. After a period of 2 months from the initial findings, the number of patients with scabies in all branches of Derma Clinic Central Java decreased by 24 patients or 20% of the number of patients at the beginning of the study.
IMPLEMENTASI MANAJEMEN RISIKO DI INSTALASI FARMASI RUMAH SAKIT UMUM DAERAH DR. R. SOEDJATI SOEMODIARDJO PURWODADI GROBOGAN Toyo, Eleonora Maryeta; Maryana, Mega; Suwarni, Sri; Rustaman, Heri; Susilawati, Linda
Jurnal Farmasi & Sains Indonesia Vol 5 No 2 (2022)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol5no2p57-68

Abstract

Risk is a state of uncertainty and can be measured quantitatively. Every service activity in the Pharmacy Installation contains risk. Risk management is a process of identifying, measuring, analyzing, and handling risks that may arise during service delivery. The implementation of risk management is expected to reduce and or eliminate losses incurred for the continuity of health services. This study aims to determine the implementation of risk management in the Pharmacy Installation of the Regional General Hospital Dr. R. Soedjati Soemodiardjo Purwodadi Grobogan. This research is a non-experimental research with descriptive method, namely retrospective data collection with total sampling technique. Samples were taken from the Quality Control Agency at the Regional General Hospital Dr. R. Soedjati Soemodiardjo Purwodadi Grobogan in the January-December 2020 period. The data obtained were tabulated, presented, and reported in percentage form for further qualitative and quantitative analysis. From the research results obtained, it is known that the most common type of incident is KPC in the prescription service category. This is influenced by factors including human resources, infrastructure, standard operating procedures, and formularies. The implementation of Risk Management in the Pharmacy Installation of the Regional General Hospital Dr. R. Soedjati Soemodiardjo Purwodadi Grobogan is still not effective, because it still experiences obstacles in several stages of the Risk Management process.
ANALISIS KEBUTUHAN TENAGA TEKNIS KEFARMASIAN BERDASARKAN BEBAN KERJA PADA PELAYANAN RESEP DI INSTALASI FARMASI RAWAT JALAN RS ROEMANI MUHAMMADIYAH SEMARANG Darsono, Dwi Aryaningtyas; Suwarni, Sri; Indrasari, Ferika; Rosita, Dian; Roslianti, Rini
Jurnal Farmasi & Sains Indonesia Vol 5 No 2 (2022)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol5no2p69-76

Abstract

One indicator of the success of an effective and efficient hospital is the availability of a sufficient number of human resources (HR) with high quality and professionalism in accordance with the functions and duties of each personnel. The Hospital Pharmacy Installation is a unit that plays a major role in supporting hospital operations. The purpose of the study was to determine the ratio of pharmaceutical technical personnel needs based on WISN analysis in the outpatient pharmaceutical installation of Roemani Muhammadiyah Hospital Semarang. This research is included in the type of descriptive qualitative research whose data management uses descriptive quantitative research studies. The method used workload indicators of staffing need (WISN) this method is accurately used to calculate the needs of human resources (HR) based on the real workload. The results showed that the need for pharmaceutical technical personnel at Roemani Muhammadiyah Hospital Semarang was 25 people, the comparison of reality and needs (ratio) of pharmaceutical technical personnel was 0.9, which showed that the number of pharmaceutical technical personnel was not in accordance with the existing workload. Factors underlying the need for pharmaceutical technical personnel in the outpatient installation include many prescriptions that accumulate in crowded hours, the work system is not yet appropriate, the pharmacy layout is not effective efficient, and the number of prescriptions served is not proportional to the current number of pharmaceutical technical personnel.

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