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Arman Harahap
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International Journal of Health and Pharmaceutical (IJHP)
Published by CV. Inara
ISSN : -     EISSN : 2808845X     DOI : https://doi.org/10.51601/ijhp
Core Subject : Health,
Nursing Public Health
International Journal of Health and Pharmaceutical (IJHP) e- ISSN : 2808-845X is a communication media and scientific publication in the health and pharmaceutical fields published by Inara Publisher. International Journal of Health and Pharmaceutical (IJHP) contains articles from research focusing on basic medicine, clinical medicine, epidemiology, preventive medicine (social medicine), pharmacy, and other medical fields. International Journal of Health and Pharmaceutical (IJHP) is published periodically four times a year (February, May, August and November).
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 426 Documents
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Correlation Analysis between Daily Routine Physical Activity and Blood Glucose Control in Diabetes Mellitus Patients at the Kampung Masjid Labuhan Batu Utara Community Health Center Siregar, Rahma; Henny, Henny; Febrini , Dewi
International Journal of Health and Pharmaceutical (IJHP) Vol. 5 No. 4 (2025): November 2025
Publisher : CV. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51601/ijhp.v5i4.496

Abstract

Elevated blood glucose and low physical activity represent critical health concerns in primary healthcare settings. This study aimed to analyze the correlation between daily routine physical activity and blood glucose control in patients with diabetes mellitus at Kampung Masjid Primary Health Center, North Labuhan Batu. A quantitative descriptive correlational design with cross-sectional approach was employed. Total sampling encompassed 55 diabetes patients meeting inclusion criteria. Data collection utilized the Global Physical Activity Questionnaire (GPAQ) and random blood glucose measurements from medical records. Spearman rank correlation analysis was conducted using SPSS version 25 following KolmogorovSmirnov normality testing. Results demonstrated a significant negative correlation (r = -0.615, p = 0.000) between physical activity levels and blood glucose concentration. Approximately 45.5% of patients engaged in low physical activity, while the mean blood glucose was 307.53 mg/dL, substantially exceeding therapeutic targets. Increased physical activity substantially improved glycemic control, indicating that physical activity represents a critical modifiable factor for diabetes management in primary healthcare. These findings support evidence-based physical activity promotion as essential for integrated diabetes management approaches combining pharmacological intervention with structured exercise supervision at Puskesmas facilities throughout Indonesia.
The Relationship Between Hormonal Contraceptive Use and Breast Cancer Incidence at Dr. Pirngadi Regional General Hospital, Medan Aqilatul Hanisah, Filzah; Hendrianto, Hendrianto
International Journal of Health and Pharmaceutical (IJHP) Vol. 5 No. 4 (2025): November 2025
Publisher : CV. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51601/ijhp.v5i4.497

Abstract

Breast cancer remains a significant public health concern in Indonesia, with emerging evidence suggesting that hormonal contraceptive type influences not only cancer incidence but also tumor aggressiveness. This cross-sectional study examined the relationship between hormonal contraceptive formulations and histopathological grading of breast cancer at RSUD Dr. Pirngadi Hospital, Medan. The study included 100 women with confirmed invasive breast cancer who were selected using the Lemeshow formula for sample size calculation. A structured data extraction form collected information on contraceptive type, duration of use, and Nottingham grading classification. Fisher's Exact Test and chi-square test analyzed associations between contraceptive types and grading categories. Results demonstrated that oral pill users predominantly developed well-differentiated cancers (51.7%), while injectable users predominantly developed poorly-differentiated tumors (56.3%), representing a highly significant inverse relationship (p-value = 0.000, OR = 0.105). Moderately-differentiated grading showed no significant association with contraceptive type. These findings indicate that contraceptive formulation substantially influences tumor characteristics beyond cancer occurrence alone. The study's cross-sectional design limits causal inference, and future prospective cohort studies with larger samples and comprehensive molecular characterization are needed. The pronounced predominance of aggressive tumor phenotypes among injectable contraceptive users necessitates more intensive breast cancer screening protocols and improved patient counseling regarding differential cancer risks across contraceptive formulations in Indonesian populations.
The Effect of Red Ginger Extract (Zingiber officinale Roscoe, Zingiberaceae) on Analgesia in Male White Rats (Rattus norvegicus) Wistar Strain with Head Injuries Marthin Simbolon, Boyke; Hasanah SB, Nurul; Br Tarigan, Elviyanti
International Journal of Health and Pharmaceutical (IJHP) Vol. 5 No. 4 (2025): November 2025
Publisher : CV. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51601/ijhp.v5i4.498

Abstract

Head injury represents a significant clinical challenge requiring effective pain management strategies. This study examined the analgesic effects of red ginger extract on head injury in male Wistar rats. The research employed an experimental post-test only control group design with five treatment groups (n = 25 subjects; n = 5 per group). Group K1 received piroxicam (40 mg per 200 g body weight); K2 served as untreated control; groups K3, K4, K5 received red ginger extract at 50, 100, and 150 micrograms per kilogram of body weight per day respectively. Behavioral pain assessment was conducted on days 8 and 21 post-injury using standardized ethological procedures. Statistical analysis utilized Kruskal-Wallis test with post-hoc Mann-Whitney U comparisons. Results demonstrated that K4 (100 μg/kg/day) achieved the lowest mean rank (8.00), indicating superior analgesic efficacy compared to other groups. K4 exhibited comparable effectiveness to piroxicam (K1, mean rank 10.00) and superior outcomes to untreated controls (K2, mean rank 21.60). Selective COX-2 inhibition and inflammatory cytokine reduction mediated these effects. The optimal dose of red ginger extract (100 μg/kg/day) provides significant neuroprotection and may serve as an alternative pain management approach in developing healthcare contexts.
The Relationship Between Nutritional Status and the Incidence of Pneumonia in Toddlers at RS Royal Prima Halim, Yeni; Fariz Hafdar, Alwan; Hakim Nasution, Ikhwanul
International Journal of Health and Pharmaceutical (IJHP) Vol. 5 No. 4 (2025): November 2025
Publisher : CV. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51601/ijhp.v5i4.501

Abstract

Pneumonia is a type of infectious disease that attacks the lower part of the respiratory system and is one of the leading causes of death in children. One factor that increases the likelihood of children getting pneumonia is their nutritional status. The purpose of this study is to determine the relationship between nutritional status and the incidence of pneumonia in toddlers at RS Royal Prima Medan. The research design is Analytical Observational Quantitative with a Cross Sectional approach and uses the Chi-square statistical test. Data collection was carried out in October 2025 at the Medical Records of RS Royal Prima Medan. The total sample of this study was 167 toddlers who met the Inclusion and Exclusion criteria. The indicators used in this study were Age, Gender, and Nutritional Status. The study results show a p-value (0.020) <0.05, indicating a relationship between Age and the incidence of Pneumonia, and a p-value (0.000) <0.05, indicating a relationship between Gender and the incidence of Pneumonia. The p-value (0.016) <0.05 indicates a relationship between Nutritional Status and the occurrence of Pneumonia. The conclusion of this study is that there is a significant relationship between Age, Gender, and Nutritional Status and the occurrence of Pneumonia in toddlers at Royal Prima Hospital Medan.
The Effect of Laughter Therapy, a Low-Salt Diet, Exercise, and Physical Activity on Reducing Blood Pressure in Elderly Patients at the Sei Kepayang Timur Community Health Center, Asahan Regency RAngelin Purba, Rona; Wahyuni Nasution, Sri; Wienaldi, Wienaldi
International Journal of Health and Pharmaceutical (IJHP) Vol. 5 No. 4 (2025): November 2025
Publisher : CV. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51601/ijhp.v5i4.502

Abstract

Hypertension is a common health problem among the elderly and carries a risk of increasing cardiovascular complications. Non-pharmacological efforts such as laughter therapy, a low-salt diet, exercise, and physical activity are important strategies in controlling blood pressure. This study aims to analyze the effectiveness of laughter therapy, a low-salt diet, exercise, and physical activity on reducing blood pressure in elderly patients at the Sei Kepayang Timur Community Health Center in Asahan Regency. The study used a quasi-experimental design with a pre-test and post-test control group approach. The number of respondents was 60 elderly people who were divided equally into an intervention group of 30 people and a control group of 30 people. Data were analyzed using comparative statistical tests (paired t-test and chi-square test) with a significance level of p < 0.05. The results showed that in the intervention group, there was a decrease in mean systolic blood pressure from 150.2 mmHg to 135.4 mmHg, with a difference of 14.8 mmHg (p = 0.000), and a decrease in diastolic blood pressure from 93.2 mmHg to 84.4 mmHg, with a difference of 8.8 mmHg (p= 0.000). Other interventions, including a low-fat diet, exercise, and physical activity, were also shown to be effective in reducing both systolic and diastolic blood pressure. In conclusion, laughter therapy, a low-salt diet, exercise, and physical activity are effective in reducing blood pressure in the elderly. Based on these study results, the elderly are advised to regularly engage in laughter therapy, maintain a low-salt diet, and increase physical activity and exercise. Health institutions need to integrate this non-pharmacological intervention program into promotive and preventive services. Future research is expected to examine long-term effectiveness and expand the sample size.
The Relationship Between Medication Adherence Based on the Morisky Medication Adherence Scale 8 (MMAS-8) and the Degree of Disease Activity Based on the Disease Activity Score-28 (DAS28) in Rheumatoid Arthritis Patients at Royal Prima Hospital Amanda Anggraini Harahap, Putri; Yani, Herlina; Budi, Andre
International Journal of Health and Pharmaceutical (IJHP) Vol. 5 No. 4 (2025): November 2025
Publisher : CV. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51601/ijhp.v5i4.503

Abstract

Rheumatoid arthritis (RA) poses a major health challenge due to poor medication adherence impacting disease control. This study aimed to analyze the relationship between medication adherence (MMAS-8) and disease activity (DAS28) in RA patients. A quantitative cross-sectional design was employed at RS Royal Prima Medan (May-July 2025), targeting outpatient RA patients with consecutive sampling (n=69). Data were collected using validated MMAS-8 and DAS28-CRP instruments, analyzed via Kolmogorov-Smirnov normality tests and Spearman's correlation. Results showed moderate adherence (47.8%), low disease activity predominant (31.9%), and significant moderate positive correlation (r=0.400, p<0.001). Higher adherence is linked to better disease control. Conclusion: Medication adherence moderately influences RA disease activity; multifaceted interventions are recommended.

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