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Ivandini Tribidasari A.
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Makara Journal of Science
Published by Universitas Indonesia
ISSN : 23391995     EISSN : 23560851     DOI : https://doi.org/10.7454/mss
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Makara Journal of Science publishes original research or theoretical papers, notes, and minireviews on new knowledge and research or research applications on current issues in basic sciences, namely: Material Sciences (including: physics, biology, and chemistry); Biochemistry, Genetics, and Molecular Biology (including: microbiology, physiology, ecology, taxonomy and evolution); and Biotechnology.
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Articles 15 Documents
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Search results for , issue "Vol. 30, No. 1" : 15 Documents clear
Morphological Characteristics of the Mediophyceae Diatom Lampriscus cf. shadboltianus var. crenulatus Collected from Gili Meno, Indonesia Rachman, Arief; Widiarti, Riani; Sukotjo, Setiarti; Wells, Mark
Makara Journal of Science Vol. 30, No. 1
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Diatoms are the most common and abundant microalgae group in seawater, with an estimated 200 genera and 200,000 species categorized into three distinct taxonomic classes: Mediophyceae, Bacillariophyceae, and Coscinodiscophyceae. This study describes the morphological characteristics of Lampriscus GM052022, a diatom belonging to the Mediophyceae family, which was collected from Gili Matra, Lombok, Indonesia. Analysis using light microscopy (LM) and electron microscopy (EM) showed that the morphological characteristics of the Lampriscus GM052022 specimen are similar to those of Lampriscus shadboltianus var. crenulatus due to the distinct crenulation lines on the frustule, which differentiate this variation from Lampriscus shadboltianus. However, the presence of distinct morphological features in this diatom specimen from Gili Meno suggests that it might not be L. shadboltianus var. crenulatus. The triangular spines (spinules) observed on the Lampriscus GM052022 valve surface have not been previously documented. However, whether the presence of spinules is a sign of different taxa or a result of polymorphism within the species or variation cannot be confirmed. Due to this characteristic, Lampriscus GM052022 is given the temporary name L. cf. shadboltianus var. crenulatus. The next step will be to conduct genetic analyses to confirm whether these morphological differences support the separation of this Gili Meno Lampriscus specimen into a new species (sp. nov.) or variation (var.).
Performance of Membrane Bioreactor in Nitrogen Removal using Anammox Bacteria Cultivated from Lake Koto Baru Zulkarnaini, Zulkarnaini; Amanda, Tiffany Azhra; Putra, Alqadri Asri; Komala, Puti Sri; Nilawati, Dewi; Widyarani, Widyarani; Sembiring, Tarzan; Mawarda, Panji Cahya; Septevani, Athanasia Amanda; Rustama, Mia Miranti; Andriyani, Rina
Makara Journal of Science Vol. 30, No. 1
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Anaerobic ammonium oxidation (anammox) is the biological conversion of ammonium to nitrogen gas (N2) using nitrite as an electron acceptor. This study evaluated the performance of a membrane bioreactor (MBR) in nitrogen removal at room temperature using Candidatus Brocadia fulgida, an anammox bacterium previously cultivated from Lake Koto Baru, Tanah Datar, Indonesia. The MBR was operated for 48 days with a hydraulic retention time of 24 h under a continuous supply of ammonium and nitrite, with both substrates provided at influent concentrations of 70, 150, and 250 mg-N/L. Samples were collected twice a week and analyzed via UV–Vis spectrophotometry. The stoichiometric ratios of ∆NO2−-N/∆NH4+-N and ∆NO3−-N/∆NH4+-N were 1.13 and 0.15, respectively, which were consistent with the anammox reaction. The maximum nitrogen removal performance, including nitrogen removal rate, ammonium conversion efficiency, and nitrogen removal efficiency (NRE), reached 0.515 kg-N/m³∙d, 92.76%, and 91.27%, respectively, at a nitrogen loading rate of 0.566 kg-N/m³∙d. Anammox bacteria from Koto Baru Lake showed high NRE at room temperature using MBR.
Identification of Xanthine Oxidase Inhibitors in Single-Clove Black Garlic using Metabolomics and Molecular Docking Approaches Setiawan, Abdul Aziz; Kumala, Shirly; Laksmitawati, Dian Ratih; Yuniarto, Ari; Yuliana, Nancy Dewi
Makara Journal of Science Vol. 30, No. 1
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Black garlic is produced through controlled fermentation under specific temperature and humidity conditions, during which the Maillard reaction enhances its sensory properties and bioactivity. The anti-hyperuricemic potential of single-clove black garlic (SBG) remains unexplored. This study combined Ultra High-Performance Liquid Chromatography–High Resolution Mass Spectrometry-based metabolomics and an in-silico approach to identify the potential xanthine oxidase inhibitors (XOI) in SBG. Methanolic extracts (10 ppm) exhibited xanthine oxidase inhibition ranging from 50.09% to 68.01%, which is comparable to allopurinol (78.74%) at the same concentration. Metabolomic profiling tentatively identified 45 compounds, and orthogonal partial least squares analysis revealed seven metabolites as strongly correlated with XOI activity, namely α-(1-deoxy-D-fructose-1-yl)-L-arginine, alliin, 2-amino-2-deoxy-D-glucose, S-allyl-L-cysteine, quercetin, and m-coumaric acid. Molecular docking showed that these compounds exhibited binding energies comparable to allopurinol, thus indicating favorable interactions within the xanthine oxidase active site. Molecular dynamics simulations confirmed the stability of ligand–enzyme complexes, with consistent hydrogen bond interactions, which support their stable binding conformations. ADMET analysis revealed that most compounds demonstrated acceptable pharmacokinetic profiles, high intestinal absorption, low blood–brain barrier permeability, and non-hepatotoxic and non-mutagenic properties. The integration of metabolomics, molecular docking, molecular dynamics, and ADMET prediction supports the potential of SBG-derived compounds as safe and effective XOIs, thereby highlighting SBG as a promising functional food candidate for the management of hyperuricemia
In Vitro and In Silico Analysis of the Antibacterial Activity of Bioactive Compounds Extracted from Pineapple Peel Sadik, Wafa Mohammad; Abdullah, Iman Tajer; Alnajar, Lana Abed
Makara Journal of Science Vol. 30, No. 1
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Antibiotic resistance is a critical global challenge that requires the discovery of alternative therapeutic agents. Plants -derived compounds, such as those found in Ananas comosus (pineapple)peel, offer promising antibacterial potential. This study aimed to evaluate the antibacterial activity of pineapple peel extract using both in vitro and in silico approaches. Ethanolic extracts of pineapple peel were fractionated using silica gel chromatography, and the resulting fractions were analyzed by GC-MS. Antibacterial activity was tested against Gram-positive and Gram-negative pathogens using the agar well diffusion method, and the inhibition zones were recorded. Molecular docking was performed to assess the interaction of identified compounds with the CoA-bound OdaA protein of Pseudomonas aeruginosa (PDB ID:7BOR). Fractions 3 and 4 exhibited the strongest antibacterial activity, producing inhibition zones up to 23 mm against P. aeruginosa at 50 mg/ml. GC-MS identified several bioactive compounds, among which 4-Methoxyphenylglyoxal hydrate showed the highest docking affinity (-5.56 Kcal/mole) and formed two hydrogen bonds with the bacterial target protein. These findings demonstrate that pineapple peel, often considered agricultural waste, is a valuable source of bioactive antibacterial agents. The strong in vitro activity combined with promising in silico binding results highlights its potential in developing novel treatments, particularly against Gram-negative pathogens
Design and In Silico Modeling of Heterocyclic-based Xanthone Derivatives as Potential Anticancer Agents Through Tyrosine Kinase Inhibition Kurniawan, Yehezkiel Steven; Yudha, Ervan; Fatmasari, Nela; Yogaswara, Radite; Pranowo, Harno Dwi; Sholikhah, Eti Nurwening; Jumina, Jumina
Makara Journal of Science Vol. 30, No. 1
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Cancer is one of the deadliest diseases nowadays, and tyrosine kinase receptors play crucial roles in cancer cell survival, differentiation, proliferation, and migration. This study designed and developed a new inhibitor from heterocyclic-based xanthone derivatives to target two tyrosine kinase receptors, epidermal growth factor receptor (EGFR) and platelet-derived growth factor receptor (PDGFR), through in silico screening. Eighteen heterocyclic-based xanthones were evaluated through molecular docking for both receptors. All heterocyclic-based xanthones gave the root mean square deviation (RMSD) value lower than 2.00 Å. Xanthone with isobenzothiazole substituent (iBzThio) was found as the most potent inhibitor with binding energies of -10.60 and -12.90 kcal/mol against EGFR and PDGFR, respectively. Further investigation has been performed through molecular dynamics (MD) simulation for 100 ns. From the results of MD simulations, i.e., RMSD, root mean square fluctuation, radius of gyration, solvent accessible surface area, hydrogen bonds, and binding energy parameters, as well as secondary structure fraction, dictionary of protein secondary structure, and Ramachandran plot, iBzThio demonstrated good stability to interact with the active site of both receptors. The binding energies of IBzThio against EGFR and PDGFR receptors were -12.58 and -12.61 kcal/mol after the MD simulations, indicating its potential application as an effective tyrosine kinase inhibitor.
Comparative Antiscabies Efficacy of Sonneratia alba Extracts: Evaluation of Plant Parts and Concentrations in Mice Maretha, Delima Engga; Taresha, Lara Mukti; Yuliana, Karina; Ariska, Iis; Lestari, Silvia Diah
Makara Journal of Science Vol. 30, No. 1
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This study evaluated the antiscabies efficacy of 70% ethanol extracts from various parts of the mangrove Sonneratia alba (leaves, flowers, bark, and roots) as a potential alternative therapy. The primary objective was to compare the healing effects of the extracts at different concentrations on scabies lesions in mice (Mus musculus). Using a completely randomized design, 24 male Swiss Webster mice were assigned to four groups: a control (K0) group and three treatment groups to receive 10% (K1), 20% (K2), and 30% (K3) extract concentrations topically twice daily. The results demonstrated that the S. alba extracts had significant effects on lesion healing (p < 0.05). The leaf and root extracts exhibited optimal efficacy at a 10% concentration, whereas the bark and flower extracts were the most effective at 30% concentration. These findings suggest that S. alba extracts, particularly those from leaves and roots, hold significant promise as a novel plant-based treatment for scabies, warranting further research into their potential clinical applications.
Anthrone-based Dummy Molecularly Imprinted Polymer for the Selective Detection of Fluorene and Phenanthrene in Simulated River Water Pinandita, Aria; Handayani, Nurrahmi; Iqbal, Muhammad; Triadhi, Untung; Rusnadi, Rusnadi; Djajanti, Samitha Dewi; Amran, Muhammad Bachri; Zulfikar, Muhammad Ali
Makara Journal of Science Vol. 30, No. 1
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A dummy-template molecularly imprinted polymer (DMIP) was synthesized via precipitation polymerization using anthrone as a template analog for the selective analysis of low-molecular-weight polycyclic aromatic hydrocarbons (PAHs), specifically fluorene and phenanthrene. Styrene, benzoyl peroxide, and ethylene glycol dimethacrylate were employed as the functional monomer, radical initiator, and crosslinking agent, respectively. The synthesized polymers were characterized by Fourier-transform infrared spectroscopy, scanning electron microscopy, and particle size analysis. The imprinting factors were 1.16 and 1.09 for fluorene and phenanthrene, respectively, indicating enhanced affinity of the imprinted sites. High-performance liquid chromatography analysis following DMIP-based solid-phase extraction yielded recoveries of 91.49% ± 3.87% for fluorene and 97.25% ± 2.85% for phenanthrene, demonstrating the DMIP’s potential as an efficient sorbent for selective extraction and quantification of low-molecular-weight PAHs in simulated river water.
Application of Microbial Fuel Cells for Leachate Bioremediation: The Effects of Nutrient Nourishment Sholikah, Umi; Chosta, Fidela; Fiqar, Tegar Palyus; Anifah, Eka Masrifatus; Hudayarizka, Riza; Hibino, Tadashi
Makara Journal of Science Vol. 30, No. 1
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Leachate contains a high organic content, which can cause environmental pollution. The organic content in leachate can be removed through bioremediation using microbial fuel cell (MFC) systems to remediate pollutants and generate bioelectricity. Organic matter is important to the MFC process as both a substrate and a nutrient source. This study investigated the effects of glucose and sodium phosphate buffer nourishment on BOD, COD, and TSS removal and bioelectricity generation. This study used leachate as a substrate and a graphite rod with a surface area of about 32.98 cm2 as an electrode. The reactor uses plastic blocks with a 3L capacity. Bioremediation using MFC was conducted in batch experiments under aerobic conditions for 20 days at various glucose dosages. All monitoring processes were conducted in real time using the internet of things (IoT). The glucose variations used were 10% (b/v) and 20% (b/v) with the addition of a sodium phosphate buffer. The removal efficiencies of BOD, COD, and TSS with 10% glucose and sodium phosphate buffer addition were 86.05%, 81.84%, and 75.50%, respectively. The highest electrical voltage was observed upon the addition of 20% glucose and sodium phosphate buffer at about 900 mV.
A Ferrocene-Modified Carbon Electrode Prepared from Coconut Shell Char for Cu(II) Detection in Water Aulia, Nabila Putri; Rahmawati, Fitria; Masykur, Abu; Heraldy, Eddy
Makara Journal of Science Vol. 30, No. 1
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A ferrocene (Fc)-modified carbon electrode was prepared from coconut shell char (CSC), which was activated with NaOH to produce an activated coconut shell carbon (Ac-CSC). The carbon electrode was designed as a printed-carbon electrode consisting of working, counter and reference electrodes in a single piece, called a screen-printed carbon electrode, or SPCE. An Fc solution was applied to the working electrode part at 10%, 20% and 30% mass of the SPCE, producing an SPCE-Fc as an electrochemical sensor for Copper ions Cu(II) detection. The prepared activated carbon was analysed by XRD, FTIR, SEM/EDX, surface area analysis and impedance measurement to determine its diffraction pattern, available specific functional groups, morphology, elemental content, surface area and electrical conductivity. The results showed that CSC consists of 52.89% amorphous carbon, 19.65% nitrogen and 23.12% oxygen. FTIR analysis showed C=O, C=C, C-H, C-O, O-H, N-H and C-S vibrations. The Ac-CSC provided an electrical conductivity rate of 26.025 S/cm. Cyclic voltammetry analysis of the Cu(II) solution with SPCE-Fc10% provided the highest current density among the other Fc contents. Therefore, a further study used SPCE-Fc10% to determine the limit of detection (LoD), interference effects, pH and scan rate effects, the repeatability of the analysis and the reproducibility of SPCE-Fc10% for Cu(II) detection. The LoD was 0.055 mM. The electrode fabrication also showed good reproducibility, as evidenced by a repeatability coefficient (R) of 0.06. The interference test showed that the SPCE-Fc10% selectively detected Cu(II), even in the presence of 5% volume of Pb(II) and Co(II) in the Cu(II) solution.
Strong Gravitational Lensing of Balart-Vagenas Regular Black Holes Pervez, Akif; Ud Din, Hassan Moin; Ramdhan, Handika Satrio
Makara Journal of Science Vol. 30, No. 1
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Gravitational lensing is an integral part of Einstein general theory of relativity. The existence of singularity in standard black holes is a hurdle for understanding the properties of black holes. The introduction of nonlinear electrodynamics (NLED) offers an intriguing possibility of constructing non-singular black hole. Gravitational lensing by the photon sphere probes the physical properties of lens objects such as black holes. This work presents a strong deflection limit analysis in a general asymptotically flat, stationary, spherically symmetric spacetime. We extend the analysis of the light deflection around the photon sphere-complete capture, and set a strong field limit that is opposite to the usual weak field limit. The deflection angle always diverges logarithmically when the minimum impact parameter is reached. We apply this general formalism to a singular Reissner-Nordström and a non-singular regular black hole. By comparing the coefficients characterizing these metric functions and observing the different collapsing objects, they are characterized by strong field limits. These coefficients are directly connected to the observables, such as the angular position and the magnification of the relativistic images. A supermassive black hole is modeled as a regular charged black hole at the galaxy's core

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