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Proceeding of Mulawarman Pharmaceuticals Conferences

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Published by Universitas Mulawarman

ISSN : - EISSN : 26144778 DOI : https://doi.org/10.25026/mpc

Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology

LINGKUP DAN TUJUAN Lingkup naskah mencakup bidang ilmu: Kimia Farmasi Biologi Farmasi Farmakologi Teknologi Farmasi dan Farmasetika Farmasi Klinik dan Komunitas Kedokteran dan Bidang ilmu lain yang terkait Tujuan penerbitan adalah memberikan informasi ilmiah tentang perkembangan ilmu pengetahuan dan teknologi bidang Farmasi dan yang terkait

Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi

Articles 612 Documents

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Aktivitas Penghambatan Radikal Bebas Difenil Pikril Hidrazil (DPPH) Ekstrak Daun Macaranga magna Turrill: DPPH Free Radical Scavenger Activity of Macaranga magna Turrill Leaves Extract Minarti Minarti; Novita Ariani; Teni Ernawati; Akhmad Darmawan
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 14 (2021): Proceeding of Mulawarman Pharmaceuticals Conferences
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Degenerative disease is a disease that has a large number of sufferers in Indonesia and throughout the world, one of the causes of many sufferers of degenerative diseases such as diabetes and cancer is the large amount of exposure to free radicals in the body as a result of an unhealthy lifestyle. Antioxidant compounds are one of the chemical compounds that can be used and utilized to inhibit the oxidation process as a result of the presence of free radicals, so that the incidence of degenerative diseases can be suppressed. In this study, the active extraction and fractionation process from Macaranga magna Turrill leaves which have antioxidant activity and can be developed as a compound inhibiting the oxidation process of free radicals using the chromatographic method, as well as testing the antioxidant activity using the free radical inhibition method 1,1-diphenyl-2- picrylhydrazyl (DPPH). Preliminary test results of antioxidant activity on the methanol extract of Macaranga magna Turrill leaves are known that this plant has potential as an antioxidant with an IC50 value of 11.13 ?g/mL, this is also supported by the test results of total flavonoids 19.47 mg QE/g extract and total phenol 37, 77 mg GAE/g extract.

Isolasi Fungi Endofit Daun Kopi Robusta (Coffea canephora): Isolation of Endophytic Fungus Robusta Coffee Leaf (Coffea canephora) Nilam Ratna Rizkyanti; Herman Herman; Fika Aryati
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 14 (2021): Proceeding of Mulawarman Pharmaceuticals Conferences
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Endophytic fungi are organisms that live in plant tissues that have the potential to produce the same secondary metabolites as their host. This study attempted to isolate and also characterize endophytic fungi from Robusta coffee leaves (Coffea canephora). Data collection was carried out in several stages, namely isolation of endophytic fungi by surface sterilization method, and conventional characterization of endophytic fungi by observing the morphology of endophytic fungi. The results showed that as many as 4 isolates of endophytic fungi were isolated from Robusta coffee leaves (Coffea canephora) with macroscopic characteristics of white color with orange circle edges, cotton-like shape, and green and orange spots on the underside of the fungus.

Efektivitas Jenis Bahan Masker Kain Berdasarkan Kemampuan Penyaringan Mikroba: Effectiveness of Fabric Mask Material Types Based on Microbial Filtration Capabilities Nilam Sari; Mukti Priastomo; Niken Indriyanti
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 14 (2021): Proceeding of Mulawarman Pharmaceuticals Conferences
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

A cloth mask is a mask that can be used repeatedly and is made of thicker fabric material. Cloth masks circulating in the community have not guaranteed quality. This study aims to find out the effectiveness of fabric mask materials based on microbial filtration capabilities as well as find out the optimal characteristics of the initial use of cloth mask materials and after washing 50 times. This study was conducted experimentally where the effectiveness of fabric mask material by spraying bacterial suspension, and testing the characteristics of fabric mask materials by conducting fiber observation, light intensity test, steam filtration test, water absorption test and water capillary on the fabric. The results of research on the effectiveness of fabric mask materials showed Asymp.Sig >0.05 so that there are significant differences from all types of fabric mask materials. Based on the results of characteristic testing, the fiber material of the initial cloth mask looks better than after 50 washes. Test the light intensity of the outer layer, inner layer, and filter layers p, f and s after washing there is an increase compared to the initial use. Steam filtration tests of outer layers, inner layers and filter layers p, f and s when the initial user takes time for steam to penetrate the fabric compared to 50 washes. The absorption test of the outer layer during initial use does not occur absorption above 60 seconds and after 50 washes begins absorption. The inner layer and filter layer at the initial use do not absorb above 60 seconds and after 50 washes there is absorption under 60 seconds. The p filter layer does not absorb during initial use and after 50 washes. Filter layer f during initial use and after 50 washes there is absorption under 60 seconds. Capillary test results for 60 seconds the outer layer and the p filter layer during initial use do not absorb while 50 times the washing occurs absorption. The inner layer, filter layer f and s increase after 50 washes. The conclusion of the study was that the effectiveness of the mask material was good enough for the inner and outer layers, the p filter layer was more effective than the f and s filter layers. The characteristic test results at initial use were very good, but after 50 washes there was a decrease.

Optimisasi Carbopol Sebagai Basis Gel pada Gel Antiseptik Berbasis Alkohol: Optimization of Carbopol as a Gel Base in Antiseptic Gel Alcohol Based Noor Linda Febrianie
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 14 (2021): Proceeding of Mulawarman Pharmaceuticals Conferences
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Alcohol-based antiseptic gels are considered to be able to replace washing hands with soap and can inhibit the growth of viruses. Alcohol-based gels have the disadvantage of being difficult to mix with gel-based ingredients. Carbopol as an alcohol-soluble gel base was chosen to be the base for this alcohol-based antiseptic gel. The concentrations used were 0.5%, 0.75%, 1%, 1.25%, 1.5%, 1.75%, and 2%. The physical test of the gel was carried out to see the optimum carbopol gel base for alcohol-based antiseptic gel. Physical test includes organoleptic observation, pH value, viscosity determination spreadability test and homogeneity test. The results obtained from organoleptic observation showed that the gel was clear, smelled antiseptic, two concentrations had a slightly sticky and sticky consistency. The pH value yields a pH range of 4.65 - 6.06. The viscosity results showed a viscosity range of 10.48725 - 21.18107 Pa.S. The Spreadability test shows the spreadability range of 6.07 - 7.03 cm. The homogeneity test resulted in an alcohol-based antiseptic gel without coarse particles. Hedonic organoleptic test produced the most preferred antiseptic gel was the antiseptic gel with a carbopol concentration of 1.25%. The results showed that the optimal carbopol was used as a gel base in an alcohol-based antiseptic gel 1.25% carbopol.

Evaluasi Penggunaan Obat pada Pasien Dispepsia di Rumah Sakit Samarinda Medika Citra Tahun 2021: Evaluation of Medication Use in Patients with Dyspepsia at Samarinda Medika Citra Hospital in 2021 Novia Syafitri; Adam M. Ramadhan; Muhammad Faisal
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 14 (2021): Proceeding of Mulawarman Pharmaceuticals Conferences
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Dyspepsia is defined as chronic or recurrent pain or discomfort centered in the upper abdomen that may originate from a variety causes. The right administration of drugs is a major concern when administrating drugs to dyspepsia patients to achieve the goal of drugs therapy itself. The aim of this study was to determine the characteristics of patients, the description of drug therapy and accuracy of medication use at Samarinda Medika Citra Hospital in January - August 2021. This study uses a non-experimental research design, data retrieval is done retrospectively and the analytical method is descriptive. The research instruments using 70 patient medical record data inclusions. The result revealed that the most characteristic data of dyspeptic patients was female by 55,71% (39 people), adult age group 26-45 years old by 42,86% (30 people), senior high school by 52,86% (37 people), other profession by 84,28% (59 people), patient with comorbidity by 71,43% (50 people). The most frequently prescribed anti-ulcer drugs for dyspepsia patients is combination of H2RA, Antiemetic and Cytoprotective approximately by 42,85% (30 people). The result showed that the right drugs by 100% (193 drugs), the right indications by 100% (193 drugs), and the right dosage by 96,37% (186 drugs).

Pengaruh Trietanolamin pada Basis Krim Minyak dalam Air yang Berbahan Dasar Asam Stearat dan Setil Alkohol: Effect of Triethanolamine on Oil-in-Water Cream Base Based on Stearic Acid and Cetyl Alcohol Novita Sari; Erwin Samsul; Angga Cipta Narsa
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 14 (2021): Proceeding of Mulawarman Pharmaceuticals Conferences
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

The cream is a semi-solid preparation with one or more ingredients dispersed in two types of emulsions, water-in-oil (W/O) and oil-in-water (O/W) type creams. Oil-in-water type cream has a high water content so that it can provide a hydration effect that can increase the penetration of the active substance. Triethanolamine in topical preparations is used as an emulsifier and alkalizing agent to form a homogeneous and stable cream. The purpose of this research was to determine the effect of triethanolamine on an oil-in-water cream base based on stearic acid and cetyl alcohol. Making the base is done by making preparations using four concentrations of triethanolamine 0.5% (F1), 1% (F2), 1.5% (F3), and 2% (F4). The cream base was then evaluated for its physical properties including organoleptic, homogeneity, pH, viscosity, spreadability, adhesion, and phase separation test. The results showed that in the organoleptic test cream bases were white, had a characteristic aroma with a semisolid form. The cream base has a homogeneity dispersion with an average pH between 6.53-7.29, viscosity between 3.5792396-3.8001904 (Pa.s), spreadability between 5.43-5.78 cm, and adhesion between 4.47-6.25 seconds. The cream base did not have phase separation and was stable in storage for 4 weeks at room temperature.

Pengaruh Pemberian Kombinasi Jus Belimbing Manis (Averrhoa carambola) dan Labu Siam (Sechium edule) terhadap Pemeliharaan Tekanan Darah: The Effect of Combination of Starfruit (Averrhoa carambola) and Chayote (Sechium edule) Juice on Blood Pressure Maintenance Nugrahiwulan Oktaviani; Riski Sulistiarini; Vita Olivia Siregar
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 14 (2021): Proceeding of Mulawarman Pharmaceuticals Conferences
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Starfruit (Averrhoa carambola) and chayote (Sechium edule) contain potassium which can balance blood pressure. This study aims to determine the characteristics of the respondents including gender, age, education, occupation, physical activity, and regular exercise, to determine the blood pressure profile of the respondents, and to determine the effect of giving a combination of starfruit juice and chayote in the Samarinda Ulu District. The method used is a quasi-experimental method by measuring pre and post treatment for 5 days. Data collected on the characteristics of respondents obtained the highest percentage of women 95%, ages 18-30 years 95%, high school education 95%, college student job 95%, low physical activity 95%, and not doing regular exercise 70% . The respondent's blood pressure profile for 14 days every 3 days shows the Mean Artery Pressure value in the normal and high normal categories. The results of the combination of starfruit juice and chayote can maintain blood pressure, with a mean decrease in systolic and diastolic 12.2 ± 7.97 mmHg and 6.5 ± 3.60 mmHg for the treatment group. Based on the results, it can be concluded that the combination of sweet star fruit juice and chayote can maintain blood pressure in normotensive respondents.

Skrinning Aktivitas Antimikroba Ekstrak Etanol Daun Mekai (Albertisia sp.): Screening of Antimicrobial Activity of Mekai (Albertisia sp.) Leaf Ethanol Extract Nur Aini Buring Incau; Maria Almeida; Niken Indriyanti
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 14 (2021): Proceeding of Mulawarman Pharmaceuticals Conferences
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Albertisia sp. is a plant used as eye medicine because to infection of the eye or eyelid tract by the Dayak population in Malinau Regency, North Kalimantan. This study aims to determine whether the extract of mekai leaf has antimicrobial activity as well as activity as an antibacterial or antifungal. The method that was applied this study is extraction with a maceration using 96% ethanol, followed by phytochemical analysis. The agar diffusion technique was used to test the antibacterial activity by measuring the diameter of the inhibition zone at of various extract concentrations. According to the findings, mekai leaves contain secondary metabolites such as flavonoids, alkaloids, steroids, saponins, and phenolics. In the antimicrobial test results, the ethanolic extract of mekai leaf showed activity than M.furfur has a 11,52 ± 7,97 mm, A.niger has a of 10,66 ± 1,36 mm and C.albicans has a 6,31 ± 7,04 mm. Ethanolic extracts of mekai leaf show activity than E.coli 1,59 ± 3,16 mm, P.acnes 2,45 ± 4,55 mm, S.thypii 1,69 ± 3,07 mm, and V.cholerae 1,94 ± 4,21 mm. From this study it was said that the ethanolic extract of mekai leaves might be developed as an antifungal rather than as an antibacterial.

Uji Antioksidan Ekstrak Metanol Kulit Batang Pule (Alstonia scholaris) khas Kalimantan dengan Metode DPPH: Antioxidant Test of Methanol Extract of Pule Bark (Alstonia scholaris) typical of Kalimantan with the DPPH Method Nur Halimah; Mahfuzun Bone; Fajar Prasetya
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 14 (2021): Proceeding of Mulawarman Pharmaceuticals Conferences
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Pule (Alstonia scholaris) is one of the plants that are empirically often used in medicine. Pule bark contains flavonoids which can generally be used as antioxidants. This study aims to determine the content of secondary metabolites and antioxidant activity of the methanol extract of pule bark by determining the IC50 value of the extract. The secondary metabolite test was carried out by reacting the extract with phenolic test reagents, steroids, terpenoids, saponins, flavonoids and alkaloids. The antioxidant activity test was carried out using the DPPH method (2,2-Diphenyl-1-Picrylhydrazil). Antioxidant activity was measured by the ability of the methanol extract of Pule bark to reduce DPPH which was measured using a UV-Vis Spectrophotometer so that absorbance data was obtained and then processed by linear regression method. The results showed that the extract contained phenolic and flavonoid compounds. While the DPPH test showed that the extract had weak antioxidant activity with an IC50 value of 472.473 ppm.

Kajian Penggunaan Obat Off-Label Pada Penyakit ISPA Pasien Pediatri di RSUD Majene: Study of Off-Label Drugs Use in Pediatric Patients at Majene General Hospital Nurul Syafitri AR; Muhammad Faisal; Niken Indriyanti
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 14 (2021): Proceeding of Mulawarman Pharmaceuticals Conferences
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Acute Respiratory Infection (ARI) is an infection that attacks the human respiratory tract with the highest number of sufferers being found at the age of toddlers. The limitations of the types of drugs that can be used in the age range of children aged 0-2 years cause the treatment of patients to use off-label drugs. categories of off-label age, off-label indication and off-label route of administration. This study is a descriptive type of research with data collection carried out retrospectively, there are 88 medical records of pediatric patients with a diagnosis of Pneumonia, Common Cold, Allergic Rhinitis and Asthma At Majene Hospital in the period January to December 2020. Male (55.68%) and female (44.31%) and found 26 off-label drug prescriptions, off-label drug use classified as off-label age 19, off-label indication use 5 and the use of off-label route of administration 2. The most widely prescribed type of off-label drug is Chlorpheniramine Maleate. According to the literature, the use of off-label drugs is based on a sound scientific basis with low risk. Based on the results of this study, it is known that the use of off-label drugs in children is quite high so that pharmacists need to monitor the risks related to drug use.

Page 49 of 62 | Total Record : 612

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Editorial Address Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus Unmul Gunung Kelua, Kota Samarinda, Kalimantan Timur, Indonesia, 75119

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Contact Name
Rolan Rusli

Contact Email
rolan@farmasi.unmul.ac.id

Phone
+6285222221907

Journal Mail Official
admin@farmasi.unmul.ac.id

Editorial Address
Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus Unmul Gunung Kelua, Kota Samarinda, Kalimantan Timur, Indonesia, 75119

Location
Kota samarinda,

Kalimantan timur

INDONESIA