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Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan
Published by Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin
ISSN : 2502647X     EISSN : 25031902     DOI : https://doi.org/10.36387/jiis
Core Subject : Health,
Medicine & Pharmacology
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan is a broad-based primary journal covering all branches of pharmacy and its sub-disciplines that contains complete research articles, short communication and review articles. JIIS is a forum for the publication of quality and original works that open discussions in the field of pharmacy and health sciences.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 38 Documents
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Search results for , issue "Vol 7 No 2 (2022): JIIS" : 38 Documents clear
POTENSI DAUN TEH HIJAU (Camellia sinensis) SEBAGAI INHIBITOR MAIN PROTEASE (Mpro) COVID-19: SEBUAH STUDI MOLECULAR DOCKING Haidar Ali Hamzah; Junoretta Haviva Ernanto; Putri Mahirah Afladhanti; Theodorus Theodorus
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 7 No 2 (2022): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v7i2.789

Abstract

Green tea is an herbal plant that has active compounds including anti-inflammatory, antioxidant, anti-allergic, and antiviral compounds. A previous study, flavonoid compound in tea leaves has been proven as antiviral. The development of effective antiviral drugs against COVID-19 remains a challenge for researchers across the world. A previous study investigated the role of the main protease enzyme (Mpro) which is useful in the viral life cycle as a promising drug target. This study aims to know the potential compounds of green tea leaves as a COVID-19 Mpro inhibitor using molecular docking. 12 compounds and lopinavir were used. Lipinski analysis was carried out to assess potential compounds as a drug. Docking was carried out by Autodock Tools 1.5.6 and Autodock Vina. The visualization was carried out by Discovery Studio v16. The results showed that all compounds compiled the criteria as a drug based on Lipinski rules. Catechin and epicatechin have the same energy bond as lopinavir with a binding energy of -7.1 kcal/mol. Catechin gallate and epicatechin gallate have the strongest energy bond with a binding energy of -9.0 and -8.2 kcal/mol. All compounds bind in the active site of the COVID-19 Mpro so they are competitive inhibitor. Catechin gallate is the strongest inhibitors.
PENGARUH GUGUS FUNGSI CINCIN PIRIDIN, BENZEN, DAN ATOM NITROGEN PADA CINCIN PIRIDIN TERHADAP PENURUNAN KADAR PLASMA PIRIDOKSIN TIKUS WISTAR Hafrizal Riza; Jordi Buannata
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 7 No 2 (2022): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v7i2.873

Abstract

In this study, researchers will conduct further studies to determine the map of functional groups that have an affinity for neuropathy-causing enzymes in the pyridine ring functional group after previous research on pyridine ring substituents. Through this study, it will be known whether there is an effect of the N atom on the pyridine ring, and the structure of the benzene ring. Therefore, the three structures, namely benzohydrazide, butyrohydrazide, formohydrazide, and isoniazid control, will be tested for their effect on the inhibition of the pyridoxal phosphokinase enzyme in experimental rats to see the effect of changing functional groups on decreasing affinity for the pyridoxal phosphokinase enzyme receptor which can be indicated by a decrease in active pyridoxine levels in the blood. mouse. The three compound structures were then examined for their interactions with the pyridoxal phosphokinase enzyme through their effect on increasing levels of pyridoxal 5 phosphate which is the active form of pyridoxine, using the Ultraviolet-Visible Spectroscopy method which showed an accumulation of enzyme analog substrates from the three compound structures with substrates from the body. The results of the ultraviolet-visible spectroscopy test showed that the active pyridoxine levels of rats in the isoniazid, benzohydrazid, and formohydrazid groups and the negative control group were 160,259, 120,548, 107,086 and 104,490, respectively. Based on the results, it was concluded that benzohydrazide and formohydrazide did not have a pharmacophore group against the pyridoxine phosphokinase enzyme.
UJI AKTIVITAS ANTIBAKTERI EKSTRAK ETIL ASETAT DAUN RAMBUSA DAN DAUN KARAMUNTING TERHADAP Streptococcus mutans Muhammad Priyadi; Nurul Chusna; Guntur Satrio Pratomo
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 7 No 2 (2022): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v7i2.875

Abstract

Empirically, many natural ingredients have been used in preventive care for the treatment of dental and oral disorders. Chronic conditions on the teeth with the appearance of plaque and tooth decay are referred to as dental caries which are characterized by toothache and also digestive disorders. Streptococcus mutans is known as the bacteria that most often causes dental caries. Karamunting and rambusa plants have enough potential as antibacterials because there have been many studies that have shown their potential as antibacterial activities. The purpose of this study was to determine the antibacterial activity of ethyl acetate extract of karamunting leaves and rambusa leaves against Streptococcus mutans. Antibacterial activity test using well diffusion method by measuring the diameter of the inhibition zone. The results showed that the ethyl acetate extract of karamunting leaves 1%, 5%, 10%, 15%, 20% had inhibition zone diameters of 4.6 mm, 4.1 mm, 0 mm, 0 mm, 0 mm, respectively while rambusa leaves 1%, 5%, 10%, 15%, 20% had inhibition zone diameters of 4.4 mm, 8.7mm, 9.4 mm, 5.3mm and 8.8mm respectively. The ethyl acetate extract of karamunting and rambusa leaves is known to have weak antibacterial activity in the resistant category.
EFEKTIVITAS ANTIBIOTIK PADA PASIEN PNEUMONIA COVID-19 : STUDI OBSERVASIONAL Farid Zulkarnain Nur Syah; Abdul Rahem; Anita Purnamayanti; Rella Indah Karunia
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 7 No 2 (2022): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v7i2.878

Abstract

COVID-19 has become a deadly pandemic worldwide. The use of empiric antibiotics in cases of COVID-19 pneumonia has the risk of triggering bacterial resistance. The purpose of the study was to analyze the use of antibiotics used in cases of COVID-19 pneumonia. The design of the study was an observational study conducted retrospectively from June 2021 to August 2021. The subjects of the study were patients with confirmed COVID-19 pneumonia, as diagnosed by the doctor based on the results of a chest CT scan and PCR. The total number of research subjects was 111. The antibiotics used were azithromycin (n = 42) and levofloxacin (n = 69). There was no significant difference between the initial clinical condition of hospital admission in subjects receiving azithromycin and subjects receiving levofloxacin (p=0.098) based on the WHO clinical progression scale score. There was a significant difference between azithromycin and levofloxacin for the length of therapy (p = 0.000) and length of hospitalization (p = 0.004). There was a significant difference (p = 0.006) in clinical conditions based on WHO clinical progression scale scores before and after using azithromycin. There was no significant difference (p = 0.114) in clinical conditions before and after using levofloxacin. There was no significant difference in mortality (p = 0.275) between the two types of antibiotics. Subject mortality was not affected by gender, advanced age (> 65 years), and comorbid disease. Azithromycin is more effective in improving the clinical condition of patients with COVID-19 pneumonia compared to levofloxacin.
EFEKTIVITAS ANTIVIRUS OSELTAMIVIR PADA SUBJEK COVID-19 DENGAN ATAU TANPA PENYAKIT PENYERTA DI PUSKESMAS ARUT SELATAN – PANGKALAN BUN Soufia Ardiani; Abdul Rahem; Anita Purnamayanti
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 7 No 2 (2022): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v7i2.879

Abstract

South Arut occupies the highest position with 51.55% of the total COVID-19 cases in Kota Waringin Barat, Central Borneo. The purpose of the study was to determine patient characteristics and analyze the effectiveness of oseltamivir in COVID-19 patients. The research design was an observational study and data collected retrospectively. Inclusion criteria were COVID-19 subjects with or without comorbidities and outpatient treatment at the Arut Selatan, Pangkalan-Bun Health Center who were given Oseltamivir. Parameters of therapeutic effectiveness were measured by the WHO Clinical Progression Scale consisting of 5 levels of clinical condition of patients with a score range of 0 (uninfected) – 10 (died). Data analysis was descriptively grouped according to clinical progression scale scores. The results of the study of 107 subjects were mostly male (56.1%) and aged 26-45 years (34.6%). The clinical results of therapy were 0.9% of subjects recovered with negative swab results (score 0), 98.2% improved (score 1), and 0.9% died (score 10). There were no subjects who needed to be referred to the hospital, Self-quarantine of 8-15 days showed 96 (89.7%) subjects experienced clinical improvement, symptoms free, and swab results were negative. It could be concluded that oseltamivir was effective for mild Covid-19 subjects in South Arut, Pangkalan Bun, Kota Waringin, Central Borneo.
TERAPI FAVIPIRAVIR PADA SUBYEK COVID-19 DERAJAT SEDANG TANPA GANGGUAN LIVER DI RS PUSAT INFEKSI PROF DR SULIANTI SAROSO Hastutik Cairn Brisbane; Abdul Rahem; Anita Purnamayanti; Rosamarlina Rosamarlina; Memy Aviatin; Adria Rusli
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 7 No 2 (2022): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v7i2.880

Abstract

The outbreak of the corona virus which first contracted in December 2019 in Wuhan, China; Currently it has been designated by the World Health Organization (WHO) as a pandemic and is known as Corona Virus Infection Disease 2019 (Covid-19). This study aimed to describe the profile of favipiravir therapy in moderate COVID-19 inpatients without liver impairment at Prof. dr. Sulianti Saroso Infection Center Hospital. The design of this study was an observational study conducted retrospectively. All the patients in this research were received favipiravir loading dose of 1600 mg bid on the first day, and 600 mg bid starting on the day-2 of therapy. The results of the research were 81 moderate Covid-19 inpatients without history or recent liver impairment who were hospitalized in the period October 2020 - July 2021 dominating by female gender (56%). Mode of hospital admission were self-referral to Prof. dr. Sulianti Saroso Infection Center Hospital (83%), primary care (Puskesmas) referral (12%), and other hospital referral (5%). There were no comorbidity in 74,1% of the subjects. Among 25,9% subjects with comorbidity, most of the patients suffered from hypertension (29%); hypertension, and cardiovascular disease (17%). diabetes (12%); diabetes and hypertension (12%); Asthma (12). None of the subjects experienced increased in liver transaminases (ALT, AST), nor ALP and total bilirubin. Eighty-one patients were either cured (12%) with negative PCR test results or improved (88%) at the end of the therapy.
AKTIVITAS ANTIOKSIDAN EKSTRAK ETANOL, METANOL, DAN AQUADES DARI KULIT BUAH MUNDAR (Garcinia forbesii) Muhammad Ikhwan Rizki; Liling Triyasmono; Khoerul Anwar; Anna Khumaira Sari
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 7 No 2 (2022): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v7i2.882

Abstract

Mundar (Garcinia forbesii) is a typical plant from South Kalimantan. Mundar pericaps can be used as a natural antioxidant. The use of solvents in the extraction process can affect the antioxidant activity. The purpose of this study was to determine of phytochemical compounds and antioxidant activity of the ethanol, methanol, and aquades extracts from pericaps of mundar (Garcinia forbesii). Mundar pericaps is dried, then made into powder. Mundar pericaps powder was extracted with three different solvents, ethanol 70%, methanol, and aquades. Phytochemical screening and analysis by thin layer chromatography were performed on the three extracts. The three extracts were tested for antioxidant activity by DPPH method. The results showed that ethanol and methanol extracts contained phytochemical compounds of phenolic, flavonoids, tannins, alkaloids, steroids, and terpenoids. Aquades extract contains phenolic, flavonoids, tannins, and alkaloids. The chromatographic profile showed that the ethanol and methanol extracts had an Rf value of 0.307. The antioxidant activity from highest to lowest was ethanol extract (192.64 ppm), methanol extract (236.64 ppm), and aquades extract (443.13 ppm) from mundar pericaps
FORMULASI DAN UJI STABILITAS FISIK GEL ANTIJERAWAT EKSTRAK ETANOL DAUN SURUHAN (Peperomia pellucida L.) Arfiani Arifin; Intan Intan; Nur Ida
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 7 No 2 (2022): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v7i2.908

Abstract

Suruhan leaves (Peperomia pellucida L.) are known to be rich in secondary metabolites including alkaloids, flavonoids, saponins, tannins and triterpenoid compounds that have potential as anti-acne so that they can be applied as active ingredients in gel preparations. The purpose of this study was to determine the best base for the formulation of an anti-acne gel preparation of suruhan leaf extract that was physically stable. The research method includes the extraction of suruhan leaves by maceration using 96% ethanol. The gel formulation was designed with variations of carbopol base, HPMC, and Na CMC with a concentration of 2%. Physical stability tests include organoleptic, homogeneity, pH, dispersion, viscosity and adhesion which were carried out before and after accelerated storage using a climatic chamber. The results of this study showed that the gel preparation of the ethanol extract of suruhan leaves using carbopol and HPMC bases produced a physically stable gel based on the results of organoleptic tests, homogeneity, pH, dispersibility, adhesion and viscosity, before and after accelerated storage.
ANALISIS BIAYA DAN INDEKS UTILITAS YANG DIUKUR MENGGUNAKAN SF-6D PADA PASIEN GAGAL GINJAL KRONIS DENGAN HEMODIALISIS DI RSUD ADJI BATARA AGUNG DEWA SAKTI KUTAI KARTANEGARA Abdul Mahmud Yumassik; Gunawan Pamudji Widodo; Tri Murti Andayani
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 7 No 2 (2022): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v7i2.942

Abstract

Hemodialysis (HD) patients with chronic kidney disease takes a long time and requires patient compliance. This will give the patient a psychological stressor which will then affect the quality of life. Apart from having an effect on quality of life, therapy hemodialysis also used a high cost, especially if the patient has complications. The purpose of this study was to determine the amount of hemodialysis costs, utility index, and the effect of complications on costs and utility index in hemodialysis patients. This study was a cross-sectional analytical research with the perspective of hospital. The research subjects were outpatient CKD who underwent hemodialysis at the HD Unit of Adji Batara Agung Dewa Sakti Hospital in September-Oktober 2020. Data were obtained use the SF-6D instrument, medical records, and financial financing. Data analysis used independent sample t-test and Kruskal-Wallis.The results showed that the average real cost of therapy in hemodialysis patients for a month was Rp. 12,014,488±0, while the real cost per hemodialysis episode is Rp. 1,316,722±273,989. The mean value of patient utility index as measured by the SF-6D was 0.717±0.143. The statistical test results show a significant value of 0.049 <0.05 on the utility index, which means that there is a relationship between complications on the utility index and a significant value of 0.125> 0.05 on costs, which means that there is no relationship between complications and costs in CKD patients with hemodialysis Keywords: Hemodialysis, Cost analysis, Index utility, SF-6D
MODEL RLB TURUNAN NAFTAKUINON INHIBITOR SEL LINE HELA Samsul Hadi; Uripto Trisno Santoso; Muhammad Luthfi Firdaus
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 7 No 2 (2022): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v7i2.966

Abstract

Cervical cancer is a disease that is dangerous for life. Naphtaquinone is an anticancer agent whose derivatives have been successfully synthesized, so it is necessary to study QSAR to evaluate its potency. The purpose of this study was to determine the molecular descriptors of naphtoquinone-derived compounds that have a significant effect on the anticancer activity of HeLa cells and compile them into a valid QSAR model. A total of 15 compounds from naphtoquinone derivatives were used for modeling. The descriptors that were tried included 1,863 topological descriptors and physico-chemical properties descriptors. Results of correlation analysis obtained 17 descriptors that are feasible to be tested in modeling. Results of backward method obtained 3 descriptors that have a significant effect, namely AATSC6Z, AATSC7m, and MAXaaCH. The MLR model based on 3 descriptors fulfills the goodness of fit requirements with R=0.873, R2=0.763, R 2 Adjusted=0.698, F value=0.0009 (Ftable=11.778). The results of the validation test using the CV-LOO method obtained a value of Q2=0.572 and CV-LMO obtained a value of Q2=0.518 so that this HKSA model can be stated as a valid HKSA model.

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