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International Journal of Health and Pharmaceutical (IJHP)
Published by CV. Inara
ISSN : -     EISSN : 2808845X     DOI : https://doi.org/10.51601/ijhp
Core Subject : Health,
Nursing Public Health
International Journal of Health and Pharmaceutical (IJHP) e- ISSN : 2808-845X is a communication media and scientific publication in the health and pharmaceutical fields published by Inara Publisher. International Journal of Health and Pharmaceutical (IJHP) contains articles from research focusing on basic medicine, clinical medicine, epidemiology, preventive medicine (social medicine), pharmacy, and other medical fields. International Journal of Health and Pharmaceutical (IJHP) is published periodically four times a year (February, May, August and November).
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 426 Documents
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Cyanide-Degrading Indigenous Aspergillus Spp. Isolated From Kabuto, A Southeast Sulawesi Fermented Food Mamangkey, Jendri; Arfa Yanti, Nur; Ode Adi Parman Rudia, La; Ode Muhamad Iman Sulaiman, La; Aryanti Pada Soa, Christina; Dian Winarty Budadana, Christyani; Hartanto, Adrian
International Journal of Health and Pharmaceutical (IJHP) Vol. 5 No. 4 (2025): November 2025
Publisher : CV. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51601/ijhp.v5i4.472

Abstract

Kabuto is a traditional cassava-roots-based food of Munanese which is resulted from natural fermentation. The natural fermentation is conducted by covering all surfaces of cassava roots with fungal colonies. This experiment aims to study the cassava root fermentation by Aspergillus spp. in order to enhance the nutritive value, especially its impact on cyanide level. Both pure samples and replicated samples of cassava roots were fermented by Aspergillus spp. in a solid-state fermentation medium for six days and with a dryness level of ± 28°C. The products were analyzed to know the water content (%), the total amount of protein (mg), and cyanide detoxification (µg.g-1). Isolate K03, K23, K1c, and K31 were positively impeding activities of antimicrobials and hydrolytic enzymes (amylase and cellulase). The isolates, K03, K23, K1c, and K31 positively impeded the growth of Staphylococcus aureus ATCC 25923 and Escherichia coli ATCC 35218. Based on the phenotypic characteristics, the isolate K03, K23, dan K1c, had similarity with Aspergillus niger, while isolate K31 had a similar microscopic and macroscopical features of Aspergillus terreus. The water content of Kabuto decreased starting on the fourth day. The isolate K03, K23, K31, and K1C preserved the water content in kabuto at 7.1%, 6.74%, 8.69%, and 7.07% respectively. The highest protein content was observed from the fermentation by Aspergillus terreus K31 (346 mg) and was able to reduce the cyanide concentration until 0.48 µg.g-1. The optimum fermentation in the preparation of kabuto was achieved at sixth day.
Factors Associated with the Incidence of Measles in Toddlers (Aged 0-5 Years) in Central Jakarta in 2024 Nofiyanti, Ely; Rahajeng, Ekowati; Ulfa, Laila
International Journal of Health and Pharmaceutical (IJHP) Vol. 5 No. 4 (2025): November 2025
Publisher : CV. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51601/ijhp.v5i4.476

Abstract

Measles remains a significant public health problem, particularly among children under five years old in urban areas. This study aimed to identify factors associated with measles incidence among children aged 0–5 years in Central Jakarta in 2024. A cross-sectional design was applied using secondary data from measles epidemiological investigations conducted by the Central Jakarta Health Sub-Department in 2024. The study included 115 children recorded in surveillance reports. Data were analyzed using univariate, bivariate, and multivariate methods with logistic regression. The results showed that several factors were associated with measles incidence, including nutritional status, age, sex, immunization history, and history of exposure. Multivariate analysis revealed that the dominant factor was nutritional status with an OR of 13.120 (95% CI: 1.698–101.320; p=0.014). In conclusion, nutritional status is the most influential factor in measles incidence among children in Central Jakarta. Efforts to improve children's nutritional status through growth monitoring, supplementation, and nutrition education should be strengthened to reduce measles risk.
The Relation Between Early Mobilization and Wound Healing Process of Patients After Laparotomy at Royal Prima Hospital, Medan, from 2020 to 2024 Mughni Muchtar, Aisyah; Puspawani , Yeni; Eliza Putri Lubis, Yolanda
International Journal of Health and Pharmaceutical (IJHP) Vol. 5 No. 4 (2025): November 2025
Publisher : CV. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51601/ijhp.v5i4.477

Abstract

An incision in the abdominal wall is made during laparatomy, a significant surgical surgery, and the healing duration for this incision can vary. Patients should engage in early mobilization, or physical activity to increase blood circulation and decrease the risk of problems, right after surgery. This can hasten the healing process of wounds. The purpose of this research is to find out how early mobilization affects wound healing, pain levels, and hospital stay duration for patients at Royal Prima Hospital Medan who have undergone a laparotomy. Using a cross-sectional design, this study employed quantitative analytical methods. Patients who underwent a laparotomy between 2020 and 2024 made up the study's population. Using inclusion and exclusion criteria, a convenience sample of 35 individuals was chosen. The data was examined using the ChiSquare test, which was derived from patient medical records. Early mobilization was performed by the majority of patients (91.4%), and 88.6% of those patients had satisfactory wound healing. "Significant relationships between early mobilization and wound healing (p = 0.000), pain severity (p = 0.003), and length of hospital stay (p = 0.018) were shown by statistical tests. It is evident that early mobilization is crucial for patients to experience faster wound healing, less pain, and a shorter hospital stay following laparotomy. In conclusion, patients' wound healing processes are significantly improved by early mobilization following laparotomy. The goal of healthcare providers is to educate patients and routinely practice early mobilization in order to hasten healing and avoid complications after surgery.
The Relationship Between Stress Levels And The Severity of Acne Vulgaris In Medical Students At Prima Indonesia University Class of 2022 Mudhia Putri, Tarisa; Arhamni, Ade; Siregar, Lisdawaty
International Journal of Health and Pharmaceutical (IJHP) Vol. 5 No. 4 (2025): November 2025
Publisher : CV. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51601/ijhp.v5i4.484

Abstract

Acne vulgaris is a chronic skin disease of the pilosebaceous follicle with multifactorial etiology. Psychological stress represents one significant etiological factor, as stress activates the hypothalamic-pituitary-adrenal axis, stimulating corticotropin-releasing hormone, which plays an important role in acne vulgaris development. Medical students experience high academic burdens that potentially cause stress, making them more susceptible to acne vulgaris with varying severity degrees. This cross-sectional analytic observational study investigated the relationship between stress levels and acne vulgaris severity among medical students at Universitas Prima Indonesia, class of 2022. A total of 35 respondents were selected through stratified random sampling. Data were collected using the Depression Anxiety Stress Scale-42 to measure stress levels and the Lehmann Acne Grading System to assess acne severity. Results showed that 60.0% of respondents experienced moderate stress, while 45.7% exhibited mild acne vulgaris. Chi-Square testing revealed a statistically significant relationship between stress levels and acne severity (p = 0.000). A clear dose-response pattern emerged, with mild stress predominantly associated with mild acne, moderate stress with moderate acne, and severe stress universally manifesting as moderate-to-severe acne manifestations. This investigation concludes that a significant correlation exists between stress levels and acne vulgaris severity in this population, necessitating stress management interventions and mental health education programs to reduce acne severity risk among medical students.
The Effect of Self-Management On Therapy Compliance To Improve The Quality of Life of Type 2 Diabetes Mellitus Patients At The UPTD Diabetes Center In Ternate City, Indonesia Aja, Nursia; Sawedi, Ismawanti; Ariana, Diah; Akmal, Dzul
International Journal of Health and Pharmaceutical (IJHP) Vol. 5 No. 4 (2025): November 2025
Publisher : CV. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51601/ijhp.v5i4.486

Abstract

Diabetes Mellitus (DM) is a metabolic disease characterized by high blood glucose levels as a result of insufficient insulin secretion, impaired insulin activity, or both. The purpose of this study was to determine and analyze the effect of self-management on the level of therapy adherence, as well as its impact on improving the quality of life of Type 2 Diabetes Mellitus sufferers. The design in this study is descriptive, the effect of Self-Management on therapy adherence to improve the quality of life of Type 2 Diabetes Mellitus sufferers with a cross-sectional research method was carried out at the same time without a follow-up period. The population in the study at the UPTD Diabetes Center Ternate City in 2024 who suffered from DM was 92 people. The sampling technique used in this study was total sampling, namely all DM sufferers who were treated and registered at the UPTD Diabetes Center in 2024 as many as 92 people. The results of the study showed that there was a significant relationship between the level of knowledge (p = < 0.000), the level of self-management ability (p = <0.000) with Type 2 Diabetes Mellitus sufferers. While the variables of therapy compliance (p = > 1.000) and improving the quality of life were not significantly related, namely (p = > 0.311) with Type 2 Diabetes Mellitus sufferers. Nurses can improve patient knowledge by providing education that focuses on improving self-management and providing therapy compliance and improving the quality of life of Type 2 Diabetes Mellitus sufferers.
The Effect of Snakehead Fish (Channa Striata) Extract On Superoxide Dismutase (SOD) Levels And Pancreatic Histology Phytology In A Rat Model With Liver Cirrhosis Yulizal, OK; Priyatama, Andre; Mardiati Lubis, Yuliani
International Journal of Health and Pharmaceutical (IJHP) Vol. 5 No. 4 (2025): November 2025
Publisher : CV. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51601/ijhp.v5i4.487

Abstract

Liver cirrhosis results in progressive liver tissue damage and systemic oxidative stress affecting the pancreas. This study aimed to evaluate the effects of snakehead fish (Channa striata) extract on superoxide dismutase (SOD) levels and pancreatic histopathology in a rat model of liver cirrhosis.Method:An experimental study used male Wistar rats induced with CCl₄. The rats were divided into groups treated with snakehead fish extract at different doses (100, 150, 200 mg/kgBW) orally for two weeks. The parameters measured included body weight, pancreatic SOD activity, and histopathological analysis using Hematoxylin-Eosin staining. Data analysis used One Way ANOVA and post-hoc test with a significance level of p < 0.05.Results:Snakehead fish extract significantly increased pancreatic SOD activity in a dose-dependent manner and improved pancreatic histology compared to the control cirrhosis group. Body weight and organ function increased, indicating reduced oxidative damage and tissue regeneration.Conclusion:Snakehead fish extract shows potential as a natural antioxidant therapy in reducing oxidative stress and repairing pancreatic tissue in cirrhosis models. Further research is needed to isolate the active compounds and verify their clinical effectiveness.
Determinants Related to User Perceptions of the Quality of Health Home Outpatient Services in DKI Jakarta After Rebranding in 2025 Narsih, Tri; Suratmi, Tri; Ulfa, Laila; Irwan, Irwan
International Journal of Health and Pharmaceutical (IJHP) Vol. 5 No. 4 (2025): November 2025
Publisher : CV. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51601/ijhp.v5i4.488

Abstract

Healthcare service quality is a key indicator in evaluating the effectiveness of healthcare facilities, influencing patient satisfaction and loyalty. Understanding users' perceptions of service quality is essential for developing strategies to improve outpatient care. This study aims to analyze factors affecting users' perceptions of service quality at Rumah Sehat outpatient units in Jakarta in 2025. A quantitative survey design was employed, involving 96 purposively sampled respondents. The data were analyzed using the chi-square test to determine the relationship between demographic characteristics, payment methods, and users' perceptions of service quality. The results indicate that users' perceptions are significantly influenced by age, education, and payment methods, with payment method being the most dominant factor. Moreover, professional, friendly, and responsive healthcare staff, along with adequate and comfortable facilities, contribute to positive user perceptions. These findings provide practical implications for Rumah Sehat management to enhance service quality, patient satisfaction, and user loyalty.
Quantifying Feel, Fragrance And Finish: A Review of Sensory Threshold In Cosmetics Suryaneta, Suryaneta; Fibrianto, Kiki
International Journal of Health and Pharmaceutical (IJHP) Vol. 5 No. 4 (2025): November 2025
Publisher : CV. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51601/ijhp.v5i4.489

Abstract

Sensory experience determines whether cosmetic products are adopted, repurchased, and trusted. Yet the knowledge needed to set defensible sensory targets is scattered across psychophysics, descriptive analysis, and category-specific practice. This review consolidates the concept of “thresholds” for cosmetics and explains how to use them to guide formulation, quality control, and claims. Author define detection and recognition thresholds as performance-based points on a psychometric function that ensure key notes and tactile cues are truly perceivable and correctly identified. Author then describe the difference threshold, or just noticeable difference, as the smallest reliable change from a reference and show how JNDs translate directly into specification bands that control batch-to-batch drift. Because perceptibility does not guarantee liking, we integrate consumer-facing acceptance and rejection thresholds to locate intensity regions that preserve preference and avoid penalties in market. Methodologically, the review emphasizes bias-resistant forced-choice designs, supported by adjustment and categorical procedures, and shows how threshold estimation aligns with descriptive sensory programs already used for creams and lotions across realistic stages of use. Taken together, these tools provide a practical bridge from small compositional or process changes to user-relevant discriminability and acceptance. Author conclude with priorities for practice, including disciplined panel management, tighter linkage between laboratory thresholds and in-use temporal profiles, and opportunities for mobile or at-home protocols that capture real-world experiences.
Factors Associated With The Occurrence of Pulmonary Tuberculosis In The Working Area of Bulasat Public Health Center Mentawai Islands Regency, In 2025 Sanjethro, Sanjethro; Jannatus Shabrina , Aisyah; Christian Lukas, Denny
International Journal of Health and Pharmaceutical (IJHP) Vol. 5 No. 4 (2025): November 2025
Publisher : CV. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51601/ijhp.v5i4.490

Abstract

Background: According to the 2024 Global TB Report, tuberculosis remains one of the leading causes of death worldwide. Indonesia ranks second among the countries with the highest TB burden. The TB problem in Bulasat Public Health Center, Mentawai Islands Regency, is partly influenced by community behavioral factors, particularly among populations living in remote and island areas. Methods: This study is a quantitative research using a case-control design involving 60 community samples within the working area of Bulasat Public Health Center. The sampling technique used was non-probability purposive sampling. Results: The findings show a significant association between pulmonary TB occurrence and sex (p-value = 0.039; OR = 3.45), age (p-value = 0.018; OR = 4.3), education (p-value = 0.011; OR = 5.7), accessibility (p-value = 0.036; OR = 3.6), perception (p-value = 0.038; OR = 3.5), attitude (p-value = 0.018; OR = 4.3), and knowledge (p-value = 0.019; OR = 4.1). Knowledge was found to be the most dominant factor influencing TB incidence. Conclusion: This study indicates that TB incidence in the Bulasat Public Health Center working area is associated with sex, age, education, accessibility, perception, attitude, and knowledge. Knowledge is the most dominant associated factor. Strengthening health education, developing information media, and enhancing cross-sector collaboration are needed to improve community knowledge about TB and reduce the incidence rate.
The Relationship between Body Mass Index (BMI) and Hypertension Incidence at Royal Prima Hospital in 2024 Dix Munthe, Dix Munthe; Delfian, Taufik
International Journal of Health and Pharmaceutical (IJHP) Vol. 5 No. 4 (2025): November 2025
Publisher : CV. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51601/ijhp.v5i4.495

Abstract

Background: Hypertension affects 1.4 billion adults globally and remains inadequately controlled. Body mass index (BMI) accounts for 65 to 75 percent of primary hypertension cases, yet hospital-based evidence from Southeast Asian populations remains limited. Objective: This study determined the relationship between BMI and hypertension incidence at Royal Prima Hospital Medan in 2024. Methods: This cross-sectional analytical study employed total population sampling including 69 respondents meeting inclusion criteria. Data were extracted from medical records and analyzed using univariate analysis and Spearman rank correlation test. Results: Among respondents, 84.1 percent experienced hypertension, with 52.2 percent possessing a BMI greater than 25 kg/m². All respondents with BMI greater than 25 kg/m² exhibited hypertension compared to 66.6 percent of those with normal BMI (p=0.000). Conclusion: A statistically significant relationship exists between elevated BMI and hypertension incidence, confirming obesity as a critical modifiable risk factor for hypertension development in hospital settings. Weight management through lifestyle modification represents an essential intervention strategy for hypertension prevention and control.

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