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Jurnal Farmasi dan Sains Indonesia (JFSI)
Published by Sekolah Tinggi Ilmu Farmasi Nusaputera
ISSN : 26219360     EISSN : 26863529     DOI : https://doi.org/10.52216
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Medicine & Pharmacology Neuroscience
Focus and Scope Jurnal Farmasi & Sains Indonesia is an open-access journal that published twice a year by Sekolah Tinggi Ilmu Farmasi Nusaputera. This journal is a media of research publication on all aspects of pharmaceutical & science that is innovative, creative, original and based on scientific. Articles published in this journal about drug discovery, drug delivery systems and drug development with specific field include: 1. Medicinal chemistry 2. Pharmacology 3. Pharmacokinetics 4. Pharmacodynamics 5. Pharmaceutical analysis 6. Drug delivery systems 7. Pharmaceutical technology 8. Pharmaceutical biotechnology 9. Herbal medicines and active components 10. Clinical evaluation of the medicine
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 268 Documents
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OPTIMASI FORMULA TABLET ATTAPULGITE DENGAN KOMBINASI LAKTOSA DAN AVICEL PH 101 TERHADAP MUTU FISIK TABLET MENGGUNAKAN SIMPLEX LATTICE DESIGN Utami, Anisa Tri; Nopiyanti, Vivin; Priyanto, Widodo
Jurnal Farmasi & Sains Indonesia Vol 8 No 2 (2025)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol8no2p29-35

Abstract

Attapulgite is one of the drugs from the adsorbent class for anti-diarrhea. In the form of light cream-colored powder and very fine. This study aims to determine the effect of the combination of lactose and avicel PH 101 on the PHysical quality of attapulgite tablets and to obtain the optimum formula. Attapulgite tablets were made by wet granulation and formula optimization using the Simplex Lattice Design method using Design Expert software version 13 to find out the combination of lactose and avicel PH 101. Attapulgite tablets were made into 8 formulas with variations in comparing the proportions of lactose and avicel PH 101 according to the results range of simplex lattice designs. Critical point parameters and optimum formulas were obtained from the response of hardness, brittleness, and disintegration time, and were verified using the one-sample t-test statistical program. The results of this research were variations in concentration of all attapulgite tablet formulas resulting in good PHysical quality of the tablets. The combination of lactose and avicel PH 101 has the effect of increasing hardness, reducing brittleness, and speeding up disintegration time. The proportion of lactose 66,739 mg and avicel PH 101 33,261 mg produces the optimum formula for attapulgite tablets with the best PHysical quality of the tablets.
Hubungan Kepatuhan Minum Obat Anti Tuberkulosis Dengan Keberhasilan Pengobatan Tuberkulosis Pada Pasien Sensitif Obat Di Puskesmas Pamolokan Kabupaten Sumenep Istiqomah, Hamlatul Jamiliyatil; Firmaniar, Rizdyana; Trisno, Zetiawan; Puspitasari, Aldita Cahyani
Jurnal Farmasi & Sains Indonesia Vol 8 No 2 (2025)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol8no2p144-149

Abstract

Tuberculosis (TB) is a contagious infectious disease caused by the bacterium Mycobacterium Tuberculosis. Tuberculosis is transmitted through sputum or saliva containing tuberculosis bacilli. Tuberculosis is one of the world's health threats. The purpose of this study was to determine the relationship between adherence to taking anti-tuberculosis drugs and the success of tuberculosis treatment in drug-sensitive patients at the Pamolokan Health Center, Sumenep Regency. This study used a quantitative method with an observational survey approach using a Cross Sectional Research design. The population in this study were all drug sensitive tuberculosis patients undergoing treatment at the Pamolokan Health Center, Sumenep Regency in the January-June period, namely 32 people with total sampling techniques. The results of this study were 30 people as much as (93.75%) had compliant treatment compliance results. Based on the results of the study, it can be concluded that there is a relationship between adherence to taking medication with the success of anti-tuberculosis treatment. It is recommended that family members pay attention to sick family members, provide motivation, care, bring medical treatment and provide support to sick family members.
Uji Efektivitas Gel Ekstrak Etanol Daun Binahong (Anredera cordifolia) Sebagai Penyembuhan Luka Pada Tikus Wistar Jantan (Rattus norvegicus) Siregar, Mardiana; Huda, Nurul; Afika, Ariyati N; Aida, Nur; Syahfitri, Siska; Anglia, Rima; Budyana, Irenia Putri
Jurnal Farmasi & Sains Indonesia Vol 8 No 2 (2025)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol8no2p157-162

Abstract

The ethanol extract of binahong leaves contains alkaloids, flavonoids, steroids, tannins and saponins. The compounds contained in the extract have an important role in healing skin incision. The aim of this study was to develop a gel formula for binahong leaf extract (Anredera cordifolia (Ten.) Steenis) with various HPMC gelling agents at concentrations of 2%, 3% and 4%. This study is an experimental study by comparing the effectiveness of incision wound healing in rats in each test group, namely negative control given gel base, positive control given Bioplacenton gel, and the gel formulation of binahong leaf with best stability properties of the gel preparation. The best formula for binahong leaf extract gel is with a concentration of 2% HPMC with consideration of evaluating the physical properties of the gel and the fastest healing effect on burns.
Pengaruh Penggunaan Obat Khelasi Besi Terhadap Perubahan Kadar Ferritin Serum Pada Pasien Thalasemia Di Rumah Sakit Umum Daerah “X” Kota Bekasi Agustiani, Elsya; Futihat, Chilyati Eky; Arianti, Anisa Rachmita; Maifitrianti, Maifitrianti
Jurnal Farmasi & Sains Indonesia Vol 8 No 2 (2025)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol8no2p57-65

Abstract

Thalassemia is a blood disorder that is inherited from both parents to their children. Ferritin levels are often elevated due to repeated blood transfusions that cause iron buildup in the body, leading to serious complications if not treated with iron chelation therapy. Iron chelation is a therapeutic method to reduce excessive iron levels in the body that is not bound in plasma and excreted from the body. To see the effect of using iron chelation drugs on reducing serum ferritin levels in patients with thalassemia beta major. Analytical observational research with a retrospective cross-sectional study design using limited secondary medical record data. The sampling technique used consecutive sampling with the inclusion criteria of beta major thalassemia patients with serum ferritin levels ≥1000ng/mL who received a single iron chelation therapy treatment. The effect of iron chelation drug administration in beta major thalassemia patients on reducing serum ferritin levels was analyzed using the Wilcoxon Signed-Ranks Test. In this study, 50 patients met the inclusion criteria. 52% of patients were female, and 40% had an age range of 0-5 years. The most common single iron chelation drug was Deferasirox (85%), with a dose of 250 mg (49%). A total of 6% of patients had decreased serum ferritin levels (≥500ng/mL and <1000ng/mL). However, the results of the data analysis showed that there was no significant decrease in serum ferritin levels after single iron chelation. This study showed that single iron chelation therapy was effective in reducing serum ferritin levels, but not significant (p value>0.05).
Analisis Metode Perencanaan Dan Pengendalian Persediaan Obat Fast Moving Di Apotek Durikulon Negara, Sri Bintang Sahara Mahaputra Kusuma; Khumairo, Lina Nurna; Suryani, Andini
Jurnal Farmasi & Sains Indonesia Vol 8 No 2 (2025)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol8no2p1-8

Abstract

Drug availability is a crucial component of pharmaceutical services to ensure optimal patient care. Inadequate inventory planning and control, particularly for fast-moving drugs, often lead to stock shortages or surpluses that disrupt services and increase operational risks. This study aimed to analyze drug inventory planning and control for fast-moving items at Pharmacy X using consumption methods, Economic Order Quantity (EOQ), safety stock, and reorder point (ROP) approaches. This descriptive quantitative research utilized stock cards and observation sheets as instruments. Data on drug usage, stock availability, and procurement patterns from November 2024 to January 2025 were collected and analyzed. The results showed that applying these methods, such as for Renadinac tablets, produced an optimal procurement plan of 539 tablets, EOQ of 416 tablets, safety stock of 490 tablets, and a reorder point of 791 tablets. Proper planning and inventory control effectively ensured drug availability and optimized stock management.
Analisis Tingkat Kepuasan Pasien Rawat Jalan Pada Pelayanan Kefarmasian Di Rumah Sakit Universitas Sebelas Maret Periode Bulan Oktober Tahun 2023 Abadi, Dzithauly Maulidiva; Rejeki, Endang Sri; Purwaningsih, Avianti Eka Dewi Aditya
Jurnal Farmasi & Sains Indonesia Vol 8 No 2 (2025)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol8no2p66-71

Abstract

Pharmaceutical health services need to be considered service standards, one of which is about patient satisfaction with pharmaceutical services in hospitals. Patient satisfaction is the patient's assessment of the service delivery received. The purpose of the study was to determine the level of patient satisfaction with pharmaceutical services and determine the relationship between the level of satisfaction with the dimensions of patient satisfaction. This type of research is descriptive non-experimental with cross sectional method. The study used 100 respondents. Data collection using accidental sampling method. Data analysis used univariate tests to obtain frequency distribution of patient satisfaction levels. Simple linear regression bivariate analysis to determine the relationship between patient satisfaction level and satisfaction dimension. The patient satisfaction level of the pharmaceutical installation of Sebelas Maret University Hospital obtained reliability results of 75.25%, responsiveness 70.43%, emphty 69.16%, assurance 77%, tangible 74.87%. The relationship between service quality and the highest level of satisfaction obtained the responsiveness dimension of 0.742
Uji Aktivitas Analgetik Ekstrak Rimpang Bangle (Zingiber purpureum R.) Pada Tikus Putih Jantan Dengan Metode Writhing Test Shahira, Iyem; Ningsih, Dwi; Herowati, Rina
Jurnal Farmasi & Sains Indonesia Vol 8 No 2 (2025)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol8no2p72-79

Abstract

Pain is an unpleasant emotional sensation caused by tissue damage. Bangle rhizome is a plant that can be used to treat pain. The purpose of this study was to determine the analgesic activity of a 96% ethanol extract of bangle rhizome in male white Wistar rats and to determine the most effective dose for producing analgesic effects. Bangle rhizome was extracted by maceration method using 96% ethanol solvent. This study used Writhing test method at 25 male divided into five groupes. Group I as negative control was administered 0,1% CMC, group II as positive control was administered acid mefenamic, group III, IV, and V was administered extract of bangle rhizome. The data obtained from this study were the number of wriggles of the test animals and the reaction time of the test animals' responses (minute). The result of the research showed that extract doses 30,843 mg/200 g BB, 61,686 mg/ 200 g BB, and 123,372 mg/ 200 g BB comparable to the positive control and different from the group given the negative control.. Extract dose 123,372 mg/ 200 gB compare with positive control was indicated that extract doses 123,372mg/ 200 g BB showed the highest analgesic activity.
PENGARUH VARIASI KONSENTRASI AVICEL PH 101 DAN LAKTOSA SEBAGAI HOST DALAM PEMBUATAN TABLET CAMPURAN INTERAKTIF GLIMEPIRID MENGGUNAKAN METODE KEMPA LANGSUNG Nugroho, Muhammad Agung; Kuncahyo, Ilham; Harjanti, Reslely
Jurnal Farmasi & Sains Indonesia Vol 8 No 2 (2025)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol8no2p80-91

Abstract

Glimepirid is an antidiabetic drug from the sulfonylurea class with low solubility, thus requiring a formulation approach to improve its bioavailability. This study aimed to examine the effect of varying concentrations of avicel pH 101 and lactose as carrier (host) materials on the physical properties and dissolution profile of glimepirid tablets prepared using the direct compression method. Three formulas were developed with avicel pH 101:lactose ratios: F1 (1:0.5), F2 (1:1), and F3 (1.5:1). Quality evaluation included tests of granule flow properties (angle of repose and flow time) and physical tablet tests (content uniformity, hardness, friability, disintegration time, and dissolution) based on the Indonesian Pharmacopoeia. ANOVA statistical analysis showed significant differences between formulas (p < 0.05). The results indicated that variations in avicel pH 101 and lactose concentrations affected the physical quality and dissolution profile of the tablets. Formula 1 had the fastest disintegration time and the highest drug release. Formula 2 demonstrated the best content uniformity, good powder flow, and stable dissolution. Formula 3 produced the hardest tablets with the lowest friability but required longer disintegration time. Formula 2 was considered the most optimal and is recommended for further development of glimepirid tablets.
Studi In Silico : Aktivitas Senyawa Tanaman Kecombrang (Etlingera elatior) Sebagai Kandidat Obat Antihiperurisemia: Studi Awal Pemanfaatan Kecombrang Sebagai Terapi Alternatif Gout Fessolsalmin, Muhammad; Naufalin, Rifda; Wulansari, Putri Dian; Susanti, Susanti; Nurzaman, Moch Herdi; Fadilah, Nitya Nurul; Mardianingrum, Richa
Jurnal Farmasi & Sains Indonesia Vol 8 No 2 (2025)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol8no2p126-135

Abstract

Hyperuricemia is a metabolic disorder caused by an increase in uric acid levels, which is at risk of ausing gout. The plant kecombrang (Etlingera elatior) is known to contain bioactive compounds that have the potential to act as xanthine oxidase inhibitors. This study aims to evaluate 50 compounds from kecombrang as antihyperuricemia candidates using an in silico approach. The analysis includes toxicity and pharmacokinetics (ADMET) predictions, Lipinski's rule of five, molecular docking, and molecular dynamics simulations. The docking results of selected compounds Aduncetin E (-8.93 kcal/mol) and Methyllinderatin (-8.78 kcal/mol) show the best affinity for xanthine oxidase enzyme with lower binding energy compared to allopurinol (-6.26 kcal/mol). Molecular simulations support the stability of the ligand-receptor complex the MMGBSA results indicate that Aduncetin E (13.4048 kcal/mol) and Methyllinderatin (-30.3009 kcal/mol) have potential that can be developed as antihyperuricemia drug candidates.
PENGEMBANGAN DAN VALIDASI METODE PENENTUAN RESIDU PELARUT DALAM BAHAN FARMASI AKTIF LAMIVUDIN MENGGUNAKAN KROMATOGRAFI GAS Safitri, Ayu Nadila; Abshar, Irham Fauzi; Herlambang, Aldillah
Jurnal Farmasi & Sains Indonesia Vol 8 No 2 (2025)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Pelarut kimia yang digunakan dalam sintesis bahan farmasi aktif dapat tertinggal sebagai residu pelarut yang berdampak negatif bagi kesehatan. Bahan farmasi aktif lamivudin beresiko mengandung residu pelarut berupa etanol, isopropil asetat, metanol dan trietilamina. Sedangkan metode penentuan residu pelarut dalam bahan farmasi aktif lamivudin sulit untuk diimplementasikan dan membutuhkan biaya yang mahal. Penelitian ini bertujuan untuk mengembangkan dan memvalidasi metode penentuan residu pelarut dalam bahan farmasi aktif lamivudin yang sederhana, tepat, dan akurat dengan menggunakan kromatografi gas. Percobaan dilakukan dengan sistem kromatografi gas (Sistem GC Shimadzu) yang dilengkapi dengan detektor ionisasi nyala. Hasil yang diperoleh dibandingkan dengan batas yang ditentukan dari pedoman standar USP. Parameter validasi dilakukan dengan mengevaluasi spesifisitas, linearitas, presisi, akurasi, batas deteksi, batas kuantifikasi, kestabilan larutan dan ketahanan. Tidak adanya interferensi puncak menunjukkan metode tersebut spesifik. Hubungan linear dievaluasi pada rentang 1-150% dan diperoleh koefisien regresi R’ untuk residu pelarut ≥0,9974. Nilai batas deteksi dan kuantifikasi memenuhi syarat dengan penentuan signal-to-noise (S/N). Nilai presisi pada enam kali pengulangan dan akurasi pada level konsentrasi 80%, 100% dan 120% menghasilkan nilai sesuai persyaratan. Pengujian ketahanan dengan modifikasi parameter tidak menunjukkan perbedaan yang signifikan. Semua larutan standar dan sampel menunjukkan kestabilan hingga 12 jam. Metode kromatografi gas yang sederhana, spesifik, akurat, presisi dan tangguh berhasil dikembangkan dan divalidasi.

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