cover
Contact Name
Rahmat Basuki
Contact Email
rhmtbsq@gmail.com
Phone
+6285743213964
Journal Mail Official
indonesjchemstud@gmail.com
Editorial Address
Desa Sibrama RT 001 RW 004 , Desa/Kelurahan Sibrama, Kec. Kemranjen, Kab. Banyumas, Provinsi Jawa Tengah
Location
Kab. banyumas,
Jawa tengah
INDONESIA
Indonesian Journal of Chemical Studies (Indones. J. Chem. Stud.)
ISSN : 2830778X     EISSN : 28307658     DOI : https://doi.org/10.55749/ijcs.v1i1
Core Subject : Science,
Indonesian Journal of Chemical Studies (IJCS) is a peer-reviewed, open-access journal that publishes original research articles, review articles, as well as short communication in all areas of basic and applied chemistry. IJCS was managed & published by the Indonesian Scholar Society. This journal is published 2 times a year, namely every June and December. IJCS covers the following topics, but is not limited to: Organic and Inorganic Chemistry; Physical and Theoretical Chemistry; Analytical and Electroanalytical Chemistry; Materials and Polymer Chemistry; Supramolecular Chemistry; Organometallic Chemistry; Coordination Chemistry; Biomolecular Chemistry; Natural Products and Medicinal Chemistry; Electrochemistry; Environmental Chemistry; Propellant Chemistry; and Chemistry for Defense.
Articles 46 Documents
Development and Characterization of Gold Nanoparticle-Modified SPCEs for the Electrochemical Sensing Diksy, Yuris; Tirta, Ardina Purnama; Herawati; Mulyawan, Reza; Hayat, Moh; Asrorudin, Udin
Indonesian Journal of Chemical Studies Vol. 4 No. 2 (2025): Indones. J. Chem. Stud. December 2025
Publisher : Indonesian Scholar Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55749/ijcs.v4i2.71

Abstract

Gold nanoparticles were successfully synthesized by reducing HAuCl4 using jengkol (Archidendron pauciflorum) extract as a reductant. The synthesized gold nanoparticles were characterized by UV–vis spectroscopy and particle size analyzer (PSA). The synthesized gold nanoparticles were deposited on the screen printed carbon electrode (SPCE) substrate using 2 methods, drop casting and differential pulse voltammetry over a potential range of (-1500) mV to 600 mV, scan rate of 100 mV/s for 5 cycles. The surface plasmon resonance (SPR) band of UV– Vis spectrum at 530.7 nm confirmed the presence of gold nanoparticles. The results of Au nanoparticle characterization using PSA show that the size of the Au-NPs formed is 33.5 nm with an optimal HAuCl4 concentration of 0.20 mM. Characterization of gold nano-deposited SPCE was carried out by measuring the peak current of the 1 mM K3Fe(CN)6/K4Fe(CN)6 system in KCl electrolyte solution (0.1 M) using cyclic voltammetry over a potential range of (-500) mV to 1000 mV, scan rate 100 mV/s for 5 cycles. Gold nanoparticles deposited by differential pulse voltammetry showed a higher current response compared to drop casting deposition.
In Silico Study: Molecular Docking and Toxicity Prediction of Pyrazoline Derivatives with Potential as Anti-Inflammatory Wiratama, Minandre; Rahmi, Azimatur; Huda, Muhammad Badrul; Hasibuan, Anggi Khairina Hanum
Indonesian Journal of Chemical Studies Vol. 4 No. 2 (2025): Indones. J. Chem. Stud. December 2025
Publisher : Indonesian Scholar Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55749/ijcs.v4i2.73

Abstract

Research on heterocyclic compounds suggested that pharmacologically active agents featuring pyrazoline played a crucial role in medicinal chemistry. When fused with other heterocycles, pyrazoline, as a quiescent heterocyclic moiety, resulted in the enhancement of biological properties. Therefore, synthesizing these compounds had attracted the attention of researchers focused on designing novel drugs. The addition of substituents to the N-pyrazoline atom and modifications to the benzene ring of pyrazoline compounds were essential for the identification of pyrazoline derivatives exhibiting enhanced biological activity. Extensive research had shown that pyrazoline compounds had significant biological effects, including anti-inflammatory effects. Inflammation was the body's reaction to infection or injury and marked by symptoms such as redness, heat, swelling, and pain. This research involved a computational analysis of pyrazoline compounds utilizing molecular docking with AutoDock Tools and AutoDock Vina software on four pyrazoline derivative compounds (pyrazolines 1-4). Simultaneously, their toxicity was assessed through online pkCSM to evaluate their potential as anti-inflammatory drug candidates. The interaction between the active site of cyclooxygenase-2 (COX-2) receptor (PDB: 4PH9) and pyrazoline derivatives showed that pyrazoline 2 (1-benzoyl-(3-(4-chlorophenyl)-5-(3,4-dimethoxy)-4,5-dihydro-2-pyrazoline) exhibited the highest binding affinity of -8.0 kcal/mol compared to pyrazoline derivatives 1, 3, 4 and ibuprofen as native ligands also in the molecular docking test with values ​​of -7.1; -7.7; -7.6; and -7.1 kcal/mol, respectively. Toxicity evaluation for pyrazoline 2 also suggested that this compound was non-toxic, non-hepatotoxic, and did not induce skin sensitization, with an Oral Rat Acute Toxicity (LOAEL) score of 1.417 log (mg/kg_bw/day).
Temperature Combustion Profiles of KNO₃, CsNO₃, and NaNO₃-Based Energetic Materials at Atmospheric Pressure Nguyen, Duy Tuan; Denisuyk, A.P.; Hoang, Trung Huu; Sizov, V.A.; Doan, Minh Khai
Indonesian Journal of Chemical Studies Vol. 4 No. 2 (2025): Indones. J. Chem. Stud. December 2025
Publisher : Indonesian Scholar Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55749/ijcs.v4i2.74

Abstract

This study investigated the thermal properties of energetic materials composed of alkaline metal nitrates, specifically KNO3, CsNO3, and NaNO3, at atmospheric pressure. This study primarily evaluated the burning surface temperature and characterized the heat release behavior of the studied compositions during combustion. To determine the thermal output, temperature profiles were obtained using thermocouple wires on the combustion surface. Given the heterogeneous structure of these formulations and the reactivity of alkali metals during combustion, finding a consistent temperature signatures presented an analytical challenge. All the tested samples exhibited very high surface combustion temperatures. The KNO3-based sample exhibited a higher maximum heat-flow density than the NaNO3-based formulation. Variations in the temperature profiles resulted from the differences in composition structure and combustion reactivity. This study showed the effect of nitrate type on the thermal performance of energetic materials. These results clarified the influence of nitrate identity on heat transfer and combustion efficiency in nitrate-based pyrotechnic formulations, and may inform the design of thermally stable, high-performance propellants and thermal generator formulations.
Physicochemical and Catechin Release Properties of Carboxymethyl Cellulose/κ-carrageenan’s Composite as Precursor of Active Green Packaging: A Preliminary Study Rahmasari, Khusna Santika; Wirasti; Maharani, Vanesa; Putri, Eka Anidya; Rahmadhani, Aulia; Sabilla, Elsa; Ishartono, Bayu
Indonesian Journal of Chemical Studies Vol. 4 No. 2 (2025): Indones. J. Chem. Stud. December 2025
Publisher : Indonesian Scholar Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55749/ijcs.v4i2.75

Abstract

The ongoing dependence on conventional petroleum-based plastic food packaging, and the increasing necessity to protect food quality against lipid oxidation, pose significant challenges that requires comprehensive scientific examinations. In response to these challenges, the development of green food packaging with biopolymer composites, enhanced with antioxidant substances, has become an urgent and promising area of investigation. This preliminary study demonstrated the novel fabrication of green food packaging films by solvent casting blended carboxymethyl cellulose (CMC) and κ-carrageenan (κ-Car) at specific ratios, resulting in a CMC/κ-Car biocomposites. Catechin (CAT), a model of phenolic-rich antioxidant, was incorporated into the CMC/κ-Car composite matrix to simulate the release of active compounds. The efficacy of the composite synthesis was assessed using spectrometric characterisation and physicochemical property evaluation. Infrared spectroscopy validated the successful synthesis and confirmation of the CMC/κ-Car composite, both in its original form and with CAT. Physicochemically, increasing κ-Car content improved tensile strength (TS), elongation at break (EAB), and water absorption capacity (WAC), with optimal performance at an 8:2 CMC/κ-Car ratio. The sustained release profile of CAT over a specific time interval revealed that the composite acted as a carrier matrix, with diffusion-driven release kinetics, as predicted by the Higuchi and Korsmeyer–Peppas equations. The findings of this preliminary study indicated that, the CMC/κ-Car composite, might have potential as a green food packaging material, improving shelf life and reducing lipid oxidation due to CAT's antioxidant properties.
Copolymerization of Tapioca Starch Waste through Grafting of Acrylic Acid Monomer with Cerium(IV) Initiator as Super Absorbent Polymer (SAP) Candidate Kurniadi, Tedi; Prasojo, Agus Eko; Putri, Riyanti; Nurwanto; Hartono, Rudi; Atmadi
Indonesian Journal of Chemical Studies Vol. 4 No. 2 (2025): Indones. J. Chem. Stud. December 2025
Publisher : Indonesian Scholar Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55749/ijcs.v4i2.81

Abstract

Indonesia, one of the world's largest tapioca starch producers, generates abundant cassava starch waste (onggok) that remains underutilized. This study aimed to enhance the value of onggok by synthesizing a superabsorbent polymer (SAP) through graft copolymerization using acrylic acid monomer and cerium(IV) initiator. Grafting was optimized by varying monomer concentrations (10–40% w/w) while maintaining the initiator concentration at 1.70% (w/w) and a reaction temperature of 53 °C. The optimal grafting occurred at 20% monomer concentration, yielding a grafting percentage of 14.83% and a monomer conversion of 74.15%. FTIR analysis showed increased absorbance ratios of –OH to C=O functional groups, confirming successful grafting. SEM images revealed a transformation from granular to porous structures, while DSC analysis demonstrated a shift in gelatinization temperature from 45.91 °C (raw onggok) to 46.69 °C (grafted), and retrogradation temperature from 140.67 °C to 141.67 °C. The water absorption capacity of the grafted copolymer reached 4.2450 g/g (5.20 g total), nearly double that of raw onggok (2.2716 g/g or 3.20 g), confirming its effectiveness as a SAP material.
Enzymatic Biodegradation of Polyethylene Terephthalate (PET) by Crude Lipase from Geotrichum candidum Haviza, Nurul; Armaini; Syafrizayanti, Syafrizayanti
Indonesian Journal of Chemical Studies Vol. 4 No. 2 (2025): Indones. J. Chem. Stud. December 2025
Publisher : Indonesian Scholar Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55749/ijcs.v4i2.90

Abstract

The issue of plastic waste, particularly polyethylene terephthalate (PET), has become a major global environmental concern due to its resistance to natural degradation. One promising approach to addressing PET waste is the use of lipase enzymes produced by microorganisms. This study aims to explore the potential of the fungus Geotrichum candidum J1 to produce crude lipase enzymes capable of degrading PET plastic. The research involved stages including isolation and rejuvenation of the fungus, enzyme production through solid-state fermentation, and lipase activity assay using the cup-plate method. Subsequently, PET degradation testing was carried out using the crude enzyme extract under controlled conditions for 30 days. The results indicated that the crude lipase from G. candidum J1 exhibited lipolytic activity, as evidenced by clear zones formed on selective media. The average total protein yield reached 2.992 ± 0.05 mg/mL, indicating stable fermentation. Degradation tests showed a weight loss of PET between 5.9% and 6.4%. Characterization by Fourier Transform Infra Red (FTIR) confirmed the cleavage of ester bonds in PET structure, evidenced by spectral changes in carbonyl groups. Observations using a Scanning Electron Microscope (SEM) revealed morphological changes, including cracks and pores, on the PET surface post-treatment. In conclusion, the crude lipase from G. candidum J1 demonstrates significant potential as a biodegradation agent for reducing PET plastic pollution in an environmentally friendly manner.