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Scientific Journal
Published by CV. Akhbar Putra Mandiri
ISSN : 28100204     EISSN : 28100204     DOI : https://doi.org/10.56260/sciena
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health
Scientific Journal(SCIENA) published by an official of Scientific.id_considers the following types of original contribution for peer review and publication: Research Articles, Review Articles, Letters to Editor, Brief Communications, Case Reports, Book Reviews, Technological Reports, and Opinion Articles. It Is published six times a year and serves the need of scientific and non-scientific personals involved/interested in Natural Science (Physics, Chemistry, Electronics, Mathematics, Astronomy, Oceanography, Engineering), Social Science, Economics, Biology and Medicine. Each issue covers topics, which are of broad readership interest to personals from General Public, Industry, Clinicians, Academia, and Government. Scientic Journal is a must read journal for every one with curiosity in science.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 216 Documents
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Etnobotani Tumbuhan Obat di Nagari Mungka Kecamatan Mungka Kabupaten Lima Puluh Kota Farras, Fadhila Annisa; Putri, Dwi Hilda; Chatri , Moralita; Handayani , Dezi
Scientific Journal Vol. 5 No. 2 (2026): SCIENA Volume V No 2, March 2026
Publisher : CV. AKBAR PUTRA MANDIRI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56260/sciena.v5i2.318

Abstract

Pendahuluan: Tumbuhan Obat merupakan tumbuhan yang digunakan sebagai bahan baku pengobatan dalam mengatasi penyakit. Tujuan penelitian: Mengetahui jenis-jenis tumbuhan obat, organ tumbuhan yang digunakan serta khasiat dan cara penggunaannya di Nagari Mungka. Metode : Jenis penelitian ini adalah deskriptif eksploratif. Sampel penelitian ini berjumlah 23 responden. Analisis data secara kualitatif dengan dukungan pustaka ilmiah, kemudian data yang diperoleh disajikan dalam bentuk tabel. Hasil : ditemukan 39 jenis tumbuhan obat yang terdiri dari 29 familia. Tumbuhan obat yang banyak ditemukan yaitu familia Euphorbiaceae, Fabaceae, Lamiaceae masing-masing sebanyak 3 species, Organ tumbuhan yang banyak digunakan adalah daun. Cara pengolahan tumbuhan obat yang digunakan dengan cara direbus, dibakar, digiling atau dihaluskan, dihancurkan, dan diremas. Sedangkan untuk pemanfaatan tumbuhan obat ada yang diminum, diurut, diusap, dioles, dtempel, digosok dan dikonsumsi langsung. Kesimpulan : Masyarakat di Nagari Mungka masih memanfaatkan tumbuhan sebagai obat tradisional.
Tinjauan Pustakaa Peranan ACEIs. ARB dan ARNI pada Penyakit Ginjal Kronik Wahyudi, Adefri; Wahyudi
Scientific Journal Vol. 5 No. 2 (2026): SCIENA Volume V No 2, March 2026
Publisher : CV. AKBAR PUTRA MANDIRI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56260/sciena.v5i2.322

Abstract

Latar Belakang: Penyakit ginjal kronik (PGK) dan penyakit kardiovaskular (PKV) merupakan dua kondisi berkaitan dan sering muncul bersamaan. Penggunaan obat yang bekerja di sistem renin angiotensin aldosteron (RAA) eperti golongan ACEIs, ARB, dan ARNI merupakan pilihan utama  pada hipertensi dan bagian pilar utama terapi pada gagal jantung fraksi ejeksi rendah. Efek samping hiperkalemia dan peningkatan kreatinin serum sering menjadi alasan bagi klinisi untuk tidak memberikan ACEIs/ARB pada pasien PGK. Metode: Pendekatan narrative review, sumber literatur dari Pubmed, Google Scholar dan Science Direct dengan kata kunci PGK, PKV, RAAS inhibitor. Kriteria inklusi berupa artikel sesuai tema penelitian, artikel terindeks scopus dan diterbitkan tahun 2016 – 2025. Kriteria eksklusi meliputi artikel yang tidak dapat diakses, tidak menjawab jenis review. Hasil: Penggunaan obat yang bekerja di sistem RAA pada PGK aman dan memberikan outcome yang baik. Penghentian terapi akan meningkatkan risiko progresivitas end stage renal disease (ERSD) 1,29 kali dan insiden PKV 1,38 kali. Kesimpulan: Penggunaan obat yang bekerja di sistem RAA seperti golongan ACEIs, ARB, dan ARNI pada pasien PGK aman, efektif dan memberikan outcome yang lebih baik.
A Case of Onychomycosis with Nail Lichen Planus: The Importance of Supportive Examinations in Establishing a Diagnosis Ariani, Tutty; Farhanah, Nindya; Gustia, Rina
Scientific Journal Vol. 5 No. 1 (2026): SCIENA Volume V No 1, January 2026
Publisher : CV. AKBAR PUTRA MANDIRI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56260/sciena.v5i1.325

Abstract

Background: Onychomycosis and Nail Lichen Planus (NLP) are two conditions that cause nail damage and may sometimes present with overlapping clinical features, leading to difficulties in achieving an accurate diagnosis. Several ancillary examinations should be considered to avoid misdiagnosis of nail disorders. Case: A 64-year-old female patient presented to the Dermatology, Venereology, and Aesthetic Clinic at Dr. M. Djamil General Hospital Padang with complaints of progressive nail thickening and whitening affecting almost all nails, occasionally accompanied by itching, for the past 6 months. The patient had previously been diagnosed with onychomycosis and had regularly taken fluconazole 150 mg weekly for 6 months, but without improvement. Physical examination was within normal limits. Dermatological and onychoscopic examination revealed subungual hyperkeratosis, longitudinal ridging, onychotrophy, onychoschizia, trachyonychia, onycholysis, yellowish discoloration, melanonychia, and leukonychia, with an OSI score indicating severe involvement and a NALSI score of 100/120. KOH examination demonstrated the presence of hyphae, fungal culture revealed Aspergillus niger, PAS staining confirmed fungal elements, while biopsy results were consistent with NLP. The patient was diagnosed with onychomycosis with concomitant NLP and was treated with pulse itraconazole at a dose of 400 mg/day for one week each month for 2–3 months. Upon completion, treatment for NLP was initiated. Discussion: In this case, the absence of comprehensive ancillary examinations particularly biopsy, initially led to a diagnosis limited only to onychomycosis, without recognition of the coexisting NLP. This highlights the importance of thorough investigations to ensure an accurate and precise diagnosis.
A A Method to Quantify Biofilms in Object Glass Using ImageJ Wicaksono, Arief Heru; Risandiansyah, Rio; Hakim, Reza; Syarieb, Ahmad Akbar; Kurniawati, Annisa; Shafira , Iftah Ghina; Maulani , Maghfirah Nur; Primadita, Hanggia
Scientific Journal Vol. 5 No. 2 (2026): SCIENA Volume V No 2, March 2026
Publisher : CV. AKBAR PUTRA MANDIRI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56260/sciena.v5i2.330

Abstract

  Background: Direct microscopic observation of biofilms is done by observing for the presence of biofilm under a microscope. However, this method is qualitative and not quantitative. Analysis of these biofilm structures using image processing software may provide a method to quantify biofilm production and degradation in glass slides. Objective: To quantify the number and area percentage of microbial structures observable on a slide. This study is an experimental in vitro study. Methods: Biofilm production was done by submerging slides in petri dishes filled with Brain Heart Infusion with 2% sucrose (w/v) and inoculating it with Staphylococcus aureus. The petri dishes were incubated undisturbed for 48 hours at 37°C (n=3).The slides were then submerged in distilled water (Group 1) or detergent (Group 2) for 5 minutes before staining with 0.1% crystal violet and observed under a light microscope at 1000x. Images from five fields of view were collected. ImageJ was then used to count the number of microcolonies, aggregate cells, and single cells or cell clusters, based on size, and their respective area percentage. Welch’s T-Test was performed using JASP version 0.18.3. Results: Direct observation of slides shows that microcolonies and cell clusters to be formed in Group 1, and none or little in Group 2, indicating differences in biofilm formation on Group 1 vs Group 2.Based on ImageJ calculation, control slides had an average percentage area for microcolonies, cell agregates, and single cells or clusters of 39.97 ± 9.99%, 8.96 ± 3.19%, and 1.39 ± 0.33%, respectively. Treatment with detergent significantly reduced percentages of microcolonies to 0.33 ± 0.68%, but increased single cell area to 5.27 ± 0.49%. Conclusion: ImageJ can be a valuable tool to quantify biofilm production in glass slides based on the number and percentage area of microcolonies, cell aggregates, and single cells or cell clusters.
Secondary Neoplasm Arising in Nevus Sebaceus of Jadassohn: A Case Report Emphasizing Early Recognition and Evaluation Agung Bima Putera; Asri, Ennesta; Sari, Indah Indria
Scientific Journal Vol. 5 No. 2 (2026): SCIENA Volume V No 2, March 2026
Publisher : CV. AKBAR PUTRA MANDIRI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56260/sciena.v5i2.332

Abstract

Background: Nevus sebaceus of Jadassohn (NSJ) is a congenital hamartomatous lesion involving epidermal, sebaceous, and adnexal structures. The lesion typically appears at birth or early childhood and remains stable for years. Secondary neoplastic transformations, either benign or malignant, may occur during adolescence or adulthood. Case: A 15-year-old girl presented with a yellowish plaque on the vertex of her scalp, first noticed at the age of five. Over time, the lesion enlarged, and a bluish-gray nodule developed two weeks prior to presentation, accompanied by localized pain. Dermatological examination revealed a cerebriform yellow-orange plaque with bluish nodules and alopecia. Dermoscopy showed yellow globules, a homogeneous yellow-orange background, and blue-gray ovoid nests. Histopathology confirmed features consistent with NSJ, including epidermal hyperplasia, papillomatosis, sebaceous glands opening into the epidermis, immature hair follicles, and ectopic apocrine glands. In addition, basaloid cell proliferation with peripheral palisading and melanin pigment suggested a secondary neoplasm. The overall findings are consistent with pigmented trichoblastoma, although the possibility of a pigmented basal cell carcinoma cannot be definitively ruled out. Discussion: The findings indicate neoplastic transformation arising within NSJ. Secondary tumors may develop even in adolescence, making early recognition crucial. Clinical changes such as rapid growth, color change, or pain should raise suspicion and prompt histopathological confirmation. Identifying secondary neoplasms influences management decisions, including the need for surgical excision.Conclusion: This case highlights the need for early recognition and thorough evaluation of NSJ lesions, particularly in adolescence, to detect and manage secondary neoplastic changes effectively.
Overlapping Chancre and Syphilitic Roseola in an Immunocompetent Patient: A Case Report Anum, Qaira; Vesri Yossy; Putera, Agung Bima
Scientific Journal Vol. 5 No. 2 (2026): SCIENA Volume V No 2, March 2026
Publisher : CV. AKBAR PUTRA MANDIRI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56260/sciena.v5i2.333

Abstract

Background: Syphilis is a sexually transmitted infection caused by Treponema pallidum that typically progresses through primary, secondary, latent, and tertiary stages. Primary syphilis presents with a painless genital chancre, whereas secondary syphilis manifests with systemic and mucocutaneous findings. Overlapping primary and secondary syphilis is uncommon and is rarely reported in immunocompetent individuals.  Case: A 38-year-old immunocompetent man presented with a painless penile ulcer that progressively enlarged over two months, accompanied by non-pruritic erythematous macules with whitish scaling on both palms for one month. Physical examination revealed a solitary, shallow, indurated genital ulcer with well-defined borders and palmar macules. Dermoscopy demonstrated “Biett’s collarette”. Serological testing showed reactive VDRL (1:32) and TPHA (1:5120), with a non-reactive HIV test. Histopathological examination of the penile ulcer revealed epidermal ulceration, dense perivascular plasma cell and lymphohistiocytic infiltration, and endarteritis obliterans, consistent with syphilitic ulcer. Urethral culture identified Neisseria gonorrhoeae, indicating concomitant gonococcal urethritis. The patient was diagnosed with overlapping primary and secondary syphilis with gonorrhea co-infection and was treated with intramuscular benzathine penicillin G, oral cefixime, and azithromycin, resulting in marked clinical improvement.  Discussion: Persistence of the chancre beyond the expected healing period together with concurrent palmar syphilitic roseola supports stage overlap rather than sequential progression. Delayed diagnosis and coexisting gonococcal infection may have contributed to this presentation despite preserved immune status. Conclusion: Overlapping primary and secondary syphilis can occur in immunocompetent patients. Recognition of this atypical presentation and comprehensive clinicopathological correlation are essential to ensure accurate diagnosis and appropriate management.

Page 22 of 22 | Total Record : 216

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