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PHARMADEMICA : Jurnal Kefarmasian dan Gizi d/a AKAFARMA - AKFAR PIM, Jalan Barito 5 Malang, Indonesia East Java Indonesia Telp. 0341 – 491132
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Pharmademica: Jurnal Kefarmasian dan Gizi
Published by Akademi Farmasi Putra Indonesia Malang
ISSN : 28083970     EISSN : 28083423     DOI : https://doi.org/10.54445/pharmademica
Core Subject : Health, Science,
Chemistry Public Health
PHARMADEMICA : Jurnal Kefarmasian dan Gizi menerbitkan artikel penelitian asli di semua bidang : Farmasi Klinis Kimia Farmasi Ilmu farmasi Farmasi Komunitas Farmakognosi Fitokimia Analisis Farmasi Pendidikan dan Pembelajaran Farmasi Biokimia Nutrisi klinis Gizi Masyarakat Makanan Fungsional
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 54 Documents
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Optimasi Formulasi, Stabilitas Fisik dan Uji Iritasi Lotion Tabir Surya Kombinasi Benzophenone-4 dan Octocrylene Najih, Yuli Ainun; Nailufa, Yuyun; Rakhma, Dita Nurlita; Azhanzi, Davan Ercha Wafi; Syah, Farid Zulkarnain Nur
PHARMADEMICA : Jurnal Kefarmasian dan Gizi Vol 5 No 2 (2026): Oktober - Maret
Publisher : LPPM-KI - POLTEKKES PIM (Formerly AKAFARMA-AKFAR PIM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54445/pharmademica.v5i2.153

Abstract

Ultraviolet (UV) radiation exposure necessitates the creation of sunscreen formulas that are stable, safe for the skin, and photoprotective. Although benzophenone-4 (BZP-4) and octocrylene (OCT) are widely used as chemical UV filters, studies on the physical stability and irritation of optimizing the combination of the two in lotion formulations are still limited. The purpose of this study is to improve the physical stability, formulation, and irritation testing of a sunscreen lotion that combines BZP-4 and OCT. Variations in single and combination concentrations (1–5%) were included into five formulations. Organoleptic testing, pH, viscosity, spreadability, adhesion, emulsion type, physical stability using centrifugation and six cycles of testing, and irritation testing based on a non-animal alternative method using the Hen's Egg Test–Chorioallantoic Membrane (HET-CAM) were all used to evaluate the preparations. A paired t-test was used for statistical analysis to compare parameters prior to and during the physical stability test. The combination formula of 1% BZP and 1% OCT produced the best physical properties (pH 6.44; viscosity 2793 cP), was stable in centrifugation and cycle tests (p>0.05), and did not irritate the skin (HET-CAM score 0.98±0.04). Conversely, single formulas and high concentrations showed moderate to strong irritation. The results of this study contribute scientifically to the conclusion that the combination lotion formulation of BZP-4 1% and OCT 1% has good physical stability and does not cause irritation.
Evaluasi Digital Adherence Technology Berbasis Kode QR (Q-Monte) untuk Pemantauan Kepatuhan Pengobatan Tuberkulosis Syah, Farid Zulkarnain Nur; Susanto, Noor Annisa; Zainuri, Akhmad
PHARMADEMICA : Jurnal Kefarmasian dan Gizi Vol 5 No 2 (2026): Oktober - Maret
Publisher : LPPM-KI - POLTEKKES PIM (Formerly AKAFARMA-AKFAR PIM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54445/pharmademica.v5i2.160

Abstract

Tuberculosis (TB) treatment adherence is a critical determinant of therapeutic success; however, monitoring adherence remains challenging in primary healthcare settings. Digital adherence technology (DAT) offers an alternative approach to monitor patient adherence more efficiently. This study aimed to evaluate the initial feasibility of implementing a QR code–based DAT system (Q-Monte) for monitoring TB treatment adherence in primary healthcare centers. This study employed a pilot feasibility design with a prospective observational approach involving 30 outpatient TB patients from two primary healthcare centers in Malang Regency. Participants were recruited using purposive sampling with the following inclusion criteria: TB patients aged ≥12 years, receiving oral anti-tuberculosis therapy, owning an Android-based smartphone and an active WhatsApp number, and being willing to be monitored for 30 days. Patients with HIV co-infection or multidrug-resistant TB (TB-MDR), those who transferred healthcare facilities during the observation period, or those with stroke comorbidity were excluded. Most participants were male (56.7%), aged 45–54 years (30.0%), had completed senior high school education (50.0%), and had no comorbidities (80.0%). Adherence was measured as the percentage of days with QR code scanning, while system usability was assessed using the System Usability Scale (SUS). The results showed an average QR code scanning adherence rate of 90.3% over 30 days, with 46.7% of patients reporting having taken medication without performing the QR code scan. The usability evaluation yielded a mean SUS score of 75.7 (grade B). These findings indicate that Q-Monte is feasible as a tool for monitoring TB treatment adherence in primary healthcare settings, although further optimization of technical support and user education is needed to improve the reliability of digital adherence recording.
Optimasi PVA dan HPMC dalam Masker Wajah Gel Peel Off Ekstrak Daun Beluntas (Pluchea indica L.) dengan Metode Simplex Lattice Design Puspitasari, Diny; Cristy, Devina Wahyu Astaning; Langu, Fina Arista
PHARMADEMICA : Jurnal Kefarmasian dan Gizi Vol 5 No 2 (2026): Oktober - Maret
Publisher : LPPM-KI - POLTEKKES PIM (Formerly AKAFARMA-AKFAR PIM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54445/pharmademica.v5i2.158

Abstract

Peel-off gel masks are widely used cosmetic skincare preparations due to their practicality, ease of removal, and non-comedogenic properties. Beluntas (Pluchea indica L.) leaf contains various bioactive compounds, particularly flavonoids, which possess antibacterial activity. This study aimed to obtain the optimum formulation of a peel-off face mask containing Beluntas leaf extract, with variations in Polivinyl alcohol (PVA) as a film-forming agent, and hydroxypropyl methylcellulose (HPMC) as a gelling agent.This experimental study employed the Simplex Lattice Design (SLD), an optimization method. Five formulations were prepared with PVA content ranging from 10-16% and HPMC concentrations from 2-4%. Each formulation was evaluated for organoleptic properties, homogeneity, pH, spreadability, drying time, adhesion, and viscosity, and the data were analyzed using Design Expert Version 13. The optimum peel-off gel mask formulation containing Beluntas leaf extract was obtained at PVA 12.92% and HPMC 3.07% with predicted spreading power 5.198, adhesion 52.910, viscosity 586.357, pH 4.626, drying time 23.502 with desirability 0.812.
Aktivitas Antibakteri dan Antioksidan Kulit Apel Rome Beauty (Malus sylvestris Mill) Fitri, Aldesra; Silya, Ardika Amanda; Ryhasanda, Olafiani; Wardana, Fendi Yoga; Siwi, Mayang Aditya Ayuning
PHARMADEMICA : Jurnal Kefarmasian dan Gizi Vol 5 No 2 (2026): Oktober - Maret
Publisher : LPPM-KI - POLTEKKES PIM (Formerly AKAFARMA-AKFAR PIM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54445/pharmademica.v5i2.165

Abstract

Rome beauty apple (Malus sylvestris Mill) is an apple variety that is widely grown in Batu City. The skin of this apple is known to contain flavonoid compounds such as quercetin, catechin, procyanidin and caffeic acid which are useful as antibacterial, antioxidant, and antiproliferative. This study was conducted to determine the total flavonoid content and antibacterial activity in the ethanol extract of macerated Roma beauty apple peel. In addition, this study also aims to determine the antioxidant activity of the ethyl acetate extract and the ethanol extract of Roma beauty apple from multistage extraction. The ethanol extract of macerated Rome beauty apple was tested for total flavonoid content and antibacterial activity using the well diffusion method, then the diameter of the inhibition zone was measured against Propionibacterium acnes and Staphylococcus aureus bacteria, while the ethyl acetate extract and the ethanol extract of Rome beauty apple from multistage extraction were tested for antioxidant activity using the 1,1-diphenyl-2-picrylhydrazyl (DPPH) method. Based on the research, it is known that the ethanol extract of Rome Beauty apple peel from maceration contains flavonoids of 47.10 mgQE/g with an inhibition zone diameter against Propionibacterium acnes and Staphylococcus aureus of 8.70 mm and 11.67 mm respectively with a concentration of 20% w/v. The results of the antioxidant activity test of the ethyl acetate extract obtained IC50 3026 ppm and the ethanol extract from multistage extraction of 4702 ppm. The test results can be concluded that the ethanol extract of Rome Beauty apple has a total flavonoid content and antibacterial activity with a moderate category against P. acnes bacteria and strong against S. aureus bacteria. The ethyl acetate extract and the ethanol extract of Rome Beauty apple peel from multistage extraction have antioxidant activity with a very weak category.

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