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Hang Tuah Medical Journal
Published by Universitas Hang Tuah
ISSN : 16931238     EISSN : 25984861     DOI : https://doi.org/10.30649/htmj.v19i2
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Medicine & Pharmacology Nursing Public Health
Hang Tuah Medical Journal: is published by Faculty of medicine, Universitas Hang Tuah with p-ISSN: 1693-1238 e-ISSN: 2598-4861. Its disciplinary focus is medical science and speciality in bio marine science. Hang Tuah Medical Journal is published in English and Indonesia for May and November. Each 90-100 page edition contains between nine and eleven scientific articles on research, case reports and study literature. Contributors of Hang Tuah Medical Journal included: medical researchers, dental practitioners, lecturers, and students drawn from Indonesia and a wide range of other countries. Hang Tuah Medical Journal as the open-access journal has been indexed by SINTA-Science and Technology Index, Garuda, Google scholar Hang Tuah Medical journal has been certificated as a Scientific Journal by Sinta (Science and Technology Index) S5 . valid until Volume 17 No.1, 2017.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 161 Documents
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Pengaruh Penggunaan Obat Antihipertensi Terhadap Sindroma Mata Kering di Surabaya WISNU TRI PAMUNGKAS; INDIRA R. A; IRMA A. PASARIBU
HANG TUAH MEDICAL JOURNAL Vol 17 No 2 (2020): Hang Tuah Medical Journal
Publisher : Universitas Hang Tuah

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Abstract Background: Hypertension prevalence in Indonesia is increasing to reach 25.8% in the population aged 18 years and over. Amlodipine is one of the drugs for hypertension therapy which is included in the Calcium Channel Blocker (CCB) class. The use of antihypertensive medication itself is one of the risk factors that cause dry eye syndrome. Purpose: This study aims to determine the effect of the use of antihypertensive drugs on dry eye syndrome in patients with hypertension at Jagir Public Health Center in Surabaya working area. Methods: This study was an observational analytic study with a cross-sectional method. The subjects in this study were 48 respondents found divided into 2 groups namely, the group taking antihypertensive drugs> 6 months and not taking medication. The DEQ-5 questionnaire was completed and Schirmer I was examined. Results: Descriptive analysis of the Schirmer I test for the frequency of dry eye syndrome was higher in respondents who took antihypertensive drugs than those who did not take antihypertensive drugs. The results of statistical analysis using the chisquare test of significance that is equal to <0.001 or it can be said that p <α (0.05), indicates there is an effect of antihypertensive drug administration on dry eye syndrome based on the Schirmer test in hypertension patients at Jagir Public Health Center in Surabaya.. Conclusion: The use of antihypertensive drugs has an effect on dry eye syndrome in patients with hypertension at the Jagir Public Health Center in Surabaya
Pengaruh Luka Iris Pada Tikus Dengan Paparan Hidrogen Peroxida 3% terhadap Epitelisasi dan Pembentukan Eksudat pada Permukaan Epitel Kulit HARMAN AGUSAPUTRA; MARIA SUGENG; AYLI SOEKAMTO; ATIK WULANDARI
HANG TUAH MEDICAL JOURNAL Vol 17 No 2 (2020): Hang Tuah Medical Journal
Publisher : Universitas Hang Tuah

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Abstract Background: Hydrogen peroxide (H2O2) as antiseptic has been used frequently to clean woundsin in hospitals and clinics. Hydrogen peroxide has the effectof strong oxidative that can kill pathogens. It can clean up debris and necrotic tissuesin wounds. Hydrogen peroxidealso has hemostatic effect that can help to stop bleeding. Besides antiseptic effects, hydrogen peroxide i s suspected of having negative effect in wound healing. Hydrogen peroxide presumably could cause delayed wound healing by exudate formation and delayed epithelial growth. Method: This study was conducted in the laboratory using 48 white mice that were divided into 2 groups. All the mice were purposely wounded. Afterwards in one group the wounds were clean up using hydrogen peroxide, while in the other group without hydrogen peroxide as control. The wounds of both groups were observed on day 1, day 3 and day 7. On day 1 and day 3, both groups did not show significant difference. Result : on day 7 showed that the wound healing in hydrogen peroxide group were delayed. Fifty percent of them had the formation of exudate and 62.5% of them showed delayed epithelial growth. Conclusion : This study could show hydrogen peroxide as wound antiseptic has delayed wound healing effect.
Pengaruh Pemberian Virgin Coconut Oil terhadap Kadar Kreatinin dan Urea Nitrogen Darah Rattus Norvegicus Jantan NOVIANE ANGRELLA; ROOSTANTIA INDRAWATI; LESTARI DEWI
HANG TUAH MEDICAL JOURNAL Vol 17 No 2 (2020): Hang Tuah Medical Journal
Publisher : Universitas Hang Tuah

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Abstract Background: Virgin Coconut Oil (VCO) is a functional product that is highly favored and have been widely applied in the everyday lives of society. The increase of the frequencies and duration of VCO consumption is suspected that VCO could negatively impact the target organ. The kidney is a vital organ in the human body, it is responsible for clearing out the residual waste products of metabolism in the body. The evalution of the kidney‟s function can be done through the measurement of creatinine and blood urea nitrogen. The purpose of this study is to determine the effect of VCO administration on kidney function. Method: 24 male wistar rats that are divided into 4 groups, which are listed as follows, K(-) or a negative-controlled group, P(1) or the first group of rats that are given VCO with a dose of 2mL/200gr of the rats‟ total BW/day, P(2) or the second group of rats that are given VCO with a dose of 3mL/200gr of the rats‟ total BW/day, and P(3) or the third group of rats that are given VCO with a dose of 4mL/200gr of the rats‟ total BW/day for 28 day Results: Administrating VCO with a dose of 2mL/200gr and 3mL/200gr of the rats‟ total BW/day does not affect the blood‟s creatinine level while with a dose of 4mL/200gr of the rats‟ total BW/day decreases the blood‟s creatinine level. Administrating VCO with a dose of 2 mL/200gr, 3 mL/200gr, and 4 mL/200gr of the rats‟ total BW/day does not affect the level of blood urea nitrogen. Conclusion: Administration of VCO dose of 4 mL / 200 g BW rat / day significantly decreased blood creatinine levels in experimental animals, while other doses did not affect the creatinine levels or blood urea nitrogen levels
Peran Ekstrak Anggur Laut terhadap Penurunan Kadar Kolesterol LDL Rattus norvegicus Jantan yang Mendapat Diet Tinggi Lemak RONALDO LAU; SULISTIANA PRABOWO; RIAMI
HANG TUAH MEDICAL JOURNAL Vol 17 No 2 (2020): Hang Tuah Medical Journal
Publisher : Universitas Hang Tuah

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Abstract Background: High fat diet increase the absorption of lipid in the intestinum, that can lead to increase LDL cholesterol level in the blood. Sea grapes extract (Caulerpa racemosa) contains antioxidant polyphenolic group that can reduce MTP and ACAT-2 in the body that can decrease LDL cholesterol level in the blood.The purpose of this study is to know the effect of sea grapes extract on decreasing LDL cholesterol of white male Wistar rats (Rattus norvegicus) fed with high fat diet. Method: 24 white male Wistar rats, that divided into 3 groups: 1) group of rats fed with standard diet for 28 days; 2) group of rats fed with high fat diet for 28 days; 3) group of rats fed with high fat diet for 28 days and given 10 gram/kg body weight/day of sea grapes extract on 15th-28th days. Then the blood LDL cholesterol level measured on the 29th day. Result : One-Way ANOVA Test showed there was significant difference (p=0.004) of LDL level between the group of rats fed with standard diet (12.37 mg/dl) compared to group of rats fed with high fat diet (17.87 mg/dl). There was significant difference (p=0.001) of LDL level between the group of rats fed with high fat diet (17.87 mg/dl) compared to group of rats fed with high fat diet and sea grapes extract (10.12 mg/dl). Conclusion: high fat diet significantly increase blood LDL cholesterol level and sea grapes extract (Caulerpa racemosa) significantly decrease blood LDL cholesterol level
Infark Serebri Tipe Kardioemboli pada Pasien dengan Fibrilasi Atrium ERIC HARTONO TEDYANTO; KEN CHRISTIAN KAWILARANG; FEISAL TANJUNG
HANG TUAH MEDICAL JOURNAL Vol 17 No 2 (2020): Hang Tuah Medical Journal
Publisher : Universitas Hang Tuah

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Abstract Background: Stroke is the leading cause of disability and the second most common cause of death in the world. Atrial fibrillation (AF) is the major risk factor for embolic stroke. Patients with atrial fibrillation have a 5 times much more risk of stroke to those who do not have atrial fibrillation. Case Report: A 40-year-old woman came to the Emergency Unit with chief complaints the left-sided limbs suddenly weakened while cooking. On ECG examination there is an irregular rhythm (irregular P-P), leading to an atrial fibrillation. CT scan revealed hypodense lesions on the temporal part of the left side, leading to a cerebral infarction. Discussion: AF puts patients at an increased risk for stroke because blood cannot be properly pumped, which caused stagnation and formed a blood clot. This clot can be released from ventricle and travel to the other organ via artery, including brain and block the blood flow which can result a infarct stroke. Conclusion: Close supervision and routine control are needed for patients with heart rhythm disorders, especially atrial fibrillation to prevent embolic stroke
Potensi Daun Kastuba (Euphorbia Pulcherrima) Sebagai Antimalaria Plasmodium Falciparum ELVINA VERONICA; NI KADEK SINTA DWI CHRISMAYANTI
HANG TUAH MEDICAL JOURNAL Vol 18 No 1 (2020): Hang Tuah Medical Journal
Publisher : Universitas Hang Tuah

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Abstract Introduction: Around 41% of people in the world at risk of malaria due to plasmodium infection. Plasmodium falciparum is the most dangerous malaria infection compared to another plasmodium because it causes 90% of total malarial deaths. ACT (Artemisinin Combination Therapy) is the gold standard of malaria medicine, is starting to become resistant, so other alternatives are needed. Poinsettia plants (Euphorbia pulcherrima) are ornamental plants and contain compounds that potential as anti-parasites. Objective: To aims the potential of poinsettia leaves as an antimalarial alternative to Plasmodium falciparum in malaria treatment. Methods: Literature studies using in vivo, in vitro, in silico research articles, and literature reviews from national and international journals accessed from Google Scholar, Elsevier, Science Direct, and Pubmed in the last 10 years using malaria, antioxidants, anti-malaria, Plasmodium falciparum, and Euphorbia pulcherrima as keywords. There were 22 relevant articles used in this literature review. Results: Antioxidants in poinsettia leaves inhibited plasmodium growth by inhibit nutrient transport at new permeation pathways and prevent hemozoin ban. Terpenoids in poinsettia inhibit schizont and trophozoite in an earlier asexual phase of Plasmodium falciparum by inhibiting isoprenoid biosynthesis. Conclusion: Poinsettia (Euphorbia pulcherrima) has the potency to be an antimalarial alternative against Plasmodium falciparum. Need further research about the dosage and side effects of the usage
Acute Cerebellar Ataxia As A Parotitis Complication: Clinical Evaluation And Management OKKY PRASETYO; ERNY PRASETYO; DENNY PRASETYO
HANG TUAH MEDICAL JOURNAL Vol 18 No 1 (2020): Hang Tuah Medical Journal
Publisher : Universitas Hang Tuah

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ABSTRACT Acute cerebellar ataxia is a motor control or coordination disorder that can be caused by several things, most often in children due to viral infections including paramyxovirus, head trauma, stroke and intoxication with varying prognosis. The paramyxovirus causes parotitis is highly neurotrophic with aseptic meningitis, encephalitis, hydrocephalus, decreased blood flow on the cerebellum and vasculitis. Those mechanisms implicated on many clinical symptoms, including cerebellar ataxia. Management is only limited to supportive and rehabilitative because symptoms will improve within 2-3 weeks
Pendekatan Pelayanan Kesehatan Holistik-Komprehensif Pada Kasus Menopause FEBRI ENDRA BUDI SETYAWAN; FENY TUNJUNGSARI; RETNO LESTARI
HANG TUAH MEDICAL JOURNAL Vol 18 No 1 (2020): Hang Tuah Medical Journal
Publisher : Universitas Hang Tuah

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Abstract Menopause is a natural process that occurs in the reproductive cycle of women aged over 40 years. These changes will affect physical and psychological state of a woman, and they are not ready to deal with this condition. Family doctors should provide information about menopause and how to manage various changes during menopause. The results of previous studies were very limited in examining various menopausal management options which were safe, comfortable and have less negative impacts. This study aimed to examine a holistic-comprehensive approach in the case of menopause. Systematic review results were obtained from 55 reference sources through Science Direct, Google Scholar, Proquest Health and Medical Complete, Proquest Nursing and Allied Health Source from 2010 to 2019. The systematic review results explain that the management of menopause cases can be optimized through a holistic-comprehensive approach. Holistic aspect includes the components of biopsychosocial and comprehensive needs which are carried out through promotive, preventive, curative and rehabilitative efforts. Menopausal women often not only experience physical symptoms, but also psychological symptoms which will impact their quality of life. It can be concluded that a holistic-comprehensive approach can be carried out as an effort by family doctors to optimize the management of menopause
Analisa Aktivitas Antibakteri Rebusan Daun Sirih Dengan Rebusan Daun Kemangi Terhadap Pertumbuhan Bakteri Streptococcus mutans ENNY WILLIANTI; THEODORA; WAHYUNI DYAH PARMASARI
HANG TUAH MEDICAL JOURNAL Vol 18 No 1 (2020): Hang Tuah Medical Journal
Publisher : Universitas Hang Tuah

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ABSTRACT Background: Betel leaf contains essential oils consisting of bethelphenol, kavikol, sesquiterpenes, hydroxycavikol, cavibetol, estragol, eugenol and carvacrol. Essential oils are antibacterial due to the presence of phenol compounds and their derivatives that can denature the bacterial cell proteins. Basil leaves contain compounds from essential oils, namely 1,8-cineole, ß-bisabolene, and methyl eugenol. These three ingredients are soluble to ethanol and can cause damage to the cell membranes of the Streptococcus mutans bacteria, which are members of the normal oral flora but can turn into pathogens if the balance of normal flora is disturbed. The aim of this study was to determine the difference in the activity of the antibacterial of decoction betel leaf (piper betle L. ) with a decoction of basil leaves (ocimum sanctum) against growth of bacteria Streptococcus mutans (in vitro study). Method: this observational research with disk diffusion techniques. This study observed and measured the diameter of the inhibitory zone in MHA formed by decoction of betel leaf (piper betle L) and basil leaf (ocimum sanctum) in units of millimeters (mm). There were 2 groups with 16 replications. Results: the results of the description test showed that the antibacterial activity of the betel leaf decoction and the highest decoction of basil leaf was 17 mm and the lowest was 15 mm, but the average antibacterial value of betel leaf decoction (15,81) greater than the average value of antibacterial activity of basil leaf (15.75). This is because there are chemicals contained in betel leaf similar as contained in basil leaf, namely essential oils. Conclusion: there is no difference in the antibacterial activity of decoction betel leaf with decoction basil leaf against growth of bacteria Streptococcus mutans.
Pengaruh Pemberian Ekstrak Teripang Pasir terhadap Hambatan Pertumbuhan Shigella Dysentriae Secara In Vitro FERIZAL NEGERI SAMUDRA; RETNO BUDIARTI; Irmawati Dikman
HANG TUAH MEDICAL JOURNAL Vol 18 No 1 (2020): Hang Tuah Medical Journal
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Abstract Background; In Indonesia, most diarrhea disease in 1995 to 2001 are caused by Shigella spp. Shigella spp infection can cause various symptom dan complication. Generally, the treatment by using antibiotic can cause antibiotic resistance. Sea cucumber (Holoturia scabra) is an herb that known, available, and easy to consume by society and has an antibacterial effect. Therefore, further research to study the effect of Holoturia Scabra on Shigella Dysentriae growth in vitro is needed. Objectives: The goal of this research is demonstrate the effect of sea cucumber (Holoturia scabra) to the growth of the Shigella dysentriae bacteria in vitro. Method: The method in this research is Posttest Only Control Group. There are 6 groups, 4 types of and 2 control groups. The concentration of the treatment group is 100%,50%, 25%, and, 12.5% while for positive control tests using chloramphenicol and aquadest as a negative control. Result: The result showed there is an influence on the intake of sand cucumber to the growth of the Shigella dysenteriae. Conclusion: Sea cucumber (Holoturia scabra) inhibit the growth of Shigella dysenteriae.

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