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Jurnal Farmasi dan Sains Indonesia (JFSI)
Published by Sekolah Tinggi Ilmu Farmasi Nusaputera
ISSN : 26219360     EISSN : 26863529     DOI : https://doi.org/10.52216
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Medicine & Pharmacology Neuroscience
Focus and Scope Jurnal Farmasi & Sains Indonesia is an open-access journal that published twice a year by Sekolah Tinggi Ilmu Farmasi Nusaputera. This journal is a media of research publication on all aspects of pharmaceutical & science that is innovative, creative, original and based on scientific. Articles published in this journal about drug discovery, drug delivery systems and drug development with specific field include: 1. Medicinal chemistry 2. Pharmacology 3. Pharmacokinetics 4. Pharmacodynamics 5. Pharmaceutical analysis 6. Drug delivery systems 7. Pharmaceutical technology 8. Pharmaceutical biotechnology 9. Herbal medicines and active components 10. Clinical evaluation of the medicine
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 244 Documents
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Analisis Efektivitas Biaya Terapi Antibiotik pada Pneumonia di RSUD Sleman Tahun 2023 Yogananda, Amrina Amalia; Faizah, Nurul; Hidayati, Listiana
Jurnal Farmasi & Sains Indonesia Vol 8 No 1 (2025)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol8no1p156-161

Abstract

Pneumonia is an infectious disease caused by microorganisms, including viruses, bacteria, fungi, and parasites. One of the pharmacological therapies used to treat pneumonia is antibiotics. In determining antibiotics, it is necessary to select the frequency to determine the most effective and cost-effective therapy. CEA is a pharmacoeconomic method presented in the cost-effectiveness ratio to assist in drug selection decisions. This study aims to determine the most cost-effective antibiotics at Sleman Regional Hospital during 2023. Data was collected retrospectively using the medical records of pneumonia patients. The number of samples obtained was 27 patients diagnosed with pneumonia. The results showed that males suffered more from pneumonia (62.96%), the most common age was >65 years (37.04%), with a length of hospitalization of ≤5 days (70.37%). The average direct medical cost for single therapy in pneumonia patients is the largest levofloxacin of Rp 9.975.494, and the combination of oral ceftriaxone + azithromycin of Rp 14.802.488. The highest therapeutic effectiveness for single therapy is ceftriaxone at 90%, and the combination of ceftriaxone + gentamicin is 100%. Based on the ACER calculation, ceftriaxone is more cost-effective than levofloxacin for single therapy with an ACER value of Rp 86.967,94. For combination therapy, ceftriaxone + gentamicin is more cost-effective than ceftriaxone-oral azithromycin with an ACER value of Rp 61.922,26.
ANALISIS KUALITAS MIKROBIOLOGI KEFIR SUSU KAMBING YANG DIPEROLEH DARI HOME INDUSTRI DIBERGAS KAB . SEMARANG Alfiyaturrakhma, Untsa; Puspitaningrum, Anisa Nova; Dahliyanti, Novita Dwi
Jurnal Farmasi & Sains Indonesia Vol 8 No 1 (2025)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol8no1p229-233

Abstract

Kefir is a fermented milk product known for its health benefits, primarily due to its probiotic microorganism content. One type of milk that is increasingly popular for making kefir is goat's milk, as it has a composition that is easier to digest and has high nutritional potential. However, the microbiological quality of goat milk kefir needs to be thoroughly analyzed to ensure its safety and probiotic effectiveness. The presence of microorganisms such as lactic acid bacteria, yeast, and potential pathogenic contaminants plays a crucial role in determining the quality of kefir, both in terms of health benefits and product stability. Therefore, analyzing the microbiological quality of goat milk kefir is essential as a foundation for developing safe, high-quality, and nutritious functional food products. Research Objective : This study aims to analyze the microbiological quality of kefir made from goat’s milk, with a focus on identifying and quantifying the dominant microorganisms involved in the fermentation process, such as lactic acid bacteria and yeast. Research Method: The analysis of microbiological quality was carried out using the Total Plate Count (TPC) method. The counts of bacteria and yeast were conducted in duplicate. The results were then compared to the Indonesian National Standard (SNI) for fermented beverages.
Gambaran Kepatuhan Penderita Hipertensi Di Puskesmas Ngaliyan Kota Semarang Dengan Pendekatan Social Cognitive Theory (SCT) Gloria, Fransisca; Safrida, Safrida; Dahliyanti, Novita Dwi; Vidiani, Anak Agung Pradnya Paramitha; Suwarni, Sri
Jurnal Farmasi & Sains Indonesia Vol 8 No 1 (2025)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol8no1p257-263

Abstract

Based on the 2018 Riskesdas, the prevalence of hypertension in Indonesia was 34.1%, where Central Java reached 37.57%, and Semarang City ranked first at 19.56%. Hypertension is a major risk factor for cardiovascular disease that occurs when a person's blood pressure is 140/90 mmHg or more, also due to patient's non-compliance in taking medication. This study aims to determine the picture of compliance in patients with hypertension using the Social Cognitive Theory (SCT) approach. This observational study used a cross-sectional method with the Hill-Bone and SCT compliance questionnaires. This study was conducted at the outpatient pharmacy service of the Ngaliyan Health Center in Semarang City in the period March-May 2024 with a total of 145 respondents. The results obtained were that the level of compliance in taking medication for hypertension patients mostly had a moderate level of compliance of 100 respondents (69%), while respondents who had a low level of compliance were 30 respondents (21%) and those who had high compliance were 15 respondents (10%). The results of the SCT approach showed that most hypertension sufferers were in the high category with 56 respondents (47%), the moderate category with 68 respondents (47%), and the low category with 21 respondents (14%).
ANALISIS FAKTOR KERENTANAN INDIVIDU TERHADAP INFEKSI FILARIASIS DI DAERAH KURIPAN KERTOHARJO PEKALONGAN SELATAN Nurainy, Farah Destyana; Puspitaningrum, Anisa Nova; Alfiyaturrakhma, Untsa
Jurnal Farmasi & Sains Indonesia Vol 8 No 1 (2025)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol8no1p53-59

Abstract

Filariasis is a chronic infectious disease caused by filarial worm infection and transmitted through mosquito bites as a vector. This disease is still a public health problem in several regions in Indonesia, including in Kuripan Kertoharjo Village, South Pekalongan District, which is an endemic area for filariasis. The purpose of this study was to analyze the factors that influence individual susceptibility to filariasis infection in the region. This study used a quantitative design with a cross-sectional approach. The sample consisted of 100 respondents who were selected purposively based on certain criteria such as domicile, age, and exposure history. Data were collected through structured questionnaires, in-depth interviews, and observations of the environmental conditions of the respondents' homes. The variables studied included demographic factors (age, gender, occupation), individual behavior (use of mosquito nets, habits of going out at night), level of knowledge about filariasis, and environmental conditions (sanitation, presence of puddles, housing density). Data analysis was carried out using the chi-square test and logistic regression to determine the relationship and influence of each variable on infection susceptibility. The results showed that low levels of knowledge, the habit of not using mosquito nets, and poor environmental conditions significantly increased the risk of individuals contracting filariasis (p < 0.05). The conclusion of this study is that susceptibility to filariasis is influenced by the interaction between behavioral factors, knowledge, and environmental conditions. Public health interventions that focus on education, behavioral change, and environmental improvement are needed to reduce the rate of filariasis transmission in endemic areas.
Optimasi dan Formulasi Sediaan Antiinflamasi Nano Spray Gel Ekstrak Fermentasi Jahe Merah (Zingiber officinale var. rubrum) Dewi, Ni Wayan Rika Kumara; Putri, Pande Putu Cintya Wiarni; Artika, Made Prita
Jurnal Farmasi & Sains Indonesia Vol 8 No 1 (2025)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol8no1p108-118

Abstract

Abstract Red ginger (Zingiber officinale var. rubrum) is one of the herbal plants that has anti-inflammatory activity. This study aims to determine the effect of red ginger fermented extract concentration on the physical quality test of nano spray gel preparation. The research method used was laboratory experimentation including fermentation process, extraction, and preparation of nano spray gel. Fermentation of red ginger powder simplisia using Trichoderma harzianum. Formulation of nano spray gel dosage form with active ingredient of red ginger fermented extract with variation of extract concentration 0% (F0); 0.25% (F1); 0.50% (F2); 0.75% (F3); and 1% (F4). Physical quality evaluation included organoleptic test, homogeneity, pH, viscosity, adhesive spreadability, spray pattern, dry time, percent transmittance and phase separation. The results showed that all formulations had good characteristics. Organoleptic tests met the criteria, all preparations were homogeneous with a pH range of 5.6-5.9, viscosity 1884-513 cps, optimal adhesive spreadability, good spray pattern, dry time less than 5 minutes, percent transmittance 98.8-99.9% and no phase separation. Statistical analysis using ANOVA showed significant differences in viscosity test (p = 0.000), dry time test (p = 0.000) and percent transmittance test (p = 0.000), while pH test (p = 0, 059) did not show significant differences. The conclusion of this study is that the concentration of red ginger fermented extract affects the physical quality of nano spray gel preparations with 1% concentration declared the most optimal. Keywords: red ginger, anti-inflammatory, fermentation, nano spray gel
Studi In Silico dari Metabolit Invertebrata Laut Indonesia terhadap Protein ACE2 dan Spike Protein SARS-CoV-2 Varian Omicron Claus, Matheus Prayoga; Putra, Masteria Yunovilsa; Wibowo, Joko Tri; Yanuar, Arry
Jurnal Farmasi & Sains Indonesia Vol 8 No 1 (2025)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol8no1p128-139

Abstract

Indonesia has a diverse marine biota with bioactive substances that may provide a way to overcome COVID-19. In this research, we explored secondary metabolites isolated from marine invertebrates in Indonesia. A total of 137 compounds from different types of invertebrates were screened against ACE2 and SARS-CoV-2 Omicron spike protein. In relation, molecular docking and ADMET prediction were investigated to find the best compound. A molecular dynamics study was performed to determine the stability of the binding between the compound and ACE2 and RBD of the Omicron spike protein virus receptor. The results showed that acanthomanzamine E and cortistatin L have prominent molecular docking properties as ACE2 and SARS-CoV-2 Omicron spike protein blockers with binding energies of -12.87 and -9.96 kcal, respectively. The ADMET results also showed that both compounds have a promising drug-likeness, with only minor exceptions in partition coefficient (logP) and half-life. In conclusion, acanthomanzamine E and cortistatin L have shown significant potential as lead compounds for drug targeting ACE2 and SARS-CoV-2 blockers.
Formulasi Dan Evaluasi Fisik Sediaan Shaving Cream Ekstrak Rimpang Kunyit (Curcuma longa Linn.) Jesica, Imelda Angie; Maillinda, Putri; Wijaya, Octa Vanessia; Mungkur, Theresia Rohani; Lisangan, Angelyn Jessica; Ayuningtyas, Nurista Dida
Jurnal Farmasi & Sains Indonesia Vol 8 No 1 (2025)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol8no1p95-102

Abstract

The hair follicle is an unavoidable part of the skin and its growth can make some people feel uncomfortable. The use of shaving cream can help the shaving process, but daily use can cause the skin to become dry. Turmeric (Curcuma longa Linn.) is often used in cosmetics because it has antioxidant and anti-inflammatory properties that maintain moisture and reduce skin redness. Curcumin in turmeric also has antiandrogenic effects that can remove fine hair. This study uses curcumin contained in turmeric as the active substance of shaving cream which has a concentration of 0.1%; 0.25%; 0.5%. Antioxidant activity testing was carried out with DPPH radical scavenging (2.2-diphenyl-1-picylhydrazyl) resulting in IC50 on turmeric extract of 94.63 ppm. The results of phytochemical screening on extracts are known to contain secondary metabolites that were successfully analyzed were Flavonoids, Alkaloids, Triterpenoids, Tannins, Anthraquinones, and Polyphenols. The physical evaluation of turmeric rhizome extract shaving cream preparation meets the requirements, except for the pH test. The results obtained IC50 values of turmeric rhizome extract shaving cream are 1377.78 ppm in F1; 1591.55 ppm in F2; and 1637.93 ppm in F3, so it is still classified as very weak and less effective. In the skin moisture test on 10 respondents with 5 women and 5 men there was an increase in % moisture after the use of shaving cream on days 1, 3, 5 and 7.
Pengaruh Pemberian Antipsikotik terhadap Sindrom Metabolik pada Pasien Skizofrenia di Rumah Sakit X Jakarta Periode Juli 2023 – Desember 2023 Anggraeni, Vivi; Futihat, Chilyati Eky; Arianti, Anisa Rachmita; Perwitasari, Melania
Jurnal Farmasi & Sains Indonesia Vol 8 No 1 (2025)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol8no1p81-94

Abstract

Schizophrenia is a severe mental disorder requiring long-term treatment with antipsychotics. Although effective in managing psychotic symptoms, antipsychotics such as Haloperidol (first-generation) and Clozapine (second-generation) carry risks of inducing metabolic syndrome, particularly hypertension and obesity. This study aims to compare the effects of Haloperidol and Clozapine use on the incidence of metabolic syndrome, specifically hypertension and obesity, in schizophrenia patients based on the 2021 PERKENI criteria. This analytical non-experimental study used a cross-sectional design with retrospective data from medical records of inpatient schizophrenia patients at X Regional Special Hospital Jakarta from July–December 2023. A total of 95 patients were selected by purposive sampling. Data were analyzed using the Mann-Whitney test. The majority of patients were male (56 patients, 58.95%) and aged 31–50 years (44 patients, 46.32%). Haloperidol was used by 50 patients (52.63%), while Clozapine was used by 45 patients (47.37%). The medication was administered orally as a single agent, 1–3 times daily, with doses ranging from 0.5 mg to 100 mg and an average treatment duration of 30 days. Total drug administrations were recorded 133 times due to some patients receiving more than one dosage form (tablet and single compound). Metabolic syndrome was observed in 40 patients (42.11%). Haloperidol significantly increased blood pressure compared to Clozapine (p = 0.036), but no significant difference was found in body mass index (p = 0.885). Haloperidol poses a higher risk of inducing hypertension than Clozapine. Routine blood pressure monitoring is essential during therapy.
Molecular Docking Study of Quercetin as an IGF1R Inhibitor for Anticancer Potential Suryani, Puput Eka; Putri, Raden Roro Erni Kusuma; Mahanani, Annisah
Jurnal Farmasi & Sains Indonesia Vol 8 No 1 (2025)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol8no1p60-68

Abstract

Cancer is one of the leading causes of death in the world and its incidence continues to increase every year. In 2024, there will be more than 20 million new cases of cancer with a death toll reaching 10 million people. This high mortality rate is a challenge in itself in developing effective, selective, and minimal side effect cancer therapies. One approach that is currently being widely developed is therapy based on suppressing the cancer cell growth signal pathway, one of which is through inhibition of the Insulin-like Growth Factor 1 Receptor (IGF1R) receptor which is known to play an important role in proliferation, metastasis, and resistance to cancer therapy. From several experiments based on quercetin as an IGF1R inhibitor, there has been no explanation whether quercetin is capable of being an IGF1R inhibitor agent at the intracellular level. This study aims to evaluate the role of quercetin on the kinase domain and its activity at the ATP-binding site in silico through the molecular docking method. Based on the results of the study, it was concluded that quercetin is capable of acting as an IGF1R protein inhibitor. This was confirmed by several bonds formed between residues Val331A, Asp292A, Glu294A, Ser287A through hydrogen bonds with quercetin
End User’s Computing Satisfaction Untuk Sistem Informasi Obat Bahan Alam Pada Tenaga Vokasi Farmasi Sebagai Pengguna Di Kota Semarang Ratu, Modestus; Suwarni, Sri; Wulandari, A. Ratna; Aditya, Martanty; Santoso, Arif
Jurnal Farmasi & Sains Indonesia Vol 8 No 1 (2025)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol8no1p196-202

Abstract

The use of herbal medicine is a method of treatment that utilizes plants, either empirically by the community or with the help of information from healthcare professionals. This research aims to evaluate the level of satisfaction and the strength of the relationship between the dimensions of satisfaction using the End User’s Computing Satisfaction method by Pharmacy Vocational Personnel towards the Natural Herbal Medicine Information System (SI-OBAL) in Semarang City. This research is a non-experimental study with the EUCS method, which is qualitatively quantified prospectively. The instrument used was a questionnaire that has been tested by experts and through validation and reliability testing. The data was analyzed using frequency statistics to describe the characteristics of the respondents and the percentage of each dimension, which includes end-user satisfaction with technological aspects such as content, accuracy, format, timeliness, and ease of use of the system. The results of the study show that the overall level of satisfaction of Pharmacy Vocational Personnel with the Natural Herbal Medicine Information System (SI-OBAL) is 84.19%, which is categorized as very satisfied. This indicates that SI-OBAL has successfully met the needs and satisfaction of Pharmacy Vocational Personnel in Semarang City.

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