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Contact Name
Haritsah Alfad
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haritsah@mail.akfarpim.ac.id
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pharmademica@gmail.com
Editorial Address
PHARMADEMICA : Jurnal Kefarmasian dan Gizi d/a AKAFARMA - AKFAR PIM, Jalan Barito 5 Malang, Indonesia East Java Indonesia Telp. 0341 – 491132
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Kab. malang,
Jawa timur
INDONESIA
Pharmademica: Jurnal Kefarmasian dan Gizi
ISSN : 28083970     EISSN : 28083423     DOI : https://doi.org/10.54445/pharmademica
Core Subject : Health, Science,
PHARMADEMICA : Jurnal Kefarmasian dan Gizi menerbitkan artikel penelitian asli di semua bidang : Farmasi Klinis Kimia Farmasi Ilmu farmasi Farmasi Komunitas Farmakognosi Fitokimia Analisis Farmasi Pendidikan dan Pembelajaran Farmasi Biokimia Nutrisi klinis Gizi Masyarakat Makanan Fungsional
Articles 58 Documents
Optimasi Formulasi, Stabilitas Fisik dan Uji Iritasi Lotion Tabir Surya Kombinasi Benzophenone-4 dan Octocrylene Yuli Ainun Najih; Yuyun Nailufa; Dita Nurlita Rakhma; Davan Ercha Wafi Azhanzi; Farid Zulkarnain Nur Syah
PHARMADEMICA : Jurnal Kefarmasian dan Gizi Vol 5 No 2 (2026): Oktober - Maret
Publisher : LPPM-KI - POLTEKKES PIM (Formerly AKAFARMA-AKFAR PIM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54445/pharmademica.v5i2.153

Abstract

Ultraviolet (UV) radiation exposure necessitates the creation of sunscreen formulas that are stable, safe for the skin, and photoprotective. Although benzophenone-4 (BZP-4) and octocrylene (OCT) are widely used as chemical UV filters, studies on the physical stability and irritation of optimizing the combination of the two in lotion formulations are still limited. The purpose of this study is to improve the physical stability, formulation, and irritation testing of a sunscreen lotion that combines BZP-4 and OCT. Variations in single and combination concentrations (1–5%) were included into five formulations. Organoleptic testing, pH, viscosity, spreadability, adhesion, emulsion type, physical stability using centrifugation and six cycles of testing, and irritation testing based on a non-animal alternative method using the Hen's Egg Test–Chorioallantoic Membrane (HET-CAM) were all used to evaluate the preparations. A paired t-test was used for statistical analysis to compare parameters prior to and during the physical stability test. The combination formula of 1% BZP and 1% OCT produced the best physical properties (pH 6.44; viscosity 2793 cP), was stable in centrifugation and cycle tests (p>0.05), and did not irritate the skin (HET-CAM score 0.98±0.04). Conversely, single formulas and high concentrations showed moderate to strong irritation. The results of this study contribute scientifically to the conclusion that the combination lotion formulation of BZP-4 1% and OCT 1% has good physical stability and does not cause irritation.
Evaluasi Digital Adherence Technology Berbasis Kode QR (Q-Monte) untuk Pemantauan Kepatuhan Pengobatan Tuberkulosis Farid Zulkarnain Nur Syah; Noor Annisa Susanto; Akhmad Zainuri
PHARMADEMICA : Jurnal Kefarmasian dan Gizi Vol 5 No 2 (2026): Oktober - Maret
Publisher : LPPM-KI - POLTEKKES PIM (Formerly AKAFARMA-AKFAR PIM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54445/pharmademica.v5i2.160

Abstract

Tuberculosis (TB) treatment adherence is a critical determinant of therapeutic success; however, monitoring adherence remains challenging in primary healthcare settings. Digital adherence technology (DAT) offers an alternative approach to monitor patient adherence more efficiently. This study aimed to evaluate the initial feasibility of implementing a QR code–based DAT system (Q-Monte) for monitoring TB treatment adherence in primary healthcare centers. This study employed a pilot feasibility design with a prospective observational approach involving 30 outpatient TB patients from two primary healthcare centers in Malang Regency. Participants were recruited using purposive sampling with the following inclusion criteria: TB patients aged ≥12 years, receiving oral anti-tuberculosis therapy, owning an Android-based smartphone and an active WhatsApp number, and being willing to be monitored for 30 days. Patients with HIV co-infection or multidrug-resistant TB (TB-MDR), those who transferred healthcare facilities during the observation period, or those with stroke comorbidity were excluded. Most participants were male (56.7%), aged 45–54 years (30.0%), had completed senior high school education (50.0%), and had no comorbidities (80.0%). Adherence was measured as the percentage of days with QR code scanning, while system usability was assessed using the System Usability Scale (SUS). The results showed an average QR code scanning adherence rate of 90.3% over 30 days, with 46.7% of patients reporting having taken medication without performing the QR code scan. The usability evaluation yielded a mean SUS score of 75.7 (grade B). These findings indicate that Q-Monte is feasible as a tool for monitoring TB treatment adherence in primary healthcare settings, although further optimization of technical support and user education is needed to improve the reliability of digital adherence recording.
Optimasi PVA dan HPMC dalam Masker Wajah Gel Peel Off Ekstrak Daun Beluntas (Pluchea indica L.) dengan Metode Simplex Lattice Design Diny Puspitasari; Devina Wahyu Astaning Cristy; Fina Arista Langu
PHARMADEMICA : Jurnal Kefarmasian dan Gizi Vol 5 No 2 (2026): Oktober - Maret
Publisher : LPPM-KI - POLTEKKES PIM (Formerly AKAFARMA-AKFAR PIM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54445/pharmademica.v5i2.158

Abstract

Peel-off gel masks are widely used cosmetic skincare preparations due to their practicality, ease of removal, and non-comedogenic properties. Beluntas (Pluchea indica L.) leaf contains various bioactive compounds, particularly flavonoids, which possess antibacterial activity. This study aimed to obtain the optimum formulation of a peel-off face mask containing Beluntas leaf extract, with variations in Polivinyl alcohol (PVA) as a film-forming agent, and hydroxypropyl methylcellulose (HPMC) as a gelling agent.This experimental study employed the Simplex Lattice Design (SLD), an optimization method. Five formulations were prepared with PVA content ranging from 10-16% and HPMC concentrations from 2-4%. Each formulation was evaluated for organoleptic properties, homogeneity, pH, spreadability, drying time, adhesion, and viscosity, and the data were analyzed using Design Expert Version 13. The optimum peel-off gel mask formulation containing Beluntas leaf extract was obtained at PVA 12.92% and HPMC 3.07% with predicted spreading power 5.198, adhesion 52.910, viscosity 586.357, pH 4.626, drying time 23.502 with desirability 0.812.
Aktivitas Antibakteri dan Antioksidan Kulit Apel Rome Beauty (Malus sylvestris Mill) Aldesra Fitri; Ardika Amanda Silya; Olafiani Ryhasanda; Fendi Yoga Wardana; Mayang Aditya Ayuning Siwi
PHARMADEMICA : Jurnal Kefarmasian dan Gizi Vol 5 No 2 (2026): Oktober - Maret
Publisher : LPPM-KI - POLTEKKES PIM (Formerly AKAFARMA-AKFAR PIM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54445/pharmademica.v5i2.165

Abstract

Rome beauty apple (Malus sylvestris Mill) is an apple variety that is widely grown in Batu City. The skin of this apple is known to contain flavonoid compounds such as quercetin, catechin, procyanidin and caffeic acid which are useful as antibacterial, antioxidant, and antiproliferative. This study was conducted to determine the total flavonoid content and antibacterial activity in the ethanol extract of macerated Roma beauty apple peel. In addition, this study also aims to determine the antioxidant activity of the ethyl acetate extract and the ethanol extract of Roma beauty apple from multistage extraction. The ethanol extract of macerated Rome beauty apple was tested for total flavonoid content and antibacterial activity using the well diffusion method, then the diameter of the inhibition zone was measured against Propionibacterium acnes and Staphylococcus aureus bacteria, while the ethyl acetate extract and the ethanol extract of Rome beauty apple from multistage extraction were tested for antioxidant activity using the 1,1-diphenyl-2-picrylhydrazyl (DPPH) method. Based on the research, it is known that the ethanol extract of Rome Beauty apple peel from maceration contains flavonoids of 47.10 mgQE/g with an inhibition zone diameter against Propionibacterium acnes and Staphylococcus aureus of 8.70 mm and 11.67 mm respectively with a concentration of 20% w/v. The results of the antioxidant activity test of the ethyl acetate extract obtained IC50 3026 ppm and the ethanol extract from multistage extraction of 4702 ppm. The test results can be concluded that the ethanol extract of Rome Beauty apple has a total flavonoid content and antibacterial activity with a moderate category against P. acnes bacteria and strong against S. aureus bacteria. The ethyl acetate extract and the ethanol extract of Rome Beauty apple peel from multistage extraction have antioxidant activity with a very weak category.
Analisis Faktor Risiko Penyakit Tidak Menular pada Remaja di Daerah Perkotaan: Studi di SMA Muhammadiyah 2 Jakarta Wilda Yunieswati; Anisa Sekar Widhi; Rosyanne Kushargina; Almira Nuraelah
PHARMADEMICA : Jurnal Kefarmasian dan Gizi Vol 5 No 2 (2026): Oktober - Maret
Publisher : LPPM-KI - POLTEKKES PIM (Formerly AKAFARMA-AKFAR PIM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54445/pharmademica.v5i2.98

Abstract

All age groups, including children, teenagers, adults, and the elderly, are at risk for non-communicable diseases (NCDs). One of the places where non-communicable illnesses may become more prevalent is urban areas. Changes in urban lifestyles may contribute to the rising prevalence of non-communicable illnesses. Basic research is necessary to understand the picture of infectious illnesses and associated risk factors, particularly in urban areas, since the growing number of NCD cases is predicted to raise the cost on the government and society. A cross-sectional research approach was employed in this investigation. The research was carried out at SMA Muhammadiyah 2 Jakarta. Eighty-one people were chosen as samples using simple random selection. Body weight, height, blood sugar, and uric acid levels measured directly are examples of primary data. In the meanwhile, questionnaires and interview techniques were used to gather information on respondent characteristics, medical history, and risk factors. The majority of responders reported normal uric acid levels (95.1%) and normal random blood sugar levels (93.8%). Nutritional status, breakfast routines, eating habits, smoking habits, personal and family medical histories, and physical activity are risk factors for non-communicable illnesses. Type 2 diabetes mellitus and uric acid were the non-communicable illnesses examined in this study; the chi-square test revealed no significant correlation between infectious diseases and their risk variables in the participants.
Pengembangan Metode Analisis Penetapan Zat Warna Merah K3 pada Produk Eyeshadow Menggunakan Spektrofotometri UV-Visible dengan Pemisahan Ekstraksi Fase Padat Rismaya Desti Parwati; Anggi Gumilar; Muhammad Naufal Dhiaulhaq
PHARMADEMICA : Jurnal Kefarmasian dan Gizi Vol 5 No 2 (2026): Oktober - Maret
Publisher : LPPM-KI - POLTEKKES PIM (Formerly AKAFARMA-AKFAR PIM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54445/pharmademica.v5i2.168

Abstract

The use of synthetic dyes such as Red K3 in cosmetics is prohibited due to its carcinogenic and toxic properties. However, this dye is still found in several eyeshadow products sold via e-commerce. This study aims to develop and validate a UV-Visible spectrophotometric method combined with Solid Phase Extraction (SPE) to identify and quantify Red K3 in eyeshadow. Method validation was performed by evaluating parameters including accuracy, precision, selectivity, linearity, and range. The validation results showed an accuracy of 99.970% and a precision of 1.571% RSD, both meeting the acceptance criteria. The calibration curve showed a linear relationship with a correlation coefficient (r) of 0.9986. The method used demonstrated good sensitivity, as indicated by the limit of detection (LOD) value of 0.657 µg/mL and the limit of quantification (LOQ) value of 2.190 µg/mL. Among 10 eyeshadow samples from e-commerce, only 1 sample (Sample C) was identified to contain Red K3. The developed method is valid and suitable for cosmetic safety monitoring, especially for products sold online.
Pengaruh Permainan Engklek Nutriranger sebagai Media Edukasi Gizi Seimbang terhadap Pengetahuan dan Sikap Siswa SD Muhammadiyah 1 Kota Malang Aurelia Faza Sepbrina; Aprinia Dian Nurhayati; Rizka Silvia; Hilma Tsurayya; Tika Dwi Tama; Zahra Anggita Pratiwi; Afinatul Jannah; Putra Ananda Dzaky
PHARMADEMICA : Jurnal Kefarmasian dan Gizi Vol 6 No 1 (2026): April - September
Publisher : LPPM-KI - POLTEKKES PIM (Formerly AKAFARMA-AKFAR PIM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54445/pharmademica.v6i1.195

Abstract

The Nutriranger engklek game is a traditional game that integrates balanced nutrition material through in-game question cards. Balanced nutrition education for elementary school-aged children is important because this period is the phase of forming eating behavior that will affect future health. Game media was chosen because it can increase active participation and student interest in the learning process. The purpose of this study was to examine the effect of engklek games on knowledge and attitudes related to the concept of balanced nutrition of students at Muhammadiyah 1 Elementary School, Malang City. The research design used was a pre-experimental with one-group pretest posttest. A total of 188 students of Muhammadiyah 1 Elementary School, Malang City who met the inclusion criteria were involved as respondents. This study has been approved based on ethics from the ethics committee of Malang State University with No. 01.07.09/UN32.14.2.8/LT/2025. The questionnaire used as a research instrument has been tested for validity and reliability. The data were processed and analyzed using descriptive tests and Wilcoxon signed rank tests, showing that the average knowledge score after education was 72.8±16.0 and the average attitude score was 90.6±9.9. These data indicate an increase in knowledge of 7.9 points and an increase in attitude of 5.1 points. There is a significant effect (p<0.001) of using the Engklek game as a nutrition education medium in improving knowledge and attitudes. The Engklek Nutriranger game has the potential to be an innovative nutrition education medium based on traditional games to improve knowledge and attitudes about balanced nutrition in elementary school children.
Studi Pendahuluan Korelasi Kadar Hemoglobin dengan Kadar Protein ASI pada Ibu Menyusui di Wilayah Kerja Puskesmas Kedungkandang, Kota Malang Dwi Oktavia Wahyuningsih Prastiwi; Aprinia Dian Nurhayati; Cassandra Permata Nusa; Arindra Nirbaya; Zahra Anggita Pratiwi; Vivi Viranda Sania Putri; Hanna Eklesia Manik; Cindy Elysia Elora; Afinatul Jannah; Wildan Agatha Saputra; Rizka Romadona; Kholidah Nur Aini
PHARMADEMICA : Jurnal Kefarmasian dan Gizi Vol 6 No 1 (2026): April - September
Publisher : LPPM-KI - POLTEKKES PIM (Formerly AKAFARMA-AKFAR PIM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54445/pharmademica.v6i1.196

Abstract

Anemia pada ibu menyusui masih menjadi masalah kesehatan yang berpotensi memengaruhi kualitas Air Susu Ibu (ASI), khususnya kandungan proteinnya yang penting bagi pertumbuhan dan imunitas bayi. Namun, masih terbatas studi yang secara khusus melakukan analisis hubungan antara tingkat hemoglobin ibu. Kadar hemoglobin yang rendah dapat menghambat proses pertumbuhan bayi sehingga meningkatkan risiko terjadinya stunting. Sumber utama zat gizi bagi bayi berasal dari ASI yang diberikan oleh ibu menyusui dengan protein yang terkandung dalam ASI. Penelitian ini bertujuan untuk menganalisis korelasi antara kadar hemoglobin pada ibu menyusui dengan kadar protein dalam ASI di wilayah kerja Puskesmas Kedungkandang, Kota Malang. Penelitian ini menerapkan pendekatan observasional melalui desain cross-sectional. Populasi dalam penelitian ini yaitu 30 ibu menyusui dengan bayi berusia 0-6 bulan. Penjelasan terkait maksud serta tahapan penelitian telah disampaikan kepada partisipan sebelum penandatanganan informed consent. Pengukuran kadar hemoglobin dianalisis menggunakan metode hematologi, sedangkan kadar protein ASI dianalisis menggunakan metode Kjeldahl. Hasil penelitian menunjukkan rerata kadar hemoglobin sebesar 12,35 g/dL yang berada dalam kisaran normal, serta rerata kadar protein ASI yaitu 1,29 g/100 mL. Hasil analisis korelasi Spearman Rank pada IBM SPSS Statistics versi 27 menunjukkan hubungan negatif yang lemah antara kedua variabel (r=- 0,278) serta tidak signifikan secara statistik (p>0,05). Penelitian ini menunjukkan bahwa kadar hemoglobin ibu menyusui tidak memiliki hubungan signifikan dengan kadar protein ASI.