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Jurnal Farmasi dan Sains Indonesia (JFSI)
Published by Sekolah Tinggi Ilmu Farmasi Nusaputera
ISSN : 26219360     EISSN : 26863529     DOI : https://doi.org/10.52216
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Medicine & Pharmacology Neuroscience
Focus and Scope Jurnal Farmasi & Sains Indonesia is an open-access journal that published twice a year by Sekolah Tinggi Ilmu Farmasi Nusaputera. This journal is a media of research publication on all aspects of pharmaceutical & science that is innovative, creative, original and based on scientific. Articles published in this journal about drug discovery, drug delivery systems and drug development with specific field include: 1. Medicinal chemistry 2. Pharmacology 3. Pharmacokinetics 4. Pharmacodynamics 5. Pharmaceutical analysis 6. Drug delivery systems 7. Pharmaceutical technology 8. Pharmaceutical biotechnology 9. Herbal medicines and active components 10. Clinical evaluation of the medicine
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 268 Documents
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Studi Fitokimia Kulit Nanas: Pengaruh Metode Pengeringan terhadap Kandungan Flavonoid Ekstrak Etanol: Studi Fitokimia Kulit Nanas: Pengaruh Metode Pengeringan terhadap Kandungan Flavonoid Ekstrak Etanol Wahyuningtiastuti, Ananta; Bulu, Atalia Tamo Ina; Priamsari, Margareta Retno; Solichah, Ayu Ina
Jurnal Farmasi & Sains Indonesia Vol 8 No 1 (2025)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol8no1p188-195

Abstract

Food waste refers to discarded food materials at the final stage of the food supply chain. One such waste product with potential for utilization in traditional medicine is pineapple peel (Ananas comosus (L.) Merr.), which contains various secondary metabolites, including flavonoids, alkaloids, saponins, and tannins. Among these metabolites, flavonoids are well-known for their antioxidant properties. This study aimed to compare the total flavonoid content in ethanol extracts of pineapple peel subjected to two different drying methods. The drying methods used were sun drying and oven drying at 50 °C. The dried pineapple peels were extracted using 96% ethanol through the Soxhlet extraction method. Phytochemical constituents were identified through colorimetric reactions and Thin Layer Chromatography (TLC). The total flavonoid content was determined colorimetrically using AlCl₃ reagent and measured by UV-Visible spectrophotometry at a wavelength of 439 nm, with quercetin used as the standard. The results indicated that the extract yields from the sun-dried and oven-dried samples were 5.60% and 5.75% (w/w), respectively. TLC analysis revealed Rf values of 0.85, 0.80, and 0.91. The total flavonoid content in the sun-dried sample was 35.44 ± 0.55 mgQE/g, while that in the oven-dried sample was 25.40 ± 0.98 mgQE/g. Statistical analysis using the Independent Sample t-test demonstrated a significant difference in total flavonoid content between the two drying methods.
FORMULASI DAN EVALUASI SEDIAAN SAMPO KOMBINASI EKSTRAK BONGGOL PISANG KEPOK (Musa x paradisiaca L.) dan MINYAK KELAPA (Virgin Coconut Oil) Akbar, Nanda Dwi; Cahyaningrum, Nineeteen Yuliya; Setiyaningsih, Wahyu; Solichah, Ayu Ina; Christina, Odilia Dea
Jurnal Farmasi & Sains Indonesia Vol 8 No 1 (2025)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol8no1p176-187

Abstract

Shampoo is a hair care product that is used to clean the hair and scalp.Shampoo containing natural ingredients can be an alternative for healthy scalp and hair.The saponin content in the kepok banana hump (Musa x paradisiaca L.) can function as a foamer and a combination of coconut oil (Virgin coconut oil) as a moisturizer (emollient).This research aims to formulate and evaluate a shampoo preparation containing banana weevil extract (Musa x paradisiaca L.) and coconut oil (Virgin coconut oil) in the shampoo preparation. This research is an experimental research. In this research, the formulation of kepok banana weevil extract (Musa x paradisiaca L.) 4%, 8% and 12% and coconut oil (Virgin coconut oil) concentrations of 10%, 12% and 15% were carried out. Extract yield was carried out using the maceration method using 96% ethanol solvent with a ratio of 1: 7.5. Evaluation of the physical properties of shampoo includes organoleptic observations, pH determination, specific gravity measurement, foam height measurement, viscosity and homogeneity testing.Data analysis was carried out using SPSS. Based on research on kepok banana weevil extract (Musa x paradisiaca L.)a thick, reddish brown colored extract was obtained, with a distinctive slightly sweet aroma with a yield of 11.4445% from 400 grams of dried banana weevil. The results of the phytochemical screening of the thick extract of banana weevils were positive for containing saponin compounds. The test results for shampoo preparations F1, F2 and F3 have a cream to brownish cream color, a liquid texture and a coconut banana smell, homogeneous preparations, pH range 6.72 – 8.23; has a foam height of 1.8 – 2.3 cm; viscosity 216 – 250 dPas and specific gravity 0.9569 – 1.0272 g/mL. The results of analysis using One Way ANOVA showed a p value <0.05 in foam height, pH value and viscosity for the three formulas, there were significant differences.This research shows that the addition of banana weevil extract (Musa x paradisiaca L.) and coconut oil (Virgin coconut oil) affects the characteristics of the shampoo preparation.
PENGARUH TINGKAT PENGETAHUAN DENGAN IMPLEMENTASI PROGRAM DAGUSIBU OBAT ANTIBIOTIK PADA MASYARAKAT DI KABUPATEN JEPARA Arofa, Izanur; Suwarni, Sri; Indrasari, Ferika; Saptawati, Tunik; Gloria, Fransisca
Jurnal Farmasi & Sains Indonesia Vol 3 No 2 (2020)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

The relatively high use of antibiotics poses a threat to the emergence and spread of antibiotic resistance, there are now several findings that antibiotics have been used freely by the public. These antibiotics are purchased to treat symptoms of flu, fever, cough, sore throat, headache and other minor pain symptoms with a duration of use of less than five days. The level of education and knowledge of the community is one of the causes of this. The DAGUSIBU program (get, use, store and dispose) is the most important thing because knowledge is one way to be able to use medicine, store, get, and dispose properly. The purpose of the study was to determine the effect of knowledge with the implementation of the DAGUSIBU program for antibiotic drugs in the community in Jepara Regency from January to March 2020. This type of research is associative research with observational methods. Data were taken prospectively with a quantitative approach from an action research questionnaire. The sample used amounted to 500 respondents. The sampling technique used purposive sampling. Data were processed with chi square and Wilcoxon statistical tests using the SPSS program. The results showed that after the treatment of counseling with video and exposure to speakers and the provision of brochures on the dangers of antibiotic resistance, there was an influence on the level of knowledge with the implementation of the antibiotic drug DAGUSIBU program in Jepara Regency. as evidenced by the p value of 0.00
PENETAPAN KADAR VITAMIN C PADA BUAH NANAS KALENG (Ananas comocus L.) DENGAN METODE SPEKTROFOTOMETRI UV-Vis DAN TITRASI IODIMETRI Ruwista, Anista; Sugiyo, Warlan; Mahesa, Sandi
Jurnal Farmasi & Sains Indonesia Vol 4 No 1 (2021)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

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Abstract

Vitamin C has an important role in the human body, namely carrying out its functions such as in the synthesis of collagen, the formation of carnitine, is involved in cholesterol metabolism, become bile acids, and plays an important role in the formation of the neurotransmitter norepinephrine. Vitamin C intake must be obtained from outside the body because this vitamin cannot be synthesized in the body through the biosynthetic pathway. Pineapple fruit is one of the fruits that contain vitamin C. The purpose of this study was to analyze the levels of vitamin C in canned pineapples for which the result of vitamin C on the AKB value on the packaging label were not known using UV-Vis spectrophotometry and iodimetric titration. The method used in the qualitative analysis of vitamin C is identification by color raction using Fehling A and B reagents and KMnO4 reagent. Quantitative analysis of vitamin C using the UV-Vis spectrophotometry method with a wavelength of 0,0031 % while the results from the iodimetric titration methode obtained an average % of vitamin C levels from canned pineapple samples of 0,050 % w/w.
Formulasi Dan Uji Aktivitas Sediaan Face Mist Ekstrak Etanol Daun Jarak Pagar (Jatropha curcas L.) Sebagai Antikosidan Dengan Metode DPPH Raru, Preiscylia; Marzuki, Asnah; Alam, Syamsul
Jurnal Farmasi & Sains Indonesia Vol 8 No 2 (2025)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol8no2p15-22

Abstract

Jarak pagar (Jatropha curcas L.) one as an antioxidant. This research aims to obtain a formulation in the form of a stable face mist dosage form and determine the IC50 value of the extra ethanol face mist preparation from jatropha leaves (Jatropha curcas L.) which has potential as an antioxidant. Experimental research method using 96% ethanol solvent, maceration method. The resulting thick extract is rotated, then preparations are made with concentrations of 0.1%, 0.3% and 0.5%, using additional ingredients glycerin as a humectant, propylene glycol as a humectant, sodium benzoate as a preservative, lavender as a fragrance and distilled water. as a solvent. Evaluation of the preparation, namely the cycling test in 6 cycles for 12 days, organoleptic observations obtained in liquid form, pH measurement results were <0.05p, homogeneity tests obtained homogeneous preparations, Viscosity test results were <0.05p, skin moisture and irritation tests were <0.05p. As well as antioxidant testing using the DPPH method using a UV-Vis spectrophotometer. The results of the research can be concluded that Jatropha curcas L. extract can be formulated as a face mist preparation that is physically and chemically stable. The IC50 values ​​using the facial mist preparation formula of Jatropha curcas (Jatropha curcas L.) leaf extract were respectively 17.0276 ppm, 16.5071 ppm, and 13.4743 ppm. The most effective face mist formulation has the highest antioxidant value in formula III.
Variasi Komponen Informasi Obat Pada Etiket Obat Resep Isnenia, Isnenia; Satriawan, Ahmad Bayu
Jurnal Farmasi & Sains Indonesia Vol 8 No 2 (2025)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol8no2p23-28

Abstract

Prescription drug label as a means of communication between pharmaceutical staff and patients.  Inadequate prescription drug labels can be a major source of medication errors. This can be exacerbated by the diversity of labels, formats, designs and information components. This study aims to observe prescription drug label in Bandar Lampung City health centers and to determine benefits of prescription drug label. This research was conducted cross-sectional on hypertensive patients regarding prescription drug label and its level of benefit. The results obtained show that there are two materials in prescription drug label. Every health center has a format for prescription drug labels. The label attached to the plastic clip does not contain the identity of the pharmaceutical service facility such as name, address and pharmacist's license. For printed paper labels, this information is a template that will be printed on all label materials that will be used. Information on the date and prescription number, patient name, instructions for use, and time to take the medication is available at all health centers. There is only one health center that has the format for address, date of birth, use, side effects, name of medicine and expiry date. More than 90% of respondents assessed that the labels provided were good and had a high level of benefit. The conclusion is that there are variations in the materials, formats and information components included in the dietetics. Medication labels are considered by patients to have a high level of benefit in the treatment process.
UJI CEMARAN MIKROBA ANGKA LEMPENG TOTAL (ALT) DAN ANGKA KAPANG KHAMIR (AKK) PADA EKSTRAK ETANOL UMBI LOBAK PUTIH (Raphanus sativus L.) Ilham, Kasmal; Solikah, Wahyu Yuliana; Emelda, Emelda; Fauzi, Rizal
Jurnal Farmasi & Sains Indonesia Vol 8 No 2 (2025)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol8no2p36-41

Abstract

White radish (Raphanus sativus L.) is a food plant with promising potential for development as a raw material for traditional medicines and functional foods. The microbiological quality of plant extracts is a critical parameter in ensuring product safety, particularly with regard to microbial contamination. By measuring the Total Plate Count (TPC) and Yeast and Mold Count (YMC), this study sought to assess the microbiological contamination of the ethanol extract of white radish tubers.  In order to measure live microorganisms expressed as CFU/g, the experiments were carried out using the pour plate technique on plate count agar (PCA).  The findings demonstrated that the ethanol extract's TPC and YMC values were both less than 1 × 10¹ CFU/g. These values are significantly lower than the maximum limits required by BPOM Regulation Number 29/2023, namely ≤10⁵ CFU/g for TPC and ≤10³ CFU/g for YMC. These findings indicate that the extraction and handling processes produced an extract with minimal microbial contamination. Overall, the results demonstrate that the ethanol extract of white radish meets microbiological safety requirements and is suitable for use as a raw material candidate in the development of traditional medicinal products.
Formulasi Self Nanoemulsifying drug delivery system Enzim Bromelain buah Nanas Ananas comosus Fresiva, Urva; Rochman, M Fatchur; Tianingsih, Flomaria; Pratiwi, Resty; Anugrahi, Amalia
Jurnal Farmasi & Sains Indonesia Vol 8 No 2 (2025)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol8no2p9-14

Abstract

The pineapple fruit's bromelain enzyme exhibits pharmacological activity as an antibacterial and anti-inflammatory. The bromelain enzyme was formulated as tablets and powders in earlier research, although this still had the disadvantage of having a higher formulation resistance. Formulating and characterizing SNEDDS of the bromelain enzyme with oil phase, surfactant, and co-surfactant—specifically, clove oil, propylene glycol, and PEG 400—is the goal of this study. The process for creating SNEDDS bromelain enzyme involves combining the carrier in different quantities, adding the enzyme, and evaluating it based on factors including homogeneity, adhesion, spreadability, clarity, and organoleptic characteristics. The active ingredient in the SNEDDS formulation that was obtained was 360 mg of bromelain enzyme per milliliter of SNEDDS. With a 2:5:3 concentration ratio of clove oil, PG, and PEG 400, the transmittance percentage of SNEDDS is 98.54 ± 0.02%, the spreadability is 2.2 cm, the adhesion is 116 seconds, and the pH is 6.48. In comparison to other carrier concentrations, SNEDDS bromelain enzyme SNEDDS with a concentration ratio of 2:5:3 for clove oil, PG, and PEG 400 yields superior characteristic results.
Tingkat Kepatuhan Minum Obat Pasien Tuberculosis Rawat Jalan di RSUD Soehadi Pridjonegoro Kabupaten Sragen Khusna, Khotimatul; Amalina, Syahida Ulya; Qonitah, Fadilah
Jurnal Farmasi & Sains Indonesia Vol 8 No 2 (2025)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol8no2p42-50

Abstract

Tuberculosis (TB) is a contagious infectious disease that is still a global health problem, with Indonesia as one of the countries with the highest cases. The success of TB therapy is highly dependent on patient compliance in taking anti-tuberculosis drugs (OAT) regularly. Factors that influence the level of medication compliance in pulmonary TB patients are gender, age, occupation, education, family support, and drug side effects. This study aims to determine the level of compliance of patients taking outpatient pulmonary TB medication at Soehadi Pridjonegoro Regional Hospital, Sragen Regency. This research uses a descriptive method with a quantitative approach. The sample used in the research was 97 respondents. Sampling using techniques purposive sampling. Data was taken using a validated questionnaire created based on the MARS questionnaire (Medication Adherence Rating Scale). The results of the study showed that patients with a high level of compliance were 65 respondents with a percentage of (67%) and moderate compliance was 32 respondents with a percentage of (33%). The conclusion of this research is that patients take outpatient pulmonary TB medication at Soehadi Pridjonegoro Hospital, Sragen Regency with a high level of compliance (67%) with a total of 65 respondents.
Evaluasi Penggunaan Obat Triheksifenidil Sebagai Terapi Adjuvan Pada Pasien Fangguan Afektif Bipolar Di Rumah Sakit Jiwa Provinsi Jawa Barat Cantika, Erika; Putri, Fitria Sulistia; Purwaeni, Purwaeni; S, Encep; Nur, Ice Laila
Jurnal Farmasi & Sains Indonesia Vol 8 No 2 (2025)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol8no2p51-56

Abstract

Background: Bipolar affective disorder is a mental disorder that attacks the psychological condition, characterized by mood swings in the form of mania and depression. The high number of mental health cases in Indonesia is one of the challenges of treatment, especially in the pharmaceutical world. Evaluation of drug use is a structured quality assurance program, and provides assurance that the drugs given are appropriate, safe, and effective. Objective: This study aims to evaluate the use of trihexyphenidyl in patients with bipolar affective disorder at the West Java Provincial Mental Hospital. Methods: The research design used was a retrospective observational study with a descriptive cross-sectional approach. The data source used in the study was written information in the medical records of mental patients diagnosed with bipolar affective disorder who received trihexyphenidyl drug therapy at the West Java Provincial Mental Hospital. Results: Based on the results of the study, 93 patients diagnosed with bipolar affective disorder using trihexyphenidyl were obtained, the results of the ANOVA test on the evaluation of drug use showed a significance value of 0.021 <0.05 so that it can be concluded that the data has differences from the research variables. Conclusion: Based on the results of the study, it can be concluded that the evaluation of the use of trihexyphenidyl drugs in patients with bipolar affective disorder is appropriate and in accordance with the rationality of drug use.

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