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Jurnal Farmanesia
Published by Universitas Sari Mutiara Indonesia
ISSN : """"     EISSN : 25282484     DOI : https://doi.org/10.51544/jf.v8i2
Core Subject : Health,
Medicine & Pharmacology
Jurnal Farmanesia dengan E-ISSN: 2528-2484 merupakan jurnal resmi yang diterbitkan oleh Program Studi S1 Farmasi Fakultas Farmasi dan Ilmu Kesehatan Universitas Sari Mutiara Indonesia, yang artikelnya dapat diakses dan diunduh secara online oleh publik (open access journal). Jurnal ini merupakan jurnal peer-review yang diterbitkan dua kali setahun dengan topik keunggulan hasil penelitian di bidang pelayanan dan praktik kefarmasian, teknologi farmasi, dan disiplin ilmu kesehatan yang berkaitan erat. Jurnal ini menerima teks bahasa Indonesia. Berikut ini adalah area penelitian yang menjadi fokus jurnal ini: 1. Farmakologi 2. Farmasetika 3. Biologi Farmasi 4. Kimia Farmasi 5. Farmakognosi 6. Fitokimia
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 248 Documents
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UJI AKTIVITAS EKSTRAK ETANOL BAWANG PUTIH (Alliumsativum L.)YANG DIHITAMKAN SEBAGAI ANTI INFLAMASI YANG DIINDUKSI OLEH KARAGENAN TERHADAP Mus musculus Wiratma, Dicky Yuswardi; Manurung, Kesaktian; Supartiningsih, Supartiningsih; Telaumbanua, May Fransisca
Jurnal Farmanesia Vol 4 No 2 (2017): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51544/jf.v4i2.2712

Abstract

One of the plants used as an alternative to traditional medicine is Garlic (Allium sativum L.). Garlic which is rich in organic organo sulfur compounds (amino acids and essential oils) in the form of allin has many benefits in treating various types of diseases. One of the processed forms of garlic is black garlic. Black garlic is a heating product from garlic that is heated at a temperature of 70oC with a relative humidity of 70-80%. This study aims to determine the use of black garlic as an anti-inflammatory, how to make black garlic and at what concentration black garlic has an anti-inflammatory effect. The method used in this research is a pure experimental method. The results of the %R measurement, the negative control group had the highest level of inflammation and the lowest was the black garlic extract group with a concentration of 60%. Meanwhile, in the %IR measurement, the black garlic extract group with a concentration of 60% had the greatest ability to block inflammation. From the tests that have been carried out, black garlic is obtained from heating results and the results of measuring the effectiveness of its anti-inflammatory activity, namely black garlic extract with a concentration of 60% have a better anti-inflammatory effect compared to other concentrations and diclofenac sodium.
SKRINING FITOKIMIA DAN UJI AKTIVITAS ANTIDIABETES DARI EKSTRAK ETANOL DAGING BUAH ALPUKAT (Persea americana Mill.) Simarmata, Yettrie; Manurung, Kesaktian; Harefa, Karnerius; Hasibuan, Mei Sri Rezeki
Jurnal Farmanesia Vol 5 No 1 (2018): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

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Abstract

Diabetes mellitus is a set of symptoms that arise in a person characterized by blood glucose levels exceeding normal (hyperglycemia) due to a lack of insulin in the body. One of the medicinal plants that can be used is avocado flesh. This study aims to determine the antidiabetic activity of avocado pulp extract (Persea americana Mill) against male white rats. This study used 25 male white rats divided into 5 groups, namely the negative control group CMC-Na 1%, the positive control group glibenclamide 0.45 mg/kg BW, the EEBA test group at doses of 50, 100, 200 mg/kg BW. The results of the one-way ANOVA analysis of the Tukey HSD test showed that the administration of EEBA at a dose of 100 mg/kg BW and EEBA at a dose of 200 mg/kg BW had a significant difference with a significance value of 0.024 and 0.026 and EEBA at a dose of 50 mg/kg BW had no significant difference with the significance 0.275. Based on the results of the study, it can be concluded that EEBA doses of 50, 100, 200 mg/kg BW have antidiabetic activity.
PENENTUAN KADAR VITAMIN C PADA JERUK MANIS (Citrussinensis) MENGGUNAKAN METODE TITRASI TITRASI NA-2,6 DICHLOROPHENOL INDOPHENOL DAN SPEKTROFOTOMETRI Nurbaya, Siti; Taufik, Muhammad; Sianipar, Artha Yuliana; Zulfan, Zulfan
Jurnal Farmanesia Vol 5 No 1 (2018): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

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Abstract

Vitamin C is one of the vitamins that is needed by humans and also one of the water-soluble vitamins, Vitamin C plays a role in the formation of intercellular collagen. For the solubility of vitamins B1, B2, B3, B5, B6, B7, B9, B12, and C are included in the types of water-soluble vitamins, and for the solubility vitamins A, D, E, and K are included in the types of soluble vitamins in fat. Vitamin C functions as an antioxidant and counteracts free radicals that can damage cells. Sources of vitamins are fresh fruits and vegetables. Sweet orange fruit contains vitamin C which is quite high. This study aims to determine and compare the results of vitamin C levels in sweet oranges using the Na 2,6 Dichlorophenol Indophenol titration method and spectrophotometry. The content of vitamin C using Na 2.6 Dichlorophenol Indophenol titration is 0.042%, while the content of vitamin C in sweet oranges using the UV-Vis spectrophotometry method produces levels of 0.351%. These results, shows that the levels of vitamin C obtained by using the UV-Vis spectrophotometry method are higher than those obtained by the iodometric method.
FORMULASI EKSTRAK TONGKOL JAGUNG (Zea mays L.) SEBAGAI TABIR SURYA DALAM SEDIAAN LOTION UNTUK WAJAH Silitonga, Maringan; Nasution, Pandapotan; Thaib, Cut Masyithah; Haloho, Mei Revolinda
Jurnal Farmanesia Vol 5 No 1 (2018): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

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Abstract

Corn cobs (Zea mays L.) can be used as sunscreen because it contains phenolic compounds. The purpose of this study was to determine the characteristics of the physical and chemical properties of sunscreen lotion preparations of corncob ethanol extract and the formula and concentration that had the highest effectiveness in the value of Sun Protection Factor (SPF). The lotion was chosen because it is a topical preparation that is often used by the community. Corn cob powder was extracted by the maceration method. The results were formulated with extract concentrations, formulation I (5%), formulation II (10%), and formulation III (15%). The three formulas were tested for organoleptic, pH test, homogeneity, and lotion type. The resulting data were analyzed descriptively. The results showed that all formulas with varying concentrations of extracts had good physicochemical characteristics during storage based on the results of pH, homogeneity, organoleptic, and emulsion-type tests. Corncob ethanol extract sunscreen lotion in Formula 1 (5%) has an SPF value of 2 (UV-A rays) and an SPF value of 7 (UV-B rays). Formula 2 (10%) has an SPF value of 2,3 (UV-A rays) and has an SPF value of 9 (UV-B rays) and Formula 3 (15%) has an SPF value of 3 (UV-A rays) and has a value of SPF 12 (UV-B Rays).
ANALISIS KADAR KALSIUM DAN BESI PADA DAUN TANAMAN BAYAM MERAH (Alternantheraamoena Voss) DAN DAUN TANAMAN BAYAM KAKAP (Amaranthus hybridus L) SECARA SPEKTROFOTOMETRI SERAPAN ATOM Sofwan, Ahmad Gazali; Nurbaya, Siti; Adiansyah, Adiansyah; Sitanggang, Pontisari
Jurnal Farmanesia Vol 5 No 1 (2018): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

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Abstract

Spinach (Amaranthus spp) is a leaf vegetable plant that is highly nutritious and favored by all levels of society. According to information, spinach plants can be used as an additional intake in the prevention of osteoporosis (bone loss) and anemia (lack of blood) because of the high calcium and iron content in them. Two types of spinach are known in the community, namely red spinach (Alternanthera amoena Voss) and spinach snapper (Amaranthus hybridus L). The purpose of this study was to determine the levels of calcium and iron in red spinach and snapper spinach leaves. The assay was carried out using an atomic absorption spectrophotometer with an air-acetylene flame. Quantitative analyzes were carried out at wavelengths of 422.7 nm for calcium and 248.3 nm for iron. The results showed that the levels of calcium and iron obtained with the levels of calcium and iron listed in the literature were different. The results also showed that there were differences in calcium and iron levels between red spinach and snapper spinach. Calcium levels in red spinach and snapper spinach leaves were 26.8016 mg/100g and 24.2759 mg/100g, respectively. The levels of iron in red spinach and snapper spinach leaves were 714.2621 mg/100g and 236.5369 mg/100g, respectively.
PENGGUNAAN JERUK NIPIS (Citrus aurantifolia) DAN LIDAH BUAYA (Aloe vera L.) SEBAGAI SEDIAAN HAIR TONIC Nurita, Elly; Thaib, Cut Masyithah; Adiansyah, Adiansyah; Hutasoit, Irmayanti
Jurnal Farmanesia Vol 5 No 1 (2018): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

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Abstract

Lignin compounds and polysaccharides, the nutritious substances in aloe vera, are useful as a carrier for the nutrients needed by the skin to repair hair roots, strengthen and stimulate hair growth. The purpose of this study was to determine the efficacy of the combination of lime extract and aloe vera extract as a hair tonic preparation for hair growth. Lime and aloe vera extracts were obtained by maceration method using 96% ethanol as solvent. The combination of lime extract and aloe vera extract is formulated to be a hair tonic, with a combination of 1 (1%:1%), combination 2 (2%:1%), and combination 3 (1%:2%). Then evaluate the stability of the hair tonic preparation, homogeneity, pH, hair growth activity, and hair weight of rabbits. The results of the stability test of the hair tonic preparation of a combination of lime extract and aloe vera extract did not change color, shape, and odor. The results of the homogeneity examination of the formulations of formulas 1, 2, and 3 were homogeneous. The result of pH observation was that the higher the concentration of the combination of lime extract and aloe vera extract, the higher the pH of the preparation. The results of the measurement of rabbit fur length showed that the highest hair growth rate was formula 3 combinations (1%:2%). The results of the three formulations of the combination of lime extract and aloe vera extract showed that the longer the hair growth of the rabbit, the heavier the weight of the rabbit's hair.
UJI AKTIVITAS EKSTRAK ETANOL DAUN SAWO MANILA (Manikara zapota L.) TERHADAP BAKTERI Bacillus cereus Manurung, Kesaktian; Adiansyah, Adiansyah; Silalahi, Yosy Cinthya Eriwaty; Hayati, Sry
Jurnal Farmanesia Vol 5 No 1 (2018): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

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Abstract

Sawo manila (Manikara zapota L.) merupakan salah satu bahan alam sebagai obat alternatif yang telah banyak dimanfaatkan oleh masyarakatnya juga untuk mengobati berbagai penyakit dan sawo merupakan tanaman dari family Sapotaceae yang digunakan dalam pengobatan tradisional. Ekstrak daun sawo manila mengandung alkaloid, tanin, flavonoid, dan saponin yang diketahui memiliki aktivitas antibakteri. Tujuan penulisan surat ini adalah untuk mengetahui aktivitas antibakteri sawo manila (Manikara zapota L.) terhadap bakteri Bacillus cereus. Penelitian ini menggunakan metode eksperimen, dengan metode ekstraksi maserasi dan metode chakra difusi untuk aktivitas antibakteri. Hasil penelitian menunjukkan bahwa simplisia memiliki kadar air 9,30%, larut dalam air 23,72%, kadar larut air ekstrak 31,15%, kadar abu total 1,11%, dan kadar ask tidak larut asam. 0,30%. Percobaan aktivitas anti bakteri ekstrak etanol daun sawo terhadap daya hambat bakteri bacillus cereus pada konsentrasi 20%, 40%, 60%, 80% dan 100% yaitu 12,62 mm, 15,0 mm, 15,74 mm, 16,9 mm , dan 18,78 mm, control positif menggunakan kotrimoksazol dan luas zona hambat 21,5 mm daun sawo manila dapat menghambat Bacillus cereus.
UJI AKTIVITAS ANTIBAKTERI HAND SANITIZER DARI EKSTRAK ETANOL BUNGA ROSELLA (Hibiscus Sabdariffa L) TERHADAP PERTUMBUHAN BAKTERI Staphylococcus aureus Adiansyah, Adiansyah; Maimunah, Siti; Sitorus, Elly Nurita; Hazlinda, Nurul
Jurnal Farmanesia Vol 5 No 1 (2018): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

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Abstract

In Indonesia with a tropical climate, rosella can thrive. Roselle plant (Hibiscus sabdariffa L.) is well known for its petals which can be used as a health drink that can cure various diseases. Roselle flower (Hibiscus sabdariffa L.) contains nutritious substances such as alkaloids, flavonoids, tannins, terpenoids, which have antibacterial properties. The purpose of this study was to determine the antibacterial hand sanitizer ethanol extract of Rosella flower (Hibiscus sabdariffa L) had good quality and stability against Staphylococcus aureus bacteria. This research was experimental, including rosella flower sample collection, simplicia drying, extract making using a rotary evaporator, phytochemical screening, characteristics of the antibacterial activity test preparation of hand sanitizer with agar diffusion method using paper discs. Roselle flower ethanol extract can be made as Hand sanitizer in spray preparations and has antibacterial activity. The difference in the concentration of the ethanol extract is 2.5%, the inhibition zone is 6.8 mm, 5% is the inhibition zone is 7.27 mm, 7.5% is the inhibition zone is 7.72 mm and 10% is 12.35 mm. The ethanolic extract of the Roselle flower (Hibiscus sabdariffa L) can be used as a hand sanitizer preparation. It has antibacterial activity against Staphylococcus aureus bacteria and is the most effective at a concentration of 10% of 12.35 mm.
PENGGUNAAN PATI KENTANG (Solanum tuberosum) LOKAL PREGELATINASI SEBAGAI BAHAN PENGEMBANG PADA TABLET PARASETAMOL GRANUL SECARA KEMPA LANGSUNG Dalimunthe, Agusmal; Thaib, Cut Masyithah; Silalahi, Yosy Cinthya Eriwaty; Tarigan, Mira Eka Diana Br
Jurnal Farmanesia Vol 6 No 1 (2019): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

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Abstract

Potatoes have a high nutritional content such as carbohydrates, starch, fat, protein, and water. Almost 90% of medicinal raw materials, both active substances and additives are obtained through imports and abroad, even though Indonesia's natural resources can be developed. This study aims to determine the effect of using pregelatinized local potato starch (Solanum tuberosum) as a developer in paracetamol tablets by direct compression. This research was conducted experimentally using five formulas with certain concentrations of F1 (4%), F2 (6%), F3 (8%), and F4 (10%). Then the tablet evaluation test was carried out, namely the weight uniformity test, tablet hardness test, tablet friability test, tablet disintegration time test. The results showed that the paracetamol tablets with local pregelatinized potato starch developer were made to meet the requirements for weight uniformity test, tablet hardness test, tablet friability test, and tablet disintegration time test. It can be concluded that local pregelatinized potato starch (Solanum tuberosum) can be used as a developer in paracetamol tablets.
UJI AKTIVITAS DAYA HAMBAT ANTIBAKTERI EKSTRAK N-HEKSANA Ocimum basilicum L. TERHADAP BAKTERI STREPTOCOCCUS MUTANS Wau, Bernadeth Intan Jutersfan; Furqan, Mainal; Lifiani, Realita
Jurnal Farmanesia Vol 10 No 1 (2023): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51544/jf.v10i1.4584

Abstract

Daun kemangi dalam dunia kesehatan dapat berfungsi sebagai salah satu antibakteri. Tujuan dari penelitian ini adalah untuk mengetahui golongan senyawa kimia dan mengetahui kemampuan ekstrak n-heksana daun kemangi (Ocimum basilicum L.) dalam menghambat pertumbuhan Streptococcus mutans dari konsentrasi 20%, 40%, dan 60% dengan kontrol positif amoxicillin dan kontrol negatif DMSO. Metode penelitian ini menggunakan metode eksperimen. Pengujian aktivitas antibakteri diuji dengan metode difusi menggunakan kertas cakram. Ekstrak daun kemangi dibuat oleh metode maserasi menggunakan n-heksana sebagai pelarut. Hasil dari uji skrining fitokimia bubuk daun kemangi menunjukkan adanya senyawa flavonoid, Steroid/Triterpenoid, Tanin, dan Saponin. Hasil antibakteri uji aktivitas menunjukkan bahwa ekstrak daun kemangi memberikan zona hambat pada konsentrasi 20%, 40%, dan 60% terhadap bakteri Streptococcus mutans yang masing-masing memiliki daya hambat zona (6,8 mm), (7,3 mm), (9,5 mm), amoxicillin 15,51 mm. Kesimpulan dari hasil penelitian dapat disimpulkan bahwa ekstrak daun kemangi (Ocimum basilicum L.) memiliki aktivitas antibakteri terhadap bakteri Streptococcus mutans.

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