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Pharmaceutical Sciences and Research (PSR)
Published by Universitas Indonesia
ISSN : 24072354     EISSN : 24770612     DOI : https://doi.org/10.7454/psr
Core Subject :
Aims Pharmaceutical Sciences and Research (PSR), an international, peer-reviewed, open access, and official journal from Faculty of Pharmacy, Universitas Indonesia, aims to disseminate research results and findings in Pharmaceutical Sciences and Practices. Major area of interest is natural products in drug discovery and development. We also consider other areas related to pharmaceutical sciences and practices. PSR publishes content in English language to promote the sharing of knowledge to international scholars. PSR publish 5 types of articles: 1. Original article 2. Case report 3. Case series 4. Review article 5. Mini review article Scope Researches in Pharmaceutical Sciences and Practices which are covered by PSR are within these subject areas: - Pharmacognosy and Phytochemistry - Pharmaceutical Chemistry - Pharmaceutical Technology - Pharmaceutical Biotechnology - Clinical Pharmacy - Pharmacology-Toxicology - Social and Administrative Pharmacy, including Pharmacoeconomy
Arjuna Subject : -
Articles 355 Documents
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Peran Tenaga Kefarmasian dalam Penanggulangan Bencana Role of Pharmacist in Disaster Management Faradilla, Meutia
Pharmaceutical Sciences and Research Vol. 5, No. 1
Publisher : UI Scholars Hub

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Abstract

Indonesia is a country that has high potency to be affected by disaster, either by natural or man-made disaster. After the 2004 tsunami, Indonesian government has improved its disaster prevention policy and program. In disaster management study, health management in disaster setting is aimed to assure the implementation of health service toward victims accordingly. As integrated part of the healthcare team in disaster management, pharmacists have to understand the importance of pharmaceutical care in pre-disaster, disaster, and post-disaster phase. This article aims to provide an overview on pharmacists’ role in disaster management from preparing and distributing medicine and medical devices to its role in therapy management, counselling, and patient education. This article also proposes to stakeholders in pharmacist professional organization to arrange plan and policy to increase and improve pharmacists’ involvement in disaster management.
Evaluation of Propolis and Milk Administration on Caffein-Induced Mus musculus Fetus Skeletal Dillasamola, Dwisari; A, Almahdy; Sari, Novita Purnama; Putri, Biomechy Oktomalio; Noverial, Noverial; Diliarosta, Skunda
Pharmaceutical Sciences and Research Vol. 5, No. 1
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Abstract

Caffeine consumption by pregnant women at doses above 300 mg/day was suggested to cause skeletal damage. Propolis with high flavonoids concentration could increase the number of osteoblasts. This research aims to evaluate the effect of propolis and milk administration on fetal skeletal of caffeine-induced female mice (Mus musculus). Mice were divided into six groups: negative group, positive group of caffeine (a dose of 75 mg/kg BW), positive group of propolis (a dose of 1400 mg/kg BW), positive group of milk (200 ml), group D1 (caffeine 75 mg/kg BW and propolis 1400 mg/kg BW) and group D2 (caffeine 75 mg/kg BW and milk 200 ml). Data were processed using one-way ANOVA. The results showed that administration of propolis and milk on caffeine-induced mice during pregnancy does not affect the mice body weight, the number of fetuses and fetal weight significantly (P> 0.05). No skeletal defects detected in group D1 and D2 (observation with Alizarin solution) compared to the negative group. In conclusion, the admnistration of propolis at the dose of 1400 mg/kg BW and 200 ml of milk can repair skeletal damage caused by caffeine induction.
Potency of (Poly) Acrylic/Carboxymethyl Starch-Chitosan Biohydrogel for Curcumin Oral Delivery Matrix Ruriani, Eka; Mangunwidjaja, Djumali; Richana, Nur; Sunarti, Titi Candra
Pharmaceutical Sciences and Research Vol. 5, No. 1
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Abstract

Biohydrogel has gathered great interest in the pharmaceuticals field. This natural polymers were biodegradable, non-toxic, biocompatible, and its specific ability to response environment change can be considered for the controlled released matric of bioactive compound. In this study, the biohydrogel was synthesized by graft-copolymerization of acrylic acid onto carboxymethyl starch (CMS) and chitosan. The objective of this research was to determine the effect of CMS-chitosan ratio on the biohydrogel characteristic. The acrylic acid was grafted on to the backbone (3:1) using cerric ammonium nitrate as the inisiator.A standarded curcumin was applied to test the binding potency of matrix. A higher CMS ratio in the polymer mixture (4:1) revealed the highest swelling power (16.9 w/w) and percentage of curcumin absorption (17.34%). All samples have pH-responsive swelling properties, with the swelling trend was observed in the order of distilled water >HCl solution > phosphate buffer solution. FTIR spectra and SEM micrographs has confirmed the graft-copolymerization of PAA/CMSCs biohydrogel by describing the appearance of peak around 1600 cm-1and the morphology of granular structure, respectively. The graft-copolymerization of acrylic acid onto the two anionic natural polymer by cerric ammonium nitrate as the initiator has resulted a pH-dependent swelling biohydrogel, and it has the ability to deliver curcumin in stomach-targeted system.
Optimasi Aktivitas Bakteriosin yang Dihasilkan oleh Bakteri Lactobacillus plantarum dari Minuman Ce Hun Tiau Sari, Rafika; Apridamayanti, Pratiwi; Octaviani, Melly
Pharmaceutical Sciences and Research Vol. 5, No. 1
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Abstract

Bacteriocin is a protein compound with a small molecular weight that has an antibacterial activity. Bacteriocin has been widely applied as a natural food preservative, as it effectively prevents the growth of pathogenic bacteria in foods and beverages. The aim of this research was to know the activity of bacteriocin produced by lactic acid bacteria Lactobacillus plantarum from Ce hun tiau beverages against Escherichia coli and Staphylococcus aureuswith different pH and temperature treatments. In this study, Lactobacillus plantarum bacteria isolated from Ce hun tiau beverages were characterized by Gram staining test. Bacteriocin was extracted from Lactobacillus plantarum bacteria which had been incubated in deMan Rogose Sharpe Broth media. Confirmation test using proteolytic enzyme and bacteriocin activity test with different pH (2, 4, 6, 8, and 10) and temperature (40°, 60°, 80°, 100°, and 121°C) treatments were conducted. The results showed that bacteriocin hadantibacterial activity against Escherichia coli but had no activity against Staphyloccus aureus. The inhibition zone was formed at pH 2 to 6 and at temperature range of 40°C to 121°C.
Aktivitas Mukolitik Kombinasi Ekstrak Etanol Daun Kemangi dan Ekstrak Etanol Daun Sirih Merah Kurniati, Neng Fisheri; Suwandi, Deden Winda; Yuniati, Safira
Pharmaceutical Sciences and Research Vol. 5, No. 1
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Abstract

A cough is a protective physiological mechanism that is useful for removing and clearing the respiratory tract from sputum and foreign particles that can cause infection. Treatments for cough disorders using medicinal plants were conducted because medicinal plants were widely known to have less side effects than synthetic drugs. Basil leaves (Ocimum sanctum L.) and red betel leaves (Piper crocatum Ruiz and Pav) have been used traditionally to treat a cough. The purpose of this study was to determine the mucolytic activity, and the effective concentration of the combination of basil and red betel leaves ethanol extract. The mucolytic activity was performed by measuring the decrease of viscosity of mucous from the cow intestinal mucosa. Mucolytic activity was evaluated upon treatment by each extract (concentration 0.1%, 0.5%, and 1%) and the combination of both. Results showed that ethanol extract of basil leaves or ethanol extract of red betel leaves could reduce viscosity of artificial sputum at the dose of 0.5% each. Moreover, the combination of these extracts synergistically decreases the viscosity. Combination of ethanol extract of basil leaves and red betel can be an alternative medicine for cough treatment.
Sensitivity of Escherichia coli Bacteria Towards Antibiotics in Patient with Diabetic Foot Ulcer Sari, Rafika; Apridamayanti, Pratiwi; Puspita, Indira Diah
Pharmaceutical Sciences and Research Vol. 5, No. 1
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Abstract

Chronic complication of diabetes mellitus is diabetic foot ulcers. Diabetic foot ulcer can be defined as an open wound in the feet which will become infected as the result of high blood sugar levels that develops and become place of bacteria. One of the bacteria in diabetic foot ulcer is Escherichia coli. Imprecise use of antibiotics in the treatment of diabetic foot ulcers can cause antibiotic resistance to bacteria. This study aims to determine antibiotic sensitivity of Escherichia coli bacteria in diabetic foot ulcer Wagner grade III and IV. Samples of diabetic foot ulcer swab’s with Wagner grade III and IV were taken as Consecutive sampling. Identification of Escherichia coli bacteria is done by using a biochemical test and Gram stain test. Antibiotic sensitivity test is conducted by using Kirby Bauer’s disc of diffusion method. Escherichia coli bacteria that were tested are sensitive to amikacine, gentamicine, ciprofloxacin, levofloxacine, ceftriaxone, cefotaxime, imipenem and meropenem antibiotics but showed resistant to cefadroxil.
Evaluasi Rasionalitas Penggunaan Obat Antihipertensi di Puskesmas Siantan Hilir Kota Pontianak Tahun 2015 Untari, Eka Kartika; Agilina, Alvani Renata; Susanti, Ressi
Pharmaceutical Sciences and Research Vol. 5, No. 1
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Abstract

Hypertension is widely known as cardiovascular disease. In addition to resulting heart failure, hypertension can result in kidney failure and cerebrovascular disease. This study was aimed to determine the percentage of treatment rationality of hypertensive patient treatment outpatient in Puskesmas Siantan Hilir Pontianak 2015 which includes the appropriate indication, appropriate drug, appropriate patient, and appropriate dose based on the guideline JNC 7. This study was cross-sectional study using medical records of outpatient hypertension patients in 2015. The total of sample analyzed in this research were 92 medical records of hypertension patients from 118 medical records. The percentage of using the angiotensin converting enzym inhibitor (captopril) was 47.46%; calcium channel blocker (amlodipine) was 34.75%; thiazid diuretic (hydrochlorothiazid) was 16.10%; loop diuretic (furosemid) was 0.85%; and potassium sparing (spironolactone) was 0.85%. The rasionality of hypertensive therapy in patients in this study were 100% appropriate indication; 70.65% appropriate drug; 100% appropriate patient; and 98.91% appropriate dose. The conclusion of this study is that overall treatment that meets all four rational treatment criterias was 69.56%.
Pengujian Aktivitas Antibakteri Sabun Cair dari Ekstrak Kulit Daun Lidah Buaya Sari, Rafika; Ferdinan, Ade
Pharmaceutical Sciences and Research Vol. 4, No. 3
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Abstract

Aloe vera is one of the typical plants found in Pontianak, West Kalimantan. This plant’s leaf peel is nontoxic and can be used as an antibacterial and anti-inflammatory agent. Nowadays, Aloe vera is one among 10 most popular plants in the world that have a potency to be developed as medicinal plant. This study aimed to determine antibacterial activity of the extract of Aloe vera leaf peel in liquid soap formulation against several pathogenic bacteria. Aloe vera leaf peel extract was prepared with maceration using ethanol. Then, it was formulated into a liquid soap. The soap was evaluated for its organoleptic, pH value, specific gravity, and foam height. Antibacterial activity assay of the liquid soap was carried out using diffusion method. The results showed that the characteristic of the liquid soap was viscous, yellowish white colored, and had distinctive smell of Aloe vera. The pH values on the day 0, 7 and 14 were 8; 8,9; and 9,4; respectively. The specific gravity was 1,033 g/ml. The foam height on minute 5, 10 and 15 were 76.92%, 19.23% and 19.23%, respectively. The liquid soap from the extract of Aloe vera leaf peel was found to have antibacterial activity against Gram positive bacteria (Staphylococcus aureus, Staphylococcus epidermidis, Bacillus subtilis, and Bacillus cereus) and Gram negative bacteria (Salmonella typhimurium, Proteus mirabilis, Pseudomonas aeruginosa, and Escherichia coli).
Formulasi, Uji Stabilitas Fisik, dan Uji Aktivitas Secara In Vitro Sediaan Spray Antibau Kaki yang Mengandung Ekstrak Etanol Daun Sirih (Piper betle L.) Iswandana, Raditya; Sihombing, Lidya KM
Pharmaceutical Sciences and Research Vol. 4, No. 3
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Abstract

Betel leaf has long been proven and widely used in Indonesia for its antibacterial activities. Betel leaf 80% ethanolic extract has high compatibility to be made as a widely used pharmaceutical product, including spray. In 2014 American Podiatric Medical Association, studied a significant increase of foot odor prevalence between our citizens. One of the reasons of foot odor is caused by bacteria, mostly by Bacillus subitilis. This study focused on creating a pharmaceutical product with a strong antibacterial that showed minimum bactericidal concentration (MBC) towards bacteria that caused foot odor. Spray product was chosen because of the great pleasant experience for the user. The study tested various concentrations of betel leaf 80% ethanolic extract, to study its antibacterial activity. Furthermore, stability testing towards its physical property on 8-week storage in three different temperature; room temperature (28±2 ºC), high temperature (40±2 ºC), and low temperature (4±2 ºC), was also conducted. All formulae showed great physical stability profile on organoleptic parameters. Betel leaf 80% ethanolic extract, in the Formula 3 showed minimum bactericidal concentration (MBC) in 2 mm area with the Formula that contained ≥ 2 mg/ml ethanolic extract.
Penentuan Nilai FICI Kombinasi Ekstrak Etanol Kulit Daun Lidah Buaya (Aloe vera (L) Burm.f) dan Gentamisin Sulfat Terhadap Bakteri Escherichia coli A’lana, Lu’lu’; Sari, Rafika; Apridamayanti, Pratiwi
Pharmaceutical Sciences and Research Vol. 4, No. 3
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Abstract

The combined use of natural materials and antibiotic compound is one of treatment that can be done against infections caused by bacteria. This combination is expected to be more potent to inhibit the bacteria with lower side effects. FICI (Fractional Inhibitory Concentration Index) is an index that can indicate the activity of a combination of natural ingredients and antibiotic compounds. FICI would indicate that the combination has a synergistic effect, additive, indifferent or antagonistic. The aim of this study is to determine the FICI to the combination of Aloe vera leaves skin (Aloe vera (L.) Burm.f.) ethanol extract and gentamicin sulphate againts Escherichia coli. FICI was determined by disc diffusion method. Combination of Aloe vera leaves skin (Aloe vera(L.) Burm.f.) ethanol extract and gentamicin sulphate with concentration of 1.25 mg/mL + 2,5 µg/mL was not form zone of inhibition; while the concentration of 2.5 mg/ml + 5 µg/ mL formed zone of inhibition of 6.95 mm; 6.75 mm; and 6.65 mm. The results showed that the combination of Aloe vera leaves skin (Aloe vera (L.) Burm.f.) ethanol extract and gentamicin sulphate against the Escherichia coli has the indifference effect on Escherichia coli, and FICI to this combination is 2.

Page 22 of 36 | Total Record : 355

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