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JKKI : Jurnal Kedokteran dan Kesehatan Indonesia
Published by Universitas Islam Indonesia
ISSN : 20854145     EISSN : 25272950     DOI : 10.208885/JKKI.Vol10.Iss3.art5
Core Subject : Health,
Medicine & Pharmacology Public Health
JKKI: Jurnal Kedokteran dan Kesehatan Indonesia is a peer-reviewed journal in the field of medical and health sciences. This journal is designed as a place of dissemination of information and scientific knowledge, which publishes three times a year. It publishes original article, article review, and case report. These comprise of biomedical sciences, clinical medicine, public health sciences, and medical science education.
Arjuna Subject : Kedokteran - Kedokteran Keluarga
Articles 16 Documents
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Search results for , issue "JKKI, Vol 15, No 2, (2024)" : 16 Documents clear
Immunopathogenesis of dengue virus and Salmonella typhi coinfection Nugraheni, Enny; Sudiro, Tjahjani Mirawati; Nainggolan, Leonard; Fithriyah; Dewi, Beti Ernawati
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 15, No 2, (2024)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol15.Iss2.art12

Abstract

Typhoid, malaria, leptospirosis, dengue virus (DENV), and other arboviruses are endemic in Indonesia. Therefore, it is more likely that DENV and other infectious diseases could be coinfected. More severe symptoms, delayed identification, and ineffective treatment of the illness can all result from Salmonella typhi coinfection. To serve as a principle for clinicians’ considerations while diagnosing and prescribing, we aim to examine the immunopathogenesis of dengue associated with Salmonella typhi coinfection. Dengue virus has the potential to increase both susceptibility and incidence of this coinfection, leading to dengue haemorrhagic fever (DHF) with more severe clinical symptoms. This is explained by regulating impact of coinfection in the presence of gram-negative membrane endotoxin, DENV replication, and lipopolysaccharide (LPS). If Salmonella typhi coinfection is not treated promptly, both dengue and Salmonella typhi can affect several organs and result in significant morbidity and death. Dengue and typhoid immunopathogenesis coinfection are unclear. When dengue monoinfection compared with Salmonella dengue dual infections are related to higher fatality and morbidity rates.
The efficacy of autologous serum therapy in chronic spontaneous urticaria: A systematic literature review and meta-analysis Suherman, Ahmad Ligar; Nopriyati; Pariyana
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 15, No 2, (2024)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol15.Iss2.art11

Abstract

Chronic spontaneous urticaria (CSU) is an autoimmune disease characterised by urtica lesions and/or angioedema accompanying an itching sensation, recurring for at least six weeks without any specific trigger. Autologous serum therapy (AST) is an adjuvant therapy for CSU that is resistant to H1 antihistamines. This therapy is an economical option in developing countries. There were a few studies discussing the role of AST in CSU. This systematic review and meta-analysis were conducted to evaluate the efficacy of AST based on urticaria activity scores (UAS or UAS7) and urticaria total severity scores (TSS) so that clinicians can consider them. Data were searched systematically in Cochrane, PubMed, Google Scholar, Willey, and EMBASE from 2000 to March 2023. Data analysis using Excel 2010 (Microsoft Corp) and MedCalc version 20.218. There were 14 studies: 4 randomised controlled trials (RCT), 9 prospective, and 1 cross-sectional. The average improvement in UAS and TSS scores at the end of therapy was 42.24% and 41.24%. Results of subgroup analysis of AST administration in the group autologous serum skin test (ASST) positive and ASST negative based on the end of therapy UAS score (p=0.18). Results of subgroup analysis of AST administration in the positive ASST and negative ASST groups based on the TSS score at the end of therapy (p=<0.001). Results of subgroup analysis of AST administration versus placebo based on TSS score (p=0.861). Based on subgroup analysis, autologous serum therapy improves TSS scores in CSU patients (ASST positive). However, AST is not significantly different from placebo.
The expression of Ki-67 and clinicohistopathological characteristics of breast cancer in Southern Sumatra, Indonesia Harist, Muhammad; Wresnindyatsih; Fertilita, Soilia; Prasetyo, Nauval Togi; Abdurrachman, Muhammad Rafi
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 15, No 2, (2024)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol15.Iss2.art6

Abstract

Background: Breast cancer is the most frequently diagnosed cancer in the world, approximately 2.3 million new cases (11.7% of all cancer cases) per year in 2020. The Ki-67 expression is clinically used to classify molecular subtypes of breast cancer into luminal A and luminal B groups.Objectives: This study aimed to investigate relationships between clinicohistopathological characteristics (ages, histopathological types, histopathological grades, molecular subtypes) of breast carcinoma patients and the Ki-67 proliferation index at dr. Moh. Hoesin General Hospital (RSMH) Palembang in 2019–2021.Method: This study applied an observational analytic study with a cross-sectional approach. 521 samples were included in this study based on inclusion and exclusion criteria. The samples in this study included invasive breast carcinoma patients who underwent histopathological examination and immunohistochemistry (IHC), recorded in the medical records at RSMH Palembang for 2019–2021 period. Then a statistical analysis was performed by using the chi-square test, which was analysed in the SPSS application.Results: The correlation between Ki-67 proliferation index and histopathological grades was statistically significant (p=0.018). The Ki-67 proliferation index was also statistically significantly associated with the molecular subtypes (p=0.000). Neither age (p=0.315) nor histopathological types (p=0.417) were significantly associated with the Ki-67 proliferation index.Conclusion: The Ki-67 expression was significantly associated with histopathological value and molecular subtype in breast carcinoma patients at RSMH Palembang in 2019–2021. The Ki-67 expression was not associated with the clinic-histopathological characteristics of ages and histopathological types.
B-cell epitope prediction of MPB83 protein as a candidate for serodiagnostic antigen of bovine tuberculosis in human: In silico study Ahmad, Shabrina Izzata Afiyati; Aziz , Ayu Munawaroh; Armiyanti, Yunita; Mufida, Diana Chusna
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 15, No 2, (2024)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol15.Iss2.art4

Abstract

Background: Bovine tuberculosis (bTB) can be transmitted to humans by inhalation or consumption of incomplete pasteurized milk and dairy products derived from infected cows. Most cases of Mycobacterium tuberculosis (M. bovis) infection are resistant to tuberculosis (TB) drugs. The risk of death during treatment for bTB has been reported to be 2.55 times higher than for TB. However, the quality of diagnostic methods for bTB remains relatively low.Objective: We aim to evaluate the potential of the B-cell epitope of the MPB83 protein as a candidate bTB serodiagnostic antigen using an in silico approach. Methods: This study was a computer-based descriptive study using secondary data from the National Center for Biotechnology Information (NCBI) protein database. The MPB83 protein sequence was obtained from M. tuberculosis variant bovis AF2122/97 from the United Kingdom. We described the characteristics of the linear epitope of the M. bovis B-cell protein MPB83 by measuring antigenicity, molecular weight, instability index, and Grand Average of Hydropathy (GRAVY) score. The tools used in this study were IBIVU PRALINE, VaxiJen v2.0, IEDB, ExPASy ProtParam, Cluspro, and the PyMOL application.Results: We found an epitope that could be used for bTB serodiagnostic antigen with low conservation, the 106KLNPDVNLVDTLN118 epitope. It has the molecular weight, instability index, and GRAVY score of 1638.76 Da, -28.44, and -0.300, respectively. Epitopes with the best criteria were simulated by docking to human major histocompatibility complex (MHC) class II. Docking results showed that the lowest binding energy was -644.8 kcal/mol. Further analysis using the PyMOL application obtained 14 hydrogen bonds with bond distances ranging from 1.7 Å to 2.2 Å, all of which showed strong hydrogen bonds.Conclusion: The B-cell epitope of MPB83 protein sequence 106KLNPDVNLVDTLN118 has a potential serodiagnostic antigen candidate for human bTB.
Potential of endophytic bacteria as producers of antibiotics: A literature review Scania, Alifah Evi; Ibrahim, Fera
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 15, No 2, (2024)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol15.Iss2.art13

Abstract

Microbial infection is a significant contributing aspect to the development of diseases, posing ongoing challenges in - healthcare. Numerous synthetic antibiotic agents have been used as therapeutic interventions; however, many microorganisms exhibit resistance to these synthetic agents. The rate at which microbes developed resistance to antibiotics has outpaced the discoveries and study of new treatments. The potential of endophytic bacteria to produce bioactive compounds or metabolites that can serve as the basis for developing new antibiotic drugs is promising is promising. This review aims to explore the metabolite potential of endophytic bacteria as a source of antibiotics. Understanding the mechanism and potential of endophytic bacteria offers opportunities for the advancing therapeutic interventions to mitigate the negative effects of various strains of antibiotic-resistant pathogenic bacteria.
Generalized fixed drug eruption suggesting potential association with dimenhydrinate: A rare case report Suryaningsih, Betty Ekawati; Noegroho, Trijanto Agoeng
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 15, No 2, (2024)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol15.Iss2.art14

Abstract

Generalized fixed drug eruption (GFDE) is a specific variant of fixed drug eruption (FDE) characterized by multifocal lesions that recur upon exposure to a particular medication. This report describes a rare case of GFDE in a 54-year-old male, who presented with chief complaints of widespread erythema and pruritic, burning sensation. Physical examination revealed the patient to be in generally good condition dermatological status showed erosion on the hard palate, patches, erythematous macules, and partially ruptured bullae forming erosion in inguinal and genitals area, buttocks, thighs, lower legs, feet, axillae, hands, forearms, and back. The lesions were described as purplish round/oval erythematous patches, ranging from 1-4 cm in diameter, partially confluent, forming larger areas up to 6x7 cm, with bullae partially ruptured into erosion. The patient was admitted to the hospital, and treated with Ringer's lactate infusion, and an intravenous injection of 125 mg methylprednisolone. On the second day, the dose of intravenous methylprednisolone was reduced to 62.5 mg in the morning and the patient was administered a 10 mg cetirizine tablet orally in the evening, triamcinolone acetonide for oral lesions, a 15-minute NaCl 0.9% compress on the genitals twice a day, and desoximetasone 0.25% cream for all lesions. By the third day, the patient’s condition had improved, and he was then discharged. The prescribed home therapy regimen included a 16 mg methylprednisolone tablet in the morning, a 4 mg tablet in the afternoon, a 10 mg cetirizine tablet once daily, a 500 mg ciprofloxacin tablet twice daily, compress, and topical applications of triamcinolone acetonide for oral lesions and desoximetasone 0.25 % cream for all other lesions. A follow-up visit three days post-discharge indicated significant dermatological improvement. The diagnosis was established through anamnesis, physical examination, and appearance of skin disorder. Dimenhydrinate was identified as the potential causative agent.
Differences in livor mortis in Wistar rats due to organophosphate induction and normal mortality: A randomized experimental study Nugroho, Novianto Adi; Sena, Muhammad Shokhiful Wafa Arya Wida; Suwandono, Adji
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 15, No 2, (2024)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol15.Iss2.art5

Abstract

Background: Pesticide intoxication, a significant global health issue, particularly in developing nations, is often caused by the most toxic pesticides, organophosphates. These substances activate the sympathetic and parasympathetic nervous systems, producing a characteristic livor mortis. It is a secondary sign of death that can be used to estimate the time and cause of death. Objective: This study aims to determine the difference in livor mortis due to organophosphate poisoning and ordinary death (decerebration) using Wistar rats.Methods: From March to April 2023, we conducted an experimental study with a posttest-only control group at the Laboratory of Animal Experiments, Faculty of Medicine, Sebelas Maret University. We used 32 male Wistar rats weighing 150-200 g, divided into control and test groups. The test group received organophosphate diazinon 1.16 ml through a nasogastric tube, while the control group was decerebrated. The data was processed with univariate analysis and an independent t-test.Results: There was a significant difference in the appearance and the persistence time of livor mortis between the control and test groups (p < 0.05). The color of livor mortis in the control group was purplish blue, while in the test group, it was reddish to blackish blue. Most of our samples displayed a distribution of livor mortis in the abdominal and dorsal regions, with a some displaying an abdominal distribution only.Conclusion: Our study reveals significant differences in the appearance and persistence time, as well as the color and distribution of livor mortis between decerebrated and organophosphate-induced dead rats.
Type 2 diabetes mellitus as an independent risk factor of pulmonary tuberculosis: A hospital based cross-sectional study Yanti, Budi; Firdausa, Sarah; Irsyah, Abid Dhiyauddin Alfani; Andayani, Novita; Salwani, Desi
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 15, No 2, (2024)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol15.Iss2.art9

Abstract

Background: The growing frequency of infectious and non-communicable illnesses on a global scale is primarily associated with the changing patterns observed in epidemiology. Diabetes mellitus (DM) significantly leads to the development of tuberculosis (TB) and less effective treatment outcomes if not identified early. Objective: This study aims to investigate type 2 DM as a risk factor for TB infection.Methods: Participants in this cross-sectional research study comprised DM patients who reported cough complaints at the TB treatment center and the internal medicine department of Zainoel Abidin Hospital. Random blood glucose and glycated hemoglobin (HbA1c) levels were measured in all respondents. The Chi-Square test assesses the association between DM and Pulmonary TB.Results: There are 48 DM patients with new pulmonary TB, an averageage of 53 years (SD 9.1). Most of them have symptoms of cough for more than 2 weeks (85.4%), loss of body weight (77.1%), chest pain (58.3%), and loss of appetite (72.9%). The high HbA1c levels were associated with TB, as detected by Xpert MTB/RIF assay and typical radiographic signs (p<0.05). DM patients with increased HbA1c were found to have a two times chance of showing results from a chest x-ray typical of TB and probability of TB infection (PR: 2.850, 95% CI (1.152-7.053); 2.745, 95% CI (0.969-7.780)) respectively.Conclusion: DM patients had two times the risk of lung damage based on chest X-rays and having TB. DM may seriously compromise the efficacy of TB control programs and impede a nation's progress toward TB elimination.
Parental decision-making in taking care of child health in Indonesia: Findings from a national survey Prasetyo, Yoyok Bekti; Fahad, Mochammad; Dewi, Yulis Setiya; Huriah, Titih; Latif, Rusnani AB
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 15, No 2, (2024)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol15.Iss2.art7

Abstract

Background: The decision-making process to search for child health services involves interaction among the mother, partner, and other family members. Parental decision-making is highly complex since it involves an emotional consideration between the benefit and the child's future. The common problem in deciding the service is the lack of capabilities, such as facility, knowledge, and skill.Objective: The purpose of this study is to analyze the influence of socio-demographic factors on parents' decision-making in obtaining health services for their children Methods: This study design was cross-sectional data from the Indonesia Demographic and Health Survey (IDHS) of 2017, which was applied in this study. The respondents involved were 8,838 women aged 15-49 who had given birth in the last five years. This study employed descriptive, chi-square, and regression statistics analysis. The results were provided as adjusted odds ratios (AORs) with 95 percent confidence intervals. The statistical analysis utilized SPSS version 21.0 software (SPSS Inc., Chicago, IL, USA).Results: Bivariate analysis revealed a significant relationship between decision-making and age, living place, educational background, and wealth index (p-values 0.030, <0.001, 0.002, and 0.006), but not with health insurance ownership (p=0.242). After multivariate analysis, only age-related decisions were associated with a significant risk. It explained that younger group (15-29) has a 0.325 times chance of making a joint decision than the 40 to 49-year-old group (AOR: 0.325; 95%CI: 0.144-0.733). Conclusion: Parental decision-making regarding childcare is related to several factors, namely age, living place, educational background, and socioeconomic status. Health education is a strategy to promote child health in Indonesia by facilitating proper decision-making.
A neglected ocular tuberculosis without antitubercular therapy: A case report Oktaliani, Rahayu; Idrus, Elfa Ali
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 15, No 2, (2024)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol15.Iss2.art15

Abstract

Ocular tuberculosis (TB) is one of the causes of uveitis, but there is often a skepticism and lack of acceptance regarding this diagnosis. We present a case of a-62-year-old female patient who complained of blurred vision, pain, and redness in her right eye. These symptoms had persisted for the past 16 months. The latest visual acuity in the right eye was 0.0167, and in the left eye was 0.63. Upon examination, keratic precipitates were found in the right eye, along with flare and cells +1/+1, pupil seclusion, a cloudy lens, and opacity in the posterior segment. The left eye was within normal limits. The patient was diagnosed with panuveitis of the right eye due to ocular TB and a complicated cataract. She had been referred by the local general hospital with complaints of blurred vision and was initially diagnosed with anterior uveitis due to ocular TB based on clinical presentation and positive Interferon-Gamma Release Assay (IGRA) test results. The patient was then referred back to the Internal Medicine Department of the local general hospital and the community health centre to start the anti-tuberculosis therapy (ATT). However, the patient refused treatment and, as a result, did not receive anti-tuberculosis drugs. Panuveitis TB, without adequate treatment, can lead to a poor prognosis.

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