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Murdani Abdullah
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Divisi Gastroenterologi, Departemen Ilmu Penyakit Dalam, FKUI/RSUPN Dr. Cipto Mangunkusumo, Jl. Diponegoro No. 71 Jakarta 10430 Indonesia
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The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy
Published by The Indonesian Society for Digestive Endoscopy
ISSN : 14114801     EISSN : 23028181     DOI : -
Core Subject : Health,
Medicine & Pharmacology
The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy is an academic journal which has been published since 2000 and owned by 3 Societies: The Indonesian Society of Gastroenterology; Indonesian Association for the Study of the Liver; The Indonesian Society for Digestive Endoscopy. The aim of our journal is to advance knowledge in Gastroenterology, Hepatology, and Digestive Endoscopy fields. We welcome authors for original articles, review articles, and case reports in the fields of Gastroenterology, Hepatology, and Digestive Endoscopy.
Arjuna Subject : Kedokteran - Ilmu Pencernaan
Articles 771 Documents
 73   74   75   76   77 
Oxidative Stress and the Severity of Gastroesophageal Reflux Disease: Is There Any Correlation? Imro'ati, Tri Asih; Sugihartono, Titong; Widodo, Budi; Nefertiti, Eva Pravitasari; Wibawa, I Dewa Nyoman
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 25, No 3 (2024): VOLUME 25, NUMBER 3, December, 2024
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/253202445-52

Abstract

Background: Oxidative stress plays a crucial role in the inflammatory response of the oesophageal epithelium; hence, therapies that affect oxidative stress may be a new approach in GERD management.  The objective is to analyze and determine the correlation between Total Oxidant Status (TOS), Total Antioxidant Status (TAS), and Oxidative Stress Index (OSI) with severity of GERD.Methods: This is an observational analytic study using a cross-sectional design,that  conducted at the Endoscopic Unit of three hospitals in Surabaya, which held from June 2020 to March 2021. The 18 to 60 years old subjects who meet the GERD-Q score 8-18 and not meet the exclusion criteria undergo an endoscopic examination to determine the GERD severity and blood test. Data analysis was using the Spearman rank correlation test.Results: This study indicates that most subjects are women, with mean age 39.31±10.99 years, most are GERD grade A, the mean value of TOS, TAS, ISO respectively is 5.18±1.60, 1.58±0.18, and 3.36±1.35. The laboratory test results show insignificant different based on GERD degree.  There is a non-significant positive correlation between TOS and GERD severity, a significant negative correlation  between TAS and  GERD severity, and a significant positive correlation between OSI and GERD severity (respectively, r = 0.121, p = 0.266 vs r = -0.323, p = 0.044 vs r = 0.345, p = 0.033).Conclusion:  The TAS and OSI may be correlated to the GERD severity but still need further investigations. 
Prevalence and Risk Factors of Functional Dyspepsia: A Population-Based Study Aydın, Selami; Oner, Can; Cetin, Hüseyin; Simsek, Engin Ersin
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 25, No 3 (2024): VOLUME 25, NUMBER 3, December, 2024
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/25320249-15

Abstract

Background: Functional dyspepsia is one of the most common functional gastrointestinal disorders and affects more than 20% of the population. This study aimed to determine the prevalence of functional dyspepsia according to Rome IV criteria and its relation with social determinants.Methods: This cross-sectional study was conducted in the Department of Family Medicine, Kartal Dr Lutfi Kırdar City Hospital Tuzla Training and Research Primary Health Care Center, Istanbul, Turkey from May - December 2019. The participants (aged 18-78) were selected using randomized sampling by a family physician according to the records. All participants underwent a clinical interview based on a questionnaire based on Rome IV criteria. The factors that were significant in the binary comparison were taken into logistic regression analysis (Backward: LR) to determine the causal relationship. P-values 0.05 were considered statistically significant.Results: A total of 350 participants were enrolled to the study (43.4 %; n=152 male and 56.6%; n=198 female). The prevalence of functional dyspepsia was 16.9% (n=59). 62.7% (n=37) of dyspeptic patients had epigastric pain syndrome and 67.8% (n=40) of them had postprandial distress syndrome. Daily tee consumption, body mass index, and family history were found as social factors related to functional dyspepsia.Conclusion: The prevalence of functional dyspepsia was 16.9% according to Rome IV criteria and most of the patients were female. Obesity was an important factor related to dyspepsia. Dyspeptic symptoms must investigate especially in obese female patients. 
Incidence and Factors of Hepatocellular Carcinoma in Hepatitis C Virus Patients Achieving Sustained Virological Response After Direct-Acting Antiviral Treatment Kurniawan, Juferdy Kurniawan; Wicaksono, Dhaneswara Adhyatama; Yunihastuti, Evy; Masnjoer, Arif
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 25, No 3 (2024): VOLUME 25, NUMBER 3, December, 2024
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/253202424-31

Abstract

Background: The incidence and risk factors for Hepatocellular Carcinoma (HCC) in Hepatitis C Virus (HCV) patients who have achieved Sustained Virological Response (SVR) after Direct-Acting Antiviral (DAA) therapy are not well established. Considering there are differences in DAA types, virus genotypes, and patient profiles in Indonesia, this study was conducted to assess the incidence and factors influencing HCC in HCV patients after SVR post DAA therapy. The objective of this study to determine the incidence and factors influencing HCC in HCV patients achieving SVR after DAA treatment.Methods: Retrospective cohort study conducted at Cipto Mangunkusumo National General Hospital, sample of HCV patients had SVR after DAA therapy in 2017 – 2019, followed until 2024. Patients were screened for abdominal ultrasound, alpha-fetoprotein (AFP) and 3-phase abdominal CT scan, if indicated. Descriptive, bivariate analysis with Fisher's exact, and multivariate analysis with logistic regression were conducted.Results: Among 180 subjects, the incidence and incidence ratio of HCC is 4.4% (0.91/100PY). Significant correlation in bivariate analysis from the variables liver cirrhosis (RR 10.5; CI 95% (1. 32 – 83.5); p = 0.0073) and type 2 DM (RR 8.47; CI 95% (2, 3 – 31.1) p = 0.0048). In multivariate analysis, there was significant correlation from type 2 DM variable (aRR 3.1; CI 95% (0.86 – 3.83); p=0.002).Conclusion: The incidence of HCC reaches 4.4% of the total population. Type 2 DM has significant correlation with the incidence of HCC in HCV patients who achieve SVR after DAA treatment. 
Effective Combination Therapy with Nizatidine and Acotiamide for Functional Dyspepsia Kajihara, Yusaku
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 26, No 1 (2025): VOLUME 26, NUMBER 1, April, 2025
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/261202555-58

Abstract

Background: The two subgroups of Functional Dyspepsia (FD), including Postprandial Distress Syndrome (PDS) and Epigastric Pain Syndrome (EPS), can overlap. PDS–EPS overlap tends to reduce patients’ quality of life. Combination therapy with nizatidine and acotiamide may improve the symptoms of FD, including PDS–EPS overlap. A previous study reported the combined effect of rabeprazole and acotiamide. This study aimed to evaluate nizatidine as an alternative to rabeprazole.Methods: This single-center retrospective study analyzed 66 patients with FD, including 45 and 21 patients receiving nizatidine/acotiamide and rabeprazole/acotiamide therapies, respectively. The regimen comprised nizatidine 150 mg twice daily, rabeprazole 10 mg once daily, and acotiamide 100 mg thrice daily. No prokinetics other than acotiamide (e.g., rikkunshito and mosapride) were simultaneously administered. The following characteristics were investigated: age, sex, diabetes mellitus, Parkinson’s disease, mental illness, subgroups of FD (PDS, EPS, or PDS–EPS overlap), and treatment-emergent adverse events. Symptom improvement rates following treatment were calculated and compared.Results: Although differences in the FD subgroups were significant in terms of patients’ backgrounds, no significant difference in PDS–EPS overlap rates was observed (55.6% [25/45] vs. 61.9% [13/21], p = 0.79). The difference in symptom improvement rates between nizatidine/acotiamide and rabeprazole/acotiamide therapies was not significant (86.7% [39/45] vs. 85.7% [18/21], p = 1).Conclusion: Nizatidine/acotiamide therapy demonstrated efficacy comparable to rabeprazole/acotiamide therapy in treating FD. Patients with FD frequently experience treatment difficulties owing to various underlying factors; however, nizatidine/acotiamide therapy with a high symptom improvement rate is a promising therapeutic option in refractory FD.Keywords: Dyspepsia, nizatidine, rabeprazole
Crohn’s Disease with Comorbidites of Syndrome of Inappropriate Anti Diuretic Hormone (SIADH) caused by Pulmonary Tuberculosis Steven, Rios; Miro, Saptino; ., Arnelis; Yoga, Vesri; Viotra, Deka; Elvira, Dwitya; ., Wahyudi
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 26, No 1 (2025): VOLUME 26, NUMBER 1, April, 2025
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/261202588-92

Abstract

Crohn's disease is an inflammatory condition of the intestines characterized by lesions that can affect the entire digestive tract from the mouth to the anus. Globally, the prevalence of inflammatory bowel disease has increased over the past 20 years, rising from 3.32 million cases in 1990 to 4.9 million cases in 2019. Previously, the management of Crohn’s disease followed the step-up therapy approach; however, this method led to higher recurrence rates. The current approach utilizes top-down therapy, as research data indicate that the remission rate is 57% with top-down therapy compared to 25% with step-up therapy. Syndrome of Inappropriate Antidiuretic Hormone (SIADH) can be caused by pulmonary tuberculosis. A 44-year-old male patient was diagnosed with Crohn’s disease based on a colonoscopy examination, which suggested chronic active colitis with mild activity and crypt distortion consistent with Crohn’s disease. An esophagogastroduodenoscopy (EGD) revealed chronic gastritis, while a histopathological examination of the colon confirmed findings consistent with Crohn’s disease. The diagnosis of pulmonary tuberculosis was established using a rapid molecular test (TCM) with positive results. Hyponatremia with hypoosmolar euvolemia was diagnosed based on serum sodium levels of 128 mmol/L, serum osmolality of 269 mosmol/L, urine osmolality of 288 mosmol/L, and urine sodium of 73 mosmol/L. Treatment included 5-ASA and anti-tuberculosis medications. Crohn’s disease increases morbidity rates and is not limited to developing countries. It is caused by immune system dysregulation, which can predispose patients to secondary infections such as tuberculosis. Pulmonary tuberculosis, in turn, can lead to SIADH.Keywords: Crohn’s disease, pulmonary tuberculosis, SIADHTop of Form
Correlation of Short Chain Fatty Acid Levels in Patients Non-Alcoholic Fatty Liver Disease with Obesity Mustika, Syifa; Safira, Zahra; Rosandi, Rulli; ., Supriono; Wibowo, Bogi Pratomo; Muthiah, Mark
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 26, No 1 (2025): VOLUME 26, NUMBER 1, April, 2025
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/261202528-35

Abstract

Background: NAFLD has the potential to develop into severe diseases like NASH and cirrhosis and is often linked to obesity, although it can also occur in non-obese individuals, complicating diagnosis. SCFAs, produced by intestinal bacteria through the fermentation of dietary fibers, are essential for metabolic health and may influence liver fat and weight regulation. The purpose of this study was to explore the connection between SCFA levels and the severity of NAFLD, including liver fibrosis, in individuals both with and without obesity.Methods: A cross-sectional investigation of 16 NAFLD patients with obesity and 11 without, with stool samples analyzed for SCFA via gas chromatography. Obesity was defined by abdominal circumference. Data were analyzed using Spearman’s correlation, Eta’s correlation, and Pearson’s test.Results: Levels of SCFAs, including butyrate, propionate, and acetate, were significantly correlated in both obese and non-obese individuals diagnosed with NAFLD (r=0.618, p=0.001; p=0.019; p=0.037; p=0.012). Obesity was found to be positively associated with the severity of NAFLD (r=0.582, p=0.001). However, obesity did not exhibit a statistically significant connection with liver fibrosis (p = 0.351).Conclusion: Obese NAFLD patients exhibited decreased SCFA levels compared to non-obese individuals. Central obesity was linked to NAFLD severity but not fibrosis progression. SCFAs and obesity are crucial in the pathogenesis of NAFLD.Keywords: Central obesity, gut microbiota, NAFLD, SCFA
Approach to Patients with Increased Liver Biochemical and Function Tests : A Literature Review Mustika, Syifa; Gersom, Camoya; Kongkam, Pradermchai
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 26, No 1 (2025): VOLUME 26, NUMBER 1, April, 2025
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/261202559-67

Abstract

This review article provides a comprehensive examination of liver injury patterns, specifically focusing on hepatocellular and cholestatic patterns, and their respective diagnostic approaches. It highlights the importance of differentiating between these patterns through detailed clinical evaluations and the use of specific liver enzymes, including aminotransferases, bilirubin, alkaline phosphatase, gamma-glutamyl transpeptidase, 5'-nucleotidase, and lactate dehydrogenase. The review further explores liver function tests, such as albumin and prothrombin time, which are crucial in assessing liver function and guiding clinical management. A wide range of liver diseases is discussed, with a focus on those exhibiting hepatocellular patterns, such as viral hepatitis, acute liver failure, fatty liver disease (both alcoholic and non-alcoholic), and drug-induced liver injury (DILI), as well as other conditions like ischemic and autoimmune hepatitis. Cholestatic illnesses such as primary biliary cholangitis (PBC), primary sclerosing cholangitis (PSC), bile duct blockages, and genetic cholestatic syndromes are also investigated. This study seeks to improve physicians' and researchers' awareness of liver diseases, serve as a valuable resource for future research and teaching, and contribute to the improvement of diagnostic and therapeutic techniques in hepatology.Keywords : Cholestatic, hepatocellular, liver enzymes, liver functions
The Evolution of Double Pylorus Associated With NSAIDs-Induced Gastric Ulcer Sihombing, Rasco Sandy; Agustinus, Taolin; Syam, Ari Fahrial
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 26, No 1 (2025): VOLUME 26, NUMBER 1, April, 2025
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/261202593-97

Abstract

Double pylorus is an uncommon condition where two communicating channels between the gastric antrum and duodenal bulb exist and found incidentally by esophagogastroduodenoscopy. This case report presented a 77-year old Timorese man with long-term frequent use of nonsteroidal anti-inflammatory drugs (NSAIDs) who came to hospital because of hematemesis and melena. The initial endoscopy showed gastric ulcer and the double pylorus. Nine months later, the double pylorus structure fused into one large opening. This elderly patient with a history of NSAIDs abuse was diagnosed with acquired double pylorus due to a gastric ulcer complication. The fusion of the two channels occurred as a result of septum destruction, likely caused by fistulous tract ulceration or mechanical damage from food bolus. This structure predisposes the patient to bile regurgitation and ulcer recurrence, emphasizing the need for continued monitoring and avoidance of ulcerogenic factors. Keywords : double pylorus, gastroduodenal fistula, NSAIDs, gastric ulcer, follow-up
Nizatidine and Acotiamide: New Treatment Combination for Functional Dyspepsia? Renaldi, Kaka
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 26, No 1 (2025): VOLUME 26, NUMBER 1, April, 2025
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/26120251-3

Abstract

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Diagnosis and Management of Portal Vein Thrombosis in Liver Cirrhosis Kurniawan, Cynthia; Jasirwan, Chyntia Olivia Maurine
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 26, No 1 (2025): VOLUME 26, NUMBER 1, April, 2025
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/261202568-75

Abstract

Portal vein thrombosis is formation of thrombus in main portal vein and its branches, that may also affect superior or mesenteric veins. Rebalanced coagulation system and changes in hepatic portal venous flow augment risk of portal vein thrombosis. Modalities to identify portal vein thrombosis include ultrasonography, contrast enhanced Computed Tomography (CT), and Magnetic Resonance Imaging (MRI). The management of portal vein thrombosis in hepatic cirrhosis is challenging due to intricate balance between thrombosis and bleeding complicating treatment decision. Treatment option consisted of close monitoring, anticoagulation, thrombolysis, and trans-jugular intrahepatic portosystemic shunt (TIPS). Anticoagulant options for management of portal vein thrombosis encompass Low Molecular Weight Heparin (LMWH), Vitamin K Antagonist (VKA), and Direct Oral Anticoagulant (DOAC). There is still no consensus regarding the thrombolysis for the management of portal vein thrombosis in cirrhosis due to lack of evidence. TIPS may be considered in portal vein thrombosis with insufficient response or contraindication to anticoagulation, repeated variceal bleeding, and/ or refractory ascites which unable to be controlled by medical or endoscopic management. This review aims to discuss the current update in diagnosis and management of portal vein thrombosis in liver cirrhosis.Keywords: Cirrhosis, portal vein thrombosis, anticoagulant

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