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Proceeding of Mulawarman Pharmaceuticals Conferences

mpc
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Published by Universitas Mulawarman

ISSN : - EISSN : 26144778 DOI : https://doi.org/10.25026/mpc

Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology

LINGKUP DAN TUJUAN Lingkup naskah mencakup bidang ilmu: Kimia Farmasi Biologi Farmasi Farmakologi Teknologi Farmasi dan Farmasetika Farmasi Klinik dan Komunitas Kedokteran dan Bidang ilmu lain yang terkait Tujuan penerbitan adalah memberikan informasi ilmiah tentang perkembangan ilmu pengetahuan dan teknologi bidang Farmasi dan yang terkait

Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi

Articles 612 Documents

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Karakteristik Granul Gastroretentive Mukoadhesif Amoksisilin dengan menggunakan Kitosan-Alginat, Na.CMC dan HPMC: Characteristics of Gastroretentive Mucoadhesive Granules Amoxicillin using Chitosan-Alginate, Na.CMC and HPMC Siti Rofi’ah Febryani; Sabaniah Indjar Gama; Angga Cipta Narsa
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 14 (2021): Proceeding of Mulawarman Pharmaceuticals Conferences
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Gastroretentive Drug Delivery System (GRDDS) is a slow-release preparation that can be bound to the surface of epithelial cells or gastric mucosa, while mucoadhesive is one of the mechanisms of action of the Gastroretentive Drug Delivery System (GRDDS), which is a drug delivery system in which the bio adhesive polymer is combined with the drug. designed to have a longer contact with the mucous membranes in the digestive tract. This study aims to see how the characteristics of the granules that are formulated in the form of mucoadhesive gastroretentive granules. The preparation method used was wet granulation using a mucoadhesive polymer, namely chitosan-alginate with the addition of HPMC and Sodium CMC. The results showed that the velocity test of the flow rate on the granule formula F1-F8 met the flow rate requirements, the results of the F9 velocity had a poor flow rate, while the results of the angle of repose measurement in the F1, F2 and F4 formulas had good flowability, which was below 30o, different with F3, F5, F6, F7, F8, and F9 which have a 30-40o angle of repose with good flowability. The results of the particle size distribution using the stratified sieve method showed that the formulas F1-F9 were mostly retained by a mesh number 20 sieve with a size of 426-850 m. The results of the test results of the gastroretentive mucoadhesive granule preparation of amoxicillin showed that the preparation met the requirements for making granules.

Penggunaan Soy wax dan Beeswax sebagai Basis Lilin Aromaterapi: Use of Soy wax and Beeswax as Aromatherapy Candle Base Theresia Fenny Oktarina; Wisnu Cahyo Prabowo; Angga Cipta Narsa
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 14 (2021): Proceeding of Mulawarman Pharmaceuticals Conferences
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

The continuous use of paraffin wax produces pollutants that have a negative impact on health and the environment. Soy wax and beeswax candles are environmentally friendly materials because they produce fewer pollutants. This study aims to determine the best formula in the manufacture of aromatherapy candle preparations. This research was conducted using an experimental method. Aromatherapy candles are made by melting soy wax, beeswax, and stearic acid. Apply optimization based on the ratio formula of 75%:25% (F1), 50%:50% (F2), 25%:75% (F3) by evaluating physical properties such as organoleptic, melting point test, and burning time test to get the base The best aromatherapy candles from the use of soy wax and beeswax ingredients with the addition of stearic acid. The results of optimization of soy wax based on an organoleptic test, F1 and F2 have an even color and do not crack, F3 has an uneven color and does not crack. The melting point of wax preparations is 48°C-52°C, burning time 373 minutes-463 minutes. On the basis of the organoleptic test beeswax, F1 and F2 had an even color and did not crack, F3 had an even color and cracks. The melting point of the basic wax is 53°C-54°C, and the burning time is 443 minutes-499 minutes. From the results, it was found that the best formulas, namely F1 and F2, met the standards according to SNI, namely the color was uniform and not cracked and the melting point ranged from 42°C-60°C.

Uji Aktivitas Antikoagulan Ekstrak Daun Ciplukan (Physalis Angulata L) Secara Invitro: Anticoagulant Activity Test of Ciplukan Leaf Extract (Physalis Angulata L) Invitro Uswatun Khasanah Duri Putri; Hajrah Hajrah; Adam M. Ramadhan
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 14 (2021): Proceeding of Mulawarman Pharmaceuticals Conferences
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Ciplukan leaf (Physalis angulata L) is empirically used as a hypercoagulation drug. The content of flavonoid secondary metabolites has potential as an anticoagulant. This study aims to determine the yield of ciplukan leaf extract and fraction, the content of secondary metabolites, and its activity as an anticoagulant. The method used in testing anticoagulant activity is Lee White and blood smear. Ciplukan leaves was extracted by maceration method using 70% ethanol solvent. The test samples for the extract and fraction of ciplukan leaves were made in 3 variations of concentration, that is 0.1%; 0.5%; and 1%. The results of ciplukan leaf extract, n hexane fraction, ethyl acetate and distilled water fraction were 14.284%; 12.9%; 10%; and 19.5%. The results of the phytochemical screening test of 70% ethanol extract contain secondary metabolites of flavonoids, alkaloids, tannins, phenols, saponins, steroids, triterpenoids. n?hexane fraction contains alkaloids, steroids and triterpenoids. The ethyl acetate fraction contains flavonoids, phenols and tannins. While the distilled water fraction contains flavonoids, phenols, tannins and saponins. Based on the test results of the Lee White method, extracts and fractions of ciplukan leaves have anticoagulant activity where blood clots do not occur after 2 hours of observation. In the blood smear method, the blood cells are round and not clustered. The best test sample concentration is at a concentration of 1%. The anticoagulant activity of the positive control was better than that of the ciplukan leaf extract and fraction.

Formulasi Lilin Aromaterapi Berbahan Aktif Minyak Atsiri Sereh Wangi (Cymbopogon winterianus) dan Jeruk Lemon (Citrus limon): Aromatherapy Candle Formulation with Active Ingredients of Citronella (Cymbopogon winterianus) and Lemon (Citrus limon) Essential Oils Vika Aura Rislianti; Laode Rijai; Fika Aryati
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 14 (2021): Proceeding of Mulawarman Pharmaceuticals Conferences
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Aromatherapy is therapy that uses aromatic compounds to treat, cut or prevent disease, infection, and anxiety by inhaling them. Citronella (Cymbopogon winterianus) and lemon (Citrus limon) have essential oils that work as aromatherapy. The aim of the study was to get aromatherapy candle preparations from essential oils of citronella and lemon. The research was carried out experimentally by making aromatherapy wax preparations from the formulation of stearic acid and paraffin wax with a ratio of 30%: 70% (F1), 40%: 60% (F2) , 50%: 50% (F3), 60%: 40% (F4), 70%: 30% (F5) and adding a combination of citronella essential oil and lemon essential oil in a ratio of 1%: 5% (A1), 2%: 4% (A2), 3%: 3% (A3), 4%: 2% (A4), 5%: 1% (A5), tests of physical stability were performed as burn time and melting point and determination of panellist’s preferences in the form of visual preference, candle aroma before combustion, candle aroma after combustion, detection of candle odor for the first time and perceived therapeutic effect. The best wax base is 60%: 40% (F4) and the best aromatherapy wax formulation is a combination of citronella essential oil and lemon essential oil 4%: 2% (A4) and 5% : 1% (A5) to produce a comfortable and pleasant therapeutic effect.

Hubungan antara Pengetahuan dan Perilaku Masyarakat Kecamatan Biatan Kabupaten Berau terhadap Penggunaan dan Resistensi Obat Antibiotik: The Relationship between Knowledge and Behavior of the People of Biatan District, Berau Regency on the Use and Resistance of Antibiotic Drugs Vina Mardiyanti Aprilia; Nur Mita; Adam M. Ramadhan; Riski Sulistiarini
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 14 (2021): Proceeding of Mulawarman Pharmaceuticals Conferences
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Antibiotics are drugs used to treat infections. Infection is a disease problem that often occurs in developing countries in Indonesia. The purpose of this study was to determine the level of knowledge and behavior of the community in the use of antibiotics and the relationship between knowledge and behavior in the use of antibiotic drugs in the people of Tanjung Redeb District, Berau Regency. This research was conducted by distributing questionnaires to 119 respondents using a cross sectional method with purposive sampling of respondents. The results showed that the level of knowledge of the people of Berau Regency was quite good, namely 47.89% and the results of research based on community behavior were well-behaved with a percentage of 42.01%. The results of the Spearman correlation analysis show that there is a relationship between the level of knowledge on behavior with a correlation coefficient of 0.258, so the relationship between variables is low.

Formulasi dan Evaluasi Nutrasetikal Gummy Candy dari Perasan Daun Kelakai (Stenochlaena Palustris (Burm.F.) Bedd): Formulation and Evaluation Nutraceutical Gummy Candy from Kelakai Leaf Juice (Stenochlaena Palustris (Burm.F.) Bedd) Winiaksa Tri Asdini; Hanggara Arifian; Nur Mita; Rolan Rusli
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 14 (2021): Proceeding of Mulawarman Pharmaceuticals Conferences
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Kelakai leaf (Stenochlaena palustris (Burm.F.) Bedd) is a typical plant of East Kalimantan with high iron content which can overcome anemia. The juice of anchovies was formulated into a nutraceutical gummy candy preparation using the Simplex Lattice Design (SLD) method. The results showed that the juice of anise leaves could be used as a gummy candy preparation with an evaluation results that meet the standard with a juice concentration of 9%, pH 5.4, chewy texture, elastic, strawberry essence aroma, sour taste, and brownish yellow color, 11.52% water content, and 2.30% ash content.

Kajian Literatur: Aktivitas Antioksidan Ekstrak Tanaman Cempedak (Artocarpus champeden Spreng): Literature Review: Antioxidant Activity of Cempedak Plant Extract (Artocarpus champeden Spreng) Aulia Alfath Rahmawati; Mirhansyah Ardana; Yurika Sastyarina
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 14 (2021): Proceeding of Mulawarman Pharmaceuticals Conferences
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Antioxidants are compounds that can counteract free radicals. One of the plants that have antioxidant activity is cempedak, because cempedak contains flavonoids compounds. This writing aims to determine the antioxidant activity of cempedak plants based on a review of several literatures. The method of writing a literature review uses a journal search from Google Scholar. Based on the literature review that has been carried out, the leaves and bark of cempedak have antioxidant activity. Based on the literature review of antioxidant activity of cempedak, methanol extract of stem bark had antioxidant activity of 100,26 ppm, leaf methanol extract 8,88 ppm, leaf ethanol extract 52,7706 ppm, leaf ethyl acetate fraction 4,282 ppm. The part of the cempedak plant that has the highest antioxidant activity is found in the leaves with the ethyl acetate fraction which shows an IC50 value of 4,282 ppm. Based on the IC50 value obtained, the ethyl acetate fraction of cempedak leaves has a very strong antioxidant activity because the IC50 is below 50 ppm.

Literature Review: Bahan Alam yang Berpotensi sebagai Antidiabetes: Literature Review: Natural Ingredients that Have Potential as Antidiabetic Novalinda Novalinda; Mukti Priastomo; Laode Rijai
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 14 (2021): Proceeding of Mulawarman Pharmaceuticals Conferences
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Antidiabetes is a treatment that is currently much needed for diabetics, because the cost of treatment is getting higher, so it is recommended to use herbs as an alternative treatment. This study aims to determine natural ingredients that have the potential as antidiabetic. The method used is a systematic review by collecting, analyzing and summarizing 25 journals with the publication year 2016-2021 with keywords namely Antidiabetes, Natural Ingredients, and In Vivo. The results of the journal analysis are Beluntas leaves 0.9 mg/20 gBW, Kecombrang leaves 100 mg/kgBW, Keji Beling leaves 300 mg/kgBW, Kembang Bulan leaves 5.14 ml/200gBW, Kenikir leaves 1400 mg/200gBW, Mango leaves 105 mg /kgBW, Pucuk Merah leaves 100 g/kgBW, Rambutan leaves 50 mg/kgBW, Sambiloto leaves 40 mg/kgBW, Breadfruit leaves 600 mg/kgBW, Avocado seeds 150 mg/kgBW, Kebiul seeds 51mg/20gBW, Green Coffee Beans Arabica 400 mg/kgBW, Dates seeds 10 mL/day, Pumpkin seeds 720 mg/kgBW, Okra seeds 5,46 mg/gBW, Areca seeds 750 mg/kgBW, Buni bark 200 mg/kgBW, Faloak bark 150 mg /kgBW, Surian bark 150 mg/kgBW, Bilimbi fruit 750 mg/kgBW, Purple Sweet Potato fruit 150 mg/kgBW, Papaya flower 200 mg/kgBW, Pineapple peel 250 mg/kgBW and Black Garlic tuber 300 mg/kgBW with this optimal dose can reduce blood glucose levels.

Kajian Literatur Tanaman Sirih Merah, Binahong, Dan Pegagan Sebagai Penyembuh Luka Insisi: Literature Study of Red Betel Plants, Binahong, and Gotu Kola as Incision Wound Healing Salinding Irene Septiani; Dewi Mayasari; Fajar Prasetya
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 14 (2021): Proceeding of Mulawarman Pharmaceuticals Conferences
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Injury is a condition where tissue function and structure of the body are damaged. Incision wounds can occur intentionally or unintentionally by sharp or blunt instrument. Red betel plants, binahong, and gotu kola are plants that can heal an incisioun wound. The results are obtained by the method of collecting data which related to the study that being studied and analyzed descriptively. The results obtained indicate the secondary metabolites that play a role in incision wound healing process are flavonoids, tannins, and triterpenoids.

Kajian Literatur: Perbandingan Efektivitas Antiplatelet Kombinasi Aspirin-Clopidogrel dan Aspirin pada Stroke Iskemik: Literature Review: Comparison of the Antiplatelet Effectiveness of the Aspirin-Clopidogrel Combination and Aspirin in Ischemic Stroke Salwa Octariani; Dewi Mayasari; Adam M. Ramadhan
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 14 (2021): Proceeding of Mulawarman Pharmaceuticals Conferences
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Ischemic stroke is a condition resulting from a lack of blood flow to the brain. One of the therapies used for ischemic stroke is antiplatelet. Single antiplatelet therapy is generally preferred over combination antiplatelet therapy, because combination therapy results in increased bleeding, which outweighs any benefits. Various studies on the effectiveness of antiplatelet between the combination of aspirin and clopidogrel with aspirin in ischemic stroke patients have been carried out. However, until now there is no consensus that the outcome is better between single aspirin therapy with the aspirin-clopidogrel combination. The aim of this study was to compare the effectiveness of the combination aspirin-clopidogrel and aspirin in ischemic stroke. The method used in this study is a literature review using Google Scholar, PubMed, and Science Direct databases. From the 5 literature that has been reviewed, it shows that in patients with minor ischemic stroke the combination of aspirin-clopidogrel is more effective than single aspirin which is seen from several parameters including Modified Rankin Scale (mRS), European Quality of Life – 5 Dimension (EQ-5D), National Institute of Health Stroke Scale (NIHSS), Activated Partial Thromboplastin Time (aPTT), leukocyte platelet aggregation and leukocyte-platelet aggregate.

Page 51 of 62 | Total Record : 612

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Editorial Address Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus Unmul Gunung Kelua, Kota Samarinda, Kalimantan Timur, Indonesia, 75119

Location Kota samarinda, Kalimantan timur INDONESIA

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Contact Name
Rolan Rusli

Contact Email
rolan@farmasi.unmul.ac.id

Phone
+6285222221907

Journal Mail Official
admin@farmasi.unmul.ac.id

Editorial Address
Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus Unmul Gunung Kelua, Kota Samarinda, Kalimantan Timur, Indonesia, 75119

Location
Kota samarinda,

Kalimantan timur

INDONESIA