cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
Rinto Susilo
Contact Email
rintosusilo88@gmail.com
Phone
+6282317004608
Journal Mail Official
medicalsains@gmail.com
Editorial Address
https://ojs.stfmuhammadiyahcirebon.ac.id/index.php/iojs/about/editorialTeam
Location
Kota cirebon,
Jawa barat
INDONESIA
Medical Sains : Jurnal Ilmiah Kefarmasian
Published by Sekolah Tinggi Farmasi Muhammadiyah Cirebon
ISSN : 25412027     EISSN : 25482114     DOI : 10.37874/ms
Core Subject : Health,
Medicine & Pharmacology
The Medical Sains journal is a scientific publication media published by the Muhammadiyah Cirebon College of Pharmacy which is published 4 (four) times in 1 (one) year, namely January-March, April-June, July-September and October-December. The journal contains research in the field of pharmacy covering the fields of formulation, pharmacology, communication pharmacy, A natural chemical chemistry, pharmacognomy and other health sciences which is a means for lecturers and researchers in the health sector to share knowledge and establish cooperation in implementing the Tri Dharma of Higher Education. Purpose and Scope The objective of the publication of the Medical Science journal is to publish articles in the field of pharmacy and other health as well as application of pharmaceutical . Based on this, the editorial board of Medical Sains invites lecturers and researchers to contribute to submit research articles related to the following themes: 1. Pharmaceutical formulation technology 2. Pharmacology 3. Community pharmacy 4. Clinical Pharmacy 5. Natural material chemistry 6. Pharmacognosy 7. Pharmaceutical Analysis and Medicinal Chemistry
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 310 Documents
 27   28   29   30   31 
SOLID EYELINER FORMULATION CONTAIN CLITORIA TERNATE L. EXTRACT IN PH ACID AND ALKALI AND IN VIVO IRRITATION TEST Linawaty Lee; Ratna Djamil; Deni Rahmat
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 3 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i3.828

Abstract

Clitoria ternatea flowers contain blue anthocyanin that has potential as natural coloring. The purpose of this study was to obtain an eyeliner product containing natural coloring that is safe, stable, and can replace hazardous chemicals. Clitoria ternatea flowers were extracted by kinetic maceration with 70% ethanol. The obtained extract was subjected to standard quality tests, phytochemical screening, and determination of total anthocyanin content and antioxidant activity (DPPH assay). Eyeliner-containing extracts were prepared in three pH variations (acidic, neutral, and alkaline). These three types of eyeliner preparations were subjected to an irritation test on shaved male albino white rabbit skin. stability test using the cycle test method, hardness, break point, and melting point were also performed. The results showed that Clitoria ternatea extract contains 0.2187% anthocyanin, has an antioxidant activity IC50 of104.7 µg/mL, and is free of heavy metals. The eyeliner contained Clitoria ternatea extract was dark blue when applied to the skin. Eyeliner preparations were stable in three stability cycle tests. The irritation test on the male albino rabbit skin showed no irritation. Clitorial ternatea extract can be used as natural coloring in eyeliner preparation. Keywords: Butterfly pea, Clitoria ternatea L., Anthocyanin, Antioxidant, Eyeliner.
ARTICLE REVIEW: EFFECT OF COUNSELING ON QUALITY OF LIFE IN TYPE-2 DIABETES MELLITUS PATIENTS Della Puspatari; Siti Saidah
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 3 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i3.831

Abstract

Quality of life is a general term for health status, although the term also has a special meaning that ranks the population according to objective and subjective aspects of health status. A disease that reflects a lot of quality of life related to a person's disease is diabetes. Many countries have explained that diabetes is a disease that is serious enough to cause high mortality. PubMed, Science Direct, and Google Scholar are several sources of articles used in searching for information regarding the effect of counseling on the quality of life of Type 2 Diabetes Mellitus patients. The majority of the articles used are the most recent articles written within the last 10 years, namely from 2013 to 2023. The keywords used in the search for these journals were “pharmacy interventions”, “patient counseling”, “quality of life”, “type 2 diabetes mellitus”. Intervention by pharmacists significantly improves the quality of life of type 2 diabetes mellitus patients. Similar studies have been conducted by researchers in several countries. It has been proven that the quality of life of patients with type 2 diabetes mellitus is significantly improved by clinically mediated pharmacist interventions on medication, illness, nutrition, exercise, lifestyle change, and self-care practices in the management of diabetes,. Through counseling that promotes patient trust and compliance, pharmacists play a crucial role in educating patients. It has an effect on patient satisfaction with DM therapy as well as on improving quality of life. Patients have high expectations for pharmacist education...
A MINI REVIEW ON ZINGIBERACEAE FAMILY AS ANTIDIABETIC PLANTS: ACTIVE INGREDIENTS AND MECHANISMS OF ACTIONS Fatiya Zata Ishmah; Agus Sulaeman
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 3 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i3.833

Abstract

Diabetes mellitus (DM) is a group of metabolic diseases characterized by hyperglycemia that occurs due to abnormalities in insulin secretion. Therapy using conventional anti-diabetic drugs is associated with serious side effects, and herbs to maintain chronic disease if conventional drugs not adequate. The purpose of this article review is to find out information about plants of the Zingiberaceae family that have anti-diabetic activity with the mechanism of action of ? -glucosidase enzyme inhibition, ? -amylase enzyme inhibition, and increased GLP-1 levels. The sources used consisted of 27 journals and reviewed 9 research journals originating from Google Scholar, Pubmed, NCBI, Elsevier, Science Direct with a span of under 10 years. The articles were then analyzed using the systematic literature review method, by collecting, evaluating, and developing research on a particular topic. From several studies conducted, the results showed that plants from the family that have antidiabetic activity include Zingiber officinale (ginger), Curcuma longa (turmeric rhizome), Curcuma aeruginosa (temu hitam), Curcuma zanthorrhiza (curcuma), Zingiber cassumunar (bangle), Kaempferia galanga (kencur), Alpinia galanga (lengkuas), Etlingera elatior (kecombrang, honje), and Elettaria cardamomum (kapulaga). Keywords: Antidiabetic; Diabetes Mellitus;  Zingiberaceae
ANTIBACTERIAL POTENTIAL OF EGGPLANT FRUIT (Solanum melongena L) ETHANOL EXTRACT AGAINST Propionibacterium acnes BACTERIAL GROWTH Irfan Zamzani; Islan Nor; Muhammad Raihan
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 3 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i3.840

Abstract

Acne is one of the skin problems that, without our realizing it, can reduce self-confidence, despair, and even depression among teenagers and young adults. The incidence of bacterial infections is increasing with the increasing cases of resistance of bacteria, such as Propionibacterium acnes, to the side effects of anti-acne drugs. Indonesia has many plants that are beneficial to humans and have properties for treating and improving health, one of which is the eggplant. The purpose of this study is to test whether eggplant has antibacterial activity against P. acnes. The eggplant was extracted using a maceration extraction method. For antibacterial activity, well diffusion agar was used with extract concentrations of 60%, 70%, 80%, and 90%. The inhibition zones of the ethanol extract of S. melongena at 60%, 70%, and 80% concentrations were 13,76 mm, 18,63 mm, and 20,79 mm, respectively, with the highest inhibition zone at 90% concentration at 20,64 mm. The ethanolic extract of S. melongena has a strong inhibitory effect on P. acnes.  Keywords: antibacterial activity, Solanum melongena L, maceration, Propionibacterium acnes.
DETERMINATION OF THE MINIMUM INHIBITORY CONCENTRATION OF THE ETHANOLIC EXTRACT OF KIPAHIT LEAVES ON THE GROWTH OF Propionibacterium acnes Joko Priyanto Wibowo; Noor Aida; Islan Nor; Irfan Zamzani
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 3 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i3.844

Abstract

Acne is a skin disorder characterized by inflammation in the form of comedones, papules, pustules, and nodules. The disease is caused by the gram-positive bacterium,  Propionibacterium acnes. Treatment of the disease using antibiotic agents such as erythromycin and clindamycin has been reported to cause some side effects. Therefore, alternative antibacterial agents derived from natural products are required to reduce the occurrence of side effects. Kipahit (Tithonia diversifolia A. Gray) is one of the plants with pharmacological activities, such as antibacterial and antiprotozoal activities. The aim of this study was to determine the minimum inhibitory concentration (MIC) of a 96% ethanolic extract of kipahit leaves on the growth of P. acnes. Kipahit leaves were extracted through the ultrasound-assisted extraction (UAE) method. Minimum inhibitory concentration (MIC) was determined using the liquid dilution method. A serial dilution was performed to prepare a series of extract concentrations: 25%, 12.5%, 6.25%, 3.13%, 1.56%, 0.78%, and 0.39%. Whereas, clindamycin and DMSO 1% were used as positive and negative controls, respectively. Phytochemical  screening showed  that  the 96% ethanolic extract of kipahit leaves contains flavonoids, alkaloids, saponins, steroids/triterpenoids, tannins, and phenolic compounds. In addition, the extract showed   inhibitory activity against P. acnes at concentrations ranging from 25% to 1,56%. In contrast, the extract showed  no inhibitory activity at concentrations of 0.78% and 0.39%. Further experiments confirmed that kipahit leaf extract acted as a bacteriostatic agent (inhibiting bacterial growth) at a minimum concentration of 1.56%.  Keywords: Acne, Propionibacterium acnes, Kipahit, MIC
REVIEW: TONIC POTENCY OF ZINGIBERACEAE FAMILY HERBAL PLANTS IN IMPROVING BODY WELLNESS Nabilah Azka Nihlah; Imam Adi Wicaksono; Keri Lestari
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 3 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i3.846

Abstract

Body wellness is closely related to health; it is the ability of a person to perform activities without fatigue. Herbal plants can be used to help improve body health and endurance. The Zingiberaceae family is widely found and used by the Indonesian people. This family is widely used as an ingredient in herbal medicines and seasonings. Herbal plants with the potential to improve body wellness can be seen in their tonic effects. Testing the tonic effect can use several methods, namely, the natatory exhaustion test, hanging test, sleep induction test, and rotarod test in mice. Among these, the natatory exhaustion method is the simplest and can be performed quickly. The method used in preparing this article is to collect and understand the primary literature from online databases, such as Google Scholar. This review article aims to provide scientific information to the public regarding herbal plants from the Zingiberaceae family, which have the potential to help maintain a healthy body. Plants that can be used as health enhancers include Red Ginger, Gajah Ginger, Temu Kunci, Temu Giring, Lempuyang Gajah, and Cardamom. Keywords: Herbal Plant, Zingiberaceae, Tonicum, Health 
REVIEW: MEDICINAL PLANTS WITH PHARMACOLOGICAL ACTIVITY AS ANTIPYRETIC Nurdiani Adiningsih; Dika Pramita Destiani
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 3 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i3.847

Abstract

Fever is a medical condition characterized by an increased body temperature beyond the normal range of 36 – 37°C. If not managed appropriately, fever may lead to complications in therapy. The conventional treatment for fever involves using antipyretics such as paracetamol/acetaminophen, and ibuprofen. However, prolonged use of these synthetic medications may have adverse side effects. Consequently, more patients are turning to herbal medicine to manage fever. This review aims to identify medicinal plants with pharmacological activity as antipyretics. We conducted a systematic literature review using Google Scholar as the search engine database. Our search keywords were “tanaman herbal”, “antipiretik", “penurun demam", and "uji aktivitas antipiretik". In this review, a total of 18 articles were meticulously analyzed. The collective findings from these studies demonstrated that all tested medicinal plants exhibited antipyretic activity. Flavonoids, tannins, and terpenoids were the primary constituents responsible for the observed antipyretic activity. Medicinal plants with alkaloids and steroid content were also believed to exhibit antipyretic activity. Keywords: fever, antipyretics, medicinal plants
ANTIMICROBIAL ACTIVITY TEST OF 96% ETHANOL EXTRACT OF FLOWERS, LEAVES, AND STEM BARK OF TIGARUN (Crateva magna DC.) AGAINST Staphylococcus aureus and Malassezia furfur Najwi Hasani; Rika Hartati; Elin Julianti
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 3 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i3.848

Abstract

Staphylococcus aureus and Malassezia furfur One of the microbes that can cause folliculitis is the inflammation of the skin in the hair follicles. The use of natural ingredients as antimicrobials must be developed as an alternative to overcome the resistance and side effects of chemical drugs. Tigarun (Crataeva magna DC.) is a typical plant in South Kalimantan that can be developed as a natural antimicrobial agent for the treatment of skin infections. Previous studies have reported that tigarun has antimicrobial activity, but no studies have reported its potential antimicrobial activity against folliculitis-causing microbes. Therefore, this study aimed to determine the antimicrobial activity of 96% ethanol extracts of the flowers, leaves, and stem bark of tigarun (Crataeva magna DC.) against microbes that cause folliculitis, including Staphylococcus aureus and Malassezia furfur. Extraction was performed by the maceration method using 96% ethanol. The antimicrobial activities of the extracts were tested using the agar diffusion method. Based on the results of the antimicrobial activity test using the agar diffusion method, the tigarun flower extract showed better antimicrobial activity than the leaf and tigarun bark extracts. Flower extract activity at 200 mg/mL concentrations against Staphylococcus aureus (10.65 ± 0.25) and the fungus Malassezia furfur (7.40 ± 0.40) with moderate inhibition zone ketogenic  Keywords: Folliculitis, tigarun, antimicrobial, agar diffusion
THE RELATIONSHIP BETWEEN KNOWLEDGE LEVEL AND RATIONAL HEADACHE PAIN SELF-MEDICATION BEHAVIOUR ON FIKES STUDENTS AT LAMONGAN MUHAMMADIYAH UNIVERSITY Siti Rahmatul Azizah; Irma Susanti; Devi Ristian Octavia
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 3 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i3.851

Abstract

The prevalence of self-medication in Indonesia is 84.23%, a figure that has been increasing over the past three years. The increase in self-medication in Indonesia, the availability of drugs that can be taken alone without a doctor's prescription, the perception of mild illness, and the relatively low price of drugs. The potential risks of self-medication are incorrect diagnosis of disease, delay in seeking necessary treatment, disease becoming more severe, wrong method administration, and wrong dose. Knowledge of rational use of drug self-medication still lacks students at 55.5%. It is important to know that student self-medication, in which students can overcome minor complaints of their own illness, does not have an impact on health and academic achievement. The incidence of headaches in students is 11-40% and mild headache levels interfere with academic performance. This study measures level knowledge behavior  to determine the relationship between level knowledge and rational headache self-medication behavior  by students at Muhammadiyah Lamongan University. The research design was cross-sectional descriptive analytics. Data were collected using online questionnaires. The sample included 166 Fike students using a purposive sampling technique. The results indicated level of knowledge: students classified sufficient (59.0%) and rational head pain self-medication behavior  classified as good (57.8%). The results of the Spearman Rho test analysis showed a p-value of <0.001 and correlation coefficient of 0.256. This study concluded that there is a relationship between level of knowledge and rational headache self-medication behavior  with low correlation strength.
INFLUENCE OF Momordica charantia (L.) ON THE PHARMACOKINETICS AND PHARMACODYNAMICS OF GLICLAZIDE IN ALLOXAN-INDUCED DIABETIC RATS Tubagus Akmal; Lucy Sasongko
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 3 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i3.854

Abstract

Diabetes mellitus is a metabolic disorder present in the top ten diseases that cause death. Diabetes treatment usually uses conventional drugs, such as gliclazide, which is the first choice in patients with type 2 diabetes mellitus who are intolerant to metformin. In addition to conventional medicine, herbal medicines are in great demand and have become a focus of research to obtain an alternative treatment for type 2 diabetes mellitus. One herb that has been widely used and studied is the bitter melon. This study aimed to determine the effects of bitter melon extract (BME) on the pharmacokinetics and pharmacodynamics of gliclazide when used simultaneously. The study was conducted on three groups of rats with alloxan-induced diabetes. Group 1 received a single dose of gliclazide (33 mg/kg BW, n = 3), group 2 received aqueous extracts of bitter melon fruit (341 mg/kg BW, n = 4), and group 3 received a combination of gliclazide and an aqueous extract of bitter melon (n = 4). The pharmacokinetic profile of gliclazide is affected by BME, where interactions occur during the absorption phase. The blood glucose levels were measured using a glucometer. Decreased blood glucose levels following administration of gliclazide, extract of bitter melon, and a combination of gliclazide and extract of bitter melon 6 hours after dosing were 74.73%, 82.977%, and 86.457%, respectively. This study demonstrated the interactions between gliclazide and BME in the absorption phase of gliclazide and its effect on blood glucose levels.

Page 30 of 31 | Total Record : 310

 27   28   29   30   31 

Filter by Year

2016 2023


Reset
Filter By Issues
All Issue Vol 8 No 4 (2023): Forthcoming Issue Vol 8 No 3 (2023) Vol 8 No 2 (2023) Vol 8 No 1 (2023) Vol 7 No 4 (2022) Vol 7 No 3 (2022): Forthcoming Issue Vol 7 No 2 (2022) Vol 7 No 1 (2022) Vol 6 No 2 (2021) Vol 6 No 1 (2021) Vol 5 No 2 (2021) Vol 5 No 1 (2020) Vol 4 No 2 (2020) Vol 4 No 1 (2019) Vol 3 No 2 (2019) Vol 3 No 1 (2018) Vol 2 No 2 (2018) Vol 2 No 1 (2017) Vol 1 No 2 (2017) Vol 1 No 1 (2016) More Issue