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Aji Winanta
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INDONESIA
Journal of Fundamental and Applied Pharmaceutical Science
Published by Universitas Muhammadiyah Yogyakarta
ISSN : 27237648     EISSN : 2723763X     DOI : 10.18196
Core Subject : Health,
Medicine & Pharmacology
JFAPS focuses on various aspects of pharmaceutical sciences such as: Pharmaceutical Technology Pharmacology & Toxicology Pharmaceutical Chemistry Drug Discovery Traditional Medicine and Medicinal Herb Pharmaceutical Microbiology and Biotechnology
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 130 Documents
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Phytochemical Analysis and Antioxidant Potential of Ethylacetate Extract of Tamarindus Indica (Tamarind) Leaves by Frap Assay Dahiru, Mubarak Muhammad; Ahmadi, Hadiza; Faruk, Maimuna Umar; Hamman, Huzaifa Huzaifa Aminu; Charles, Abreme Gahana
Journal of Fundamental and Applied Pharmaceutical Science Vol. 3 No. 2 (2023): February
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/jfaps.v3i2.16708

Abstract

Oxidative stress is characterized by an imbalance in the generation of free radicals and their subsequent elimination by endogenous antioxidants. It is a characteristic of several diseases, especially during the progression stage, which can lead to fatal effects. This study aims to investigate the phytochemical components and antioxidant capability of Tamarindus indica and assess its capability as a candidate for managing diseases associated with oxidative stress. The gravimetric method detected and quantified phytochemicals, while the reducing power assay determined the antioxidant potential. Saponins, steroids, and flavonoids were detected in 6.83 ±0.44, 4.30 ±0.60, and 10.17% ±0.60, respectively, without alkaloids, glycosides, and terpenoids. The antioxidant test showed a concentration-dependent increase in absorbance of both the extract and standard (Ascorbic acid). However, Ascorbic acid had higher absorbance. At 100% concentration, the sample had an absorbance of 0.388 ±0.022, which was lower than the absorbance of Ascorbic acid (0.411 ±0.009) at 40% concentration. It can be concluded that Tamarind leaves could be utilized to manage diseases associated with oxidative stress, evidenced by their antioxidant potential credited to the phytochemical content of the leaves. However, there is a need for further studies to ascertain the exact compounds and their modes of action.
Studies on Antioxidant and Antineoplastic Potentials of Oldenlandia corymbosa Linn. Leaves Aziz, Md. Abdul; Nime, Md. Julkar; Rahman, Md. Habibur; Khatun, Ziasmin; Habib, Md. Rowshanul; Siddika, Ayesha; Khatun, Marina; Karim, Md. Rezaul
Journal of Fundamental and Applied Pharmaceutical Science Vol. 3 No. 2 (2023): February
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/jfaps.v3i2.17737

Abstract

Various bioactive properties, including antioxidant and antineoplastic properties, are extracted from plant species. Oldenlandia corymbosa Linn. is an important medicinal plant that grows as a weedy annual herb throughout Bangladesh. However, no previous studies have reported the antineoplastic and antioxidant potentials of Oldenlandia corymbosa leaves. Based on this fact, this investigation evaluated the methanol extract of Oldenlandia corymbosa Linn. leaves (MELO) for its antioxidant and antineoplastic properties. Different in vitro experiments were applied here to measure the phytochemical content and antioxidant activity of MELO. Functional assays were utilized to measure the antineoplastic activity of MELO against Ehrlich Ascites Carcinoma (EAC) in mice. MELO contains rich phenolic compounds, flavonoids, flavonol, and proanthocyanidin. In vitro antioxidant assay, MELO exhibited significant ABTS▪ (IC50: 98.07 μg/mL) and DPPH (IC50: 151.21μg/mL) radicals scavenging activity when compared with the positive control (Ascorbic acid). MELO also showed total antioxidant and ferrous-reducing properties. In the antineoplastic study, dose-dependent reduction in viable EAC cell count was observed in MELO-treated groups. In contrast, treatment with MELO significantly (P<0.05) increased the mean survival time and life span (65.21%) of EAC-bearing mice. The altered hematological parameters of mice of the EAC control group were restored to the normal level by treating MELO. MELO also induced the apoptotic features observed in the morphology of DAPI-stained EAC cells. As identified by GC/MS analysis, the Phytochemical profiles of MELO are also consistent with their antioxidant, antineoplastic and apoptotic properties. Thus, the methanol extract of Oldenlandia corymbosa leaves (MELO) has the potential to consider a good source of antioxidants and antineoplastic agents.
In-Vivo Anti-Inflammatory Activity of Kelubut Leaf Ethyl Acetate Extract (Passiflora foetida L.) from Samarinda City Mochtar, Chaerul Fadly; Devi, Reni Selviana; Hamzah, Hasyrul; Faradillah, Ayu; Hafidzah, Elva; Varizza, Fathiah Putri; Aisyiyah, Novia Misnawati; Husna, Qur'anni Akhwatun
Journal of Fundamental and Applied Pharmaceutical Science Vol. 4 No. 1 (2023): August
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/jfaps.v4i1.18287

Abstract

Kelubut (Passiflora foetida L.), as an anti-inflammatory, is widely found in various regions in Indonesia, including in Central Kalimantan. Its main chemical compounds include alkaloids, phenols, glycosides, flavonoids, and cyanogenic compounds. Flavonoids show more than a hundred kinds of bioactivity, including antipyretic, analgesic, and anti-inflammatory. This study aims to determine the anti-inflammatory activity of kelubut leaf extract (Passiflora foetda L.) against mice (Mus musculus). This research went through a Pretest and Posttest Control Group Design with 5 treatment groups, negative control, positive control, and ethyl acetate extract of kelubut leaves with 3 doses of 250 mg/KgBW, 125mg/KgBW and 62.5 mg/KgBB. Before being given treatment, each treatment group was induced by carrageenin by sub-planar injection into the sole of the left leg of the mouse. Then, the edema developed rapidly and persisted for 6 hours. After being induced by carrageenin, the researchers waited for 30 minutes and measured the volume of edema every 30 minutes to 120 minutes. The inhibition of all groups of ethyl acetate extract of kelubut leaves showed anti-inflammatory activity, but the resulting abilities were different. Inflammation inhibition by ethyl acetate extract at a dose of 250 mg/KgBW was 92.78%, at a dose of  125 mg/KgBW, was 91.76%, and at a dose of 62.5 mg/KgBW was 84.61%. From the results obtained, the ethyl acetate extract group of kelubut leaves at a dose of 250 mg/KgBW had the greatest inflammatory inhibition activity compared to a dose of 125 mg/KgBW and 62.5 mg/KgBW.
The Effects of Heating Temperatures on Passion Fruit Juice's Ascorbic Acid and Total Phenol Levels Siswandi, Alodia Jeconiah; Prismawan, Deka; Kambira, Pretty Falena Atmanda
Journal of Fundamental and Applied Pharmaceutical Science Vol. 4 No. 1 (2023): August
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/jfaps.v4i1.18648

Abstract

The Passiflora edulis f. flavicarpa, a yellow passion fruit, is known for its distinctive aroma and tart flavor. The pulp of the yellow passion fruit can be used to make tea, jam, and syrup commercially. Commercial items are processed using oven heating, which involves prolonged exposure to high temperatures. As a result, fruit content, particularly water content, may alter. The benefit of reducing the water content is that less microbial growth medium means the product has a longer shelf life. However, fruit flesh’s nutritional composition will also change due to the ascorbic acid and phenolic compounds' thermolability and other factors. In this study, the yellow passion fruit pulp juice is heated in a controlled manner at 60°C, 70°C, and 80°C for 7 hours using an oven. The purpose is to assess changes in the amounts of ascorbic acid and total phenol that occurred. A paired T-test was used to assess the association between weight loss, ascorbic acid levels, and phenolic levels in the control and treatment groups. The amount of ascorbic acid was determined using the 2.6 dichloroindophenol titrimetry method, and the amount of phenol was determined using the Folin-Cioceltau method and UV-Vis spectrophotometry. According to this study, increasing the temperature to 60 °C or 80 °C significantly reduces weight and ascorbic acid levels. Also, the heating temperature unaffected the amount of phenol in each group.
Analysis of Pork Fatty Acid in Cornet in The Curug Market Using Gas Chromatography Widyatari, Ade Dwi; Rusdiana, Nita; Rasydy, Laode Akbar
Journal of Fundamental and Applied Pharmaceutical Science Vol. 4 No. 2 (2024): February
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/jfaps.v4i2.18878

Abstract

Counterfeiting of food products with non-halal ingredients is starting to become a new problem in Indonesian society, the majority of whom are Muslim. One example of processed meat that is susceptible to the addition of pork components is corned beef. This research aims to determine the content and levels of fatty acids in corned beef. The method used to analyze halal food products is the GC method. The results showed that corned beef 1, 2, and 3 had dominant fatty acids such as myristic acid (1.58), (2.08), and (1.54), palmitic acid (49.91), (48.19) and (48.67), stearic acid (9.27), (10.20) and (7.24), oleic acid (58.89), (49.37) and  (59.64), and linoleic acid (12.78), (8.16) and (11.53).
Analysis of Calcium, Iron, Ash, Fat, and Water Content in Fresh and Processed Cow's Milk Using Atomic Absorption Spectrophotometry Methods Amalia, Rizka; Pindona, Zelvia; Rusdiana, Nita; Pratiwi, Dina
Journal of Fundamental and Applied Pharmaceutical Science Vol. 4 No. 1 (2023): August
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/jfaps.v4i1.18938

Abstract

Milk is a source of nutrition for the body's growth, containing calcium and iron minerals. This study analyzes the optimal calcium, iron, ash, water, and fat levels in fresh and processed cow's milk. This study used five samples: pure milk (S1), pasteurized pure milk (S2), pasteurized milk with sugar (S3), pasteurized milk with paste coloring and citric acid (S4), and pasteurized milk with powder coloring(S5). The results showed that the calcium content of milk 4 (S4) treated with pasteurized milk added with sugar and paste coloring and citric acid had a higher calcium content than the other four samples by 98.61 mg/kg, at levels of milk iron 5 (S5) treated with pasteurized milk added with sugar and powdered dyes had a higher iron content than the other four samples by 73.81 mg/kg. The ash content of pure milk was higher at 0.96%. The fat content of pasteurized milk, the taste of coloring paste and powder, was higher than the other three samples at 2.80%. The water content of pasteurized added sugar milk was higher than the other four samples at 88.58%. Pure milk had the most optimal calcium (Ca) and iron (Fe) levels from the other four samples.
Evaluation of the Antithrombotic Activity of Acmella oleracea L. Flower Ethanol Extract Tiaravista, Amanda Gita; Putri, Laras Widawaty; Nurrochmad, Arief; Widyarini, Sitarina; Fakhrudin, Nanang
Journal of Fundamental and Applied Pharmaceutical Science Vol. 4 No. 1 (2023): August
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/jfaps.v4i1.19055

Abstract

Acmella oleracea L. (hereinafter abbreviated as AOE) is one of the plants with the potential for antithrombosis, one of the deadliest cardiovascular diseases in Indonesia. The antithrombotic activity test on AOE leaf extract revealed that it could lyse blood clots. However, no information regarding the AOE flower as an antithrombosis is provided. This study, thus, aims to determine the chromatography profile and the antithrombotic activity of the AOE flower ethanol extract. To identify the AOE chemical profile, thin-layer chromatography was carried out. Antithrombotic testing was performed on male rats of the Sprague-Dawley strain. Then, the antithrombotic activity was tested using the FeCl3-induced rat method, with the observed parameter being total occlusion time. The test animals were also divided into six groups: normal, solvent (CMC-Na 0.9%), comparator drug (clopidogrel 8.67 mg/kg), and AOE (doses 125, 250, and 375 mg/kg). The data obtained were then analyzed statistically using Kruskal-Wallis, followed by Tukey's. The TLC profile results confirmed the presence of the alkaloid compound in AOE. The authors also found that AOE at doses of 125, 250, and 375 mg/kg significantly prolonged the occlusion time comparable to that of clopidogrel at 8.67 mg/kg (p > 0.05). This finding indicates that AOE has antithrombotic activity in FeCl3-induced rats.
Analysis of Triclosan Content in Cisadane River Water Using Gc-Ms (Gas Chromatography Mass Spectrometry) Cahyowati, Merliani Nur; Rudiana, Nita; Pratiwi, Dina
Journal of Fundamental and Applied Pharmaceutical Science Vol. 5 No. 1 (2024): August
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/jfaps.v5i1.19096

Abstract

The Ministry of Environment and Forestry states that 75% of river water in Indonesia has been polluted by household and industrial waste. Triclosan (2,4,4-trichloro-2-hydroxydiphenyl-ether) is an antibacterial that is widely used in various health and household supply products, such as detergents, toothpaste, mouthwash, bath soap and so on. This study approach employs liquid-liquid extraction on sampels, which are subsequently subjected to SIM mode analysis untilizing the Gas Chromatography Mass Spectometry (GC-MS) method. River water samples were taken from 3 points, namely village areas, fishing and industry. The results of this study indicate that the levels of the three Cisadane river water samples are positive for Triclosan with levels less than 0.3%, namely at the fishing point 598x10-9%, industrial point 1076x10-9% and residential point 1584x10-9% with a retention time of 19, 37 minutes.
Local Application of Timolol 0.5% Solution in Treating Chronic Non-Healing Ulcers – A Prospective Study Valluru, Sivaramakrishna; R, Ramachandra; Chandana, Jyothi Sasikanth
Journal of Fundamental and Applied Pharmaceutical Science Vol. 4 No. 1 (2023): August
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/jfaps.v4i1.19143

Abstract

Chronic non-healing ulcers are a variety of ulcers that occur mainly over the lower limb and are resistant to conventional therapy. There are modern treatments like various types of dressings and topical preparations available in the market. However, they are costly and may not be freely available to the general population. Topical usage of  β2-AR  antagonists like timolol may promote wound healing by enabling keratinocyte migration into the wound to initiate the re-epithelisation. The objective of this study is to assess the effectiveness of topical timolol 0.5% in accelerating the wound healing process by observing the signs of healing. It is a prospective observational study conducted in Government General Hospital, Rangaya Medical Medical College, Kakinada, after getting  Institutional Ethical Committee approval from March 2021 to March 2023. One hundred patients with Chronic non-healing foot ulcers were taken for this study. Mean age was 47.64.60% of the study population was in the 20-55 years age group. Reduction in mean ulcer area was on day 15 and day 30 with topical application of timolol.
Preparation and Evaluation of Mouth Dissolving Tablet of Albendazole Using Different Concentrations of Super-Disintegrant Bavaskar, Kedar Rupa; Pote, Supriya; Vidhate, Prasad; Patil, Vinit; Jain, Ashish
Journal of Fundamental and Applied Pharmaceutical Science Vol. 4 No. 2 (2024): February
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/jfaps.v4i2.19148

Abstract

Anthelmintic medications are anticipated to act more quickly and have greater absorption. Mouth-dissolving albendazole tablets were created using a direct compression approach and a mixture of super disintegrants to accomplish rapid disintegration of the tablets in the oral cavity. The preparation of ten batches of mouth-dissolving tablets using different grades of Kollidon, crospovidone, sodium starch glycolate, and croscarmellose sodium as super disintegrants produced the greatest results. For a compatibility investigation, FTIR was used to characterize the drug and physical mixture. An optimization technique was used to forecast the most effective formulation out of all the prepared combinations. All the physical characteristics of the tablet are within the limit. All preformulation results indicated good flow properties. Disintegration time and drug content of the F4 batch were found to be 28 seconds and 95.69%, respectively. In vitro release of the drug was performed in a phosphorus buffer pH 6.8 for 40 min, in which F4 shows maximum drug release. Based on the stability studies, it was confirmed that the optimized formulation remained at accelerated stability conditions. It was discovered that the mouth-dissolving tablet exhibits effective drug release.

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