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Jurnal Farmasi dan Sains Indonesia (JFSI)
Published by Sekolah Tinggi Ilmu Farmasi Nusaputera
ISSN : 26219360     EISSN : 26863529     DOI : https://doi.org/10.52216
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Medicine & Pharmacology Neuroscience
Focus and Scope Jurnal Farmasi & Sains Indonesia is an open-access journal that published twice a year by Sekolah Tinggi Ilmu Farmasi Nusaputera. This journal is a media of research publication on all aspects of pharmaceutical & science that is innovative, creative, original and based on scientific. Articles published in this journal about drug discovery, drug delivery systems and drug development with specific field include: 1. Medicinal chemistry 2. Pharmacology 3. Pharmacokinetics 4. Pharmacodynamics 5. Pharmaceutical analysis 6. Drug delivery systems 7. Pharmaceutical technology 8. Pharmaceutical biotechnology 9. Herbal medicines and active components 10. Clinical evaluation of the medicine
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 244 Documents
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UJI STABILITAS FISIK DAN AKTIVITAS SEDIAAN LOTION ANTIOKSIDAN EKSTRAK DAUN KELOR (MORINGA OLEIFERA L.) DENGAN METODE DPPH More, Evanisia; Kristyanti, Yulia; Beama, Christin A; Seran, Yuliana Caranina
Jurnal Farmasi & Sains Indonesia Vol 8 No 1 (2025)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol8no1p119-127

Abstract

The Moringa plant (Moringa Oleifera Lamk) is one of the plants that is used for nutritional and health needs. Moringa leaves contain tannin compounds, steroids and triterpenoids, flavonoids, saponins, alkaloids, which have antioxidant activity. The aim of this research is to determine the physical stability of the Moringa leaf extract lotion preparation and to determine the antioxidant activity of the Moringa leaf extract lotion preparation using the DPPH method. This type of research is an experimental study consisting of 4 test groups, namely lotion preparation without extract, 1% Moringa leaf extract lotion preparation, 3% Moringa leaf extract lotion preparation and 5% Moringa leaf extract lotion preparation. The parameter observed was the storage of the Moringa leaf extract lotion preparation for 1 month. The lotion preparation of Moringa Oleifera L. leaf extract at concentrations of 0%, 1%, 3% and 5% showed no significant changes in the organoleptic test, homogeneity test, pH test, viscosity test, spreadability test and stickiness test so it is said that the preparation is stable during storage. Moringa leaf extract (Moringa Oleifera L.) lotion preparations with concentrations of 0%, 1%, 3% and 5% have IC50 values ​​respectively, namely (86.35), (66.60), (44.12), (11.89). Keywords: Moringa plant (Moringa Oleifera L.), lotion preparation, antioxidant
FORMULASI DAN UJI STERILITAS SEDIAAN KRIM EKSTRAK DAUN RAMANIA (Bouea macrophylla Griffith) Mukti, Yusuf Anggoro; Aryzki, Saftia; Ramadina, Najwa; Adawiyah, Rabiatul
Jurnal Farmasi & Sains Indonesia Vol 8 No 1 (2025)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol8no1p103-107

Abstract

This study focuses on the formulation and evaluation of a cream based on Ramania leaf extract (Bouea macrophylla Griffith), known for its anti-inflammatory, antioxidant, and antimicrobial properties. The aim of the study is to develop an effective topical cream using different concentrations of Ramania leaf extract. Two different formulations were prepared and evaluated through various tests, including organoleptic evaluation, spreadability, adhesiveness, pH, homogeneity, viscosity, and stability. An experimental method was employed to determine the optimal formulation. The results showed that formulations 1 and 2, containing 5% and 6% Ramania leaf extract, demonstrated the best characteristics, including a homogeneous semi-solid texture, appropriate pH, sufficient adhesiveness, and optimal spreadability. These findings suggest that the Ramania leaf extract cream has the potential to be used as a topical product with good stability and potential therapeutic benefits. Keywords: Ramania leaf extract, topical cream, formulation evaluation.
FORMULASI DAN EVALUASI SIFAT FISIK SEDIAAN GEL EKSTRAK ETANOL DAUN PETAI CINA (Leucanea leucocephala (Lam.) de Wit) DENGAN VARIASI KONSENTRASI BASIS KARBOPOL 940 Suri, Natasha Triska; Nawangsari, Desy; Febrina, Dina
Jurnal Farmasi & Sains Indonesia Vol 8 No 1 (2025)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol8no1p33-40

Abstract

Chinese petai leaves (Leucaena leucocephala (Lam.) De Wit.) contain compounds in the flavonoid, saponin, and tannin groups that have antioxidant activity. Chinese petai leaves need to be developed in the form of a gel preparation with a karbopol 940 base. Karbopol 940 is a gelling agent that is very commonly used in cosmetic production due to its high compatibility and stability, non-toxicity when applied to the skin, and ease of spreading on the skin. This study aims to determine the formulation of ethanol extract gel from petai cina leaves with physical properties and physical stability, to assess the irritation effects on the skin of albino rabbits, and to evaluate the respondents' preference for the gel preparation. This research is an experimental study. The extraction method used was maceration with 70% ethanol as the solvent. The formulation of the ethanol extract gel from the Chinese petai leaves used a carbopol 940 base with concentration differences of F1 0,5%, F2 1%, and F3 2%. The research results showed that the organoleptic physical properties had a distinctive smell, were brown in color, and had a gel form. The homogeneity test indicated that the gel preparation was homogeneous. The pH test results met the standards. Based on statistical testing, it was found that pH, viscosity, and spreadability obtained p-value <0,05, indicating a significant difference due to the varying concentrations of carbopol used in each formula. The adhesion test results did not show a significant effect. In the irritation test, it showed very mild irritation and the preference level indicated the highest percentage of 34,60%.
Systematic review Evaluasi Keamanan Penggunaan Obat Tradisional di Indonesia Manno, Muhammad Reski; Anggraini, Diva Nur; Anasiru, Rayhan; Oetari, R.A
Jurnal Farmasi & Sains Indonesia Vol 8 No 1 (2025)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol8no1p172-175

Abstract

Indonesia, as a country with abundant biodiversity, has long used traditional medicinal plants to treat various diseases. The use of traditional medicine by the Indonesian people has been going on for a long time and is diverse, although there are still shortcomings in research related to its efficacy and safety. This study aims to evaluate how the Indonesian people use traditional medicine, including dosage, frequency, processing methods, and applications, as well as to assess the safety and effectiveness of its use. The method used is a systematic review with PRISMA guidance, where a literature search was conducted in the PubMed database using keywords related to the use of traditional medicine in Indonesia. From the search results, ten relevant articles were obtained which were analyzed. The results of the study indicate that although the use of traditional medicine is quite good, further research is still needed regarding the right dosage, the right choice of ingredients, and safe use methods. In addition, the importance of education, supervision, and the role of pharmacists and related agencies in ensuring the safety and effectiveness of traditional medicine in the community is also emphasized. This study is expected to contribute to increasing the understanding of the Indonesian people regarding the safe and effective use of traditional medicine.
Formulasi dan Uji Penyembuhan Luka Sayat Sediaan Krim Ekstrak Metanol Daun Kelor (Moringa oleifera Lam.) pada Kelinci (Oryctolagus cuniculus) Kristyanti, Yulia; More, Evanisia
Jurnal Farmasi & Sains Indonesia Vol 8 No 1 (2025)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol8no1p41-52

Abstract

The development of a cut wound cream dosage form from Moringa (Moringa oleifera Lam.) leaf extract has been carried out. The purpose of this study was to determine the most optimal dose of moringa leaf extract cream preparation that can heal cut wounds in male rabbits (Oryctolagus cuniculuc). Moringa leaves were macerated with 96% methanol, cream formulation with varying doses of extract, namely 10% (F I), 12% (F II), 14% (F III), negative control (cream base without extract) and positive control (Bionect). Healing test on male rabbit skin that has been given skin incision treatment for all formulas and controls. The results showed that the test animals gave a healing effect on the average decrease in wound length successively in each treatment group, namely positive control, F III, F II, FI and negative control showed an average decrease in wound length of 0.75 cm, 0.76 cm, 0.87 cm, 1.02 cm and 1.19 cm on the11, 12, 13 and 14 days.
FORMULASI DAN UJI EFEKTIVITAS PATCH ANTIPIRETIK EKSTRAK ETANOL DAUN JAMBU BIJI (Psidium guajava L) PADA TIKUS PUTIH Beama, Christin Aprillian; Poso, Maria Carolinda
Jurnal Farmasi & Sains Indonesia Vol 8 No 1 (2025)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol8no1p203-210

Abstract

Guava leaves (Psidium guajava L) are one of the traditional medicines empirically used by the community in Indonesia for fever treatment. Guava leaves (Psidium guajava L) contain several compounds, one of which is flavonoids, which play a role in antipyretic activity. This study aims to determine the effectiveness of the formulation of guava leaf extract patches (Psidium guajava L) in reducing fever in white rats, and to identify the most effective concentration of the guava leaf extract patch formulation (5%, 10%, and 15%) in lowering fever in white rats. This study used a True Experimental Design (Posttest-Only Control Design). The test subjects in this study were 25 white rats divided into 5 groups. The positive control group was given a "Bye-bye Fever" patch, the negative control group was given a patch without extract, and the three treatment groups were given guava leaf extract patches with concentrations of 5%, 10%, and 15%, respectively. Fever induction was performed by injecting the test subjects with5% peptone (2 ml) intraperitoneally. Rectal temperatures were measured before and after the administration of 5% peptone and following the application of the test material at 15,30, 45, 60,75, 90, 105,120, 150, and 180 minutes. The results showed that the administration of ethanol extract patches from guava leaves (Psidium guajava L) at a concentration of 15% reduced rectal temperature more significantly compared to concentrations of 10% and 5% over a period of 180 minutes. In this study, the 15% concentration of ethanol extract from guava leaves proved to be the most effective antipyretic concentration.
PERBANDINGAN KRIM ANTIBAKTERI EKSTRAK PEGAGAN (Centella asiatica (L.) Urban) DENGAN VARIASI BASIS COLD CREAM DAN VANISHING CREAM TERHADAP Staphylococcus aureus Sutrisno, Sahya Rania; Rahmawati, Ismi
Jurnal Farmasi & Sains Indonesia Vol 8 No 1 (2025)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol8no1p162-171

Abstract

Cosmetic care products are designed to enhance human appearance. Centella asiatica (L). Urban, commonly known as gotu grain, is a natural ingredient that can be effectively used in anti-acne creams. The objective of this study is to investigate and compare the antimicrobial efficacy of cold cream and vanishing cream bases against Staphylococcus aureus, with a focus on determining their potential inhibitory effects. The preparation of cold cream involved a melt-emulsification process utilizing surfactants. In contrast, the vanishing cream was prepared using a melting method. Physical quality assessment was conducted through visual observation, evaluating organoleptic properties and homogeneity. The physical and antibacterial properties of the creams were evaluated using various standardized methods. Viscosity was measured using a Brookfield Viscometer, pH levels were assessed with a pH meter, spreadability and adhesion were evaluated using respective testers, and antibacterial activity was determined via the disc diffusion method. Statistical analysis of the physical quality test results was performed using the Independent Samples T-test, while antibacterial activity data were analyzed using One-Way ANOVA. The results of the physical quality evaluation revealed significant differences in the organoleptic properties among the gotu-gotu extract cream, cold cream base variation, and vanishing cream. However, no significant differences were observed in terms of homogeneity among the three formulations. The vanishing cream exhibited a significantly higher spreadability, with a mean value of 5.98 cm (n=3), compared to the cold cream base variation. Conversely, the vanishing cream displayed lower viscosity (mean: 3,560 cP, n=3) and adhesion (mean: 1.61 seconds, n=3) values compared to the cold cream base variation. The gotu-gotu extract cream formulated with a vanishing cream base exhibited potent antibacterial activity against Staphylococcus aureus, as evidenced by a significant inhibition zone diameter of 17.6 mm. This result meets the criteria for strong inhibition strength and is comparable to the positive control, demonstrating superior antibacterial efficacy relative to the cold cream base variation.
IDENTIFIKASI POTENSI INTERAKSI OBAT ANTIVIRUS PADA PASIEN TERDIAGNOSA COVID-19 di RSUD Prof. Dr. W.Z. JOHANES KUPANG Fraga, Aurelia Da Silva Sequeira; Berkanis, Appolonaris; Lodo, Mirdo Albertho Rohi; Beama, Christin Aprilian
Jurnal Farmasi & Sains Indonesia Vol 8 No 1 (2025)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol8no1p211-220

Abstract

COVID-19 is a disease caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) virus. This virus was first identified in Wuhan, China and is one of the new species of Corona virus that can cause pneumonia and threaten the world because it spreads very quickly and causes death so that the WHO declared a pandemic status. Range COVID-19 occurs in patients with comorbid or comorbid conditions. Treatment of COVID-19 patients uses drugs such as antivirals, antibiotics, and immunomodulators. Concomitant use of antivirals and other drugs should be considered so as to prevent the possibility of Drug Related Problems such as drug interactions. The purpose of the study was to determine the potential interaction of antiviral drugs in COVID-19 patients at RSUD Prof. Dr. W.Z. Johanes Kupang. This study is an observational descriptive study that collected data retrospectively by looking at medical record data of patients diagnosed with COVID-19 with cardiovascular comorbidities. The population in this study is medical record data of patients diagnosed with COVID-19 who underwent hospitalization in 2022, which was 103 patients and samples obtained by 23 patients. Evaluation of drug interactions based on the mechanism of action and severity in patients shows that potential drug interactions occur pharmacodynamically (3 events) and pharmacokinetics (14 events) while based on severity shows the potential interactions occur at mild severity as many as 3 events and moderate as many as 14 events. Keywords: Antivirus, COVID-19, Comorbid, Drug related problem, Drug Interaction
EFEKTIVITAS PENYEMBUHAN LUKA BAKAR AKIBAT PEMBERIAN GEL ESTRAK ETANOL DAUN CENGKEH (Syzygium aromaticum L.) PADA KELINCI (Oryctolagus cuniculus) Puruhita, Ranatri; Aldila, Silvy; Ariyani, Destiana Putri
Jurnal Farmasi & Sains Indonesia Vol 8 No 1 (2025)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol8no1p221-228

Abstract

Burns are damage to the organs that can happen when heat exposure from fire, chemicals, electricity, or radiation damages or destroys skin tissue. For burns, topical treatment can hasten the healing process. Because clove leaves have antiseptic qualities and antibacterial and anti-inflammatory activity, their secondary metabolites—flavonoids, tannins, and saponins—can be used to treat open wounds and stop infection. The purpose of this study is to create a gel formulation using clove leaf extract that will treat burn wounds without causing skin infections. Two formulations of the gel preparation, each with a 10% and 15% concentration, were evaluated on test rabbits. Using a hot iron plate, the rabbits' backs were shaved to cause burns. Clove leaf extract gel was used for the treatment group, Bioplacenton® was used as the positive control, and gel base was used as the negative control. Measurements of the wound's diameter were taken on days 0 and 15, and SPSS was used to analyze the results. Clove leaf extract burn gel is 60.98% effective in formula 1 and 77.16% effective in formula 2. Formula 2 is the gel formulation that works best for treating rabbit burns.
Gambaran Terapi Obat Pulang Pasien Geriatri Setelah Menjalani Rawat Inap Di Bangsal Penyakit Dalam Di RS Panti Wilasa Dr. Cipto Semarang Triananingsih, Novi; NSH, Maria Caecilia; Rahmawati, Fita
Jurnal Farmasi & Sains Indonesia Vol 8 No 1 (2025)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Geriatric patients are elderly patients (>60 years) who have various chronic diseases with polypharmacy that varies by age group. This study aims to determine the differences in the age of elderly patients according to age group in the internal medicine ward of Panti Wilasa RSUD Dr. Cipto. This study is a descriptive study with retrospective data collection on discharge prescriptions of geriatric patients after undergoing inpatient care in the internal medicine ward obtained from medical record data. Sampling used a purposive sampling technique. In this study were classified into three groups: age 60 to 74 years; age 75 to 90 years; and age > 90 years. During the study period 86% were aged 60-74 years and 14% were aged 75-90 years, while in this study there were no ages over 90 years. In this study the most common gender was male, namely in the 60-74 age group 50.5% while in the 75-90 age group 73.3%. The length of hospitalization in the 60-75 age group was 49.5% and the 75-90 age group 60%, namely 4-5 days. And the top 5 types of drugs that are widely used in this age group are omeprazole, aspirin, metoclopramide, spironolactone and warfarin. The number of diagnoses received by the age group 60-74 years with 2 diagnoses 34.7%, with 3 diagnoses 31.6%. While the number of diagnoses received by the age group 75-90 years with 2 diagnoses 40%, with 3 diagnoses 33.3%. This shows that elderly patients have the same therapeutic picture in terms of age group.   Keywords: Geriatric Patients, Internal Medicine Ward, Polypharmacy, Chronic Disease.

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