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JKKI : Jurnal Kedokteran dan Kesehatan Indonesia
Published by Universitas Islam Indonesia
ISSN : 20854145     EISSN : 25272950     DOI : 10.208885/JKKI.Vol10.Iss3.art5
Core Subject : Health,
Medicine & Pharmacology Public Health
JKKI: Jurnal Kedokteran dan Kesehatan Indonesia is a peer-reviewed journal in the field of medical and health sciences. This journal is designed as a place of dissemination of information and scientific knowledge, which publishes three times a year. It publishes original article, article review, and case report. These comprise of biomedical sciences, clinical medicine, public health sciences, and medical science education.
Arjuna Subject : Kedokteran - Kedokteran Keluarga
Articles 468 Documents
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Correlation of neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, lymphocyte-to-monocyte ratio and carcinoembrionic antigen level in colorectal cancer Oktania Candrawati; Bambang Eko Broto Hari Utomo; lmam Sofii
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 9, No 2, (2018)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol9.Iss2.art4

Abstract

Background: Colorectal cancer is one of cancer that has a high mortality rate. Cancer is associated with a systemic inflammatory response. Carcinoembryonic antigen (CEA) is a colorectal cancer prognostic marker, but this examination is quite expensive and not always ubiquitously available. Therefore, systemic inflammatory markers through routine blood examination are expected as a colorectal cancer marker. Objective: The present study is to determine a correlation of neutrophil-lymphocyte ratio (NLR), the platelet-lymphocyte ratio (PLR), the lymphocyte-monocyte ratio (LMR) and CEA level in colorectal cancer patients. Methods: This retrospective cross-sectional study was conducted in November 2016-January 2017 at Dr. Sardjito Hospital, Yogyakarta. As many as 209 patients who underwent surgery in January 2015-Decemberr 2016 with colorectal cancer histopathologic diagnosis were included. Demographic, clinical, histopathology and preoperative NLR, PLR, LMR and CEA level was obtained from medical records. Correlation of NLR, PLR, LMR and CEA level was analyzed with Somer’s test. Result: As many as 51.2% of subjects were male. Most subjects (n 42.6%) were diagnosed at 45-60 years old. The most common location of the tumor is in rectum (65.1%). Histopathology examination showed well differentiation in 51.7% subjects. The Somer’s analysis showed there was correlation of NLR and CEA level (p=0.023, r=0.164), there was a correlation between PLR and CEA level (p=0.016, r=0.146). Higher NLR and PLR was proportional to higher CEA level. There was a correlation of LMR and CEA level (p=0.001, r=-0.188), lower LMR correlates to higher CEA level.Conclusion: There is significant positive correlation of NLR and CEA level, PLR and CEA level, and negative correlation of LMR and CEA level in colorectal cancer patients.
The Accuracy of Increased Blood Concentration of Prostate-Specific Antigen to Prostate Malignancy Ardi Pramono; Gibran Raka Pramodya; Cornel Anggara; Amaro Yudho Wibowo
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 9, No 1, (2018)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol9.Iss1.art7

Abstract

Background: Circumcision is the most widely minor surgery in the world, whether done by doctors, paramedics, or by traditional. Circumcision that removes part or all of the penis prepuce with the aim of removing smegma (dirt). Society circumcised their children at the age of 5-12 years. Analgesics may be given to patients, for instance, paracetamol, nonsteroidal anti-inflammatory drug (NSAIDs) such as aspirin and opioid groups such as tramadol.Objective: The aim of this study was to compare the effectiveness of paracetamol analgesics and tramadol in circumcised patients given prior to the act of circumcision.Methods:This study was a quasi-experimental study to determine different analgesic effects of paracetamol and tramadol administration, prior to circumcision. The subjects of this study are children aged 5-12 years as many as 36 children, which is divided into 2 groups of paracetamol and tramadol group. One hour before circumcision, subjects were given group-appropriate analgesics, then the Visual Analog Scale (VAS) was measured 1 hour after circumcision. The data obtained were made intopercentage on the scale of VAS <5 and> 5.Results: In the paracetamol group, there were 5 children (27.8%) with VAS 1-3 (mild pain), 13 children (72.2%) with moderate pain (VAS value 4-7). In the tramadol group, there were 15 children (83.3%) with mild pain (VAS score 1-3), and the remaining 3 children (16.7%) had moderate pain. No side effects of both analgesic drugs were found.Conclusion: Patients with mild pain complaints were more likely found in the tramadol group than in paracetamol group. Tramadol gave stronger preemptive analgesic results in circumcision compared to paracetamol.
Characterization, formulation and evaluation of glibenclamide with ß-cyclodextrin inclusion complexes tablets Yandi Syukri; Farida Ulfa; Asih Lestari; Lelita Ayu Saputri; Rochmy Istikharah; Aris Perdana Kusuma
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 9, No 3, (2018)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol9.Iss3.art3

Abstract

Background: Glibenclamide is an oral antidiabetic drug which is practically insoluble in water. Formation of ß-cyclodextrin inclusion complex was able to increase glibenclamide solubility. Objective: Aims of this study are to characterize, formulate and evaluate  inclusion complex tablets of glibenclamide to meet the requirements in Pharmacopeia.Methods: Inclusion complex was prepared in a 1: 1 and 1: 2 molar ratio  by spray drying method. Characterization were performed by using Fourier Transform Infrared (FTIR) spectroscopy and Scanning Electron Microscope (SEM). Further, it was formulated into tablets by direct compression technique using primojel and crospovidone as disintegrants.   Uniformity weight, hardness, friability, disintegration, and tablets were evaluated include dissolution. Dissolution studies of inclusion complex were performed by using United States Pharmacopeia (USP) II apparatus.  Drug concentration dissolution was determined with high pressure liquid chromatography (HPLC).Results: Result of FTIR and SEM provided evidence of  glibenclamide and ß-cyclodextrin complex formation after using spray drying methods. The tablet evaluation with primojel and crospovidone as disintegrant showed that increase concentration of disintegrant would increase disintegration time of the tablets. All of the formulas meet the requirements in the Pharmacopoeia.Conclusion: The inclusion complex of glibenclamide–ß cyclodextrin successfully used for enhancing the solubility of glibenclamide. The tablets meet the requirements in Pharmacopeia.
Comparison of meloxicam, tamsulosin and combination of both drugs with 16 Fr and 20 Fr catheter on trial without catheter successfulness in patients with benign prostatic hyperplasia Hasroni Fathurrahman; Doddy Moesbadianto Soebadi
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 9, No 3, (2018)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jkki.vol9.iss3.art4

Abstract

Background: Acute urinary retention, is one of the main complications of Benign Prostatic Hyperplasia (BPH) in elderly patients. Trial Without Catheter (TWOC) is a way to evaluate whether a patient can urinate spontaneously after an episode of urinary retention. Objective: To prove that the combination of meloxicam 15 mg and tamsulosin 0.4 mg orally once daily for three weeks with 20 Fr catheter is more effective in the TWOC successfulness in BPH patients than meloxicam 15 mg or tamsulosin 0.4 mg alone with 16 Fr catheter. Methods: Patients BPH who had the first episode of urinary retention and fulfil the inclusion criteria were randomised. There were six treatment groups (n=6). The treatment group are meloxicam 15 mg + catheter 16 Fr (K1), combination of meloxicam 15 mg and tamsulosin 0.4 mg + catheter 16 Fr (K2), tamsulosin 0.4 mg + catheter 16 Fr (K3), meloxicam 15 mg + catheter 20 Fr (K4), combination of meloxicam 15 mg and tamsulosin 0.4 mg + catheter 20 Fr (K5), tamsulosin 0.4 mg + catheter 20 Fr (K6). For each group, drugs were given orally once daily for seven days. Efficacy of TWOC was assessed by the ability of spontaneous urinary after the first 24 hour post urethral catheter treatment, with Q-max result on uroflowmetry = 5 cc/sec and PVR = 100 cc. Result: All subjects from K1 and K4 experience a recurrent episode of urinary retention (100%), 83.3% in K3 and 66.7% in K6. In the combination group, K2 had 50% incidence of repeat urinary retention, while K5 had16.7%. From the whole group, a statistically significant difference with p <0.05 only can be found in K1 and K5 (p = 0.02).Conclusion: The combination of meloxicam 15 mg and tamsulosin 0.4 mg + 20 Fr catheter had a better effect in TWOC efficacy compared with the meloxicam 15 mg + catheter 16 Fr group.
Retention of basic life support in medical students of Airlangga University Inna Maya Sufiyah; Bambang Pujo Semedi; Sundari Indah Wiyasihati
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 9, No 2, (2018)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol9.Iss2.art9

Abstract

Background: Cardiac arrest is one of the leading cause of death in the world with steadily increasing number over the years. Basic life support has been proven to lower the risks of tissue damage and further complication. Several study shows that BLS skill are lacking in some doctors and nurses.Objective: Therefore, the purpose of this study is knowing the retention of basic life support in medical student of Airlangga University.Methods: This descriptive study used cross sectional design. Subjects were students at faculty of medicine in Airlangga University who trained one year ago and completed their study of Basic Life Support. Fifty two subject were asked to practice their BLS techniques then scored based on modified American Hearth Assosiation (AHA)’s Basic life support skill checklist.Results: Based on the data, the percentage of students who did the retest correctly: response checked by shouting 92.31% students, response checked by tapping 69.23% students, call for help 44.23% students, airway checked 48.08% students, breathing checked 46.15% students, correct hand placement 100% students, compression rate 78.85% students, compression ratio 75% students, position 94.23% students, and compression depth 78.85% students. Conclusion: One year post training and test, 14 from 52 students could complete all the steps in basic life support skill. Less than a half of the students successfully done 3 out of 10 points that were being tested. Meanwhile, many aspects in circulation point show higher results all above 75%.
The effect of the onset of seizure on clock drawing test score of epilepsy patients Baiq Kania Kartika Yaksa; Herpan Syafii Harahap; Emmy Amalia; Yanna Indrayana
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 9, No 2, (2018)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol9.Iss2.art6

Abstract

Background: Epilepsy is one of the causing factors of cognitive impairment which affects the patient’s quality of life. The most critical risk factor for cognitive impairment in epilepsy patients is the onset of seizure. Performing detection of cognitive impairment in those patients is crucial. Clock Drawing Test (CDT) is a validated instrument for the detection of cognitive impairment in epilepsy patients.Objective: This study was aimed to investigate the effect of the onset of seizure on CDT score in epilepsy patients.Methods: This study was a cross-sectional study involving 64 epilepsy patients of Mutiara Sukma Mental Hospital, West Nusa Tenggara, who met the inclusion but not exclusion criteria. The clinical and demographic characteristics data collected in this study were age, gender, type of seizure, etiology, length of education, duration of treatment, and antiepileptic drugs (AED). Cognitive function evaluation has been done by using the CDT instrument. Analysis of the effect of the beginning of seizure on CDT score was carried out by observing the influence of the clinical and demographic characteristics data.Results: There was a significant difference between the onset of seizure on CDT score (p<0.05). There were significant differences in aetiology and age in both groups of onsets of the seizure (p <0.05), but not in the characteristics of gender, type of seizure, level of education, duration of treatment and AED in both groups of onsets of the seizure (p>0.05).Conclusion: The onset of the seizure in epilepsy patients affect CDT score. This effect might be attributed to etiology and age of epilepsy patients.
Diphtery Outbreak in Indonesia in 2017 Asri Hendrawati
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 9, No 1, (2018)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol9.Iss1.art2

Abstract

No Abstract
Relationship between breastfeeding and the incidence of diarrhoea in children aged 6-24 months Manmeet Kaur Gurbachan Singh; Mahrani Lubis
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 9, No 2, (2018)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol9.Iss2.art8

Abstract

Background: Diarrhoea is still a global problem with high mortality. Children who are malnourished or have impaired immunity have the highest risk of diarrhoea. Exclusive breastfeeding in infants is known could protect the babies against diarrhoea.Objective: This study aims to determine the relationship between exclusive breastfeeding with the incidence of diarrhoea in children aged 6-24 months.Methods: This is an observational study where the data collected during August-November 2017 at Padang Bulan Primary Health Care. The subjects are a mother who has children between 6-24 months. The primary data was obtained through interviews using a validated structured questionnaire. The relationship between exclusive breastfeeding and the incidence of diarrhoea were analysed using Chi-square. Statistical analysis was performed in 95% coefficient interval (alpha=0,05).Results: Amongst 98 children, 53.1% are female. Children who have received exclusive breastfeeding were 53 children (54.1%). The number of children who had diarrhoea was 68.4% while many diarrhoea frequencies were 49%. Only 29 children (29.6%) had diarrhoea with exclusively breastfeeding, while 38 children (38.8%) had diarrhoea without exclusive breastfeeding. There is a relationship between exclusive breastfeeding to the incidence of diarrhoea in children aged 6-24 months (p= 0,002).Conclusion: There is a significant relationship between exclusive breastfeeding and the incidence of diarrhoea in children aged 6-24 months.
Correlation between the effect of increasing body weight with plantar pressure and ankle-knee radiographic angle parameters changes Dimas Triaryo; Luthfi Hidayat; Rahadyan Magetsari
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 10, No 1, (2019)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol10.Iss1.art5

Abstract

Background: Understanding the biomechanical structure of the body is important to preventing and treating the musculoskeletal system problems. The increase in body mass index contributes to the elevated peak plantar pressure and decreased longitudinal arch of the foot. This condition, consequently, may cause mal-alignment of the lower extremity, leading to promote cartilage breakdown, osteophyte formation, subchondral bone hypertrophy, lead to progression of knee joint destruction and functional deficits. Objective: The aim of the study was to examine the correlation between body weight, plantar pressures, ankle and knee angle measurement parameters.Methods: The research study sample included 30 female who met inclusion and exclusion criteria. In order to evaluate the structural characteristic of plantar foot, we used the blueprint method on bare-foot and also when carrying 15 and 25 kilogram of load. Furthermore, to measure knee-angle parameters, we also performed a bilateral standing radiograph approach of lower extremity. Results: This study showed a significant correlation between BMI/Body mass index and HW/heel width (p = 0,00) with low positive correlation for both sides. Furthermore, BMI and PAW/plantar arch width (p = 0,00) showed a moderate positive correlation for both sides. In contrast to that, BMI and MFA/mid-foot area (p = 0,00) showed a moderate positive correlation for the right side but low positive correlation for the left side. Another measurement such as BMI and AI/arch index (p = 0,00) had a strong positive correlation on the right side and moderate positive correlation on the left side. Moreover, BMI and AAL/Ankle angle alignment (p = 0,00) revealed a strong positive correlation for both sides, BMI and XCTP/trans-condylar tibial plateau angle (p < 0,05) had a low positive correlation for both sides, meanwhile BMI and AA/ankle angle (p = 0,00) showed a low positive correlation for both sides. Conclusion: Increasing axial load was statistically significant correlated with increasing plantar pressure and ankle-knee radiographic angle parameter. The results also revealed that increasing axial load was found to have strong correlation to the arch index (AI) and ankle angle alignment (AAL). It was a compensatory phenomenon, which can cause structural disturbances and function of the lower limb.
Profil Gizi Buruk pada Balita di Kabupaten Lombok Utara Hafizah Hafizah; Pariawan Lutfi Ghazali
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 2, No 5, (2010)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

According to data in 2005, number of malnutrition's under 5th years children cases in NTB reach 10% from all of under 5th year children on the average 498.000 people. Amount number of malnutrition's under 5th year children can be caused of social-economy status, parent's education and knowledge about nutrition, child rearing patterns and accompanying disease. Malnutrition profile of under 5th year children is very important to know the life of malnutrition under 5th year children that seen from nutrition status, age, clinical symptom, social-economy and accompanying disease, also to know what makes it easier malnutrition and what therapy that must given to malnutntion patient. Knowing malnutrition profile in under 5th year children in North Lombok NTB in 2008 and 2009. This study is was done of subject's medical report and observation, that is under 5th year children that have malnutrition in 2008 and 2009 using z score by weight/height. This study's structured form that includes the information required in the research, that is structured form that contains required info, like identity (name, age, sex, address source of funds), accompanying diseases, clinical symptom. The data obtained were performed using Excel program, then result from that frequency distribution was shown in table and diagram. The study results that amount of malnutrition patients reach 59 patients (97%) from 59 one, the highest age who suffer from malnutrition 18-24 month (20%), accompanying diseases suffered by most of diarrhea (25%), most climcal symptom are thin (39%), he source of funds used by many is not known that is as much 52%, and patient who received additional therapy as much as that 68%. Conclusions from this study, amount number of malnutrition's under 5th year children with 18- 24 month of age that accompanied by concomitant diseases in North Lombok in 2008 and 2009 was caused by low social-economy and less parent's education and knowled#e about nutrition.

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