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Jurnal Farmasi dan Sains Indonesia (JFSI)
Published by Sekolah Tinggi Ilmu Farmasi Nusaputera
ISSN : 26219360     EISSN : 26863529     DOI : https://doi.org/10.52216
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Medicine & Pharmacology Neuroscience
Focus and Scope Jurnal Farmasi & Sains Indonesia is an open-access journal that published twice a year by Sekolah Tinggi Ilmu Farmasi Nusaputera. This journal is a media of research publication on all aspects of pharmaceutical & science that is innovative, creative, original and based on scientific. Articles published in this journal about drug discovery, drug delivery systems and drug development with specific field include: 1. Medicinal chemistry 2. Pharmacology 3. Pharmacokinetics 4. Pharmacodynamics 5. Pharmaceutical analysis 6. Drug delivery systems 7. Pharmaceutical technology 8. Pharmaceutical biotechnology 9. Herbal medicines and active components 10. Clinical evaluation of the medicine
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 27 Documents
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Search results for , issue "Vol 6 No 2 (2023)" : 27 Documents clear
HUBUNGAN TINGKAT PENGETAHUAN DENGAN KEPATUHAN MINUM OBAT PADA PASIEN HIPERTENSI DI PUSKESMAS MANAHAN SURAKARTA Widodo, Arvia Wahyu; Pambudi, Risma Sakti; Ahwan, Ahwan
Jurnal Farmasi & Sains Indonesia Vol 6 No 2 (2023)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol6no2p1-7

Abstract

Hypertension is an increase in systolic blood pressure more than equal to 140 mmHg and diastolic more than equal to 90 mmHg. Good knowledge must be possessed by people with hypertension in order to better understand the importance of routine blood pressure control and to know the dangers caused if they do not take medication regularly. Compliance with taking antihypertensive medication is very important to increase the effectiveness of treatment and prevent complications. This study aims to determine the relationship between the level of knowledge and medication adherence in hypertensive patients at the Manahan Surakarta Health Center. The method used is an analytic observational method with a cross sectional approach. The instruments used in this study were the HK-LS (Hypertension Knowledge-Level Scale) questionnaire and the MMAS-8 (Morisky Medication Adherence) questionnaire to obtain primary data. Data collection was conducted in March 2023 with a sample size of 100 hypertensive patients. Knowledge of hypertension is low knowledge of 8%, moderate knowledge of 23% and high knowledge of 69%. The results of the presentation of medication adherence are low adherence of 16%, moderate adherence of 29%, high adherence of 55%. Based on bivariate analysis using Spearman's rank analysis a correlation coefficient of 0.571 was obtained with a p value of 0.000 <0.05 which means that Ho was rejected and Ha was accepted, that is, there was a significant relationship between knowledge about hypertension and adherence to taking medication in hypertensive patients at the Manahan Surakarta Health Center.
FORMULASI DAN STABILITAS SERUM WAJAH SARANG BURUNG WALET PUTIH (Collocalia fuchiphaga) SEBAGAI ANTIAGING Olipiya, Olipiya; Nurmaulawati, Rina; Cahyaningrum, Yanuar As’hari
Jurnal Farmasi & Sains Indonesia Vol 6 No 2 (2023)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol6no2p8-16

Abstract

White swallow's nest (Collocalia fuchiphaga) is known to have benefits as an antioxidant so it can prevent skin aging. Serum preparations have advantages as skin care cosmetics because they contain active substances in high concentrations, are light and easy to apply. This study aims to make formulations, test physical quality, physical stability, irritation in test animals and test antioxidant activity using the DPPH method (2,2-diphenyl-1-picrylhydrazyl) as a facial serum containing white swallow's nest (Collocalia fuchiphaga) . In this study, a facial serum formulation containing white swallow's nest (Collocalia fuchiphaga) was prepared with various concentrations of 10%, 20% and 30%. The results showed that the 3 formulations had good physical quality tests based on the results of tests carried out in accordance with the standards. Based on the results of the physical stability test, the test results on pH, spreadability and viscosity showed no change in storage for 28 days. The antioxidant activity test results of the 3 formulations yielded IC50 values ​​of F1 (52.523 ppm), F2 (52.181 ppm), and F3 (51.165 ppm). The formulation of white swallow's nest serum (Collocalia fuchiphaga) does not cause primary irritation to rabbit test animals. Based on the results of the data analyzed statistically with a confidence level of 95%, the data obtained was p> 0.05 so that the 3 formulas showed no significant difference. It can be concluded from this study that facial serum containing white swallow's nest (Collocalia fuchiphaga) can be used as an antiaging preparation and does not irritate the skin.
Formulasi Antibakteri Mouthwash Ekstrak Etanol Daun Kirinyuh (Chromolaena odorata (L.) R.M.King & H.Rob.) Pada Bakteri Streptococcus mutans STCC 31987 Erdiyati, Esti; Prabandari, Rani; Sunarti, Sunarti; Nawangsari, Desi
Jurnal Farmasi & Sains Indonesia Vol 6 No 2 (2023)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol6no2p17-27

Abstract

Kirinyuh leaves (Chromolaeina odorata (L.) R.M.King &; H.Rob.) contain secondary metabolites in the form of flavonoids, saponins, steiroids, tannins that can inhibit the growth of antibacterial growth. Based or its antibacterial properties, kirinyuh leaf extract can be developed into mouthwash to prevent dental plaque. The purpose of this study was to determine the physical stability test of the kirinyuh leaf ethanol extract mouthwash preparation and to determine the antibacterial activity of the kirinyuh leaf ethanol extract against Streptococcus mutans ATCC 31987 bacteria, so that a  formulation of the kirinyuh leaf ethanol extract mouthwash preparation could be made. Mouthwash is an antiseptic preparation that is used to clean the oral cavity and is used by gargling. The extraction used was remaceration method with 70% ethanol solvent, made in various extracts with concentrations of 10%, 20%, 30%. Further evaluation of the preparation includes : organoleptic test, pH test, viscosity test. The results of the One Way ANOVA analysis showed that there was no significant difference in the pH test, viscosity test with a p>0,05 value. Organoleptic test during 6 cycles of storage in a stable state during storage. The results showed that the ethanol extract of kirinyuh leaf mouthwash was able to inhibit the growth of Streptococcus mutans bacteria, namely in F1 the weak category was 2.43±0.81 mm, F2 was 10.21±3.56 mm the strong categori, F3 was 13.38±2.72 mm strong category.   Keywords : Antibacterial, Kirinyuh leaves, Mouthwash
Skrining Fitokimia Dan Analisis Kuantitatif Ekstrak Daun Randu (Ceiba pentandra (L.) Gaertn.) Dengan HPLC Dan Uji Aktivitas Antibakteri Terhadap Pertumbuhan Bakteri P. aeruginosa ATCC 27853 Putri, Amalia Eka; Salsabila, Luqyana
Jurnal Farmasi & Sains Indonesia Vol 6 No 2 (2023)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol6no2p28-42

Abstract

Nosocomial pneumonia or commonly known as hospital acquired pneumonia (HAP) is an infection that occurs in the lung parenchyma caused by pathogens in the hospital. Nosocomial pneumonia is the 6th leading cause of death in Indonesian hospitals with a mortality rate of 20-50%. Nosocomial pneumonia is caused by pathogenic microorganisms such as the gram-negative bacterium Pseduomonas aeruginosa ATCC 27853. One of the plants that has the potential as an antibacterial is the randu plant (Ceiba pentandra (L.) Gaertn.) because it contains compounds such as alkaloids, flavonoids, saponins and tannins. The purpose of this study was to determine the levels of quercetin compounds contained from randu plants using HPLC and to determine the antibacterial activity of randu plants against Pseduomonas aeruginosa ATCC 27853 by looking at the size of the inhibition zone formed. The method used is the disc diffusion method. The results of this study indicate that the randu leaf extract contains the compound quercetin which is included in the class of flavonoid compounds with a concentration of 2.075%. 5%. The results of testing the antibacterial activity of randu leaf extract against Pseduomonas aeruginosa ATCC 27853 in the negative control did not form an inhibition zone, the positive control produced an inhibition zone of 29.7 mm, at a concentration of 15%, 25% and 35% produced an inhibition zone of 13.3 mm, 14.6mm and 15.6mm. optimal antibacterial activity is found at a concentration of 15%.
Uji Efektivitas Antioksidan Serum Ekstrak Daun Randu (Ceiba Pentandra (L.) Gaertn.) Dengan Metode DPPH Muadifah, Afidatul; Ummah, Ratih Salimil; Tilarso, Dara Pranidya
Jurnal Farmasi & Sains Indonesia Vol 6 No 2 (2023)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol6no2p43-54

Abstract

The development of cosmetics from natural ingredients has been widely applied in several cosmetic industries, one of the developing cosmetic dosage forms is serum. One of the plants that can be used for serum is randu leaf (Ceiba pentandra (L.) Gaertn.) which contains secondary metabolites including flavonoids, alkaloids, saponins, and tannins which act as natural antioxidants for antiaging. This study aims to determine the optimum levels of flavonoids in randu leaf extract using a UV-Vis spectrophotometer, physical quality of preparations and antioxidant activity in serum preparations using the DPPH method. In determining the levels of flavonoids in the randu leaf extract with concentration series of 20 ppm, 40 ppm, 60 ppm using a UV-Vis spectrophotometer, the results obtained were the optimum concentration of cotton leaf extract in the 60 ppm concentration series, which was 229.3 µg/ml. Then the serum preparation was made, it was found that the serum preparations of randu leaf extract and vitamin C had fulfilled the physical quality test requirements. The antioxidant activity test of serum preparations was continued using the DPPH method using a UV-Vis spectrophotometer and ascorbic acid as a comparison. The ????????50 value for the randu leaf extract serum preparation was 75.0159 ppm which was classified as having strong antioxidant activity while the vitamin C serum preparation was 4.674 ppm which was classified as having very strong antioxidant activity
EVALUASI SEDIAAN SABUN MANDI CAIR EKSTRAK ETANOL DAUN JAMBU BOL (Syizigium malaccense L.) Reubun, Yonathan Tri Atmodjo; Batubara, Kevin Septiyanto
Jurnal Farmasi & Sains Indonesia Vol 6 No 2 (2023)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol6no2p55-60

Abstract

Bath soap is a skin care cosmetic product that can moisturize and protect the skin from sunlight and dirt that comes from outside. Of the various forms of soap preparations on the market, one type of soap that is currently being produced is in liquid dosage form because its use is more practical and the form is more attractive than other forms of soap. The use of natural ingredients as bath soap has been widely used in several soap products, one of the plants that can be used as an active ingredient in liquid soap is guava leaves. The purpose of this study was to determine the antioxidant activity of the ethanol extract of guava leaves (Syizigium malaccense L.) in liquid body soap preparations. The method used in this study was extraction using 96% ethanol solvent and the formulation of liquid bath soap was carried out, after which tests were carried out which included organoleptic tests, foam height tests, specific gravity tests, stability tests, and antioxidant activity tests. The results showed that the ethanol extract liquid bath soap of guava leaves is brown in color, liquid in shape, has a characteristic odor, and has a smooth texture. The foam height test result was 2 cm, the specific gravity test result was 1.020 g/mL and the antioxidant activity test result for the guava bol ethanol extract liquid bath soap was 9.6898. The conclusion of this study is that guava leaf extract can be used as a liquid bath soap preparation and has a good inhibitory concentration based on the results.
Uji Aktivitas Antioksidan Ekstrak Terpurifikasi dari Selada Laut (Ulva lactuca L.) dari Perairan Pantai Pidakan Pacitan dengan Metode DPPH (1,1-Diphenyl-2-picrylhydrazyl) Ainiyah, Nur; Erikania, Susanti; Nurmaulawati, Rina
Jurnal Farmasi & Sains Indonesia Vol 6 No 2 (2023)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol6no2p61-70

Abstract

Free radicals in the absence of antioxidants can damage important cells in the body so that they can cause degenerative diseases. Natural antioxidants can be found from plants that contain phenolic compounds throughout plant parts such as wood, seeds, fruits, roots, flowers, and leaves. One plant that has antioxidant activity is sea lettuce. This study aims to determine the antioxidant activity of purified sealettuce extract results expressed with IC50. The method chosen to make lettuce ethanol extract was the maceration used 96% ethanol solvent, then purified with a split funnel using 96% ethanol solvent and n-hexane. Purified extracts was screened for phytochemicals. Furthermore, antioxidant testing was carried out with the DPPH method by UV-Vis spectrophotometry. After antioxidant testing, data and statistics were analyzed using the SPSS Independent Samples T-Test. The results of this study showed that purified extracts contained flavonoids, alkaloids, saponins, phenols and tannins. In purified extracts of sea lettuce, an average IC50 value of 47.99 ppm was obtained and an average IC50 value of 4,38 ppm was obtained. Based on the Independent Samples T-Test of purified sea lettuce extract and vitamin C showed a significant difference from each treatment as evidenced by a significance value (p < 0.05).
Tingkat Pengetahuan Swamedikasi Terhadap Penanganan Penyakit Skabies (Sarcopies scabiei) di Pondok Pesantren Se-Kota Singkawang Apriliyanti, Dea Nur; Kusharyanti, Indri; Purwanti, Nera Umilia
Jurnal Farmasi & Sains Indonesia Vol 6 No 2 (2023)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol6no2p71-80

Abstract

Data obtained from the Indonesian Ministry of Health, in Indonesia the number of scabies sufferers was 6,915,135 (2.9%) out of a population of 238,452,952 people in 2017. The factor that is believed to be related to the incidence of scabies is a person's level of knowledge. This research method is quantitative with a cross-sectional approach, presenting the level of knowledge with primary data obtained through a questionnaire. The sampling technique used non-probability sampling and obtained a total of 106 respondents who met the inclusion criteria. The results of the study were 48.1% of respondents who got results in the good range, 28.3% sufficient, and 23.6% lacking.
Skrining Fitokimia, Formulasi, dan Karakteristik Fisik Sediaan Soothing Gel Daging Daun Lidah Buaya (Aloe vera (L.) Burm.f.) Sinaga, Rosalinda Mahdalena; Lubis, Minda Sari; Dalimunthe, Gabena Indrayani; Rahayu, Yayuk Putri
Jurnal Farmasi & Sains Indonesia Vol 6 No 2 (2023)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol6no2p81-88

Abstract

Aloe vera (Aloe vera (L.) Burm.f.) can make the skin not dry quickly and feel moisturised. Soothing gel works effectively to restore skin moisture, provide comfort and a cooling effect on red and irritated skin so that the skin condition returns to normal, and prevents skin dryness. The aim of the study was to determine the various secondary metabolites in aloe vera leaf extract to determine differences in concentrations of aloe vera leaf extract in soothing gel preparations on the physical characteristics of the preparations and to determine physical changes before and after stability tests were carried out using the cycling test method. The research method was used experimental, with the independent variables varying the concentration of aloe vera leaf extract 0% (blank), 1%, 2%, and 3%, the dependent variable secondary metabolites and physical characteristics. The sample preparation method is wet sorting and other methods used are phytochemical screening, viscometry, and cycling tests. The results of the phytochemical screening showed that aloe vera leaf extract contains secondary metabolites of flavonoids, glycosides, tannins, saponins, and steroids.
FORMULASI SABUN TRANSPARAN BERBASIS MINYAK KELAPA MURNI (VCO) Ropiqa, Meri; Azmi, Khulul; Septina, Diani Ria
Jurnal Farmasi & Sains Indonesia Vol 6 No 2 (2023)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol6no2p89-93

Abstract

VCO has been widely used as a base of soap formulation. It was used due to its high fatty acid contain resists to oxidation causing stinky smell. The highest abundant of fatty acid in VCO was reported as lauric acid (52%). Lauric acid was known contribute to moisturize the skin. Hence widely used as a base of soap manufacture. The type of soap formulate in this study was the transparent soap due its appealing appearance. To find the best formulation of transparent soap according to SNI. Methods: transparent soap was formulated using hot process technique with two different concentrations of VCO which were 20% and 30%. The obtained soaps were then tested using SNI criteria such as organoleptic, pH, foam stability, and fatty acid. According to T-test, it was resulted p value>0,05 showing those two formulation did not have significance differentiation on pH test and foam stability test. The fatty acid concentration test of those two formulation showed different result significantly but it was still fulfilling the SNI requirement (≤ 2,5%). The formulas obtained of transparent soap using VCO as the base was known fulfill the quality standard of SNI.

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