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INDONESIA
Jurnal Farmasi dan Sains Indonesia (JFSI)
Published by Sekolah Tinggi Ilmu Farmasi Nusaputera
ISSN : 26219360     EISSN : 26863529     DOI : https://doi.org/10.52216
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Medicine & Pharmacology Neuroscience
Focus and Scope Jurnal Farmasi & Sains Indonesia is an open-access journal that published twice a year by Sekolah Tinggi Ilmu Farmasi Nusaputera. This journal is a media of research publication on all aspects of pharmaceutical & science that is innovative, creative, original and based on scientific. Articles published in this journal about drug discovery, drug delivery systems and drug development with specific field include: 1. Medicinal chemistry 2. Pharmacology 3. Pharmacokinetics 4. Pharmacodynamics 5. Pharmaceutical analysis 6. Drug delivery systems 7. Pharmaceutical technology 8. Pharmaceutical biotechnology 9. Herbal medicines and active components 10. Clinical evaluation of the medicine
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 268 Documents
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Uji aktivitas penyembuhan luka sayat menggunakan sediaan patch ektrak etanol daun jambu biji (psidium guajava l.) secara in vivo Hafidz, Mulyadi Dai Muhammad; Rizkulloh, Lina Rahmawati; Nofriyaldi, Ali
Jurnal Farmasi & Sains Indonesia Vol 8 No 2 (2025)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol8no2p100-107

Abstract

The ethanol extract of (Psidium guajava L.) leaves, containing key phytocmhemicals such as tannins, flavonoids, and saponins, has demonstrated potential in enhancing wound repair. This research aimed to formulate a transdermal patch and investigate its in vivo wound-healing activity. Extraction was carried out through maceration of the simplicia using 96% ethanol as the solvent. Patches were formulated with HPMC and PVP, containing 2.5%, 5%, and 10% extract (F1, F2, F3). Physical evaluation (homogeneity, pH, thickness, adhesion) was performed. Rabbits (n=5) with a 2 cm dorsal incision were treated daily with patches (F1-F3), A negative control was represented by a (patch without extract) while the positive control used (povidone-iodine). Wound length was measured for 7 days. All evaluations met the physical requirements except pH at (F2: 6,6±0,1; F3: 6,8±0,1). F3 (10% extract) showed the highest wound healing activity, reducing wound length to 2 mm on day 7, significantly better than the control (7 mm) and lower concentrations (F1: 4 mm; F2: 3 mm). Guava leaf extract patches were effective at healing incised wounds, with concentration-dependent efficacy.
PENGARUH KUALITAS PELAYANAN TERHADAP LOYALITAS PASIEN RAWAT JALAN RUMAH SAKIT LUDIRA HUSADA TAMA YOGYAKARTA: - Primantana, Y.B. Arya; Dwiastuti, Rini
Jurnal Farmasi & Sains Indonesia Vol 8 No 2 (2025)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol8no2p92-99

Abstract

This study analyzes the effect of service quality on outpatient loyalty through patient satisfaction at RS Ludira Husada Tama Yogyakarta. Using purposive sampling, 150 outpatients completed SERVQUAL-based questionnaires analyzed with SEM-PLS. Results showed that tangible (p=0.017) and assurance (p=0.002) dimensions significantly influenced patient satisfaction, while reliability (p=0.554), responsiveness (p=0.646), and empathy (p=0.902) did not. Patient satisfaction significantly influenced loyalty (p=0.001). The findings indicate that physical facilities and service assurance are critical factors in building patient loyalty through satisfaction in outpatient settings.. Keywords: service quality, patient satisfaction, patient loyalty, outpatient, SERVQUAL
Evaluasi Efek Samping Penggunaan Nsaid Pada Pasien Osteoartritis Di Instalasi Rawat Jalan RSUD R.A. Kartini Jepara Ningrum, Nuzulatul Wahyu Mustika; Etikasari, Ria; Husna, Ulviani Yulia
Jurnal Farmasi & Sains Indonesia Vol 8 No 2 (2025)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol8no2p118-125

Abstract

Osteoarthritis (OA) is a common degenerative disease in the elderly and a leading cause of disability. Excessive joint pain results in limited daily activities. In pharmacological therapy, Nonsteroidal Anti-inflammatory Drugs (NSAIDs) are the main choice for OA treatment. Appropriate use of NSAIDs in OA patients is essential to achieve optimal therapeutic outcomes. This study aimed to analyze and evaluate adverse effects of NSAID use in OA patients at the Outpatient Installation of RSUD R.A. Kartini Jepara. The research was conducted using a descriptive observational method with a retrospective design based on secondary data from medical records. Samples were determined through purposive sampling with inclusion criteria: OA patients aged 45–75 years who had at least three visits during January–December 2024. Exclusion criteria were incomplete or unreadable medical records. Data were analyzed descriptively to present patient characteristics, NSAID usage profiles, and adverse effects. The results showed that OA patients were predominantly female (72.9%), aged 65–75 years (46.9%), and had BMI >27 (53.1%). Most patients had disease duration >12 months (38.4%) and received NSAID therapy for more than 3 weeks (70.8%). Hypertension was the most common comorbidity (50%), while the most frequently used concomitant medications were gastrointestinal drugs (23.98%) and antihypertensives (23.17%). Meloxicam was the most frequently prescribed NSAID (51%). The most common adverse effects were gastrointestinal disorders, including dyspepsia (56.10%) and vertigo (17.07%).
Penetapan Kadar Total Fenolik dan Flavonoid Ekstrak dan Fraksi Ekstrak Kulit Buah Pepaya Muda (Carica papaya L.) Saptawati, Tunik; Ardani, Annisa Dea; Rachma, Firstca Aulia; Suwarni, Sri
Jurnal Farmasi & Sains Indonesia Vol 8 No 2 (2025)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol8no2p136-143

Abstract

Papaya peel (Carica Papaya L.) is a plant that has several pharmacological activities because it contains secondary metabolites in the form of phenolics and flavonoids. This study aims to determine the total phenolic and flavonoid levels in the extract and fraction of papaya peel using the colorimetric method. The research method for determining total phenolic content with the Folin-Ciocalteu method, using gallic acid as a comparator, and the determination of total flavonoid content using the AlCl3 complex formation method with quercetin as a comparator, both using UV-Visible spectrophotometry. The results of the total phenolic content of the ethanol extract of papaya peel, the water fraction of papaya peel, the ethyl fraction of papaya peel, and the n-hexane fraction of papaya peel were 79.6393%, 65.5173%, 84.5257%, and 48.0085%, respectively. The results of the total flavonoid content of the ethanol extract of papaya fruit peel, the water fraction of papaya fruit peel, the ethyl acetate fraction of papaya fruit peel, and the n-hexane fraction of papaya fruit peel were 55.1744%, 33.2677%, 87.2572%, and 21.1696%, respectively. Based on these results, it can be concluded that the greatest total phenolic and total flavonoid content was in the ethyl acetate fraction of unripe papaya fruit peel extract.
Identifikasi Bahan Kimia Obat dalam Sediaan Jamu Pegal Linu Menggunakan Metode Spektroskopi Inframerah Christina, Odilia Dea; Yudhantara, Sandi Mahesa; Solichah, Ayu Ina; Bulu, Atalia Tamo Ina
Jurnal Farmasi & Sains Indonesia Vol 8 No 2 (2025)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol8no2p150-156

Abstract

Pegel linu herbal medicine is one of the traditional remedies widely consumed by the community to relieve pain and fatigue. The high market demand, particularly through online marketplaces, has the potential to be misused by irresponsible producers by illegally adding pharmaceutical chemicals to enhance therapeutic effects. This study aimed to identify the presence of pharmaceutical adulterants, namely paracetamol, sodium diclofenac, and dexamethasone, in peg el linu herbal medicines circulating in the market using Fourier Transform Infrared (FTIR) spectroscopy. Ten herbal medicine samples were selected using purposive sampling based on criteria such as the absence of distribution permit numbers or the presence of exaggerated therapeutic claims. The samples were prepared through extraction procedures and analyzed using FTIR-ATR by comparing the sample spectra with reference standards. The results showed that one sample tested positive for paracetamol and one sample tested positive for dexamethasone, while sodium diclofenac was not detected in any of the samples. The presence of pharmaceutical adulterants was identified based on the appearance of characteristic functional groups such as O–H, N–H, and C=O at specific wavenumbers. These findings indicate that some peg el linu herbal medicines circulating in the market still contain illegal pharmaceutical adulterants, which may pose potential health risks to consumers.
Konseling Apoteker Sebagai Upaya Meningkatkan Kepuasan Pasien Tukak Lambung Di Apotek Kimia Farma Indriani, Syifa Alifia; Johar, Hendra Farma
Jurnal Farmasi & Sains Indonesia Vol 8 No 2 (2025)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol8no2p176-184

Abstract

Pharmaceutical services refer to how "patient care" is delivered. Pharmacist counseling is a crucial component aimed at improving therapeutic understanding and patient satisfaction, particularly in patients with peptic ulcers, who require discipline and adherence to appropriate medication. This study aimed to assess patient satisfaction with services before and after pharmacist counseling regarding peptic ulcers at Kimia Farma pharmacies. The sampling technique used was purposive sampling for peptic ulcer patients, resulting in a sample size of 100 respondents. This study employed a one-group pre-test-post-test and quasi-experimental method. Data analysis used SPSS 29 for Windows and Microsoft Office Excel 2016 to test SERVQUAL values, normality tests, and the Wilcoxon test. The Wilcoxon test demonstrated a significant difference in patient perceptions of the services received before and after pharmacist counseling. The Wilcoxon test also demonstrated a significant difference between expected and actual pharmacy services before and after pharmacist counseling. This indicates that pharmacist counseling has a significant impact on improving patient perceptions and satisfaction with the services received.
Formulasi Lilin Aromaterapi Kombinasi Minyak Atsiri Kulit Jeruk Nipis (Citrus aurantifolia) Dan Bunga Melati (Jasminum sambac L.) Dengan Cera Alba Sebagai Basis Sudarsono, Agustina Putri Pitarisa; Ramanda, Aulia Avida
Jurnal Farmasi & Sains Indonesia Vol 8 No 2 (2025)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol8no2p163-169

Abstract

Aromatherapy is an alternative treatment method that utilizes volatile essential oils to provide therapeutic Aromatherapy is an alternative treatment method using volatile essential oils to provide therapeutic effects such as relaxation and improved blood circulation. Lime peel essential oil contains limonene as a repellent, while jasmine flower essential oil contains linalool that promotes calmness. Cera alba is used as a candle base to support structure and burning stability. This study aimed to evaluate the effect of combining lime peel and jasmine essential oils with varying cera alba concentrations on the physical properties and acceptability of aromatherapy candles. Five candle formulas were prepared: F0 without essential oils as a control, and F1–F4 with varying concentrations of lime peel (0.1–0.3%) and jasmine (7–9%). Evaluations included organoleptic tests, melting point, burning time, and hedonic tests by panelists. Results showed that essential oil combinations influenced melting point, burning time, and aroma. Formula F3 (lime peel 0.2%, jasmine 7%, cera alba 82.8%) met all physical standards with an average melting point of 57°C, burning time of 168.67 minutes, and was most preferred by panelists. Statistical analysis confirmed normality and homogeneity, and post hoc tests (p < 0.05) indicated significant differences among formulas, demonstrating that essential oil combination and cera alba concentration determine candle quality and panelist preference.
Uji Aktivitas Antinosiseptik dan Analgetik Kombinasi Ekstrak Etanol Rumput Teki (Cyperus Rotundus L.) dan Ekstrak Etanol Daun Tapak Liman (Elephantopus Scaber L.) pada Mencit Putih Galur Swiss: Antinosiseptik dan Analgetik Ekstrak Etanol Rumput Teki dan Daun Tapak Liman Palupi, Poppy Diah; Leki, Karol Giovani Battista
Jurnal Farmasi & Sains Indonesia Vol 8 No 2 (2025)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol8no2p170-175

Abstract

Pain is an unpleasant sensory and emotional experience associated with actual or potential tissue damage. Medicinal plants have been increasingly explored as alternative analgesic agents due to their bioactive compounds. Cyperus rotundus L. contains flavonoids reported to possess analgesic properties, while Elephantopus scaber L. has traditionally been used for pain relief. This study aimed to evaluate the analgesic and antinociceptive activities of a combined ethanolic extract of Cyperus rotundus and Elephantopus scaber in male Swiss mice. This experimental laboratory study involved 10 groups of male Swiss mice (n=5 per group). Analgesic activity was assessed using the tail-flick test, while antinociceptive activity was evaluated using the hot plate test. Negative controls received CMC-Na 0.5% but were exposed to nociceptive stimuli. Positive controls received mefenamic acid (500 mg/kg BW) for analgesic testing and tramadol (50 mg/kg BW) for antinociceptive testing. Treatment groups received combined ethanolic extracts (ERTDTL) at doses of 700/400, 900/600, and 1100/800 mg/kg BW. Pain response latency was recorded 30 minutes after treatment. Data were analyzed using one-way ANOVA followed by the Dunnett post hoc test. The combined extract demonstrated significant analgesic and antinociceptive effects at all tested doses in mice subjected to thermal nociceptive stimuli. These findings suggest that the combination of extracts from Cyperus rotundus and Elephantopus scaber has potential as a natural analgesic agent.

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