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PHARMADEMICA : Jurnal Kefarmasian dan Gizi d/a AKAFARMA - AKFAR PIM, Jalan Barito 5 Malang, Indonesia East Java Indonesia Telp. 0341 – 491132
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Pharmademica: Jurnal Kefarmasian dan Gizi
Published by Akademi Farmasi Putra Indonesia Malang
ISSN : 28083970     EISSN : 28083423     DOI : https://doi.org/10.54445/pharmademica
Core Subject : Health, Science,
Chemistry Public Health
PHARMADEMICA : Jurnal Kefarmasian dan Gizi menerbitkan artikel penelitian asli di semua bidang : Farmasi Klinis Kimia Farmasi Ilmu farmasi Farmasi Komunitas Farmakognosi Fitokimia Analisis Farmasi Pendidikan dan Pembelajaran Farmasi Biokimia Nutrisi klinis Gizi Masyarakat Makanan Fungsional
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 45 Documents
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Uji Aktivitas Antibakteri Lendir Bekicot (Achatina Fulica) Terhadap Bakteri Escherichia Coli Dan Uji Kadar Total Protein Otu, Larasati Rambu; Iswandi, Iswandi; Wulandari, Destik
PHARMADEMICA : Jurnal Kefarmasian dan Gizi Vol 4 No 1 (2024): April - September
Publisher : LPPM-KI - POLTEKKES PIM (Formerly AKAFARMA-AKFAR PIM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54445/pharmademica.v4i1.54

Abstract

Snails (Achatina fulica) have mucus whose main contents include beta agglutinin, Achasin protein, oacharan sulfate and glycoconjugates. Snail mucus can also treat wound infections in the digestive tract and surgical site infections (SSI), one of which is caused by Escherichia coli bacteria. This research utilizes the antibacterial content in snail mucus to inhibit Escherichia coli bacterial colonies and determine the total protein levels in snail mucus. The antibacterial activity test used the disk diffusion method and analysis of total protein levels in snail mucus was analyzed using the biuret method with a UV-Vis spectrophotometer and albumin as a standard solution. The research results were entered in tabular data and analyzed descriptively. The results of quantitative tests on the antibacterial activity of snail mucus showed that there was antibacterial activity of snail mucus against Gram negative Escherichia coli bacteria with concentrations of 100%, 50% and 25% having clear zones of 14, 11.88 and 8.66 mm respectively. The results of calculating the total protein content using the UV-Vis Spectrophotometer method were 11%. This test produced a high total protein content
Mutu Fisik Sabun Padat Ekstrak Biji Kopi (Coffea Robusta) Misgiati, Misgiati; Ardianto, Rahmat
PHARMADEMICA : Jurnal Kefarmasian dan Gizi Vol 4 No 1 (2024): April - September
Publisher : LPPM-KI - POLTEKKES PIM (Formerly AKAFARMA-AKFAR PIM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54445/pharmademica.v4i1.55

Abstract

Soap is a cleaning product produced from the reaction between oil or fat with potassium hydroxide or sodium hydroxide base. Based on its consistency, soap is divided into two types, namely liquid soap and solid soap. Solid soap is more often used by the public. Utilization of natural ingredients as an innovation for soap is still rarely done. The content of coffee is able to prevent premature aging of the skin, function to smooth the skin, and neutralize irritated skin. This study aims to determine the physical quality and pH of solid soap mixed with coffee extract. Production of coffee extract using the maceration method with 70% ethanol solvent. This type of research is descriptive, with the aim of knowing the physical quality and pH of solid body soap by adding coffee extract. Based on the results of the research conducted, it can be concluded that the results of the evaluation of the physical quality of the coffee extract solid soap preparations fulfilled the physical quality test requirements, which included organoleptic tests, water content tests, foam stability tests, and pH.
Penggunaan Polivinil Pirolidon (PVP) sebagai Bahan Pengikat pada Formula Granul: Literatur Review Safitri, Rusiana Yulia; Bhagawan, Weka Sidha; Primiani, Cicilia Novi Primiani
PHARMADEMICA : Jurnal Kefarmasian dan Gizi Vol 4 No 1 (2024): April - September
Publisher : LPPM-KI - POLTEKKES PIM (Formerly AKAFARMA-AKFAR PIM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54445/pharmademica.v4i1.56

Abstract

Granule preparations are lumps of small particles that are uneven in shape and become single, larger particles. The process of making granule preparations uses a technique, namely granulation. In the granulation process, a binder is needed to unite the powder particles into a granule preparation. The binder material that is often used is polyvinyl pyrrolidone (PVP). The use of PVP is able to produce an optimal granule preparation that meets the requirements. This research reviews the use of PVP as a binding agent in making granule preparations. This research method uses a literature study method in the form of primary references in the form of national journals from the last 10 years searched in the Google Scholar, PubMed, and ScienceDirect databases. Search for this data source using the keywords Use of PVP as a binding agent in granule preparations. The results and conclusions of the research show that the use of PVP as a binding agent in granular preparations can produce preparations that meet the requirements.
Studi Formulasi Sabun Padat Santan dengan Variasi Konsentrasi Minyak Kelapa dan Minyak Sawit wuryandari, wahyu; Pamella, Melani Safira
PHARMADEMICA : Jurnal Kefarmasian dan Gizi Vol 4 No 2 (2025): Oktober - Maret
Publisher : LPPM-KI - POLTEKKES PIM (Formerly AKAFARMA-AKFAR PIM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54445/pharmademica.v4i2.57

Abstract

Solid soap is a cleansing product derived from the saponification of fatty acids and bases. The fatty acids used were coconut oil and palm oil. Coconut oil and palm oil contained lauric acid, palmitic acid, and oleic acid, each of which functioned to produce lather, hardness, and moisturizing properties in the soap. Coconut milk contained oleic acid, stearate, and linoleate, serving as moisturizers. Coconut milk could be used as a substitute for water to dissolve NaOH. This study aimed to ascertain the physical and chemical quality of solid coconut milk soap with variations in concentrations of coconut oil and palm oil. The study was conducted as an experimental research. Solid coconut milk soap was manufactured using the cold process method. The soap was formulated into three different recipes. The results of physical and chemical quality tests of the three formulations showed water content testing yielded 7.88% (formula 1), 7.95% (formula 2), and 9.63% (formula 3). Foam height testing resulted in 11.6 cm (formula 1), 11.3 cm (formula 2), and 11.3 cm (formula 3). pH testing showed values of 9.63 (formula 1), 9.76 (formula 2), and 9.73 (formula 3). Free alkali testing indicated 0.089% (formula 1), 0.094% (formula 2), and 0.084% (formula 3). The conclusion drawn from this research is that solid coconut milk soap with variations in concentrations of coconut oil and palm oil meets the 2021 Indonesian National Standards for organoleptic properties, water content, pH, and free alkali content.
Mutu Fisik dan Aktivitas Antifungi Sampo Ekstrak Mentimun (Cucumis sativus) terhadap Candida albicans Jamilatun, Makhabbah; Rusita, Youstiana Dwi; Sari, Esti Perwita
PHARMADEMICA : Jurnal Kefarmasian dan Gizi Vol 4 No 2 (2025): Oktober - Maret
Publisher : LPPM-KI - POLTEKKES PIM (Formerly AKAFARMA-AKFAR PIM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54445/pharmademica.v4i2.58

Abstract

Dandruff can be caused by microorganisms such as fungi, one of which is Candida albicans. Candida albicans fungus can be inhibited with flavonoids, saponins, and alkaloids. One of the plants that contain this compound is cucumber (Cucumis sativus). Cucumbers are also able to stimulate hair growth and nourish hair loss. This research aims to determine the physical quality to determine quality and antifungal activity of cucumber fruit extract shampoo. The method used in this research was quantitative experimental with four formulas for varying the concentration of active substances from cucumber: F1 (0%), F2 (0.06%), F3 (0.08%), and F4 (0.1%). Cucumber extraction was done using the soxhletation method using 70% ethanol solvent.   The organoleptic test results showed that F0, F1, F2, and F3 had a clear yellow color, a typical herbal odor, thick texture; and homogeneous. The pH of F0, F1, F2, and F3 respectively is 8.52; 8.76; 8.62 and 8.86. The viscosities of F0, F1, F2, and F3 are 1352 mPas, 1441 mPas, 1631 mPas, dan 1690 mPas, respectively. The height of the foam F0, F1, F2, and F3 respectively is 8.3 cm; 8.6cm; 8.6cm; and 8 cm. Antifungal activity has an inhibition zone of F0, F1, F2, and F3 respectively, namely 21.22 mm; 22.47mm; 22.82mm; 24.35mm. The results obtained show that the cucumber extract shampoo meets the physical qualities and has very strong antifungal activity.
Analisa Kandungan Formaldehid Pada Sediaan Cat Kuku (Kutek) yang Diperjualbelikan di Pasar Kota Wonogiri Andriastuti, Deitra Aprilia; Nasikin, M. Ali; Rakhmayanti, Regia Desty
PHARMADEMICA : Jurnal Kefarmasian dan Gizi Vol 4 No 1 (2024): April - September
Publisher : LPPM-KI - POLTEKKES PIM (Formerly AKAFARMA-AKFAR PIM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54445/pharmademica.v4i1.61

Abstract

Nail polish is a pigment that is deposited in a volatile solvent to cover the natural color of the nail and as an attractiveness enhancer that uses formaldehyde. Formaldehyde (H2CO) with the trade name formalin solution, which functions as a nail polish hardener, so that the nail polish is more adhesive and thicker. This study aims to determine whether nail polish preparations traded in the Wonogiri city market contain formaldehyde with levels that exceed the limit according to the Regulation of the Head of the Food and Drug Supervisory Agency of the Republic of Indonesia Number 18 of 2015, which is <5%. Qualitative analysis used resorcinol reagent, while quantitative analysis used UV-Vis spectrophotometry at a wavelength of 550 nm. The sample used in this study was nail polish taken from the market in Wonogiri, 9 samples with sample codes A, B, C, D, E, F, G, H, and I. The results showed that 9 samples of nail polish studied meet the requirements of the level limit of less than 5%, with the largest level obtained at 3.349% for the code I sample and the smallest level at 0.750% for the code E sample. Keywords: nail polish, formaldehyde, UV-Vis spectrophotometry  
Analisis Kandungan Hidrokuinon pada Hand Body Lotion yang Dijual di Kecamatan Klaten Tengah dengan Metode Spektrofotometri Uv Vis Ningrum, Ayu Dwi Retno; Rakhmayanti, Regia Desty; Nasikin, M. Ali
PHARMADEMICA : Jurnal Kefarmasian dan Gizi Vol 4 No 2 (2025): Oktober - Maret
Publisher : LPPM-KI - POLTEKKES PIM (Formerly AKAFARMA-AKFAR PIM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54445/pharmademica.v4i2.66

Abstract

Hydroquinone is a compound used as a whitening agent and to prevent pigmentation. The use of hydroquinone in hand body lotion is prohibited by BPOM because it can cause skin irritation, redness, burning sensation, bluish or blackish skin (ochronosis), cancer. This study aims to identify the content and determine the levels of hydroquinone in hand body lotion sold in Klaten Tengah District using the UV-Vis spectrophotometry method. The research method used is quantitative descriptive. The samples obtained were eight and were coded A, B, C, D, E, F, G, and H. The results showed that all samples were positive for hydroquinone with levels of 2.54%; 0.20%; 0.14%; 0.17%; 0.30%; 1.25%; 0.37%; and 2.10% so that they do not meet the requirements of BPOM RI No.23 of 2019.  
Gambaran Peresepan Antibiotik di Poli Telinga Hidung Tenggorokan (THT) di Rumah Sakit X Kabupaten Situbondo Nanda, Solikhati Ika; Syah, Farid Zulkarnain Nur
PHARMADEMICA : Jurnal Kefarmasian dan Gizi Vol 4 No 2 (2025): Oktober - Maret
Publisher : LPPM-KI - POLTEKKES PIM (Formerly AKAFARMA-AKFAR PIM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54445/pharmademica.v4i2.70

Abstract

Antibiotics are chemical compounds used to treat bacterial infections by inhibiting the growth or killing bacteria. Antibiotics are classified as prescription medications, meaning their use must be based on a doctor's recommendation and prescription. The selection of antibiotics should be based on information about the spectrum of microorganisms causing the infection, microbiological test results, pharmacokinetic and pharmacodynamic profiles of the antibiotics, as well as their affordability. The prescribing of antibiotics in hospitals, both in terms of the types of antibiotics used and the medical reasons for their use, may vary depending on the guidelines for antibiotic use at each hospital. This study aims to provide an overview of antibiotic prescribing in the Ear, Nose, and Throat (ENT) clinic at Situbondo District Hospital. The research design is descriptive observational. The samples used were all doctor prescriptions from the ENT clinic at the hospital, filled at the outpatient pharmacy depot during November 2023. The sampling technique employed was total sampling, resulting in 110 prescriptions. The findings showed that the most commonly prescribed antibiotics were Co-Amoxiclav (66.2%), Cefixime (20.0%), Levofloxacin (7.6%), Azithromycin (4.1%), and a combination of Polymyxin B Sulfate and Neomycin Sulfate (2.1%). Regarding the duration of antibiotic therapy, oral antibiotics were prescribed for 2 to 7 days, while ear drops were used for 20 to 27 days.
Studi Fitokimia Dan Farmakologi Buah Pisang Kayu (Musa Paradisiaca L. Var. Kayu) Sebagai Antidiare Wulandari, Winda; Klau, Ivan Charles S.; Nurmalasari, Devy Artanti; Santyas, Aisyah Adellina; Zahra, Maulidya Rachma Az; Maharani, Tiara Anisa; Sofia, Armelia Idawati; Parnaen, Shawa Satria; Ningsih, Arista Wahyu
PHARMADEMICA : Jurnal Kefarmasian dan Gizi Vol 4 No 2 (2025): Oktober - Maret
Publisher : LPPM-KI - POLTEKKES PIM (Formerly AKAFARMA-AKFAR PIM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54445/pharmademica.v4i2.71

Abstract

Banana kayu is a fruit that contains phenolics. Phenolic compounds have pharmacological effects as antidiarrheal agents. Objective: This article review aims to identify the chemicals present in the banana kayu plant (Musa paradisiaca L. Var. Kayu) and examine its pharmacological effects. Method: The employed methodology is the literature search technique. Results: This journal review article examines the pharmacological activity of banana kayu, namely antidiarrheal, antibacterial, antimicrobial, antiviral, anti-inflammatory, astringent, and antioxidant properties in various portions of the banana kayu. Banana kayu comprises components including alkaloids, tannins, saponins, flavonoids, steroids, and serotonin. Conclusion: Multiple assessments indicate that the fruit of the banana kayu plant possesses diverse compounds with numerous benefits.
Potensi Antioksidan Ekstrak Cangkang Kepiting Rajungan (Portunus pelagicus) dari Pekalongan, Jawa Tengah, Indonesia Ermawati, Nur; Mahbub, Khafid; Yuniarsih, Sri Mumpuni; Wiranti, Kharisma Wido; Octaviani, Felicia Aurelia
PHARMADEMICA : Jurnal Kefarmasian dan Gizi Vol 5 No 1 (2025): April - September
Publisher : LPPM-KI - POLTEKKES PIM (Formerly AKAFARMA-AKFAR PIM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54445/pharmademica.v5i1.79

Abstract

Free radicals contribute to oxidative stress, which plays a key role in degenerative diseases. Antioxidants neutralize free radicals, preventing cellular damage. This study evaluates the antioxidant activity of Portunus pelagicus shell extract from Wonokerto, Pekalongan Regency, using the 1,1-diphenyl-2-picrylhydrazyl (DPPH) method. Extraction was performed through demineralization, deproteinization, and maceration with virgin coconut oil. Phytochemical analysis confirmed the presence of terpenoids, which are known for their antioxidant properties, but Thin Layer Chromatography (TLC) did not detect astaxanthin. Antioxidant activity testing at concentrations of 5, 10, 50, and 100 ppm resulted in an IC50 value of 549.40 ppm, indicating very weak antioxidant potential. The absence of astaxanthin and the weak activity may be due to extraction method limitations, solvent choice, or low concentrations of active compounds. These findings highlight the need for optimized extraction techniques to enhance the bioactive potential of crab shell-derived compounds. This study contributes to marine biowaste utilization and provides insights into improving antioxidant properties for pharmaceutical and nutraceutical applications.

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